Catia Sternini, M.D.

Titles

Professor, Department of Medicine
Digestive Diseases/Gastroenterology
Neurobiology
Member, Brain Research Institute
Molecular, Cellular & Integrative Physiology GPB Home Area
Neuroscience GPB Home Area
Neuroscience IDP

Contact Information

Email
csternin@ucla.edu
Phone
Lab Number: 310-825-5483Office Phone Number: 310-825-6526
Address
Work Address: Office650 C. Yuung Dr. SouthLos Angeles, CA 90095UNITED STATES LaboratoryDigestive Diseases Division CA 90095UNITED STATES LaboratoryVAGLAHS1301 Wilshire BlvdLos Angeles, CA 90073UNITED STATES

Biography

The “Brain in the Gut” and Taste Receptors

Publications:

Anselmi Laura, Huynh Jennifer, Vegezzi Gaia, Sternini Catia   Effects of methylnaltrexone on guinea pig gastrointestinal motility Naunyn-Schmiedeberg's archives of pharmacology, 2013; 386(4): 279-86.
Latorre Rocco, Mazzoni Maurizio, De Giorgio Roberto, Vallorani Claudia, Bonaldo Alessio, Gatta Pier Paolo, Corinaldesi Roberto, Ruggeri Eugenio, Bernardini Chiara, Chiocchetti Roberto, Sternini Catia, Clavenzani Paolo   Enteroendocrine profile of α-transducin immunoreactive cells in the gastrointestinal tract of the European sea bass (Dicentrarchus labrax) Fish physiology and biochemistry, 2013; 145(3): .
Mazzoni Maurizio, De Giorgio Roberto, Latorre Rocco, Vallorani Claudia, Bosi Paolo, Trevisi Paolo, Barbara Giovanni, Stanghellini Vincenzo, Corinaldesi Roberto, Forni Monica, Faussone-Pellegrini Maria S, Sternini Catia, Clavenzani Paolo   Expression and regulation of α-transducin in the pig gastrointestinal tract Journal of cellular and molecular medicine, 2013; 17(4): 466-74.
Sternini Catia   In search of a role for carbonation: is this a good or bad taste? Gastroenterology, 2013; 145(3): 500-3.
Anselmi Laura, Jaramillo Ingrid, Palacios Michelle, Huynh Jennifer, Sternini Catia   Ligand-induced μ opioid receptor internalization in enteric neurons following chronic treatment with the opiate fentanyl Journal of neuroscience research, 2013; 91(6): 854-60.
Saccani Francesca, Anselmi Laura, Jaramillo Ingrid, Bertoni Simona, Barocelli Elisabetta, Sternini Catia   Protective role of μ opioid receptor activation in intestinal inflammation induced by mesenteric ischemia/reperfusion in mice Journal of neuroscience research, 2012; 90(11): 2146-53.
Patierno Simona, Anselmi Laura, Jaramillo Ingrid, Scott David, Garcia Rachel, Sternini Catia   Morphine induces μ opioid receptor endocytosis in guinea pig enteric neurons following prolonged receptor activation Gastroenterology, 2011; 140(2): 618-26.
Young Steven H, Rey Osvaldo, Sternini Catia, Rozengurt Enrique   Amino acid sensing by enteroendocrine STC-1 cells: role of the Na+-coupled neutral amino acid transporter 2 American journal of physiology. Cell physiology, 2010; 298(6): C1401-13.
Hao Shuzhen, Dulake Michelle, Espero Elvis, Sternini Catia, Raybould Helen E, Rinaman Linda   Central Fos expression and conditioned flavor avoidance in rats following intragastric administration of bitter taste receptor ligands American journal of physiology. Regulatory, integrative and comparative physiology, 2009; 296(3): R528-36.
Anselmi Laura, Stella Salvatore L, Brecha Nicholas C, Sternini Catia   Galanin inhibition of voltage-dependent Ca(2+) influx in rat cultured myenteric neurons is mediated by galanin receptor 1 Journal of neuroscience research, 2009; 87(5): 1107-14.
