Baljit S. Khakh, Ph.D.

Titles

Professor, Neuroscience IDP
Neurobiology
Physiology
Member, Brain Research Institute
Molecular Pharmacology GPB Home Area
Molecular, Cellular & Integrative Physiology GPB Home Area
Neuroscience GPB Home Area
Faculty, Molecular, Cellular, and Integrative Physiology IDP

Contact Information

Email
bkhakh@mednet.ucla.edu
Phone
Work Phone Number: 310-825-6258
Address
Office Address: Departments of Physiology, and NeurobiologyUCLAUNITED STATES

Biography

Baljit S. Khakh received a Ph.D. degree from the University of Cambridge in 1995. During his graduate studies, he also spent some time at the Geneva Biomedical Research Institute. Dr. Khakh completed a postdoctoral fellowship in the laboratory of Dr. Graeme Henderson at the University of Bristol, followed by a fellowship at the California Institute of Technology, working in the laboratories of Drs. Henry A. Lester and Norman Davidson as a Wellcome Trust International Prize Traveling Research Fellow, and Senior Research Fellow in the Division of Biology. In 2001, Dr. Khakh returned to Cambridge in the Division of Neurobiology at the MRC Laboratory of Molecular Biology. Dr. Khakh joined UCLA in April 2006.

Publications:

Tong Xiaoping, Shigetomi Eiji, Looger Loren L, Khakh Baljit S   Genetically encoded calcium indicators and astrocyte calcium microdomains The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2013; 19(3): 274-91.
Shigetomi Eiji, Jackson-Weaver Olan, Huckstepp Robert T, O'Dell Thomas J, Khakh Baljit S   TRPA1 channels are regulators of astrocyte basal calcium levels and long-term potentiation via constitutive D-serine release The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013; 33(24): 10143-53.
Shigetomi Eiji, Bushong Eric A, Haustein Martin D, Tong Xiaoping, Jackson-Weaver Olan, Kracun Sebastian, Xu Ji, Sofroniew Michael V, Ellisman Mark H, Khakh Baljit S   Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses The Journal of general physiology, 2013; 141(5): 633-47.
Hamby Mary E, Coppola Giovanni, Ao Yan, Geschwind Daniel H, Khakh Baljit S, Sofroniew Michael V   Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012; 32(42): 14489-510.
Khakh Baljit S, North R Alan   Neuromodulation by extracellular ATP and P2X receptors in the CNS Neuron, 2012; 76(1): 51-69.
E. Shigetomi, X. Tong, K. Kwan, D.P. Corey, & B.S. Khakh   TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy via GAT-3 Nature Neuroscience, 2012; 15: 70-80.
Toulme Estelle, Khakh Baljit S   Imaging P2X4 receptor lateral mobility in microglia: regulation by calcium and p38 MAPK The Journal of biological chemistry, 2012; 287(18): 14734-48.
Shigetomi Eiji, Tong Xiaoping, Kwan Kelvin Y, Corey David P, Khakh Baljit S   TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3 Nature neuroscience, 2012; 15(1): 70-80.
Richler Esther, Shigetomi Eiji, Khakh Baljit S   Neuronal P2X2 receptors are mobile ATP sensors that explore the plasma membrane when activated The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011; 31(46): 16716-30.
Richler E, Shigetomi E, Khakh BS.   Neuronal P2X2 Receptors Are Mobile ATP Sensors That Explore the Plasma Membrane When Activated J Neurosci, 2011; 31: 16716-30.
Reeves Alexander M B, Shigetomi Eiji, Khakh Baljit S   Bulk loading of calcium indicator dyes to study astrocyte physiology: key limitations and improvements using morphological maps The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011; 31(25): 9353-8.
Shigetomi Eiji, Kracun Sebastian, Khakh Baljit S   Monitoring astrocyte calcium microdomains with improved membrane targeted GCaMP reporters Neuron glia biology, 2010; 6(3): 183-91.
Shigetomi E, Kracun S, Sofroniew MV, Khakh BS.   A genetically targeted optical sensor to monitor calcium signals in astrocyte processes Nature Neuroscience, 2010; 13: 759-66.
Shigetomi Eiji, Kracun Sebastian, Sofroniew Michael V, Khakh Baljit S   A genetically targeted optical sensor to monitor calcium signals in astrocyte processes Nature neuroscience, 2010; 13(6): 759-66.
Toulme Estelle, Garcia Angie, Samways Damien, Egan Terrance M, Carson Monica J, Khakh Baljit S   P2X4 receptors in activated C8-B4 cells of cerebellar microglial origin The Journal of general physiology, 2010; 135(4): 333-53.
Kracun Sebastian, Chaptal Vincent, Abramson Jeff, Khakh Baljit S   Gated access to the pore of a P2X receptor: structural implications for closed-open transitions The Journal of biological chemistry, 2010; 285(13): 10110-21.
Kracun Sebastian, Chaptal Vincent, Abramson Jeff, Khakh Baljit S   Gated access to the pore of a P2X receptor: structural implications for closed-open transitions The Journal of biological chemistry, 2010; 285(13): 10110-21.
Shigetomi Eiji, Khakh Baljit S   Measuring near plasma membrane and global intracellular calcium dynamics in astrocytes Journal of visualized experiments : JoVE, 2009; 301(26): .
Singh Harpreet, Warburton Sarah, Vondriska Thomas M, Khakh Baljit S   Proteomics to identify proteins interacting with P2X2 ligand-gated cation channels Journal of visualized experiments : JoVE, 2009; 301(27): .
Khakh Baljit S, Burnstock Geoffrey   The double life of ATP Scientific American, 2009; 301(6): 84-90, 92.
Chaumont Severine, Compan Vincent, Toulme Estelle, Richler Esther, Housley Gary D, Rassendren Francois, Khakh Baljit S   Regulation of P2X2 receptors by the neuronal calcium sensor VILIP1 Science signaling, 2008; 1(41): ra8.
E. Richler, S. Chaumont, E. Shigetomi, A. Sagasti & BS. Khakh.   Tracking transmitter-gated P2X cation channel activation in vitro and in vivo, Nature Methods, 2008; 5: 87-93.
D.N. Bowser & BS. Khakh   Two forms of astrocyte single vesicle exocytosis imaged with total internal reflection fluorescence microscopy, Proc Natl Acad Sci USA, 2007; 104: 485-91.
Khakh, B. S. North, R. A.   P2X receptors as cell surface ATP sensors in health and disease, Nature, 2006; 442: 527-532.
Khakh, B. S.   Molecular physiology of P2X receptors and ATP signalling at synapses Nat Rev Neurosci, 2001; 2(3): 165-74.
Khakh, B.S. Zhou, X. Sydes, J. Galligan, J.J. Lester, H.A.   State-dependent cross-inhibition between transmitter-gated cation channels, Nature, 2000; 406: 405-410.
Khakh, B.S. Lester, H.A.   Dynamic Selectivity Filters in Ion Channels, Neuron, 1999; 23: 653-658.
Khakh, B.S. Bao, X. Labarca, C. Lester, H.A.   Neuronal P2X receptor-transmitter-gated cation channels change their ion selectivity in seconds, Nat Neurosci, 1999; 2(4): 322-330.