
Arthur P. Arnold, Ph.D.
Titles
Distinguished Research Professor, Integrative Biology and Physiology
Member, Brain Research Institute
Contact Information
Email
arnold@ucla.edu Phone
Lab Number:
(310)825-9340
Office Phone Number: (310)825-2169
Office Phone Number: (310)825-2169
Address
Laboratory Address:
LaboratoryTerasaki 1129
UNITED STATES
Work Address:
Office1129 Terasaki
UNITED STATES
Publications
A selected list of publications:
Umar Soban, Cunningham Christine M, Itoh Yuichiro, Moazeni Shayan, Vaillancourt Mylene, Sarji Shervin, Centala Alex, Arnold Arthur P, Eghbali Mansoureh
The Y Chromosome Plays a Protective Role in Experimental Hypoxic
Pulmonary Hypertension
American journal of respiratory and critical care medicine,
2018; 197(7):
952-955.
McCarthy Margaret M, Woolley Catherine S, Arnold Arthur P
Incorporating sex as a biological variable in neuroscience: what do we
gain?
Nature reviews. Neuroscience,
2017; 18(12):
707-708.
Mauvais-Jarvis Franck, Arnold Arthur P, Reue Karen
A Guide for the Design of Pre-clinical Studies on Sex Differences in
Metabolism
Cell metabolism,
2017; 25(6):
1216-1230.
Arnold Arthur P, Cassis Lisa A, Eghbali Mansoureh, Reue Karen, Sandberg Kathryn
Sex Hormones and Sex Chromosomes Cause Sex Differences in the
Development of Cardiovascular Diseases
Arteriosclerosis, thrombosis, and vascular biology,
2017; 37(5):
746-756.
Arnold Arthur P
Y chromosome's roles in sex differences in disease
Proceedings of the National Academy of Sciences of the United States of America,
2017; 114(15):
3787-3789.
Arnold Arthur P
A general theory of sexual differentiation
Journal of neuroscience research,
2017; 95(1-2):
291-300.
Miller Leah R, Marks Cheryl, Becker Jill B, Hurn Patricia D, Chen Wei-Jung, Woodruff Teresa, McCarthy Margaret M, Sohrabji Farida, Schiebinger Londa, Wetherington Cora Lee, Makris Susan, Arnold Arthur P, Einstein Gillian, Miller Virginia M, Sandberg Kathryn, Maier Susan, Cornelison Terri L, Clayton Janine A
Considering sex as a biological variable in preclinical research
FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
2017; 31(1):
29-34.
Link Jenny C, Hasin-Brumshtein Yehudit, Cantor Rita M, Chen Xuqi, Arnold Arthur P, Lusis Aldons J, Reue Karen
Diet, gonadal sex, and sex chromosome complement influence white
adipose tissue miRNA expression
BMC genomics,
2017; 18(1):
89.
Maric-Bilkan Christine, Arnold Arthur P, Taylor Doris A, Dwinell Melinda, Howlett Susan E, Wenger Nanette, Reckelhoff Jane F, Sandberg Kathryn, Churchill Gary, Levin Ellis, Lundberg Martha S
Report of the National Heart, Lung, and Blood Institute Working Group
on Sex Differences Research in Cardiovascular Disease: Scientific
Questions and Challenges
Hypertension (Dallas, Tex. : 1979),
2016; 67(5):
802-7.
Arnold Arthur P, Reue Karen, Eghbali Mansoureh, Vilain Eric, Chen Xuqi, Ghahramani Negar, Itoh Yuichiro, Li Jingyuan, Link Jenny C, Ngun Tuck, Williams-Burris Shayna M
The importance of having two X chromosomes
Philosophical transactions of the Royal Society of London. Series B, Biological sciences,
2016; 371(1688):
20150113.
Burgoyne Paul S, Arnold Arthur P
A primer on the use of mouse models for identifying direct sex
chromosome effects that cause sex differences in non-gonadal tissues
Biology of sex differences,
2016; 7(1):
68.
Link Jenny C, Chen Xuqi, Prien Christopher, Borja Mark S, Hammerson Bradley, Oda Michael N, Arnold Arthur P, Reue Karen
Increased high-density lipoprotein cholesterol levels in mice with XX
versus XY sex chromosomes
Arteriosclerosis, thrombosis, and vascular biology,
2015; 35(8):
1778-86.
Holásková Ida, Franko Jennifer, Goodman Robert L, Arnold Arthur P, Schafer Rosana
The XX Sex Chromosome Complement is Required in Male and Female Mice
for Enhancement of Immunity Induced by Exposure to
3,4-Dichloropropionanilide
American journal of reproductive immunology (New York, N.Y. : 1989),
2015; 74(2):
136-47.
Itoh Yuichiro, Mackie Ryan, Kampf Kathy, Domadia Shelly, Brown Judith D, O'Neill Rachel, Arnold Arthur P
Four core genotypes mouse model: localization of the Sry transgene and
bioassay for testicular hormone levels
BMC research notes,
2015; 8(8):
69.
