Aldons J. Lusis, Ph.D.

Titles

Professor, Medicine

Human Genetics

Microbiology, Immunology & Molecular Genetics

Vice Chair, Human Genetics

Member, Brain Research Institute

CTSI

Center for Duchenne Muscular Dystrophy

Genetics & Genomics GPB Home Area

JCCC Cancer and Stem Cell Biology Program Area

Molecular Pharmacology GPB Home Area

Molecular, Cellular & Integrative Physiology GPB Home Area

Workforce Development

Faculty, Cardiology

BWF-IT-MD

Center for Metabolic Disease Prevention

Contact Information

Email
jlusis@mednet.ucla.edu
Phone
Fax Number: 310-825-1595
Work Phone Number: (310) 825-1359
310-825-2957
Address

Mailing Address:

10833 Le Conte Avenue
CAMPUS - 167917, A2-237 CHS
Los Angeles, CA 90095
UNITED STATES

Work Address:

Office
MRL 3-730
Los Angeles, CA 90095
UNITED STATES
Laboratory
MRL
Los Angeles, CA 90095
UNITED STATES

Publications

Wang JJ, Rau C, Avetisyan R, Ren S, Romay MC, Stolin G, Gong KW, Wang Y, Lusis AJ.   Genetic dissection of cardiac remodeling in an isoproterenol-induced heart failure mouse model, PLoS Genet. , 2016; 12:e1006038.
Pillai Indulekha C L, Li Shen, Romay Milagros, Lam Larry, Lu Yan, Huang Jie, Dillard Nathaniel, Zemanova Marketa, Rubbi Liudmilla, Wang Yibin, Lee Jason, Xia Ming, Liang Owen, Xie Ya-Hong, Pellegrini Matteo, Lusis Aldons J, Deb Arjun   Cardiac Fibroblasts Adopt Osteogenic Fates and Can Be Targeted to Attenuate Pathological Heart Calcification Cell stem cell, 2016; .
Rau Christoph D, Romay Milagros C, Tuteryan Mary, Wang Jessica J-C, Santolini Marc, Ren Shuxun, Karma Alain, Weiss James N, Wang Yibin, Lusis Aldons J   Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice Cell systems, 2016; .
Wang Jessica Jen-Chu, Rau Christoph, Avetisyan Rozeta, Ren Shuxun, Romay Milagros C, Stolin Gabriel, Gong Ke Wei, Wang Yibin, Lusis Aldons J   Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model PLoS genetics, 2016; 12(7): e1006038.
Bennett Brian J, Davis Richard C, Civelek Mete, Orozco Luz, Wu Judy, Qi Hannah, Pan Calvin, Sevag Packard René R, Eskin Eleazar, Yan Mujing, Kirchgessner Todd, Wang Zeneng, Li Xinmin, Gregory Jill C, Hazen Stanley L, Gargalovic Peter S, Lusis Aldons J   Correction: Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains PLoS genetics, 2016; 12(3): e1005913.
Zhu Weifei, Gregory Jill C, Org Elin, Buffa Jennifer A, Gupta Nilaksh, Wang Zeneng, Li Lin, Fu Xiaoming, Wu Yuping, Mehrabian Margarete, Sartor R Balfour, McIntyre Thomas M, Silverstein Roy L, Tang W H Wilson, DiDonato Joseph A, Brown J Mark, Lusis Aldons J, Hazen Stanley L   Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk Cell, 2016; 165(1): 111-24.
Org Elin, Parks Brian W, Joo Jong Wha J, Emert Benjamin, Schwartzman William, Kang Eun Yong, Mehrabian Margarete, Pan Calvin, Knight Rob, Gunsalus Robert, Drake Thomas A, Eskin Eleazar, Lusis Aldons J   Genetic and environmental control of host-gut microbiota interactions Genome research, 2015; 25(10): 1558-69.
Hui Simon T, Parks Brian W, Org Elin, Norheim Frode, Che Nam, Pan Calvin, Castellani Lawrence W, Charugundla Sarada, Dirks Darwin L, Psychogios Nikolaos, Neuhaus Isaac, Gerszten Robert E, Kirchgessner Todd, Gargalovic Peter S, Lusis Aldons J   The genetic architecture of NAFLD among inbred strains of mice eLife, 2015; 4: e05607.
Parks Brian W, Sallam Tamer, Mehrabian Margarete, Psychogios Nikolas, Hui Simon T, Norheim Frode, Castellani Lawrence W, Rau Christoph D, Pan Calvin, Phun Jennifer, Zhou Zhenqi, Yang Wen-Pin, Neuhaus Isaac, Gargalovic Peter S, Kirchgessner Todd G, Graham Mark, Lee Richard, Tontonoz Peter, Gerszten Robert E, Hevener Andrea L, Lusis Aldons J   Genetic architecture of insulin resistance in the mouse Cell metabolism, 2015; 21(2): 334-46.
Parks Brian W, Nam Elizabeth, Org Elin, Kostem Emrah, Norheim Frode, Hui Simon T, Pan Calvin, Civelek Mete, Rau Christoph D, Bennett Brian J, Mehrabian Margarete, Ursell Luke K, He Aiqing, Castellani Lawrence W, Zinker Bradley, Kirby Mark, Drake Thomas A, Drevon Christian A, Knight Rob, Gargalovic Peter, Kirchgessner Todd, Eskin Eleazar, Lusis Aldons J   Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice Cell metabolism, 2013; 17(1): 141-52.
Bennett Brian J, de Aguiar Vallim Thomas Q, Wang Zeneng, Shih Diana M, Meng Yonghong, Gregory Jill, Allayee Hooman, Lee Richard, Graham Mark, Crooke Rosanne, Edwards Peter A, Hazen Stanley L, Lusis Aldons J   Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation Cell metabolism, 2013; 17(1): 49-60.