Sternini Catia, Anselmi Laura, Rozengurt Enrique   Enteroendocrine cells: a site of 'taste' in gastrointestinal chemosensing Current opinion in endocrinology, diabetes, and obesity, 2008; 15(1): 73-8.
Hao S, Sternini C, Raybould HE.   Role of CCK1 and Y2 receptors in activation of hindbrain neurons induced by intragastric administration of bitter taste receptor ligands, Am J Physiol Regul Integr Comp Physiol, 2008; 294(1): R33-8.
Hao Shuzhen, Sternini Catia, Raybould Helen E   Role of CCK1 and Y2 receptors in activation of hindbrain neurons induced by intragastric administration of bitter taste receptor ligands American journal of physiology. Regulatory, integrative and comparative physiology, 2008; 294(1): R33-8.
Kimura T, Koya RC, Anselmi L, Sternini C, Wang HJ, Comin-Anduix B, Prins RM, Faure-Kumar E, Rozengurt N, Cui Y, Kasahara N, Stripecke R.   Lentiviral Vectors with CMV or MHCII Promoters Administered In Vivo: Immune Reactivity Versus Persistence of Expression, Mol Ther, 2007; 15(7): 1390-9.
Dellabianca A, Sacchi M, Anselmi L, De Amici E, Cervio E, Agazzi A, Tonini S, Sternini C, Tonini M, Candura SM.   Role of carbon monoxide in electrically induced non-adrenergic, non-cholinergic relaxations in the guinea-pig isolated whole trachea, Br J Pharmacol, 2007; 150(2): 220-6.
Rozengurt Enrique, Sternini Catia   Taste receptor signaling in the mammalian gut Current opinion in pharmacology, 2007; 7(6): 557-62.
Sternini C.   Taste receptors in the gastrointestinal tract. IV. Functional implications of bitter taste receptors in gastrointestinal chemosensing, Am J Physiol Gastrointest LIver Physiol, 2007; 292(2): G457-61.
Sternini Catia   Taste receptors in the gastrointestinal tract. IV. Functional implications of bitter taste receptors in gastrointestinal chemosensing American journal of physiology. Gastrointestinal and liver physiology, 2007; 292(2): G457-61.
Rozengurt N, Wu SV, Chen MC, Huang C, Sternini C, Rozengurt E.   Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon, Am J Physiol Gastrointest Liver Physiol, 2006; 291(5): G792-802.
Rozengurt Nora, Wu S Vincent, Chen Monica C, Huang Carlos, Sternini Catia, Rozengurt Enrique   Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon American journal of physiology. Gastrointestinal and liver physiology, 2006; 291(5): G792-802.
Freeman SL, Glatzle J, Robin CS, Valdellon M, Sternini C, Sharp JW, Raybould HE.   Ligand-induced 5-HT3 receptor internalization in enteric neurons in rat ileum, Gastroenterology, 2006; 131(1): 97-107.
Freeman Samara L, Glatzle Jorg, Robin Carla S, Valdellon Melissa, Sternini Catia, Sharp James W, Raybould Helen E   Ligand-induced 5-HT3 receptor internalization in enteric neurons in rat ileum Gastroenterology, 2006; 131(1): 97-107.
Cattaruzzza F, Cenac N, Barocelli E, Impicciatore M, Hyun E, Vergnolle N, Sternini C.   Protective effect of proteinase-activated receptor 2 activation on motility impairment and tissue damage induced by intestinal ischemia/reperfusion in rodents, Am J Pathol, 2006; 169(1): 177-88.
Cattaruzza Fiore, Cenac Nicolas, Barocelli Elisabetta, Impicciatore Mariannina, Hyun Eric, Vergnolle Nathalie, Sternini Catia   Protective effect of proteinase-activated receptor 2 activation on motility impairment and tissue damage induced by intestinal ischemia/reperfusion in rodents The American journal of pathology, 2006; 169(1): 177-88.
Bradesi S, Kokkotou E, Simeonidis S, Patierno S, Ennes HS, Mittal Y, McRoberts JA, Ohning G, McLean P, Marvizon JC, Sternini C, Pothoulakis C, Mayer EA.   The role of neurokinin 1 receptors in the maintenance of visceral hyperalgesia induced by repeated stress in rats, Gastroenterology, 2006; 130(6): 1729-42.
