Christopher J. Evans, Ph.D.
Titles
Co-Chair, Workforce Development
Director, Brain Research Institute
Hatos Center for Neuropharmacology
Professor, Psychiatry and Biobehavioral Sciences
Member, CTSI
Center for Addictive Behaviors
Neuroscience GPB Home Area
Investigator, Center for Translational Technologies
Awards and Honors:
Stanford University Peptide NeurochemistryContact Information
Lab Number: (310) 206-7883
Office Phone Number: (310) 206-7884
Work Address:
LaboratoryMacDonald Research Laboratories, Rm 2609
675 Charles Young Drive
Los Angeles, CA 90095
UNITED STATES Office
MacDonald Research Laboratories, Room 2760
675 Charles Young Drive
Los Angeles, CA 90095
UNITED STATES
Biography
Christopher Evans received his Ph.D. from Imperial College London, conducting his thesis research on endorphins and enkephalins, at the Medical Research Council Institute in Mill Hill. After a postdoctoral fellowship at Stanford University, Dr. Evans joined the UCLA faculty in the Department of Psychiatry and Biobehavioral Science. His research accomplishments have included identification of a number of novel endogenous opioid peptides and the cloning of the first opioid receptor. Dr. Evans is currently Director of the UCLA Brain Research Institute and the Stefan Hatos Professor directing the Shirley and Stefan Hatos Center for Neurophamacology in the UCLA Semel Institute. Dr. Evans is also director of a NIH-funded center - The Center for Opioid Receptors and Drugs of Abuse or CSORDA. CSORDA, with continuous NIH funding for over 25 years. The aims of CSORDA are to understand the action of opioid drugs such as morphine and heroin at the molecular, cellular and behavioral levels.
Publications
Pradhan Amynah, Smith Monique, McGuire Brenna, Evans Christopher, Walwyn Wendy
Chronic inflammatory injury results in increased coupling of delta
opioid receptors to voltage-gated Ca2+ channels
Molecular pain,
2013; 9(4):
8.
Williams John T, Ingram Susan L, Henderson Graeme, Chavkin Charles, von Zastrow Mark, Schulz Stefan, Koch Thomas, Evans Christopher J, Christie Macdonald J
Regulation of μ-opioid receptors: desensitization, phosphorylation,
internalization, and tolerance
Pharmacological reviews,
2013; 65(1):
223-54.
Mittal Nitish, Tan Miao, Egbuta Onyemachi, Desai Nina, Crawford Cynthia, Xie Cui-Wei, Evans Christopher, Walwyn Wendy
Evidence that Behavioral Phenotypes of Morphine in β-arr2-/- Mice Are
Due to the Unmasking of JNK Signaling
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
2012; 10(2):
.
Matynia Anna, Parikh Sachin, Chen Bryan, Kim Paul, McNeill David S, Nusinowitz Steven, Evans Christopher, Gorin Michael B
Intrinsically photosensitive retinal ganglion cells are the primary
but not exclusive circuit for light aversion
Experimental eye research,
2012; 105(23):
60-9.
Pradhan Amynah A, Smith Monique L, Kieffer Brigitte L, Evans Christopher J
Ligand-directed signalling within the opioid receptor family
British journal of pharmacology,
2012; 167(5):
960-9.
Piault Elisabeth, Doshi Sameepa, Brandt Barbara A, Angün Colpan, Evans Christopher J, Bergqvist Agneta, Trocio Jeffrey
Linguistic validation of translation of the self-assessment goal
achievement (saga) questionnaire from English
Health and quality of life outcomes,
2012; 10:
40.
Romero-Calderón Rafael, O'Hare Elizabeth D, Suthana Nanthia A, Scott-Van Zeeland Ashley A, Rizk-Jackson Angela, Attar Aida, Madsen Sarah K, Ghiani Cristina A, Evans Christopher J, Watson Joseph B
Project brainstorm: using neuroscience to connect college students
with local schools
PLoS biology,
2012; 10(4):
e1001310.
Ma Yao-Ying, Cepeda Carlos, Chatta Payush, Franklin Lana, Evans Christopher J, Levine Michael S
Regional and cell-type-specific effects of DAMGO on striatal D1 and D2
dopamine receptor-expressing medium-sized spiny neurons
ASN neuro,
2012; 4(2):
.
Washburn Lorraine R, Zekzer Dan, Eitan Shoshana, Lu Yuxin, Dang Hoa, Middleton Blake, Evans Christopher J, Tian Jide, Kaufman Daniel L
A potential role for shed soluble major histocompatibility class I
molecules as modulators of neurite outgrowth
PloS one,
2011; 6(3):
e18439.
Lasch Kathryn F, Evans Christopher J, Schatell Dori
A qualitative analysis of patient-reported symptoms of anemia
Nephrology nursing journal : journal of the American Nephrology Nurses' Association,
2011; 36(6):
621-4, 631-2; quiz 633.
