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Chih-Ming Ho, Ph.D.
Director, Institute for Cell Mimetic Space Exploration (CMISE)
Professor, Mechanical and Aerospace Engineering
Member, Brain Research Institute
Neuroengineering Training Program
Professor, Mechanical and Aerospace Engineering
Member, Brain Research Institute
Neuroengineering Training Program
PhoneFax Number: (310) 206-2302Work Phone Number: (310) 825-9993
AddressMailing Address: UCLAMechanical and Aerospace Engineering Department; School of Engineering and Applied Science Engineering IV, Room 38-137J 420 Westwood Plaza Los Angeles, CA 90095UNITED STATES
BiographyDr. Chih-Ming Ho currently serves as UCLA Associate Vice Chancellor for Research and holds the Ben Rich-Lockheed Martin Chair Professor in School of Engineering. He is a member of the Executive Committee of California NanoSystem Institute (CNSI). He graduated from Mechanical Engineering Department of the National Taiwan University. After receiving his Ph.D. from The Johns Hopkins University, Dr. Ho started his career at the University of Southern California and rose to the rank of Full Professor. In 1991, he moved to the University of California, Los Angeles to lead the establishment of the micro-electro-mechanical-system (MEMS) field in UCLA and served as the founding Director of the Center for Micro Systems. To this day, the UCLA MEMS research has been recognized as one of the best in the world. He is an internationally renowned scientist in fluidics, which is one of the backbone processes in bio-nano technology. In 1997, Dr. Ho was inducted as a member of the National Academy of Engineering. In the next year, he was elected as an Academician of Academia Sinica, which honors scholars of Chinese origin with exceptional achievements in liberal arts and the sciences. Dr. Ho has made seminal impacts in micro/nano fluidics, bio-technology and turbulence. He has published 190 papers and holds seven patents, and has presented over 60 keynote talks in international conferences. He was elected Fellow of the American Physical Society as well as American Institute of Aeronautics and Astronautics for his contributions in a wide spectrum of technical areas.
Wei, F., Liao, W., Xu, Z., Yang, Y., Wong, D.T., Ho, C.-M. A Bio-abiotic Interface Constructed by Nanoscale DNA-Dendrimer and Conducting Polymer for Ultra-sensitive Bio-molecular Diagnosis Small, 2009; 5: 1784 ? 1790.
Wei, F. and Ho, C.-M Aptamer-based Electrochemical Biosensor for Botulinum Neurotoxin Analytical and Bioanalytical Chemistry, 2009; 393: 1943 ? 1948.
Gu, F., Li, Y., Zhou, C., Wong, D.T.W., Ho, C.-M., Qi, F., and Shi, W. Bacterial 16S rRNA/rDNA Profiling in the Liquid Phase of Human Saliva The Open Dentistry Journal, 2009; 3: 80 ? 84.
Tsutsui, H. and Ho, C.M. Cell Separation by Non-Inertial Force Fields in Microfluidic Systems Mechanics Research Communication, 2009; 36: 92 ? 103.
Wong, T.-S., Brough, B., and Ho, C.-M. Creation of Functional Micro/Nano Systems through Top-down and Bottom-up Approaches Molecular and Cellular Biomechanics, 2009; 6(1): 1 ? 56.
Wong, T.-S. and Ho, C.-M. Dependence of Macroscopic Wetting on Nanoscopic Surface Textures Langmuir, 2009; 25: 12851 ? 12854.
Wei, F., Liao, W., Zhang, L., Arellano-Garcia, M., Hu, Shen, Wong, D.T., and Ho, C.M. Electrochemical Sensor for Oral Cancer Detection with Multiplex Salivary Biomarkers Clinical Cancer Research, 2009; 15: OF1 ? OF7.
Sun, C.P., Usui, T., Yu, F., Al-Shyoukh, I., Shamma, J., Sun, R., and Ho, C.M. Integrative Systems Control Approach for Reactivating Kaposi?s Sarcoma-Associated Herpesvirus (KSHV) with Combinatory Drugs Integrative Biology, 2009; 1: 123 ? 130.
Wong, I. and Ho, C.-M Surface Molecular Property Modifications for Poly(dimethylsiloxane) (PDMS) Based Microfluidic Devices Microfluidics and Nanofluidics, 2009; 7: 291 ? 306.
Wong, T.-S., Huang, A.P.-H., and Ho, C.-M. Wetting Behaviors of Individual Nanostructures Langmuir, 2009; 25: 6599 ? 6603.
