Juan Carlos G. Marvizón, Ph.D.

Titles

Member, Brain Research Institute

Adjunct Professor, Medicine

Digestive Diseases/Gastroenterology

CURE: Digestive Diseases Research Center

Contact Information

Email
marvizon@g.ucla.edu
Phone
Cell-phone Number: (310) 384 7535
Fax Number: (310) 268 4963
Work Phone Number: (310) 478 3711 extension 41850
Address

Work Address:

Office
VA Greater Los Angeles Healthcare System
11301 Wilshire Blvd.
Los Angeles, CA 90073
UNITED STATES

Biography

Dr. Marvizón’s research field is pain neurophysiology. He investigates chronic pain disorders at the physiological, cellular and molecular levels using the Latent Sensitization animal model. Latent Sensitization is triggered by injuries that cause long-term inflammation or nerve damage, such as skin incision, injection of inflammatory agents or nerve transection. This is followed by a period of increased sensitivity to mechanical (for example, poking with nylon filaments known as von Frey filaments) or thermal (focusing a hot light on the paw) stimuli. The key part of the Latent Sensitization model is that when that period of hypersensitivity has ended it can be reinstated temporarily by an injection of an antagonist of opioid receptors (mu, delta or kappa) or of alpha-2 adrenergic receptors. This reveals that the neural pathways that process pain remain sensitized but at the same time are suppressed by the activation of these opioid or adrenergic receptors. It is likely that similar process occur in chronic pain patients. Another important characteristic of Latent Sensitization is that pain can also be reinstated by stress (like making a rat swim in a bucket of water or exposing it to a new environment). Again, this happen to chronic pain patients. The research group led by Dr. Marvizón is currently using novel transgenic mouse techniques like conditional knock-out and chemogenetics (DREADD) to study the pathways linking stress to pain. Dr. Marvizón writes in defense of animal research for the organization Speaking of Research (https://speakingofresearch.com/ ).  For more information about his projects and his general view on science, please visit his blog Pain, Brain & Science (http://pain-brain-science.blogspot.com/ ).