Lam Hoa, Maga Matthew, Pradhan Amynah, Evans Christopher J, Maidment Nigel T, Hales Tim G, Walwyn Wendy
Analgesic tone conferred by constitutively active mu opioid receptors
in mice lacking β-arrestin 2
Molecular pain,
2011; 7(8):
24.
Evans Christopher J, Chiou Chiun-Fang, Fitzgerald Kristina A, Evans William J, Ferrell Betty R, Dale William, Fried Linda P, Gandra Shravanthi R, Dennee-Sommers Brooke, Patrick Donald L
Development of a new patient-reported outcome measure in sarcopenia
Journal of the American Medical Directors Association,
2011; 12(3):
226-33.
Brubaker Linda, Khullar Vik, Piault Elisabeth, Evans Christopher J, Bavendam Tamara, Beach James, Yeh Yating, Kopp Zoe S, Kelleher Con J, Trocio Jeffrey
Goal attainment scaling in patients with lower urinary tract symptoms:
development and pilot testing of the Self-Assessment Goal Achievement
(SAGA) questionnaire
International urogynecology journal,
2011; 22(8):
937-46.
Ng-Mak Daisy S, Fitzgerald Kristina A, Norquist Josephine M, Banderas Benjamin F, Nelsen Linda M, Evans Christopher J, Healy Cynthia G, Ho Tony W, Bigal Marcelo
Key concepts of migraine postdrome: a qualitative study to develop a
post-migraine questionnaire
Headache,
2011; 51(1):
105-17.
Poole Daniel P, Pelayo Juan-Carlos, Scherrer Gregory, Evans Christopher J, Kieffer Brigitte L, Bunnett Nigel W
Localization and regulation of fluorescently labeled delta opioid
receptor, expressed in enteric neurons of mice
Gastroenterology,
2011; 141(3):
982-991.e1-8.
Pradhan Amynah A A, Walwyn Wendy, Nozaki Chihiro, Filliol Dominique, Erbs Eric, Matifas Audrey, Evans Christopher, Kieffer Brigitte L
Ligand-directed trafficking of the δ-opioid receptor in vivo: two
paths toward analgesic tolerance
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2010; 30(49):
16459-68.
Escande-Beillard Nathalie, Washburn Lorraine, Zekzer Dan, Wu Zhongqi-Phyllis, Eitan Shoshy, Ivkovic Sonja, Lu Yuxin, Dang Hoa, Middleton Blake, Bilousova Tina V, Yoshimura Yoshitaka, Evans Christopher J, Joyce Sebastian, Tian Jide, Kaufman Daniel L
Neurons preferentially respond to self-MHC class I allele products
regardless of peptide presented
Journal of immunology (Baltimore, Md. : 1950),
2010; 184(2):
816-23.
Walwyn Wendy M, Miotto Karen A, Evans Christopher J
Opioid pharmaceuticals and addiction: the issues, and research
directions seeking solutions
Drug and alcohol dependence,
2010; 108(3):
156-65.
Iguchi Martin Y, Evans Christopher J
What neurobiology tells us about addiction
Addiction (Abingdon, England),
2010; 105(5):
793-5; discussion 795-6.
Walwyn Wendy, John Scott, Maga Matthew, Evans Christopher J, Hales Tim G
Delta receptors are required for full inhibitory coupling of
mu-receptors to voltage-dependent Ca(2+) channels in dorsal root
ganglion neurons
Molecular pharmacology,
2009; 76(1):
134-43.
Hofford Rebecca S, Hodgson Stephen R, Roberts Kris W, Bryant Camron D, Evans Christopher J, Eitan Shoshana
Extracellular signal-regulated kinase activation in the amygdala
mediates elevated plus maze behavior during opioid withdrawal
Behavioural pharmacology,
2009; 20(7):
576-83.
Yu Y Joy, Arttamangkul Seksiri, Evans Christopher J, Williams John T, von Zastrow Mark
Neurokinin 1 receptors regulate morphine-induced endocytosis and
desensitization of mu-opioid receptors in CNS neurons
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2009; 29(1):
222-33.
Kieffer Brigitte L, Evans Christopher J
Opioid receptors: from binding sites to visible molecules in vivo
Neuropharmacology,
2009; 56 Suppl 1(1):
205-12.
Bryant Camron D, Roberts Kristofer W, Culbertson Christopher S, Le Alan, Evans Christopher J, Fanselow Michael S
Pavlovian conditioning of multiple opioid-like responses in mice
Drug and alcohol dependence,
2009; 103(1-2):
74-83.
Marquez Paul, Bebawy David, Lelièvre Vincent, Coûté Anne-Claire, Evans Christopher J, Waschek James A, Lutfy Kabirullah
The role of endogenous PACAP in motor stimulation and conditioned
place preference induced by morphine in mice
Psychopharmacology,
2009; 204(3):
457-63.
