
Alapakkam P. Sampath, Ph.D.
Titles
Professor, Brain Research Institute
Stein Eye Institute
Member, Molecular, Cellular & Integrative Physiology GPB Home Area
Neuroscience GPB Home Area
Contact Information
Email
asampath@jsei.ucla.edu Phone
Work Phone Number:
310-825-2024
Address
Laboratory Address:
Jules Stein A-200CA
UNITED STATES
Publications
A selected list of publications:
Fain Gordon, Sampath Alapakkam P
Rod and cone interactions in the retina
F1000Research,
2018; 7:
.
Ingram Norianne T, Fain Gordon L, Sampath Alapakkam P
Elevated energy requirement of cone photoreceptors
Proceedings of the National Academy of Sciences of the United States of America,
2020; 117(32):
19599-19603.
Ellis Erika M, Frederiksen Rikard, Morshedian Ala, Fain Gordon L, Sampath Alapakkam P
Separate ON and OFF pathways in vertebrate vision first arose during
the Cambrian
Current biology : CB,
2020; 30(11):
R633-R634.
Peng Yi-Rong, Sampath Alapakkam P
LRR-ning the Rules: Synapse Organization in the Primary Rod Pathway
Neuron,
2020; 105(6):
949-951.
Ingram Norianne T, Sampath Alapakkam P, Fain Gordon L
Membrane conductances of mouse cone photoreceptors
The Journal of general physiology,
2020; 152(3):
949-951.
Ingram Norianne T, Sampath Alapakkam P, Fain Gordon L
Voltage-clamp recordings of light responses from wild-type and mutant
mouse cone photoreceptors
The Journal of general physiology,
2019; 151(11):
1287-1299.
Wang Tian, Pahlberg Johan, Cafaro Jon, Frederiksen Rikard, Cooper A J, Sampath Alapakkam P, Field Greg D, Chen Jeannie
Activation of Rod Input in a Model of Retinal Degeneration Reverses
Retinal Remodeling and Induces Formation of Functional Synapses and
Recovery of Visual Signaling in the Adult Retina
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2019; 39(34):
6798-6810.
Morshedian Ala, Kaylor Joanna J, Ng Sze Yin, Tsan Avian, Frederiksen Rikard, Xu Tongzhou, Yuan Lily, Sampath Alapakkam P, Radu Roxana A, Fain Gordon L, Travis Gabriel H
Light-Driven Regeneration of Cone Visual Pigments through a Mechanism
Involving RGR Opsin in Müller Glial Cells
Neuron,
2019; 102(6):
1172-1183.e5.
Sarria Ignacio, Cao Yan, Wang Yuchen, Ingram Norianne T, Orlandi Cesare, Kamasawa Naomi, Kolesnikov Alexander V, Pahlberg Johan, Kefalov Vladimir J, Sampath Alapakkam P, Martemyanov Kirill A
LRIT1 Modulates Adaptive Changes in Synaptic Communication of Cone
Photoreceptors
Cell reports,
2018; 22(13):
3562-3573.
Martemyanov Kirill A, Sampath Alapakkam P
The Transduction Cascade in Retinal ON-Bipolar Cells: Signal
Processing and Disease
Annual review of vision science,
2017; 3(13):
25-51.
Pahlberg Johan, Frederiksen Rikard, Pollock Gabriel E, Miyagishima Kiyoharu J, Sampath Alapakkam P, Cornwall M Carter
Voltage-sensitive conductances increase the sensitivity of rod
photoresponses following pigment bleaching
The Journal of physiology,
2017; 595(11):
3459-3469.
Field Greg D, Sampath Alapakkam P
Behavioural and physiological limits to vision in mammals
Philosophical transactions of the Royal Society of London. Series B, Biological sciences,
2017; 372(1717):
3459-3469.
Wang Yuchen, Fehlhaber Katherine E, Sarria Ignacio, Cao Yan, Ingram Norianne T, Guerrero-Given Debbie, Throesch Ben, Baldwin Kristin, Kamasawa Naomi, Ohtsuka Toshihisa, Sampath Alapakkam P, Martemyanov Kirill A
The Auxiliary Calcium Channel Subunit α2δ4 Is Required for Axonal
Elaboration, Synaptic Transmission, and Wiring of Rod Photoreceptors
Neuron,
2017; 93(6):
1359-1374.e6.