Bradesi Sylvie, Kokkotou Efi, Simeonidis Simos, Patierno Simona, Ennes Helena S, Mittal Yash, McRoberts James A, Ohning Gordon, McLean Peter, Marvizon Juan Carlos, Sternini Catia, Pothoulakis Charalabos, Mayer Emeran A   The role of neurokinin 1 receptors in the maintenance of visceral hyperalgesia induced by repeated stress in rats Gastroenterology, 2006; 130(6): 1729-42.
Tonini M, Vicini R, Cervio E, De Ponti F, De Giorgio R, Barbara G, Stanghellini V, Dellabianca A, Sternini C.   5-HT7 receptors modulate peristalsis and accommodation in the guinea pig ileum, Gastroenterology, 2005; 129(5): 1557-66.
Tonini Marcello, Vicini Riccardo, Cervio Elisabetta, De Ponti Fabrizio, De Giorgio Roberto, Barbara Giovanni, Stanghellini Vincenzo, Dellabianca Antonio, Sternini Catia   5-HT7 receptors modulate peristalsis and accommodation in the guinea pig ileum Gastroenterology, 2005; 129(5): 1557-66.
Calcina F, Barocelli E, Bertoni S, Furukawa O, Kaunitz J, Impicciatore M, Sternini C.   Effect of N-methyl-d-aspartate receptor blockade on neuronal plasticity and gastrointestinal transit delay induced by ischemia/reperfusion in rats, Neuroscience, 2005; 134(1): 39-49.
Anselmi L, Lakhter A, Hirano AA, Tonini M, Sternini C.   Expression of galanin receptor messenger RNAs in different regions of the rat gastrointestinal tract, Peptides, 2005; 26(5): 815-9.
Anselmi Laura, Lakhter Alexander, Hirano Arlene A, Tonini Marcello, Sternini Catia   Expression of galanin receptor messenger RNAs in different regions of the rat gastrointestinal tract Peptides, 2005; 26(5): 815-9.
Anselmi L, Stella SL Jr, Lakhter A, Hirano A, Tonini M, Sternini C.   Galanin receptors in the rat gastrointestinal tract, Neuropeptides, 2005; 39(3): 349-52.
Anselmi Laura, Stella Salvatore L, Lakhter Alexander, Hirano Arlene, Tonini Marcello, Sternini Catia   Galanin receptors in the rat gastrointestinal tract Neuropeptides, 2005; 39(3): 349-52.
Anselmi L, Cervio E, Guerrini S, Vicini R, Agazzi A, Dellabianca A, Reeve JR jr, Tonini M, Sternini C.   Identification of galanin receptor 1 on excitatory motor neurons in the guinea pig ileum, Neurogastroenterol Motil, 2005; 17(2): 273-80.
Cottrell GS, Roosterman D, Marvizon JC, Song B, Wick E, Pikios S, Wong H, Berthelier C, Tang Y, Sternini C, Bunnett NW, Grady EF.   Localization of calcitonin receptor-like receptor and receptor activity modifying protein 1 in enteric neurons, dorsal root ganglia, and the spinal cord of the rat, J Comp Neurol, 2005; 490(3): 239-55.
Cottrell Graeme S, Roosterman Dirk, Marvizon Juan-Carlos, Song B, Wick Elizabeth, Pikios Stella, Wong Helen, Berthelier Claire, Tang Yat, Sternini Catia, Bunnett Nigel W, Grady Eileen F   Localization of calcitonin receptor-like receptor and receptor activity modifying protein 1 in enteric neurons, dorsal root ganglia, and the spinal cord of the rat The Journal of comparative neurology, 2005; 490(3): 239-55.
Patierno S, Zellalem W, Ho A, Parsons CG, Lloyd KC, Tonini M, Sternini C.   N-methyl-D-aspartate receptors mediate endogenous opioid release in enteric neurons after abdominal surgery, Gastroenterology, 2005; 128(7): 2009-19.
Patierno Simona, Zellalem Wubanche, Ho Anthony, Parsons Chris G, Lloyd K C Kent, Tonini Marcello, Sternini Catia   N-methyl-D-aspartate receptors mediate endogenous opioid release in enteric neurons after abdominal surgery Gastroenterology, 2005; 128(7): 2009-19.
