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Wednesday October 22, 2014 - 8:30am - 5:00pm - The Neuroscience Research Building Auditorium
THE INAUGURAL UCLA INTEGRATIVE CENTER FOR NEURAL REPAIR SYMPOSIUM
Sponsored by the BRI and UC Office of the President
For more details, please click here.
November 4, 2014 - 4pm - The Neuroscience Research Building Auditorium
THE 12th ANNUAL ARNOLD SCHEIBEL DISTINGUISHED POSTDOCTORAL FELLOW IN NEUROSCIENCE LECTURE
JASON STEIN, PhD, from the laboratory of DANIEL GESCHWIND, presents "Evaluating Human Neural Stem Cell Models using a Transcriptomic Rubric".
Hosted by Christopher Evans, Ph.D.
Abstract: Neural stem cells have been adopted to model a wide range of neuropsychiatric conditions in vitro. However, how well such models correspond to in vivo brain has not been evaluated in an unbiased, comprehensive manner. Our work using transcriptomic analyses has enabled comparison of in vitro systems to developing human fetal brain. Using our analysis methods, we observe strong conservation of in vivo gene expression and network architecture in differentiating primary human neural progenitor cells. Conserved modules are enriched in genes associated with autism, supporting the utility of these stem cells for studying neuropsychiatric disease. We also developed and validated a machine learning approach called CoNTExT that identifies the developmental maturity and regional identity of in vitro models. We observed strong differences between in vitro models, including hiPSC-derived neural progenitors from multiple laboratories. This work provides a systems biology framework for evaluating in vitro systems and supports their value in studying the molecular mechanisms of human neurodevelopmental disease.
December 2, 2014 - 4pm - The Ackerman Union Grand Ballroom
THE TWENTY-SIXTH ANNUAL BRAIN RESEARCH INSTITUTE NEUROSCIENCE POSTER SESSION DISTINGUISHED LECTURE
RACHEL WONG, PhD, Professor, Department of Biological Structure, the University of Washington, Seattle, Washington, presents "Circuit Assembly, Disassembly and Reassembly in the Vertebrate Retina".
Hosted by Christopher Evans, PhD.
BELOW: The 2013 Poster Session Lecture was presented by Nobel Laureate Dr. Martin Chalfie. Over 300 people attended.