Publications

Chen Wenling, Ennes Helena S, McRoberts James A, Marvizón Juan Carlos   Mechanisms of μ-opioid receptor inhibition of NMDA receptor-induced substance P release in the rat spinal cord Neuropharmacology, 2018; 128: 255-268.
Walwyn Wendy M, Chen Wenling, Kim Hyeyoung, Minasyan Ani, Ennes Helena S, McRoberts James A, Marvizón Juan Carlos G   Sustained Suppression of Hyperalgesia during Latent Sensitization by μ-, δ-, and κ-opioid receptors and α2A Adrenergic Receptors: Role of Constitutive Activity The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016; 36(1): 204-21.
Marvizon Juan Carlos, Walwyn Wendy, Minasyan Ani, Chen Wenling, Taylor Bradley K   Latent sensitization: a model for stress-sensitive chronic pain Current protocols in neuroscience, 2015; 71(1): 9.50.1-14.
Chen Wenling, Walwyn Wendy, Ennes Helena S, Kim Hyeyoung, McRoberts James A, Marvizón Juan Carlos G   BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals The European journal of neuroscience, 2014; 39(9): 1439-54.
Zhang Guohua, Chen Wenling, Marvizón Juan Carlos G   Src family kinases mediate the inhibition of substance P release in the rat spinal cord by μ-opioid receptors and GABA(B) receptors, but not α2 adrenergic receptors The European journal of neuroscience, 2010; 32(6): 963-73.
Zhang Guohua, Chen Wenling, Lao Lijun, Marvizón Juan Carlos G   Cannabinoid CB1 receptor facilitation of substance P release in the rat spinal cord, measured as neurokinin 1 receptor internalization The European journal of neuroscience, 2010; 31(2): 225-37.
Marvizón Juan Carlos G, Chen Wenling, Murphy Niall   Enkephalins, dynorphins, and beta-endorphin in the rat dorsal horn: an immunofluorescence colocalization study The Journal of comparative neurology, 2009; 517(1): 51-68.
Chen Wenling, Song Bingbing, Zhang Guohua, Marvizón Juan Carlos G   Effects of veratridine and high potassium on micro-opioid receptor internalization in the rat spinal cord: stimulation of opioid release versus inhibition of internalization Journal of neuroscience methods, 2008; 170(2): 285-93.
Chen Wenling, Song Bingbing, Marvizón Juan Carlos G   Inhibition of opioid release in the rat spinal cord by alpha2C adrenergic receptors Neuropharmacology, 2008; 54(6): 944-53.
Chen Wenling, Song Bingbing, Lao Lijun, Pérez Orlando A, Kim Woojae, Marvizón Juan Carlos G   Comparing analgesia and mu-opioid receptor internalization produced by intrathecal enkephalin: requirement for peptidase inhibition Neuropharmacology, 2007; 53(5): 664-76.
Song Bingbing, Chen Wenling, Marvizón Juan Carlos G   Inhibition of opioid release in the rat spinal cord by serotonin 5-HT(1A) receptors Brain research, 2007; 1158(5): 57-62.
Bradesi Sylvie, Kokkotou Efi, Simeonidis Simos, Patierno Simona, Ennes Helena S, Mittal Yash, McRoberts James A, Ohning Gordon, McLean Peter, Marvizon Juan Carlos, Sternini Catia, Pothoulakis Charalabos, Mayer Emeran A   The role of neurokinin 1 receptors in the maintenance of visceral hyperalgesia induced by repeated stress in rats Gastroenterology, 2006; 130(6): 1729-42.
Cottrell Graeme S, Roosterman Dirk, Marvizon Juan-Carlos, Song B, Wick Elizabeth, Pikios Stella, Wong Helen, Berthelier Claire, Tang Yat, Sternini Catia, Bunnett Nigel W, Grady Eileen F   Localization of calcitonin receptor-like receptor and receptor activity modifying protein 1 in enteric neurons, dorsal root ganglia, and the spinal cord of the rat The Journal of comparative neurology, 2005; 490(3): 239-55.
Kondo Ichiro, Marvizon Juan Carlos G, Song Bingbing, Salgado Frances, Codeluppi Simone, Hua Xiao-Ying, Yaksh Tony L   Inhibition by spinal mu- and delta-opioid agonists of afferent-evoked substance P release The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005; 25(14): 3651-60.
Marvizon Juan Carlos G, Wang Xueren, Lao Li-Jun, Song Bingbing   Effect of peptidases on the ability of exogenous and endogenous neurokinins to produce neurokinin 1 receptor internalization in the rat spinal cord British journal of pharmacology, 2003; 140(8): 1389-98.
Song Bingbing, Marvizón Juan Carlos G   Dorsal horn neurons firing at high frequency, but not primary afferents, release opioid peptides that produce micro-opioid receptor internalization in the rat spinal cord The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003; 23(27): 9171-84.
Song Bingbing, Marvizón Juan Carlos G   Peptidases prevent mu-opioid receptor internalization in dorsal horn neurons by endogenously released opioids The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003; 23(5): 1847-58.
Wang Xueren, Marvizón Juan Carlos G   Time-course of the internalization and recycling of neurokinin 1 receptors in rat dorsal horn neurons Brain research, 2002; 944(1-2): 239-47.
Marvizón Juan Carlos G, McRoberts James A, Ennes Helena S, Song Bingbing, Wang Xueren, Jinton Lisa, Corneliussen Brit, Mayer Emeran A   Two N-methyl-D-aspartate receptors in rat dorsal root ganglia with different subunit composition and localization The Journal of comparative neurology, 2002; 446(4): 325-41.