Tan Miao, Walwyn Wendy M, Evans Christopher J, Xie Cui-Wei
p38 MAPK and beta-arrestin 2 mediate functional interactions between
endogenous micro-opioid and alpha2A-adrenergic receptors in neurons
The Journal of biological chemistry,
2009; 284(10):
6270-81.
Piault Elisabeth, Evans Christopher J, Espindle Derek, Kopp Zoe, Brubaker Linda, Abrams Paul
Development and validation of the Overactive Bladder Satisfaction
(OAB-S) Questionnaire
Neurourology and urodynamics,
2008; 27(3):
179-90.
Wassum Kate M, Evans Christopher J
International Narcotics Research Conference - 39th Annual Meeting
IDrugs : the investigational drugs journal,
2008; 11(9):
646-9.
Gioiosa, L.Chen, X.Watkins, R.Klanfer, N.Bryant, C. D.Evans, C. J.Arnold, A. P.
Sex chromosome complement affects nociception in tests of acute and chronic exposure to morphine in mice
Horm Behav,
2008; 53(1):
124-30.
Walwyn, W. Evans, C. J. Hales, T. G.
Beta-arrestin2 and c-Src regulate the constitutive activity and recycling of mu opioid receptors in dorsal root ganglion neurons
J Neurosci,
2007; 27(19):
5092-104.
Parthan Anju, Evans Christopher J, Le Kim
Chronic low back pain: epidemiology, economic burden and
patient-reported outcomes in the USA
Expert review of pharmacoeconomics & outcomes research,
2006; 6(3):
359-69.
Evans Christopher J, Parthan Anju, Le Kim
Economic and humanistic burden of fibromyalgia in the USA
Expert review of pharmacoeconomics & outcomes research,
2006; 6(3):
303-14.
Kho, S. T. Lopez, I. A. Evans, C. Ishiyama, A. Ishiyama, G.
Immunolocalization of orphanin FQ in rat cochlea
Brain Res,
2006; 1113(1):
146-52.
Bryant Camron D, Roberts Kristofer W, Byun Janet S, Fanselow Michael S, Evans Christopher J
Morphine analgesic tolerance in 129P3/J and 129S6/SvEv mice
Pharmacology, biochemistry, and behavior,
2006; 85(4):
769-79.
Walwyn, W. M. Wei, W. Xie, C. W. Chiu, K. Kieffer, B. L. Evans, C. J. Maidment, N. T.
Mu opioid receptor-effector coupling and trafficking in dorsal root ganglia neurons
Neuroscience,
2006; 142(2):
493-503.
Bryant Camron D, Eitan Shoshana, Sinchak Kevin, Fanselow Michael S, Evans Christopher J
NMDA receptor antagonism disrupts the development of morphine
analgesic tolerance in male, but not female C57BL/6J mice
American journal of physiology. Regulatory, integrative and comparative physiology,
2006; 291(2):
R315-26.
Walwyn Wendy, Maidment Nigel T, Sanders Matthew, Evans Christopher J, Kieffer Brigitte L, Hales Tim G
Induction of delta opioid receptor function by up-regulation of
membrane receptors in mouse primary afferent neurons
Molecular pharmacology,
2005; 68(6):
1688-98.
Evans Christopher J, Trudeau Elyse, Mertzanis Polyxane, Marquis Patrick, Peña Beatriz M, Wong Josephine, Mayne Tracy
Development and validation of the Pain Treatment Satisfaction Scale
(PTSS): a patient satisfaction questionnaire for use in patients with
chronic or acute pain
Pain,
2004; 112(3):
254-66.
Walwyn, W. M. Keith, D. E., Jr. Wei, W. Tan, A. M. Xie, C. W. Evans, C. J. Kieffer, B. L. Maidment, N. T.
Functional coupling, desensitization and internalization of virally expressed mu opioid receptors in cultured dorsal root ganglion neurons from mu opioid receptor knockout mice
Neuroscience,
2004; 123(1):
111-21.
Evans Christopher J
Health and work productivity assessment: state of the art or state of
flux?
Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine,
2004; 46(6 Suppl):
S3-11.
Evans Christopher J
Secrets of the opium poppy revealed
Neuropharmacology,
2004; 47 Suppl 1(6 Suppl):
293-9.
Eitan, S. Bryant, C. D. Saliminejad, N. Yang, Y. C. Vojdani, E. Keith, D., Jr. Polakiewicz, R. Evans, C. J.
Brain region-specific mechanisms for acute morphine-induced mitogen-activated protein kinase modulation and distinct patterns of activation during analgesic tolerance and locomotor sensitization
J Neurosci,
2003; 23(23):
8360-9.
