Brent L. Fogel, M.D., Ph.D.

Titles

Assistant Professor, Neurology
Member, Genetics & Genomics GPB Home Area
Neuroscience GPB Home Area
Assistant Professor In-Residence, Brain Research Institute
Neuroscience IDP

Awards and Honors:

UCLA

Contact Information

Email
bfogel@ucla.edu
Phone
Work Phone Number: 310-825-6816
Address
Work Address: 695 Charles E. Young Drive South, Gonda Room 1206Los Angeles, CA 90095UNITED STATES

Biography

Dr. Brent Fogel obtained a Ph.D. in Microbiology and Molecular Genetics from the Medical College of Wisconsin as well as an M.D. degree. He completed his residency training in Neurology at UCLA as well as a fellowship in Neurogenetics. He is currently an Assistant Professor in the Neurogenetics Program of the Department of Neurology at the David Geffen School of Medicine at UCLA. Dr. Fogel’s research studies basic molecular mechanisms of neuronal function to understand how impairment can lead to neurodevelopmental conditions such as autism spectrum disorder and neurodegenerative disorders such as cerebellar ataxia. Clinically, Dr. Fogel also treats patients with various disorders of balance and coordination at the UCLA Ataxia Center and directs the Ataxia and Neurogenetics Biobank Program using genome-wide methods to identify rare and novel causes of neurodegenerative disease, particularly cerebellar ataxia. He has authored many research and clinical articles, reviews, and book chapters on spinocerebellar ataxia, clinical neurogenetics, and neurodevelopmental disease. Dr. Fogel’s work has been funded by the American Academy of Neurology, the American Brain Foundation, the National Institutes of Health, and the National Ataxia Foundation.

Publications:

