Carolyn R. Houser, Ph.D.

Titles

Professor, Neurobiology
Member, Brain Research Institute
Neuroscience GPB Home Area
Neuroscience IDP

Contact Information

Email
houser@mednet.ucla.edu
Phone
Lab Number: 310-206-6563Office Phone Number: 310-206-1567
Address
Work Address: LaboratoryCHSLos Angeles, CA 90095UNITED STATES OfficeCHSLos Angeles, CA 90095UNITED STATES

Biography

Research Interest: Neurochemical anatomy, neuronal plasticity and development of the CNS

Publications:

Peng Zechun, Zhang Nianhui, Wei Weizheng, Huang Christine S, Cetina Yliana, Otis Thomas S, Houser Carolyn R   A reorganized GABAergic circuit in a model of epilepsy: evidence from optogenetic labeling and stimulation of somatostatin interneurons The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013; 33(36): 14392-405.
Mathews Paul J, Lee Ka Hung, Peng Zechun, Houser Carolyn R, Otis Thomas S   Effects of climbing fiber driven inhibition on Purkinje neuron spiking The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012; 32(50): 17988-97.
Houser Carolyn R, Zhang Nianhui, Peng Zechun, Huang Christine S, Cetina Yliana   Neuroanatomical clues to altered neuronal activity in epilepsy: from ultrastructure to signaling pathways of dentate granule cells Epilepsia, 2012; 53 Suppl 1(50): 67-77.
Houser Carolyn R, Zhang Nianhui, Peng Zechun, Huang Christine S, Cetina Yliana   Neuroanatomical clues to altered neuronal activity in epilepsy: from ultrastructure to signaling pathways of dentate granule cells Epilepsia, 2012; 53 Suppl 1(50): 67-77.
Soussi Rabia, Zhang Nianhui, Tahtakran Siroun, Houser Carolyn R, Esclapez Monique   Heterogeneity of the supramammillary-hippocampal pathways: evidence for a unique GABAergic neurotransmitter phenotype and regional differences The European journal of neuroscience, 2010; 32(5): 771-85.
Li Yi, Peng Zechun, Xiao Bo, Houser Carolyn R   Activation of ERK by spontaneous seizures in neural progenitors of the dentate gyrus in a mouse model of epilepsy Experimental neurology, 2010; 224(1): 133-45.
Wyeth Megan S, Zhang Nianhui, Mody Istvan, Houser Carolyn R   Selective reduction of cholecystokinin-positive basket cell innervation in a model of temporal lobe epilepsy The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010; 30(26): 8993-9006.
Heusner CL, Beutler LR, Houser CR, Palmiter RD.   Deletion of GAD67 in dopamine receptor-1 expressing cells causes specific motor deficits, Genesis, 2008; 46(7): 357-67.
Houser CR, Huang CS, Peng Z.   Dynamic seizure-related changes in extracellular signal-regulated kinase activation in a mouse model of temporal lobe epilepsy, Neuroscience, 2008; .
Glykys J, Peng Z, Chandra D, Homanics GE, Houser CR, Mody I.   A new naturally occurring GABA(A) receptor subunit partnership with high sensitivity to ethanol, Nat Neurosci, 2007; 10(1): 40-8.
Zhang N, Wei W, Mody I, Houser CR.   Altered localization of GABA(A) receptor subunits on dentate granule cell dendrites influences tonic and phasic inhibition in a mouse model of epilepsy, J Neurosci, 2007; 27(28): 7520-31.
Houser CR.   Interneurons of the dentate gyrus: An overview of cell types, terminal fields and neurochemical identity, Prog Brain Res, 2007; 163: 217-811.
Liang J, Zhang N, Cagetti E, Houser CR, Olsen RW, Spigelman I.   Chronic intermittent ethanol-induced switch of ethanol actions from extrasynaptic to synaptic hippocampal GABAA receptors, J Neurosci, 2006; 26(6): 1749-58.
Chandra D, Jia F, Liang J, Peng Z, Suryanarayanan A, Werner DF, Spigelman I, Houser CR, Olsen RW, Harrison NL, Homanics GE.   GABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol, Proc Natl Acad Sci U S A, 2006; 103(41): 15230-5.