Lutfy, K. Eitan, S. Bryant, C. D. Yang, Y. C. Saliminejad, N. Walwyn, W. Kieffer, B. L. Takeshima, H. Carroll, F. I. Maidment, N. T. Evans, C. J.
Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors
J Neurosci,
2003; 23(32):
10331-7.
Charles, A. C. Mostovskaya, N. Asas, K. Evans, C. J. Dankovich, M. L. Hales, T. G.
Coexpression of delta-opioid receptors with micro receptors in GH3 cells changes the functional response to micro agonists from inhibitory to excitatory
Mol Pharmacol,
2003; 63(1):
89-95.
Li, Y. Eitan, S. Wu, J. Evans, C. J. Kieffer, B. Sun, X. Polakiewicz, R. D.
Morphine induces desensitization of insulin receptor signaling
Mol Cell Biol,
2003; 23(17):
6255-66.
Reeve, J. R., Jr. Keire, D. A. Coskun, T. Green, G. M. Evans, C. Ho, F. J. Lee, T. D. Davis, M. T. Shively, J. E. Solomon, T. E.
Synthesis of biologically active canine CCK-58
Regul Pept,
2003; 113(1-3):
71-7.
Arjomand, J. Cole, S. Evans, C. J.
Novel orphanin FQ/nociceptin transcripts are expressed in human immune cells
J Neuroimmunol,
2002; 130(1-2):
100-8.
Kieffer Brigitte L, Evans Christopher J
Opioid tolerance-in search of the holy grail
Cell,
2002; 108(5):
587-90.
Zaki, P. A. Keith, D. E., Jr. Thomas, J. B. Carroll, F. I. Evans, C. J.
Agonist-, antagonist-, and inverse agonist-regulated trafficking of the delta-opioid receptor correlates with, but does not require, G protein activation
J Pharmacol Exp Ther,
2001; 298(3):
1015-20.
Arjomand, J. Evans, C. J.
Differential splicing of transcripts encoding the orphanin FQ/nociceptin precursor
J Neurochem,
2001; 77(3):
720-9.
Ishiyama, A. Ishiyama, G. Baloh, R. W. Evans, C. J.
Heroin-induced reversible profound deafness and vestibular dysfunction
Addiction,
2001; 96(9):
1363-4.
Evans, C. J.
Agonist selective mu-opioid receptor trafficking in rat central nervous system
Mol Psychiatry,
2000; 5(2):
121.
Piros, E. T. Charles, R. C. Song, L. Evans, C. J. Hales, T. G.
Cloned delta-opioid receptors in GH(3) cells inhibit spontaneous Ca(2+) oscillations and prolactin release through K(IR) channel activation
J Neurophysiol,
2000; 83(5):
2691-8.
Melone, M. Brecha, N. C. Sternini, C. Evans, C. Conti, F.
Etorphine increases the number of mu-opioid receptor-positive cells in the cerebral cortex
Neuroscience,
2000; 100(3):
439-43.
Zaki, P. A. Keith, D. E., Jr. Brine, G. A. Carroll, F. I. Evans, C. J.
Ligand-induced changes in surface mu-opioid receptor number: relationship to G protein activation?
J Pharmacol Exp Ther,
2000; 292(3):
1127-34.
Rabizadeh, S. Ye, X. Sperandio, S. Wang, J. J. Ellerby, H. M. Ellerby, L. M. Giza, C. Andrusiak, R. L. Frankowski, H. Yaron, Y. Moayeri, N. N. Rovelli, G. Evans, C. J. Butcher, L. L. Nolan, G. P. Assa-Munt, N. Bredesen, D. E.
Neurotrophin dependence domain: a domain required for the mediation of apoptosis by the p75 neurotrophin receptor
J Mol Neurosci,
2000; 15(3):
215-29.
Charles, A. C. Piros, E. T. Evans, C. J. Hales, T. G.
L-type Ca2+ channels and K+ channels specifically modulate the frequency and amplitude of spontaneous Ca2+ oscillations and have distinct roles in prolactin release in GH3 cells
J Biol Chem,
1999; 274(11):
7508-15.
Lo, E. H. Pierce, A. R. Matsumoto, K. Kano, T. Evans, C. J. Newcomb, R.
Alterations in K+ evoked profiles of neurotransmitter and neuromodulator amino acids after focal ischemia-reperfusion
Neuroscience,
1998; 83(2):
449-58.
Monteillet-Agius, G. Fein, J. Anton, B. Evans, C. J.
ORL-1 and mu opioid receptor antisera label different fibers in areas involved in pain processing
J Comp Neurol,
1998; 399(3):
373-83.
Murray, S. R. Evans, C. J. von Zastrow, M.
Phosphorylation is not required for dynamin-dependent endocytosis of a truncated mutant opioid receptor
J Biol Chem,
1998; 273(39):
24987-91.
Unterwald, E. M. Anton, B. To, T. Lam, H. Evans, C. J.