Lever I J, Bradbury E J, Cunningham J R, Adelson D W, Jones M G, McMahon S B, Marvizón J C, Malcangio M   Brain-derived neurotrophic factor is released in the dorsal horn by distinctive patterns of afferent fiber stimulation The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001; 21(12): 4469-77.
McRoberts J A, Coutinho S V, Marvizón J C, Grady E F, Tognetto M, Sengupta J N, Ennes H S, Chaban V V, Amadesi S, Creminon C, Lanthorn T, Geppetti P, Bunnett N W, Mayer E A   Role of peripheral N-methyl-D-aspartate (NMDA) receptors in visceral nociception in rats Gastroenterology, 2001; 120(7): 1737-48.
Marvizón J C, Grady E F, Waszak-McGee J, Mayer E A   Internalization of mu-opioid receptors in rat spinal cord slices Neuroreport, 1999; 10(11): 2329-34.
Marvizón J C, Grady E F, Stefani E, Bunnett N W, Mayer E A   Substance P release in the dorsal horn assessed by receptor internalization: NMDA receptors counteract a tonic inhibition by GABA(B) receptors The European journal of neuroscience, 1999; 11(2): 417-26.
Marvizón J C, Eskandari S, Ennes H S, Mayer E A   Substance P induces brief, localized increase in [Ca2+]i in dorsal horn neurons Neuroreport, 1998; 9(15): 3369-74.
Marvizón J C, Martínez V, Grady E F, Bunnett N W, Mayer E A   Neurokinin 1 receptor internalization in spinal cord slices induced by dorsal root stimulation is mediated by NMDA receptors The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997; 17(21): 8129-36.
Marvizón J C, Baudry M   Allosteric interactions and modulator requirement for NMDA receptor function European journal of pharmacology, 1994; 269(2): 165-75.
Lewin A H, Skolnick P, Marvizon J C, Paul I A, Bowen J P   Requirements for high affinity binding of glycine analogs to the glycine site of the NMDA receptor complex European journal of pharmacology, 1993; 247(1): 1-10.
Shahi K, Marvizon J C, Baudry M   High concentrations of glycine induce long-lasting changes in synaptic efficacy in rat hippocampal slices Neuroscience letters, 1993; 149(2): 185-8.
Marvizón J C, Baudry M   NMDA receptor activation by spermine requires glutamate but not glycine European journal of pharmacology, 1993; 244(1): 103-4.
Ruiz-Gómez A, Fernández-Shaw C, Morato E, Marvizón J C, Vázquez J, Valdivieso F, Mayor F   Sulfhydryl groups modulate the allosteric interaction between glycine binding sites at the inhibitory glycine receptor Journal of neurochemistry, 1991; 56(5): 1690-7.
Marvizón J C, Skolnick P   An endogenous modulator of N-methyl-D-aspartate receptor-coupled glycine receptors European journal of pharmacology, 1990; 188(1): 23-32.
Ruiz-Gómez A, García-Calvo M, Vázquez J, Marvizón J C, Valdivieso F, Mayor F   Thermodynamics of agonist and antagonist interaction with the strychnine-sensitive glycine receptor Journal of neurochemistry, 1989; 52(6): 1775-80.
Skolnick P, Marvizón J C, Jackson B W, Monn J A, Rice K C, Lewin A H   Blockade of N-methyl-D-aspartate induced convulsions by 1-aminocyclopropanecarboxylates Life sciences, 1989; 45(18): 1647-55.
Alonso T, Morgan R O, Marvizon J C, Zarbl H, Santos E   Malignant transformation by ras and other oncogenes produces common alterations in inositol phospholipid signaling pathways Proceedings of the National Academy of Sciences of the United States of America, 1988; 85(12): 4271-5.
Marvizón J C, Skolnick P   [3H]glycine binding is modulated by Mg2+ and other ligands of the NMDA receptor-cation channel complex European journal of pharmacology, 1988; 151(1): 157-8.
Marvizón J C, García Calvo M, Vázquez J, Mayor F, Ruíz Gómez A, Valdiviesco F, Benavides J   Activation and inhibition of 3H-strychnine binding to the glycine receptor by Eccles' anions: modulatory effects of cations Molecular pharmacology, 1986; 30(6): 598-602.
Marvizón J C, Vázquez J, García Calvo M, Mayor F, Ruíz Gómez A, Valdivieso F, Benavides J   The glycine receptor: pharmacological studies and mathematical modeling of the allosteric interaction between the glycine- and strychnine-binding sites Molecular pharmacology, 1986; 30(6): 590-7.
Marvizon J C, Rumigny J F, Benedetti M S, Gomeni C, Benavides J   Glycine binding to rat CNS membranes: possible cooperative interaction Advances in biochemical psychopharmacology, 1983; 37(6): 15-22.
Marvizón J G, Mayor F, Aragón M C, Giménez C, Valdivieso F   L-Aspartate transport into plasma membrane vesicles derived from rat brain synaptosomes Journal of neurochemistry, 1981; 37(6): 1401-6.
Mayor F, Marvizón J G, Aragón M C, Gimenez C, Valdivieso F   Glycine transport into plasma-membrane vesicles derived from rat brain synaptosomes The Biochemical journal, 1981; 198(3): 535-41.
Aragón M C, Giménez C, Mayor F, Marvizón J G, Valdivieso F   Tyrosine transport by membrane vesicles isolated from rat brain Biochimica et biophysica acta, 1981; 646(3): 465-70.