Li N, Ho CM Aptamer-based optical probes with separated molecular recognition and signal transduction modules Journal of the American Chemical Society, 2008; 130(8): 2380-2381.
Wong PK, Yu FQ, Shahangian A, Cheng GH, Sun R, Ho CM Closed-loop control of cellular functions using combinatory drugs guided by a stochastic search algorithm Proceedings of the National Academy of Sciences of the United States of America, 2008; 105(13): 5105-5110.
Wei, F. Wang, J. Liao, W. Zimmermann, B. G. Wong, D. T. Ho, C. M. Electrochemical detection of low-copy number salivary RNA based on specific signal amplification with a hairpin probe Nucleic Acids Res, 2008; 36(11): e65.
Ma, Y. Sun, C. P. Fields, M. Li, Y. Haake, D. A. Churchill, B. M. Ho, C. M. An unsteady microfluidic T-form mixer perturbed by hydrodynamic pressure J Micromech Microeng, 2008; 18: 45015.
Meng DD, Cubaud T, Ho CM, Kim CJ A methanol-tolerant gas-venting microchannel for a microdirect methanol fuel cell Journal of Microelectromechanical Systems, 2007; 16(6): 1403-1410.
Lee YK, Shih C, Tabeling P, Ho CM Experimental study and nonlinear dynamic analysis of time-periodic micro chaotic mixers Journal of Fluid Mechanics, 2007; 575: 425-448.
Brough B, Christman KL, Wong TS, Kolodziej CM, Forbes JG, Wang K, Maynard HD, Ho CM Surface initiated actin polymerization from top-down manufactured nanopatterns Soft Matter, 2007; 3(5): 541-546.
Benahmed, A. J. Ho, C. M. Bandgap-assisted surface-plasmon sensing Appl Opt, 2007; 46(16): 3369-75.
Huang, T.J., Flood, A.H., Brough, B., Liu, Y., Bonvallet, P.A., Kang, S., Chu , C.W., Guo, T.F., Lu, W., Yang, Y., Stoddart, J.F. and Ho, C.M. "Understanding and Harnessing Biomimetic Molecular Machines for NEMS Actuation Materials" IEEE Transactions on Automation Science and Engineering, 2006; 3(2): .
Choi CH, Ulmanella U, Kim J, Ho CM, Kim CJ Effective slip and friction reduction in nanograted superhydrophobic microchannels Physics of Fluids, 2006; 18(8): .
Brough B, Northrop BH, Schmidt JJ, Tseng HR, Houk KN, Stoddart JF, Ho CM Evaluation of synthetic linear motor-molecule actuation energetics Proceedings of the National Academy of Sciences of the United States of America, 2006; 103(23): 8583-8588.
Chen, J. M. Ho, C. M. Path to bio-nano-information fusion Ann N Y Acad Sci, 2006; 1093(number): 123-42.
Cubaud T, Ulmanella U, Ho CM Two-phase flow in microchannels with surface modifications Fluid Dynamics Research, 2006; 38(11): 772-786.
Liu, Y. Flood, A. H. Bonvallet, P. A. Vignon, S. A. Northrop, B. H. Tseng, H. R. Jeppesen, J. O. Huang, T. J. Brough, B. Baller, M. Magonov, S. Solares, S. D. Goddard, W. A. Ho, C. M. Stoddart, J. F. Linear artificial molecular muscles J Am Chem Soc, 2005; 127(27): 9745-59.
Qiao Lin, Yong Xu, Fukang Jiang, Yu-Chong Tai, and Chih-Ming Ho. "A Parametrized Three-Dimensional Model for MEMS Thermal Shear-Stress Sensors" Journal of Microelectromechanical Systems, 2005; 14(3): 625-633.
Pak Kin Wong, Winny Tan and Chih-Ming Ho. "Cell Relaxation after Electrodeformation: Effect of latrunculin A on actin cytoskeleton" Journal of Biomechanics, 2005; 38(3): 529-535.
Yang, C.Y., Brooks, E., Li, Y., Denny, P., Ho, C.M., Qi, F., Shi, W., Wolinsky, L., Wu, B., Wong, D. and Montamagno, C. "Detection of Picomolar Levels of Interleukin-8 in Human Saliva by SPR" Lab on a Chip, 2005; 5(10): 1017-1023.
Yi Liu et al. "Linear Artificial Molecular Muscles" Journal of American Chemical Society, 2005; 127(27): 9745-9759.