Quantitative immunolocalization of mu opioid receptors: regulation by naltrexone
Neuroscience,
1998; 85(3):
897-905.
Keith, D. E. Anton, B. Murray, S. R. Zaki, P. A. Chu, P. C. Lissin, D. V. Monteillet-Agius, G. Stewart, P. L. Evans, C. J. von Zastrow, M.
mu-Opioid receptor internalization: opiate drugs have differential effects on a conserved endocytic mechanism in vitro and in the mammalian brain
Mol Pharmacol,
1998; 53(3):
377-84.
Rocha, L. L. Evans, C. J. Maidment, N. T.
Amygdala kindling modifies extracellular opioid peptide content in rat hippocampus measured by microdialysis
J Neurochem,
1997; 68(2):
616-24.
Yu, T. P. Fein, J. Phan, T. Evans, C. J. Xie, C. W.
Orphanin FQ inhibits synaptic transmission and long-term potentiation in rat hippocampus
Hippocampus,
1997; 7(1):
88-94.
Olive, M. F. Anton, B. Micevych, P. Evans, C. J. Maidment, N. T.
Presynaptic versus postsynaptic localization of mu and delta opioid receptors in dorsal and ventral striatopallidal pathways
J Neurosci,
1997; 17(19):
7471-9.
Gylys, K. H. Tran, N. Magendzo, K. Zaki, P. Evans, C. J.
cAMP decreases steady-state levels of delta-opioid receptor mRNA in NG108-15 cells
Neuroreport,
1997; 8(9-10):
2369-72.
Sternini, C. Spann, M. Anton, B. Keith, D. E., Jr. Bunnett, N. W. von Zastrow, M. Evans, C. Brecha, N. C.
Agonist-selective endocytosis of mu opioid receptor by neurons in vivo
Proc Natl Acad Sci U S A,
1996; 93(17):
9241-6.
Anton, B. Fein, J. To, T. Li, X. Silberstein, L. Evans, C. J.
Immunohistochemical localization of ORL-1 in the central nervous system of the rat
J Comp Neurol,
1996; 368(2):
229-51.
Zhu, J. Yin, J. Law, P. Y. Claude, P. A. Rice, K. C. Evans, C. J. Chen, C. Yu, L. Liu-Chen, L. Y.
Irreversible binding of cis-(+)-3-methylfentanyl isothiocyanate to the delta opioid receptor and determination of its binding domain
J Biol Chem,
1996; 271(3):
1430-4.
Tian, J. Clare-Salzler, M. Herschenfeld, A. Middleton, B. Newman, D. Mueller, R. Arita, S. Evans, C. Atkinson, M. A. Mullen, Y. Sarvetnick, N. Tobin, A. J. Lehmann, P. V. Kaufman, D. L.
Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice
Nat Med,
1996; 2(12):
1348-53.
Keith, D. E. Murray, S. R. Zaki, P. A. Chu, P. C. Lissin, D. V. Kang, L. Evans, C. J. von Zastrow, M.
Morphine activates opioid receptors without causing their rapid internalization
J Biol Chem,
1996; 271(32):
19021-4.
Keith, D. E., Jr. Evans, C. J.
Mu opioid receptor-like sequences are present throughout vertebrate evolution
J Mol Evol,
1996; 43(3):
179-84.
Johnson, J. Chen, T. K. Rickman, D. W. Evans, C. Brecha, N. C.
Multiple gamma-Aminobutyric acid plasma membrane transporters (GAT-1, GAT-2, GAT-3) in the rat retina
J Comp Neurol,
1996; 375(2):
212-24.
Li, X. Keith, D. E., Jr. Evans, C. J.
Multiple opioid receptor-like genes are identified in diverse vertebrate phyla
FEBS Lett,
1996; 397(1):
25-9.
Rocha, L. Maidment, N. T. Evans, C. J. Ackermann, R. F. Engel, J., Jr.
Opioid peptide release and mu-receptor binding during amygdala kindling in rats: regional discordances
Epilepsy Res Suppl,
1996; 12(number):
215-28.
Rocha, L. Briones, M. Ackermann, R. F. Anton, B. Maidment, N. T. Evans, C. J. Engel, J., Jr.
Pentylenetetrazol-induced kindling: early involvement of excitatory and inhibitory systems
Epilepsy Res,
1996; 26(1):
105-13.
Trapaidze, N. Keith, D. E. Cvejic, S. Evans, C. J. Devi, L. A.
Sequestration of the delta opioid receptor. Role of the C terminus in agonist-mediated internalization
J Biol Chem,
1996; 271(46):
29279-85.
Befort, K. Tabbara, L. Bausch, S. Chavkin, C. Evans, C. Kieffer, B.
The conserved aspartate residue in the third putative transmembrane domain of the delta-opioid receptor is not the anionic counterpart for cationic opiate binding but is a constituent of the receptor binding site
Mol Pharmacol,
1996; 49(2):
216-23.
