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As an emerging research model, zebrafish provide the following advantages: Zebrafish have a completed Genome (ZV9) with a continuing annotation project; development occurs ex-utero; they are highly genetically malleable- mutagenesis can be conducted providing the opportunity for realistic genetic screens, and transgenics can be made readily allowing for in vivo fluorescently-labeled cell tracking during development and optogenetic dissection of neurocircuits. Due to their size and permeability, the zebrafish has also become a popular model for high-throughput small molecule screening.  A number of BRI faculty, as well as postdoctoral and graduate students would like to explore the possibility of using this model to address questions concerning development, behavior, gene regulation and the fate of targeted cell types. The affinity group will provide a forum for interested researchers within the BRI to explore the power and pitfalls of using this model. The meetings will alternate between journal clubs and short informal presentations from faculty and postdocs from both within UCLA or surrounding institutions who are using zebrafish for their research. The presentations will be followed by open discussions. The affinity group will provide collaborative opportunities for UCLA researchers already using zebrafish in their research and furthermore give alternatives to those currently using invertebrate models, or expensive and restrictive mammalian models.


· Affinity Group Summary
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Affinity Group Participants
· How to Join

 

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