Ingram Norianne T, Sampath Alapakkam P, Fain Gordon L
Why are rods more sensitive than cones?
The Journal of physiology,
2016; 594(19):
5415-26.
Cao Yan, Sarria Ignacio, Fehlhaber Katherine E, Kamasawa Naomi, Orlandi Cesare, James Kiely N, Hazen Jennifer L, Gardner Matthew R, Farzan Michael, Lee Amy, Baker Sheila, Baldwin Kristin, Sampath Alapakkam P, Martemyanov Kirill A
Mechanism for Selective Synaptic Wiring of Rod Photoreceptors into the
Retinal Circuitry and Its Role in Vision
Neuron,
2015; 87(6):
1248-1260.
Majumder Anurima, Pahlberg Johan, Muradov Hakim, Boyd Kimberly K, Sampath Alapakkam P, Artemyev Nikolai O
Exchange of Cone for Rod Phosphodiesterase 6 Catalytic Subunits in Rod
Photoreceptors Mimics in Part Features of Light Adaptation
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2015; 35(24):
9225-35.
Majumder Anurima, Pahlberg Johan, Boyd Kimberly K, Kerov Vasily, Kolandaivelu Saravanan, Ramamurthy Visvanathan, Sampath Alapakkam P, Artemyev Nikolai O
Transducin translocation contributes to rod survival and enhances
synaptic transmission from rods to rod bipolar cells
Proceedings of the National Academy of Sciences of the United States of America,
2013; 110(30):
12468-73.
Mao Wen, Miyagishima K J, Yao Yun, Soreghan Brian, Sampath Alapakkam P, Chen Jeannie
Functional comparison of rod and cone Gα(t) on the regulation of
light sensitivity
The Journal of biological chemistry,
2013; 288(8):
5257-67.
Arman A Cyrus, Sampath Alapakkam P
Dark-adapted response threshold of OFF ganglion cells is not set by
OFF bipolar cells in the mouse retina
Journal of neurophysiology,
2012; 107(10):
2649-59.
Cao Yan, Pahlberg Johan, Sarria Ignacio, Kamasawa Naomi, Sampath Alapakkam P, Martemyanov Kirill A
Regulators of G protein signaling RGS7 and RGS11 determine the onset
of the light response in ON bipolar neurons
Proceedings of the National Academy of Sciences of the United States of America,
2012; 109(20):
7905-10.
Doroudchi M Mehdi, Greenberg Kenneth P, Liu Jianwen, Silka Kimberly A, Boyden Edward S, Lockridge Jennifer A, Arman A Cyrus, Janani Ramesh, Boye Shannon E, Boye Sanford L, Gordon Gabriel M, Matteo Benjamin C, Sampath Alapakkam P, Hauswirth William W, Horsager Alan
Virally delivered channelrhodopsin-2 safely and effectively restores
visual function in multiple mouse models of blindness
Molecular therapy : the journal of the American Society of Gene Therapy,
2011; 19(7):
1220-9.
Altimus Cara M, Güler Ali D, Alam Nazia M, Arman A Cyrus, Prusky Glen T, Sampath Alapakkam P, Hattar Samer
Rod photoreceptors drive circadian photoentrainment across a wide
range of light intensities
Nature neuroscience,
2010; 13(9):
1107-12.
Okawa Haruhisa, Miyagishima K Joshua, Arman A Cyrus, Hurley James B, Field Greg D, Sampath Alapakkam P
Optimal processing of photoreceptor signals is required to maximize
behavioural sensitivity
The Journal of physiology,
2010; 588(Pt 11):
1947-60.
Matthews Hugh R, Sampath Alapakkam P
Photopigment quenching is Ca2+ dependent and controls response
duration in salamander L-cone photoreceptors
The Journal of general physiology,
2010; 135(4):
355-66.