Piros, E. T. Prather, P. L. Law, P. Y. Evans, C. J. Hales, T. G.
Voltage-dependent inhibition of Ca2+ channels in GH3 cells by cloned mu- and delta-opioid receptors
Mol Pharmacol,
1996; 50(4):
947-56.
Piros, E. T. Prather, P. L. Loh, H. H. Law, P. Y. Evans, C. J. Hales, T. G.
Ca2+ channel and adenylyl cyclase modulation by cloned mu-opioid receptors in GH3 cells
Mol Pharmacol,
1995; 47(5):
1041-9.
Milligan, C. E. Webster, L. Piros, E. T. Evans, C. J. Cunningham, T. J. Levitt, P.
Induction of opioid receptor-mediated macrophage chemotactic activity after neonatal brain injury
J Immunol,
1995; 154(12):
6571-81.
Olive, M. F. Bertolucci, M. Evans, C. J. Maidment, N. T.
Microdialysis reveals a morphine-induced increase in pallidal opioid peptide release
Neuroreport,
1995; 6(8):
1093-6.
Prather, P. L. McGinn, T. M. Erickson, L. J. Evans, C. J. Loh, H. H. Law, P. Y.
Ability of delta-opioid receptors to interact with multiple G-proteins is independent of receptor density
J Biol Chem,
1994; 269(33):
21293-302.
Law, P. Y. McGinn, T. M. Wick, M. J. Erikson, L. J. Evans, C. Loh, H. H.
Analysis of delta-opioid receptor activities stably expressed in CHO cell lines: function of receptor density?
J Pharmacol Exp Ther,
1994; 271(3):
1686-94.
Mastrogiacomo, A. Evans, C. J. Gundersen, C. B.
Antipeptide antibodies against a Torpedo cysteine-string protein
J Neurochem,
1994; 62(3):
873-80.
Kaufman, D. L. Xia, Y. R. Keith, D. E., Jr. Newman, D. Evans, C. J. Lusis, A. J.
Localization of the delta-opioid receptor gene to mouse chromosome 4 by linkage analysis
Genomics,
1994; 19(2):
405-6.
Rocha, L. Maidment, N. T. Evans, C. J. Ackermann, R. F. Engel, J., Jr.
Microdialysis reveals changes in extracellular opioid peptide levels in the amygdala induced by amygdaloid kindling stimulation
Exp Neurol,
1994; 126(2):
277-83.
Reeve, J. R., Jr. Eysselein, V. E. Ho, F. J. Chew, P. Vigna, S. R. Liddle, R. A. Evans, C.
Natural and synthetic CCK-58. Novel reagents for studying cholecystokinin physiology
Ann N Y Acad Sci,
1994; 713(number):
11-21.
Liu, Y. Schweitzer, E. S. Nirenberg, M. J. Pickel, V. M. Evans, C. J. Edwards, R. H.
Preferential localization of a vesicular monoamine transporter to dense core vesicles in PC12 cells
J Cell Biol,
1994; 127(5):
1419-33.
Von Zastrow, M. Keith, D. E., Jr. Evans, C. J.
Agonist-induced state of the delta-opioid receptor that discriminates between opioid peptides and opiate alkaloids
Mol Pharmacol,
1993; 44(1):
166-72.
Keith, D. E., Jr. Anton, B. Evans, C. J.
Characterization and mapping of a delta opioid receptor clone from NG108-15 cells
Proc West Pharmacol Soc,
1993; 36(number):
299-306.
Ruppert, C. Sandrasagra, A. Anton, B. Evans, C. Schweitzer, E. S. Tobin, A. J.
Rat-1 fibroblasts engineered with GAD65 and GAD67 cDNAs in retroviral vectors produce and release GABA
J Neurochem,
1993; 61(2):
768-71.
Evans, C. J. Keith, D. E., Jr. Morrison, H. Magendzo, K. Edwards, R. H.
Cloning of a delta opioid receptor by functional expression
Science,
1992; 258(5090):
1952-5.
Maidment, N. T. Siddall, B. J. Rudolph, V. R. Erdelyi, E. Evans, C. J.
Dual determination of extracellular cholecystokinin and neurotensin fragments in rat forebrain: microdialysis combined with a sequential multiple antigen radioimmunoassay
Neuroscience,
1991; 45(1):
81-93.
Wagner, J. J. Evans, C. J. Chavkin, C.
Focal stimulation of the mossy fibers releases endogenous dynorphins that bind kappa 1-opioid receptors in guinea pig hippocampus
J Neurochem,
1991; 57(1):
333-43.
Madden, J. th Evans, C. J. Tyler, A. N. Esch, F. S. Bohlen, P. Makk, G. Weber, E.
Isolation and characterization of opioid peptides from rabbit cerebellum
J Neurochem,
1991; 56(6):
1914-20.