Fogel Brent L, Vickrey Barbara G, Walton-Wetzel Jenny, Lieber Eli, Browner Carole H   Utilization of Genetic Testing Prior to Subspecialist Referral for Cerebellar Ataxia Genetic testing and molecular biomarkers, 2013; .
Giorgio Elisa, Rolyan Harshvardhan, Kropp Laura, Chakka Anish Baswanth, Yatsenko Svetlana, Gregorio Eleonora Di, Lacerenza Daniela, Vaula Giovanna, Talarico Flavia, Mandich Paola, Toro Camilo, Pierre Eleonore Eymard, Labauge Pierre, Capellari Sabina, Cortelli Pietro, Vairo Filippo Pinto, Miguel Diego, Stubbolo Danielle, Marques Lourenco Charles, Gahl William, Boespflug-Tanguy Odile, Melberg Atle, Hassin-Baer Sharon, Cohen Oren S, Pjontek Rastislav, Grau Armin, Klopstock Thomas, Fogel Brent, Meijer Inge, Rouleau Guy, Bouchard Jean-Pierre L, Ganapathiraju Madhavi, Vanderver Adeline, Dahl Niklas, Hobson Grace, Brusco Alfredo, Brussino Alessandro, Padiath Quasar Saleem   Analysis of LMNB1 Duplications in Autosomal Dominant Leukodystrophy Provides Insights into Duplication Mechanisms and Allele-Specific Expression Human mutation, 2013; .
Hsu Sandy Chan, Sears Renee L, Lemos Roberta R, Quintns Beatriz, Huang Alden, Spiteri Elizabeth, Nevarez Lisette, Mamah Catherine, Zatz Mayana, Pierce Kerrie D, Fullerton Janice M, Adair John C, Berner Jon E, Bower Matthew, Brodaty Henry, Carmona Olga, Dobrici? Valerija, Fogel Brent L, Garca-Estevez Daniel, Goldman Jill, Goudreau John L, Hopfer Suellen, Jankovi? Milena, Jaum Serge, Jen Joanna C, Kirdlarp Suppachok, Klepper Joerg, Kosti? Vladimir, Lang Anthony E, Linglart Agns, Maisenbacher Melissa K, Manyam Bala V, Mazzoni Pietro, Miedzybrodzka Zofia, Mitarnun Witoon, Mitchell Philip B, Mueller Jennifer, Novakovi? Ivana, Paucar Martin, Paulson Henry, Simpson Sheila A, Svenningsson Per, Tuite Paul, Vitek Jerrold, Wetchaphanphesat Suppachok, Williams Charles, Yang Michele, Schofield Peter R, de Oliveira Joo R M, Sobrido Mara-Jess, Geschwind Daniel H, Coppola Giovanni   Mutations in SLC20A2 are a major cause of familial idiopathic basal ganglia calcification Neurogenetics, 2013; 14(1): 11-22.
Fogel Brent L, Baker Cameron, Curnow Andrew, Perlman Susan L, Geschwind Daniel H, Coppola Giovanni   Mutations in PDYN are not responsible for multiple system atrophy Journal of neurology, 2013; 14(1): .
Fogel Brent L, Pribadi Mochtar, Pi Sarah, Perlman Susan L, Geschwind Daniel H, Coppola Giovanni   C9ORF72 expansion is not a significant cause of sporadic spinocerebellar ataxia Movement disorders : official journal of the Movement Disorder Society, 2012; .
Mochel Fanny, Schiffmann Raphael, Steenweg Marjan E, Akman Hasan O, Wallace Mary, Sedel Frédéric, Laforêt Pascal, Levy Richard, Powers J Michael, Demeret Sophie, Maisonobe Thierry, Froissart Roseline, Da Nobrega Bruno Barcelos, Fogel Brent L, Natowicz Marvin R, Lubetzki Catherine, Durr Alexandra, Brice Alexis, Rosenmann Hanna, Barash Varda, Kakhlon Or, Gomori J Moshe, van der Knaap Marjo S, Lossos Alexander   Adult polyglucosan body disease: Natural History and Key Magnetic Resonance Imaging Findings Annals of neurology, 2012; 72(3): 433-41.
Fogel Brent L   Childhood Cerebellar Ataxia Journal of child neurology, 2012; .
Fogel Brent L, Wexler Eric, Wahnich Amanda, Friedrich Tara, Vijayendran Chandran, Gao Fuying, Parikshak Neelroop, Konopka Genevieve, Geschwind Daniel H   RBFOX1 Regulates Both Splicing and Transcriptional Networks in Human Neuronal Development Human molecular genetics, 2012; .
Fogel Brent L, Lee Ji Yong, Lane Jessica, Wahnich Amanda, Chan Sandy, Huang Alden, Osborn Greg E, Klein Eric, Mamah Catherine, Perlman Susan, Geschwind Daniel H, Coppola Giovanni   Mutations in rare ataxia genes are uncommon causes of sporadic cerebellar ataxia Movement disorders : official journal of the Movement Disorder Society, 2012; 27(3): 442-6.
Wexler Eric, Fogel Brent L   New-onset psychosis in a patient with spinocerebellar ataxia type 10 The American journal of psychiatry, 2011; 168(12): 1339-40.
Becker Esther B E, Fogel Brent L, Rajakulendran Sanjeev, Dulneva Anna, Hanna Michael G, Perlman Susan L, Geschwind Daniel H, Davies Kay E   Candidate screening of the TRPC3 gene in cerebellar ataxia Cerebellum (London, England), 2011; 10(2): 296-9.
Fogel Brent L   Interpretation of genetic testing: variants of unknown significance Continuum (Minneapolis, Minn.), 2011; 17(2 Neurogenetics): 347-52.
Fogel Brent L, Lee Ji Yong, Perlman Susan   Aberrant splicing of the senataxin gene in a patient with ataxia with oculomotor apraxia type 2 Cerebellum (London, England), 2009; 8(4): 448-53.
Fogel Brent L, Young Pari, Thompson Arthur R, Perlman Susan   A family with combined mutations of the hemophilia A and X-linked adrenoleukodystrophy genes Neurogenetics, 2008; 9(3): 215-8.
Fogel Brent L, Perlman Susan   Clinical features and molecular genetics of autosomal recessive cerebellar ataxias Lancet neurology, 2007; 6(3): 245-57.
Fogel Brent L, Perlman Susan   Novel mutations in the senataxin DNA/RNA helicase domain in ataxia with oculomotor apraxia 2 Neurology, 2006; 67(11): 2083-4.
Fogel Brent L, Perlman Susan   An approach to the patient with late-onset cerebellar ataxia Nature clinical practice. Neurology, 2006; 2(11): 629-35; quiz 1 p following 635.
Fogel Brent, Cardenas Doris, Ovbiagele Bruce   Magnetic resonance imaging abnormalities in the corpus callosum of a patient with neuropsychiatric lupus The neurologist, 2006; 12(5): 271-3.
Fogel Brent, Wu Mark, Kremen Sarah, Murthy Kolar, Jackson George, Vanek Zeba   Creutzfeldt-Jakob disease presenting with alien limb sign Movement disorders : official journal of the Movement Disorder Society, 2006; 21(7): 1040-2.
Fogel Brent L, McNally Lisa M, McNally Mark T   Efficient polyadenylation of Rous sarcoma virus RNA requires the negative regulator of splicing element Nucleic acids research, 2002; 30(3): 810-7.
Fogel B L, McNally M T   A cellular protein, hnRNP H, binds to the negative regulator of splicing element from Rous sarcoma virus The Journal of biological chemistry, 2000; 275(41): 32371-8.
Fogel B L, McNally M T   Trace contamination following reuse of anion-exchange DNA purification resins BioTechniques, 2000; 28(2): 299-302.