Swartz BE, Houser CR, Tomiyasu U, Walsh GO, DeSalles A, Rich JR, Delgado-Escueta A.   Hippocampal cell loss in posttraumatic human epilepsy, Epilepsia, 2006; 47(8): 1373-82.
Farrar C, Houser CR, Clarke S.   Activation of the PI3K/Akt signal transduction pathway and increased levels of insulin receptor in protein repair-deficient mice, Aging Cell, 2005; 4(1): 1-12.
Farrar CE, Huang CS, Clarke SG, Houser CR.   Increased cell proliferation and granule cell number in the dentate gyrus of protein repair-deficient mice, J Comp Neurol, 2005; 493(4): 527-37.
Peng Z, Houser CR.   Temporal patterns of fos expression in the dentate gyrus after spontaneous seizures in a mouse model of temporal lobe epilepsy, J Neurosci, 2005; 25(31): 7210-20.
Peng Z, Huang CS, Stell BM, Mody I, Houser CR.   Altered expression of the delta subunit of the GABAA receptor in a mouse model of temporal lobe epilepsy, J Neurosci, 2004; 24(39): 8629-39.
Houser CR, Esclapez M.   Downregulation of the alpha5 subunit of the GABA(A) receptor in the pilocarpine model of temporal lobe epilepsy, Hippocampus, 2003; 13(5): 633-45.
Wei W, Zhang N, Peng Z, Houser CR, Mody I.   Perisynaptic localization of delta subunit-containing GABA(A) receptors and their activation by GABA spillover in the mouse dentate gyrus, J Neurosci, 2003; 23(33): 10650-61.
Peng Z, Hauer B, Mihalek RM, Homanics GE, Sieghart W, Olsen RW, Houser CR.   GABA(A) receptor changes in delta subunit-deficient mice: altered expression of alpha4 and gamma2 subunits in the forebrain, J Comp Neurol, 2002; 446(2): 179-97.
Houser CR, Esclapez M, Zhang N.   GABA neurons of the hippocampal formation: Localization, vulnerability and plasticity, GABA in the Nervous System: The View at Fifty Years, 2000; 337-56.
Dupuy-Davies S, Houser CR.   Evidence for changing positions of GABA neurons in the developing rat dentate gyrus Hippocampus, 1999; 9(2): 186-99.
Houser CR.   Neuronal loss and synaptic reorganization in temporal lobe epilepsy, Adv Neurol, 1999; 79: 743-61.
Houser, CR, Dupuy, ST, Zhang N.   Prominent expression of glutamate decarboxylase during early hippocampal development, Childhood Epilepsies and Brain Development, 1999; pp.13-24.
Zhang N, Houser CR.   Ultrastructural localization of dynorphin in the dentate gyrus in human temporal lobe epilepsy: a study of reorganized mossy fiber synapses, J Comp Neurol, 1999; 405(4): 472-90.
Esclapez M, Houser CR.   Up-regulation of GAD65 and GAD67 in remaining hippocampal GABA neurons in a model of temporal lobe epilepsy, J Comp Neurol, 1999; 412(3): 488-505.
Esclapez, M, Chang D, Houser CR.   Subpopulations of GABA neurons in the dentate gyrus express high levels of the alpha1 subunit of the GABA-A receptor, Hippocampus, 1996; 6: 225-238.
Esclapez M, Houser CR.   Somatostatin neurons are a subpopulation of GABA neurons in the rat dentate gyrus: Evidence from co-localization of pre-prosomatostatin and glutamate decarboxylase mRNAs, Neuroscience, 1995; 64: 339-355.
Esclapez M, Tillakaratne NJ, Tobin AJ, Houser CR.   Comparative localization of mRNAs encoding two forms of glutamic acid decarboxylase with nonradioactive in situ hybridization methods J Comp Neurol, 1993; 331(3): 339-62.
Houser CR   GABA neurons in seizure disorders: A review of immunocytochemical studies, Neurochem Res, 1991; 16: 295-308.
Kafman DL, Houser CR, Tocin AJ   Two forms of the gamma-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions, J Neurochem, 1991; 56: 720-723.
Houser, CR   Granule cell dispersion in the dentate gyrus of humans with temporal lobe epilepsy, Brain Res, 1990; 535: 195-204.
Houser CR, Miyashiro JE, Swartz BE, Walsh GO, Rich JR, Delgado-Escueta AV.   Altered patterns of dynorphin immunoreactivity suggest mossy fiber reorganization in human hippocampal epilepsy J Neurosci, 1990; 10(1): 267-82.