Maidment, N. T. Siddall, B. Rudolph, V. D. Evans, C. J.
Postmortem changes in rat brain extracellular opioid peptides revealed by microdialysis
J Neurochem,
1991; 56(6):
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Abood, M. E. Eberwine, J. H. Erdelyi, E. Evans, C. J.
Regulation of both preproenkephalin mRNA and its derived opioids by haloperidol--a method for measurement of peptides and mRNA in the same tissue extract
Brain Res Mol Brain Res,
1990; 8(3):
243-8.
Tecott, L. H. Rubenstein, J. L. Paxinos, G. Evans, C. J. Eberwine, J. H. Valentino, K. L.
Developmental expression of proenkephalin mRNA and peptides in rat striatum
Brain Res Dev Brain Res,
1989; 49(1):
75-86.
Feistner, G. J. Hojrup, P. Evans, C. J. Barofsky, D. F. Faull, K. F. Roepstorff, P.
Mass spectrometric charting of bovine posterior/intermediate pituitary peptides
Proc Natl Acad Sci U S A,
1989; 86(16):
6013-7.
Maidment, N. T. Brumbaugh, D. R. Rudolph, V. D. Erdelyi, E. Evans, C. J.
Microdialysis of extracellular endogenous opioid peptides from rat brain in vivo
Neuroscience,
1989; 33(3):
549-57.
Stevens, K. E. Leslie, F. M. Evans, C. J. Belluzzi, J. D. Stein, L.
BAM-18: analgesia, hyperalgesia and locomotor effects
Neuropeptides,
1988; 12(1):
21-7.
Eberwine, J. H. Barchas, J. D. Hewlett, W. A. Evans, C. J.
Isolation of enzyme cDNA clones by enzyme immunodetection assay: isolation of a peptide acetyltransferase
Proc Natl Acad Sci U S A,
1987; 84(5):
1449-53.
Boarder, M. R. Evans, C. Adams, M. Erdelyi, E. Barchas, J. D.
Peptide E and its products, BAM 18 and Leu-enkephalin, in bovine adrenal medulla and cultured chromaffin cells: release in response to stimulation
J Neurochem,
1987; 49(6):
1824-32.
Hurlbut, D. E. Evans, C. J. Barchas, J. D. Leslie, F. M.
Pharmacological properties of a proenkephalin A-derived opioid peptide: BAM 18
Eur J Pharmacol,
1987; 138(3):
359-66.
Lorenz, R. G. Tyler, A. N. Faull, K. F. Makk, G. Barchas, J. D. Evans, C. J.
Characterization of endorphins from the pituitary of the spiny dogfish Squalus acanthias
Peptides,
1986; 7(1):
119-26.
Bartolome, J. V. Bartolome, M. B. Daltner, L. A. Evans, C. J. Barchas, J. D. Kuhn, C. M. Schanberg, S. M.
Effects of beta-endorphin on ornithine decarboxylase in tissues of developing rats: a potential role for this endogenous neuropeptide in the modulation of tissue growth
Life Sci,
1986; 38(25):
2355-62.
Stevens, K. E. Leslie, F. M. Evans, C. J. Barchas, J. D. Belluzzi, J. D. Stein, L.
Intraventricular administration of BAM-18: antinociceptive and locomotor activity in the rat
NIDA Res Monogr,
1986; 75(number):
446-9.
Kaldany, R. R. Campanelli, J. T. Makk, G. Evans, C. J. Scheller, R. H.
Proteolytic processing of a peptide precursor in Aplysia neuron R14
J Biol Chem,
1986; 261(13):
5751-7.
Hurlbut, D. E. Evans, C. J. Barchas, J. D. Leslie, F. M.
The pharmacological profile of BAM 18
NIDA Res Monogr,
1986; 75(number):
81-4.
Evans, C. J. Erdelyi, E. Hunter, J. Barchas, J. D.
Co-localization and characterization of immunoreactive peptides derived from two opioid precursors in guinea pig adrenal glands
J Neurosci,
1985; 5(12):
3423-7.
Lorenz, R. G. Evans, C. J. Barchas, J. D.
Effects of dehydration on pro-dynorphin derived peptides in the neuro-intermediate lobe of the rat pituitary
Life Sci,
1985; 37(16):
1523-8.
Evans, C. J. Barchas, J. D. Esch, F. S. Bohlen, P. Weber, E
Isolation and characterization of an endogenous C-terminal fragment of the alpha-neo-endorphin/dynorphin precursor from bovine caudate nucleus
J Neurosci,
1985; 5(7):
1803-7.
Roth, K. A. Makk, G. Beck, O. Faull, K. Tatemoto, K. Evans, C. J. Barchas, J. D.
Isolation and characterization of substance P, substance P 5-11, and substance K from two metastatic ileal carcinoids
Regul Pept,
1985; 12(3):
185-99.