Lu YC, Sternini C, Rozengurt E, Zhukova E.   Release of transgenic human insulin from gastric g cells: a novel approach for the amelioration of diabetes, Endocrinology, 2005; 146(6): 2610-9.
Lu Yu-Chun, Sternini Catia, Rozengurt Enrique, Zhukova Elena   Release of transgenic human insulin from gastric g cells: a novel approach for the amelioration of diabetes Endocrinology, 2005; 146(6): 2610-9.
Patierno, S Raybould, HE Sternini, C   Abdominal surgery induces mu opioid receptor endocytosis in enteric neurons of the guinea-pig ileum Neuroscience. , 2004; 123(1): 101-9.
Guerrini S, Raybould HE, Anselmi L, Agazzi A, Cervio E, Reeve JR Jr, Tonini M, Sternini C.   Role of galanin receptor 1 in gastric motility in rat, Neurogastroenterol Motil, 2004; 16(4): 429-38.
Sternini C, Anselmi L, Guerrini S, Cervio E, Pham T, Balestra B, Vicini R, Baiardi P, D'agostino GL, Tonini M.   Role of galanin receptor 1 in peristaltic activity in the guinea pig ileum, Neuroscience, 2004; 125(1): 103-12.
Sternini C, Patierno S, Selmer IS, Kirchgessner A.   The opioid system in the gastrointestinal tract, Neurogastroenterol Motil, 2004; 16(Suppl 2): 3-16.
Raybould Helen E, Glatzle Jorg, Robin Carla, Meyer James H, Phan Thomas, Wong Helen, Sternini Catia   Expression of 5-HT3 receptors by extrinsic duodenal afferents contribute to intestinal inhibition of gastric emptying American journal of physiology. Gastrointestinal and liver physiology, 2003; 284(3): G367-72.
Raybould, HE Glatzle, J Robin, C Meyer, JH Phan, T Wong, H Sternini, C   Expression of 5-HT3 receptors by extrinsic duodenal afferents contribute to intestinal inhibition of gastric emptying American journal of physiology. Gastrointestinal and liver physiology. , 2003; 284(3): G367-72.
Minnis, JG Patierno, S Kohlmeier, SE Brecha, NC Tonini, M Sternini, C   Ligand-induced mu opioid receptor endocytosis and recycling in enteric neurons Neuroscience. , 2003; 119(1): 33-42.
Ho, A Lievore, A Patierno, S Kohlmeier, SE Tonini, M Sternini, C   Neurochemically distinct classes of myenteric neurons express the mu-opioid receptor in the guinea pig ileum The Journal of comparative neurology. , 2003; 458(4): 404-11.
Ho Anthony, Lievore Annarita, Patierno Simona, Kohlmeier Sean E, Tonini Marcello, Sternini Catia   Neurochemically distinct classes of myenteric neurons express the mu-opioid receptor in the guinea pig ileum The Journal of comparative neurology, 2003; 458(4): 404-11.
Pham, T Guerrini, S Wong, H Reeve, J Sternini, C   Distribution of galanin receptor 1 immunoreactivity in the rat stomach and small intestine The Journal of comparative neurology. , 2002; 450(3): 292-302.
Pham Thomas, Guerrini Stefania, Wong Helen, Reeve Joseph, Sternini Catia   Distribution of galanin receptor 1 immunoreactivity in the rat stomach and small intestine The Journal of comparative neurology, 2002; 450(3): 292-302.
Glatzle, J Sternini, C Robin, C Zittel, TT Wong, H Reeve, JR Raybould, HE   Expression of 5-HT3 receptors in the rat gastrointestinal tract Gastroenterology. , 2002; 123(1): 217-26.
Glatzle Jörg, Sternini Catia, Robin Carla, Zittel Tilman T, Wong Helen, Reeve Joseph R, Raybould Helen E   Expression of 5-HT3 receptors in the rat gastrointestinal tract Gastroenterology, 2002; 123(1): 217-26.