Orozco Luz D, Bennett Brian J, Farber Charles R, Ghazalpour Anatole, Pan Calvin, Che Nam, Wen Pingzi, Qi Hong Xiu, Mutukulu Adonisa, Siemers Nathan, Neuhaus Isaac, Yordanova Roumyana, Gargalovic Peter, Pellegrini Matteo, Kirchgessner Todd, Lusis Aldons J   Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages Cell, 2012; 151(3): 658-70.
Romanoski Casey E, Che Nam, Yin Fen, Mai Nguyen, Pouldar Delila, Civelek Mete, Pan Calvin, Lee Sangderk, Vakili Ladan, Yang Wen-Pin, Kayne Paul, Mungrue Imran N, Araujo Jesus A, Berliner Judith A, Lusis Aldons J   Network for activation of human endothelial cells by oxidized phospholipids: a critical role of heme oxygenase 1 Circulation research, 2011; 109(5): e27-41.
Wang Zeneng, Klipfell Elizabeth, Bennett Brian J, Koeth Robert, Levison Bruce S, Dugar Brandon, Feldstein Ariel E, Britt Earl B, Fu Xiaoming, Chung Yoon-Mi, Wu Yuping, Schauer Phil, Smith Jonathan D, Allayee Hooman, Tang W H Wilson, DiDonato Joseph A, Lusis Aldons J, Hazen Stanley L   Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease Nature, 2011; 472(7341): 57-63.
Farber Charles R, Bennett Brian J, Orozco Luz, Zou Wei, Lira Ana, Kostem Emrah, Kang Hyun Min, Furlotte Nicholas, Berberyan Ani, Ghazalpour Anatole, Suwanwela Jaijam, Drake Thomas A, Eskin Eleazar, Wang Q Tian, Teitelbaum Steven L, Lusis Aldons J   Mouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesis PLoS genetics, 2011; 7(4): e1002038.
Bennett Brian J, Farber Charles R, Orozco Luz, Kang Hyun Min, Ghazalpour Anatole, Siemers Nathan, Neubauer Michael, Neuhaus Isaac, Yordanova Roumyana, Guan Bo, Truong Amy, Yang Wen-pin, He Aiqing, Kayne Paul, Gargalovic Peter, Kirchgessner Todd, Pan Calvin, Castellani Lawrence W, Kostem Emrah, Furlotte Nicholas, Drake Thomas A, Eskin Eleazar, Lusis Aldons J   A high-resolution association mapping panel for the dissection of complex traits in mice Genome research, 2010; 20(2): 281-90.
Meng Haijin, Vera Iset, Che Nam, Wang Xuping, Wang Susanna S, Ingram-Drake Leslie, Schadt Eric E, Drake Thomas A, Lusis Aldons J   Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics Proceedings of the National Academy of Sciences of the United States of America, 2007; 104(11): 4530-5.
Schadt Eric E, Lamb John, Yang Xia, Zhu Jun, Edwards Steve, Guhathakurta Debraj, Sieberts Solveig K, Monks Stephanie, Reitman Marc, Zhang Chunsheng, Lum Pek Yee, Leonardson Amy, Thieringer Rolf, Metzger Joseph M, Yang Liming, Castle John, Zhu Haoyuan, Kash Shera F, Drake Thomas A, Sachs Alan, Lusis Aldons J   An integrative genomics approach to infer causal associations between gene expression and disease Nature genetics, 2005; 37(7): 710-7.
Bodnar Jackie S, Chatterjee Aurobindo, Castellani Lawrence W, Ross David A, Ohmen Jeffrey, Cavalcoli James, Wu Chenyan, Dains Katherine M, Catanese Joe, Chu Michael, Sheth Sonal S, Charugundla Kanti, Demant Peter, West David B, de Jong Pieter, Lusis Aldons J   Positional cloning of the combined hyperlipidemia gene Hyplip1 Nature genetics, 2002; 30(1): 110-6.
Shih D M, Gu L, Xia Y R, Navab M, Li W F, Hama S, Castellani L W, Furlong C E, Costa L G, Fogelman A M, Lusis A J   Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis Nature, 1998; 394(6690): 284-7.
Warden C H, Hedrick C C, Qiao J H, Castellani L W, Lusis A J   Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II Science (New York, N.Y.), 1993; 261(5120): 469-72.
Rajavashisth T B, Andalibi A, Territo M C, Berliner J A, Navab M, Fogelman A M, Lusis A J   Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low-density lipoproteins Nature, 1990; 344(6263): 254-7.
Kirchgessner T G, Chuat J C, Heinzmann C, Etienne J, Guilhot S, Svenson K, Ameis D, Pilon C, d'Auriol L, Andalibi A   Organization of the human lipoprotein lipase gene and evolution of the lipase gene family Proceedings of the National Academy of Sciences of the United States of America, 1989; 86(24): 9647-51.
Lusis A J, West R, Mehrabian M, Reuben M A, LeBoeuf R C, Kaptein J S, Johnson D F, Schumaker V N, Yuhasz M P, Schotz M C   Cloning and expression of apolipoprotein B, the major protein of low and very low density lipoproteins Proceedings of the National Academy of Sciences of the United States of America, 1985; 82(14): 4597-601.
Lusis A J, Taylor B A, Wangenstein R W, LeBoeuf R C   Genetic control of lipid transport in mice. II. Genes controlling structure of high density lipoproteins The Journal of biological chemistry, 1983; 258(8): 5071-8.