Wallace, E. F. Weber, E. Barchas, J. D. Evans, C. J.
A putative processing enzyme from Aplysia that cleaves dynorphin A at the single arginine residue
Biochem Biophys Res Commun,
1984; 119(1):
415-22.
Bostwick, D. G. Roth, K. A. Evans, C. J. Barchas, J. D. Bensch, K. G.
Gastrin-releasing peptide, a mammalian analog of bombesin, is present in human neuroendocrine lung tumors
Am J Pathol,
1984; 117(2):
195-200.
Roth, K. A. Evans, C. J. Weber, E. Barchas, J. D. Bostwick, D. G. Bensch, K. G.
Gastrin-releasing peptide-related peptides in a human malignant lung carcinoid tumor
Cancer Res,
1983; 43(11):
5411-5.
Roth, K. A. Evans, C. J. Lorenz, R. G. Weber, E. Barchas, J. D. Chang, J. K.
Identification of gastrin releasing peptide-related substances in guinea pig and rat brain
Biochem Biophys Res Commun,
1983; 112(2):
528-36.
Evans, C. J. Erdelyi, E. Weber, E. Barchas, J. D.
Identification of pro-opiomelanocortin-derived peptides in the human adrenal medulla
Science,
1983; 221(4614):
957-60.
Boarder, M. R. Weber, E. Evans, C. J. Erdelyi, E. Barchas, J.
Measurement of total opioid peptides in rat brain and pituitary by radioimmunoassay directed at the alpha-N-acetyl derivative
J Neurochem,
1983; 40(16):
1517-22.
Weber, E. Esch, F. S. Bohlen, P. Paterson, S. Corbett, A. D. McKnight, A. T. Kosterlitz, H. W. Barchas, J. D. Evans, C. J.
Metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain
Proc Natl Acad Sci U S A,
1983; 80(23):
7362-6.
Weber, E. Evans, C. J. Chang, J. K. Barchas, J. D.
Antibodies specific for alpha-N-acetyl-beta-endorphins: radioimmunoassays and detection of acetylated beta-endorphins in pituitary extracts
J Neurochem,
1982; 38(2):
436-47.
Mues, G. Fuchs, I. Wei, E. T. Weber, E. Evans, C. J. Barchas, J. D. Chang, J. K.
Blood pressure elevation in rats by peripheral administration of Tyr-Gly-Gly-Phe-Met-Arg-Phe and the invertebrate neuropeptide, Phe-Met-Arg-Phe-NH2
Life Sci,
1982; 31(23):
2555-61.
Weber, E. Evans, C. J. Chang, J. K. Barchas, J. D.
Brain distributions of alpha-neo-endorphin and beta-neo-endorphin: evidence for regional processing differences
Biochem Biophys Res Commun,
1982; 108(1):
81-8.
Weber, E. Evans, C. J. Barchas, J. D.
Mapping of hypothalamic opioid peptide neurons by a novel immunohistochemical technique: relation to alpha-Neo-endorphin and vasopressin systems
Adv Biochem Psychopharmacol,
1982; 33(number):
519-26.
Weber, E. Evans, C. J. Barchas, J. D.
Predominance of the amino-terminal octapeptide fragment of dynorphin in rat brain regions
Nature,
1982; 299(5878):
77-9.
Evans, C. J. Lorenz, R. Weber, E. Barchas, J. D.
Variants of alpha-melanocyte stimulating hormone in rat brain and pituitary evidence that acetylated alpha-MSH exists only in the intermediate lobe of pituitary
Biochem Biophys Res Commun,
1982; 106(3):
910-9.
Weber, E. Evans, C. J. Barchas, J. D.
Acetylated and nonacetylated forms of beta-endorphin in rat brain and pituitary
Biochem Biophys Res Commun,
1981; 103(3):
982-9.
Weber, E.Truscott, R. J.Evans, C.Sullivan, S.Angwin, P.Barchas, J. D.
Alpha-N-acetyl beta-endorphins in the pituitary: immunohistochemical localization using antibodies raised against dynorphin(1-13)
J Neurochem,
1981; 36(6):
1977-85.
Evans, C. J. Weber, E. Barchas, J. D.
Isolation and characterization of alpha-N-acetyl beta-endorphin(1-26) from the rat posterior/intermediate pituitary lobe
Biochem Biophys Res Commun,
1981; 102(3):
897-904.
Weber, E. Evans, C. J. Samuelsson, S. J. Barchas, J. D.
Novel peptide neuronal system in rat brain and pituitary
Science,
1981; 214(4526):
1248-51.
Austen, B. M.Evans, C. J.Smyth, D. G.
Susceptibility of neuroactive peptides to aminopeptidase digestion is related to molecular size
Biochem Biophys Res Commun,
1979; 91(4):
1211-7.
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