Chen Xuqi, Wang Lixin, Loh Dawn H, Colwell Christopher S, Taché Yvette, Reue Karen, Arnold Arthur P
Sex differences in diurnal rhythms of food intake in mice caused by
gonadal hormones and complement of sex chromosomes
Hormones and behavior,
2015; 75(8):
55-63.
Itoh Yuichiro, Arnold Arthur P
Are females more variable than males in gene expression? Meta-analysis
of microarray datasets
Biology of sex differences,
2015; 6(1688):
18.
Manwani Bharti, Bentivegna Kathryn, Benashski Sharon E, Venna Venugopal Reddy, Xu Yan, Arnold Arthur P, McCullough Louise D
Sex differences in ischemic stroke sensitivity are influenced by
gonadal hormones, not by sex chromosome complement
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism,
2015; 35(2):
221-9.
Itoh Yuichiro, Arnold Arthur P
X chromosome regulation of autosomal gene expression in bovine
blastocysts
Chromosoma,
2014; 123(5):
481-9.
Arnold Arthur P
Conceptual frameworks and mouse models for studying sex differences in
physiology and disease: why compensation changes the game
Experimental neurology,
2014; 259(5):
2-9.
Ngun Tuck C, Ghahramani Negar M, Creek Michelle M, Williams-Burris Shayna M, Barseghyan Hayk, Itoh Yuichiro, Sánchez Francisco J, McClusky Rebecca, Sinsheimer Janet S, Arnold Arthur P, Vilain Eric
Feminized behavior and brain gene expression in a novel mouse model of
Klinefelter Syndrome
Archives of sexual behavior,
2014; 43(6):
1043-57.
Seu E, Groman S M, Arnold A P, Jentsch J D
Sex chromosome complement influences operant responding for a
palatable food in mice
Genes, brain, and behavior,
2014; 13(6):
527-34.
Li Jingyuan, Chen Xuqi, McClusky Rebecca, Ruiz-Sundstrom Maureen, Itoh Yuichiro, Umar Soban, Arnold Arthur P, Eghbali Mansoureh
The number of X chromosomes influences protection from cardiac
ischaemia/reperfusion injury in mice: one X is better than two
Cardiovascular research,
2014; 102(3):
375-84.
Ghahramani Negar M, Ngun Tuck C, Chen Pao-Yang, Tian Yuan, Krishnan Sangitha, Muir Stephanie, Rubbi Liudmilla, Arnold Arthur P, de Vries Geert J, Forger Nancy G, Pellegrini Matteo, Vilain Eric
The effects of perinatal testosterone exposure on the DNA methylome of
the mouse brain are late-emerging
Biology of sex differences,
2014; 5(7):
8.
Du Sienmi, Itoh Noriko, Askarinam Sahar, Hill Haley, Arnold Arthur P, Voskuhl Rhonda R
XY sex chromosome complement, compared with XX, in the CNS confers
greater neurodegeneration during experimental autoimmune
encephalomyelitis
Proceedings of the National Academy of Sciences of the United States of America,
2014; 111(7):
2806-11.
Arnold Arthur P, Chen Xuqi, Link Jenny C, Itoh Yuichiro, Reue Karen
Cell-autonomous sex determination outside of the gonad
Developmental dynamics : an official publication of the American Association of Anatomists,
2013; 242(4):
371-9.
Kuljis Dika A, Loh Dawn H, Truong Danny, Vosko Andrew M, Ong Margaret L, McClusky Rebecca, Arnold Arthur P, Colwell Christopher S
Gonadal- and sex-chromosome-dependent sex differences in the circadian
system
Endocrinology,
2013; 154(4):
1501-12.
Link Jenny C, Chen Xuqi, Arnold Arthur P, Reue Karen
Metabolic impact of sex chromosomes
Adipocyte,
2013; 2(2):
74-9.
Chen Xuqi, McClusky Rebecca, Itoh Yuichiro, Reue Karen, Arnold Arthur P
X and Y chromosome complement influence adiposity and metabolism in
mice
Endocrinology,
2013; 154(3):
1092-104.
Chen Xuqi, Williams-Burris Shayna M, McClusky Rebecca, Ngun Tuck C, Ghahramani Negar, Barseghyan Hayk, Reue Karen, Vilain Eric, Arnold Arthur P
The Sex Chromosome Trisomy mouse model of XXY and XYY: metabolism and
motor performance
Biology of sex differences,
2013; 4(1):
15.
Drnevich Jenny, Replogle Kirstin L, Lovell Peter, Hahn Thomas P, Johnson Frank, Mast Thomas G, Nordeen Ernest, Nordeen Kathy, Strand Christy, London Sarah E, Mukai Motoko, Wingfield John C, Arnold Arthur P, Ball Gregory F, Brenowitz Eliot A, Wade Juli, Mello Claudio V, Clayton David F
Impact of experience-dependent and -independent factors on gene
expression in songbird brain
Proceedings of the National Academy of Sciences of the United States of America,
2012; 109 Suppl 2(3):
17245-52.