Wang T. H., Y. Peng, C. Chen, P. K. Wong, C. M. Ho. "Single-Molecule Tracing on a Fluidic Microchip for Quantitative Detection of Low-Abundance Nucleic Acids" Journal of the American Chemical Society (JACS), 2005; 127(15): 5354-5359.
Li, Y., Denny, P., Ho, C.M., Montemagno, C., Shi, W., Qi, F., Wu, B., Wolinsky, L., and Wong, D.T. "The Oral Fluid MEMS/NEMS Chip (OFMNC): Diagnostic & Translational Applications" Adv Dent Res , 2005; 18(June): 3-5.
Cubaud T, Tatineni M, Zhong XL, Ho CM Bubble dispenser in microfluidic devices, Physical Review E, 2005; 72(3): .
Cubaud, T. Tatineni, M. Zhong, X. Ho, C. M. Bubble dispenser in microfluidic devices Phys Rev E Stat Nonlin Soft Matter Phys, 2005; 72(3 Pt 2): 037302.
Wong, P. K. Tan, W. Ho, C. M. Cell relaxation after electrodeformation: effect of latrunculin A on cytoskeletal actin J Biomech, 2005; 38(3): 529-35.
Wong, P. K. Chen, C. Y. Wang, T. H. Ho, C. M. Electrokinetic bioprocessor for concentrating cells and molecules Anal Chem, 2004; 76(23): 6908-14.
Pak Kin Wong, Che-Yang Chen, Tza-Huei Wang, and Chih-Ming Ho. "Electrokinetic Bioprocessor for Concentrating Cells and Molecules Analytical Chemistry" Anal. Chem, 2004; 76(23): 6908?6914.
Suzuki, H., Ho, C.M. and Kasagi, N. "A Chaotic Mixer for Magnetic Bead-Based Micro Cell Sorter" Journal of Microelectromechanical Systems, 2004; 13(5): 779-799.
Tony Jun Huang, Branden Brough, Chih-Ming Ho, Yi Liu, Amar H. Flood, Paul A. Bonvallet, Hsian-Rong Tseng, J. Fraser Stoddart, Marko Baller, and Sergei Magonov. "A nanomechanical device based on linear molecular motors" Applied Physics Letters, 2004; 85(22): 5391-5393.
Pak Kin Wong, Jeff Tza-Huei Wang, Joanne H. Deval, Chih-Ming Ho. "Electrokinetics in Micro Devices for Biotechnology Applications" IEEE/ASME Transactions on Mechatronics, 2004; 9: 366-376.
Lin, Q., Jiang, F., Wang, X., Xu, Y., Han, Z., Tai, Y.C., Lew, J. and Ho, C.M. "Experiments and Simulations of MEMS Thermal Sensors for Wall Shear Stress Measurements in Aerodynamic Control Applications" J. of Micromechanics and Microengineering, 2004; 14(12): 1640-1649.
Wong, P.K., Ulmanella, U. and Ho, C.M. "Fabrication of Microsurgical Tools for Single-Cell and Intracytoplasmic Injection" Journal of Microelectromechanical System, 2004; 13(6): 940-946.
Maie A. R. St. John; Yang Li; Xiaofeng Zhou; Paul Denny; Chih-Ming Ho; Carlo Montemagno; Wenyuan Shi; Fengxia Qi; Benjamin Wu; Uttam Sinha; Richard Jordan; Lawrence Wolinsky; No-Hee Park; Honghu Liu; Elliot Abemayor; David T. W. Wong "Interleukin 6 and Interleukin 8 as Potential Biomarkers for Oral Cavity and Oropharyngeal Squamous Cell Carcinoma" Arch Otolaryngol Head Neck Surg, 2004; 130: 929 - 935.
Tony Jun Huang, Hsian-Rong Tseng, Lin Sha, Weixing Lu, Branden Brough, Amar H. Flood, Bi-Dan Yu, Paul C. Celestre, Jane P. Chang, J. Fraser Stoddart, and Chih-Ming Ho. "Mechanical Shuttling of Linear Motor-Molecules in Condensed Phases on Solid Substrates" Nano Letters, 2004; 4(11): 2065 - 2071.
Hsiai T, Cho, S.K., Wong, P, Ing M., Salazar, A., Navab, M., Demer, L., Ho, C. M. "Micro Sensors: Linking Real-Time Oscillatory Shear Stress with Vascular Inflammatory Responses" Ann Biomed Eng, 2004; 32(2): 189-201.
Huang, A.; Lew, J.; Xu, Y.; Tai, Y.-C.; Ho, C.-M. "Microsensors and Actuators for Macrofluidic Control" