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Samuel Eiduson Student Lecture

The Samuel Eiduson Student Lectureship was initiated in 1993 to recognize extraordinarily meritorious contributions by a neuroscience graduate student. This lectureship was named in honor of Dr. Samuel Eiduson for his many years of dedication to the Neuroscience Program and the Brain Research Institute. Dr. Eiduson served as the Chairman of the Interdepartmental Program for Neuroscience from its inception in 1972 until 1985, and was instrumental in forwarding the careers of many UCLA neuroscientists and graduates. Each year one student who has conducted especially commendable work during his/her thesis study delivers a lecture describing his/her work.

This year the Twenty-First Samuel Eiduson Student Lecture, “Multimodality MRI-based Brain Network Analysis: Applications to Genetic Risk for Alzheimer’s Disease,” was presented May 14, 2013, by Jesse Brown, a senior graduate student working in the laboratory of Dr. Susan Bookheimer, in the Interdepartmental Ph.D Program for Neuroscience.

Jesse entered the NSIDP in the fall of 2007, and defended his dissertation in March of this year, and has already accepted a post-doctoral position at UCSF with William Seeley, a recent recipient of a McArthur “genius” award. From the start, it was clear that Jesse was going to excel in neuroscience. During his undergraduate years at Berkeley, he majored in cognitive science. He studied a range of specialized areas including neuroscience, linguistics, philosophy and artificial intelligence. Upon graduation, he spent several years gaining research experience before applying to graduate school. He worked with Scott Makeig at UCSD, where he worked on analyzing data from combined fMRI/EEG studies, which are highly innovative and technically extremely challenging. He then worked at Scripps in Dr. Francisco Asturias’ structural biology laboratory. One project focused on resolving the structure of the E. coli holoenzyme using electron microscopy; this project involved resolving the structure of human RNA polymerase II, obtaining images of human RNAP II at 11.5A using electron microscopy; this work was published in PLoS Biology; a second project involved a subcomplex of the transcriptional protein mediator, which resulted in authorship on a paper in Molecular Cell. All of this was accomplished in only two years at Scripps.

On entering the NSIDP, Jesse expressed a strong interest in applying his research skills to patients with disorders of aging. At first, Jesse rotated in Russ Poldrack’s lab, where he began working on machine learning approaches to fMRI classification. Dr. BookheimerI was delighted when he agreed to join her laboratory to work on imaging studies in genetic risk for AD. Jesse excelled in the laboratory way beyond expectations. He brought his excellent knowledge of machine learning statistics into the lab, and since joining has worked on a series of projects using various imaging modalities. His research has focused on connectivity, developing our capabilities in diffusion tensor imaging and ultimately developing graph theoretical analytic approaches to functional and structural imaging data in AD.

Dr. Bookheimer states: “In my 20 years serving as an IDP mentor at UCLA I have been privileged to have truly outstanding students, virtually all of whom have gone on to successful academic careers. However even among this amazing group, Jesse Brown stands out as the best student I have had. Through his own work and his collaborations, Jesse has 11 published papers, two as first author, with another two expected to be published soon. This is a truly outstanding graduate record. Jesse is destined to become an outstanding, innovative independent neuroscientist. It has been an honor for me to serve as his mentor.” Jesse is a truly remarkable student and this award is truly well-deserved.

Previous Samuel Eiduson Student Lecturers
Year Student Lecture Title
1993
1st Eiduson Student Lecturer
David Rector

“Illuminating the Brain: Neural Activation Produces Changes in Light Scattering”

1994
2nd Eiduson Student Lecturer
Michael DeRosa “Why Do Children Seize? What Epileptic Brain Tissue Tells Us”
1995
3rd Eiduson Student Lecturer
Kerry Thompson “Focal Status Epilepticus in the Immature Brain”
1996
4th Eiduson Student Lecturer
Li-Tao Zhong “A Novel Type of Cell Death Receptor in Neocortical Neurons”
1997
5th Eiduson Student Lecturer
Christine Schulteis “Aspects of Shaker Potassium Channel Biogenesis Revealed by Analysis of Mutant Subunits”
1998
6th Eiduson Student Lecturer
Paul Thompson “Mathematical/Computational Strategies for Human Brain Mapping and Pathology Detection”
1999
7th Eiduson Student Lecturer
Albert Cha “Using Optical Probes to Study the Behavior of Voltage-Gated Ion Channels”
2000
8th Eiduson Student Lecturer
Paul Gray “Every Breath You Take: Looking for the Respiratory Rhythm Generator”
2001
9th Eiduson Student Lecturer
Holly Carlisle “The Role of NMDA Receptor Associated Proteins in Hippocampal LTP”
2002
10th Eiduson Student Lecturer
Robert Agate “Sex Chromosomes as Carriers for Genes Involved in Sex Specific Brain Development”
2003
11th Eiduson Student Lecturer
Christopher Cain “Overcoming Fear: Behavioral Pharmacology and Physiology of Fear Extinction in Mice”
2004
12th Eiduson Student Lecturer
Spencer Smith “The Role of Spontaneously Firing Neurons and New Tools for Exploring Them”
2005
13th Eiduson Student Lecturer
Keri Martinowich “Epigenetic Gene Regulation in Mental Retardation Disorders”
2006
14th Eiduson Student Lecturer
John Ohab “A Novel Neurovascular Niche for Neurogenesis after Stroke”
2007
15h Eiduson Student Lecturer
Louisa Wang “The Circadian Regulation of Learning and Memory”
2008
16th Eiduson Student Lecturer
Woj Wojtowicz “A Role for Molecular Diversity and Specificity in Wiring the Fly Brain”
2009
17th Eiduson Student Lecturer
Doris Payer “Neural Correlates of Emotion and Inhibitory Control During Early Abstinence from Methamphetamine”
2010
18th Eiduson Student Lecturer
David Rousso “Successive Actions of FoxP Transcription Factors in Spinall Cord Neurogenesis and the Establishment of Motor Circuits"
2011
19th Eiduson Student Lecturer
Jason Stein "Searching for Genetic Influences on Brain Structure"
2012
20th Eiduson Student Lecturer
Stephanie Groman “Dopamine D2-Like Receptors: At the Nexus between Self Control and Addiction”
2013
21st Eiduson Student Lecturer 
Jesse Brown “Multimodality MRI-based Brain Network Analysis: Applications to Genetic Risk for Alzheimer’s Disease”

 

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