Salvioli Beatrice, Bovara Monica, Barbara Giovanni, De Ponti Fabrizio, Stanghellini Vincenzo, Tonini Marcello, Guerrini Stefania, Cremon Cesare, Degli Esposti Marzia, Koumandou Magdalina, Corinaldesi Roberto, Sternini Catia, De Giorgio Roberto   Neurology and neuropathology of the pancreatic innervation JOP : Journal of the pancreas, 2002; 3(2): 26-33.
Schmidlin, F Dery, O DeFea, KO Slice, L Patierno, S Sternini, C Grady, EF Bunnett, NW   Dynamin and Rab5a-dependent trafficking and signaling of the neurokinin 1 receptor The Journal of biological chemistry. , 2001; 276(27): 25427-37.
Zhukova, E Afshar, A Ko, J Popper, P Pham, T Sternini, C Walsh, JH   Expression of the human insulin gene in the gastric G cells of transgenic mice Transgenic research. , 2001; 10(4): 329-41.
Wong, HC Sternini, C Yang, H Pham, T Walsh, JH   Monoclonal antibody to rat galanin: production, characterization, and in vivo immunoneutralization activity Hybridoma. , 2001; 20(2): 109-15.
Tonini, M Spelta, V De Ponti, F De Giorgio, R D'Agostino, G Stanghellini, V Corinaldesi, R Sternini, C Crema, F   Tachykinin-dependent and -independent components of peristalsis in the guinea pig isolated distal colon Gastroenterology. , 2001; 120(4): 938-45.
Melone, M Brecha, NC Sternini, C Evans, C Conti, F   Etorphine increases the number of mu-opioid receptor-positive cells in the cerebral cortex Neuroscience. , 2000; 100(3): 439-43.
De Giorgio R, Arakawa J, Wetmore CJ, Sternini C   Neutrophin-3 and neutrophin receptor immunoreactivity in peptidergic enteric neurons, Peptides, 2000; 21: 1421-26.
Sternini, C Brecha, NC Minnis, J D'Agostino, G Balestra, B Fiori, E Tonini, M   Role of agonist-dependent receptor internalization in the regulation of mu opioid receptors Neuroscience. , 2000; 98(2): 233-41.
Tonini, M De Giorgio, R De Ponti, F Sternini, C Spelta, V Dionigi, P Barbara, G Stanghellini, V Corinaldesi, R   Role of nitric oxide- and vasoactive intestinal polypeptide-containing neurones in human gastric fundus strip relaxations British journal of pharmacology. , 2000; 129(1): 12-20.
McConalogue, K Grady, EF Minnis, J Balestra, B Tonini, M Brecha, NC Bunnett, NW Sternini, C   Activation and internalization of the mu-opioid receptor by the newly discovered endogenous agonists, endomorphin-1 and endomorphin-2 Neuroscience. , 1999; 90(3): 1051-9.
Sternini C, Wong H, Pham T, De Giorgio R, Miller LJ, Kuntz SM, Reeve JR, Walsh JH, Raybould HE   Expression of cholecystokinin A receptors in neurons innvervating the rat stomach and intestine, Gastroenterology, 1999; 117: 1136-46.
Lecci A, De Giorgio R, Bartho L, Sternini C, Tramontana M, Corinaldesi R, Giuliani S, Maggi CA   Tachykinin NK(1)receptor-mediated inhibitory responses in the guinea pig small intestine, Neuropeptides, 1999; 33: 91-97.
Sternini C, Wong H, Wu SV, De Giorgio R, Yang M, Reeve J, Jr., Brecha NC, Walsh JH   Somatostatin 2A receptor is expressed by enteric neruons, and by interstitial cells of Cajal and enterochromaffin-like cells, Journal of Comparative Neurology, 1997; 386: 396-408.
Sternini, C Spann, M Anton, B Keith, DE Bunnett, NW von Zastrow, M Evans, C Brecha, NC   Agonist-selective endocytosis of mu opioid receptor by neurons in vivo Proceedings of the National Academy of Sciences of the United States of America. , 1996; 93(17): 9241-6.
Sternini, C Su, D Gamp, PD Bunnett, NW   Cellular sites of expression of the neurokinin-1 receptor in the rat gastrointestinal tract The Journal of comparative neurology. , 1995; 358(4): 531-40.