Arnold Arthur P, Lusis Aldons J
Understanding the sexome: measuring and reporting sex differences in
gene systems
Endocrinology,
2012; 153(6):
2551-5.
McCarthy Margaret M, Arnold Arthur P, Ball Gregory F, Blaustein Jeffrey D, De Vries Geert J
Sex differences in the brain: the not so inconvenient truth
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2012; 32(7):
2241-7.
Arnold Arthur P
The end of gonad-centric sex determination in mammals
Trends in genetics : TIG,
2012; 28(2):
55-61.
Chen Xuqi, McClusky Rebecca, Chen Jenny, Beaven Simon W, Tontonoz Peter, Arnold Arthur P, Reue Karen
The number of x chromosomes causes sex differences in adiposity in
mice
PLoS genetics,
2012; 8(5):
e1002709.
Arnold Arthur P, Chen Xuqi, Itoh Yuichiro
What a difference an X or Y makes: sex chromosomes, gene dose, and
epigenetics in sexual differentiation
Handbook of experimental pharmacology,
2012; 28(214):
67-88.
Itoh Yuichiro, Kampf Kathy, Arnold Arthur P
Possible differences in the two Z chromosomes in male chickens and
evolution of MHM sequences in Galliformes
Chromosoma,
2011; 120(6):
587-98.
Robinson Dionne P, Huber Sally A, Moussawi Mohamad, Roberts Brian, Teuscher Cory, Watkins Rebecca, Arnold Arthur P, Klein Sabra L
Sex chromosome complement contributes to sex differences in
coxsackievirus B3 but not influenza A virus pathogenesis
Biology of sex differences,
2011; 2(6):
8.
Arnold AP, Itoh Y, Melamed E
A bird's eye view of sex chromosome dosage compensation,
Annual Review of Genomics and Human Genetics,
2008; in press:
.
*Gioiosa L, *Chen X (co-first authors), Watkins R, Klanfer N, Bryant CD, Evans CJ, Arnold AP
Sex chromosome complement affects nociception in tests of actue and chronic exposure to morphine in mice,
Hormones and Behavior,
2008; 54:
124-130.
Chen X, Watkins R, Delot E, Releine R, Schiestl RH, Burgoyne PS, Arnold AP
Sex difference in neural tube defects in p53-null mice is caused by differences in the complement of X not Y genes,
Developmental Neurobiology,
2008; 68:
265-273.
*Itoh Y, *Melamed E (*co-first authors), Yang X, Kampf K, Wang S, Yehya N, Van Nas A, Replogle K, Band MR, Clayton DF, Schadt EE, Lusis AJ, Arnold AP
Dosage compensation is less effective in birds than in mammals
Journal of Biology,
2007; 6:
2.
Melamed E, Arnold AP
Regional differences in dosage compensation on the chicken Z chromosome,
Genome Biology,
2007; 8:
R202.
Quinn JJ, Hitchcott PK, Umeda EA, Arnold AP, Taylor JR
Sex chromosome complement determines habit formation,
Nature Neuroscience,
2007; 10:
1398-1400.
Gatewood JD, Wills A, Shetty S, Xu J, Arnold AP, Burgoyne PS, Rissman EF.
Sex chromosome complement and gonadal sex influence aggressive and parental behaviors in mice,
Journal of Neuroscience,
2006; 26:
2335-2342.
Palaszynski KM, Smith DL, Burgoyne PS, Arnold AP, Voskuhl RR
A yin-yang effect between sex chromosomes and sex hormones on the immune response,
Endocrinology,
2005; 146:
3280-3285.
Chen X, Agate RJ, Itoh Y, Arnold AP
Sexually dimorphic expression of trkB, a Z-linked gene, in early posthatch zebra finch brain,
Proceedings of the National Academy of Sciences USA ,
2005; 102:
7730-7735.
Arnold AP
Sex chromosomes and brain gender
Nature Reviews Neuroscience ,
2004; 5(9):
701-8.
Arnold, AP Burgoyne, PS
Are XX and XY brain cells intrinsically different?
Trends in endocrinology and metabolism: TEM. ,
2004; 15(1):
6-11.
Agate RJ, Grisham W, Wade J, Mann S, Wingfield J, Schanen C, Palotie A, Arnold AP
Neural not gonadal origin of brain sex differences in a gynandromorphic finch,
Proceedings of the National Academy of Sciences USA,
2003; 100:
4873-4878.
Carruth LC, Reisert I, Arnold AP
Direct effect of sex chromosome genes on brain sexual differentiation,
Nature Neuroscience ,
2002; 5:
933-934.
De Vries GJ, Rissman EF, Simerly RB, Yang L-Y , Scordalakes EM, Auger C, Swain A, Lovell-Badge R, Burgoyne PS, Arnold AP
Sex chromosome effects on the induction of sexually dimorphic neural and behavioral development,
Journal of Neuroscience,
2002; 22:
9005-9014.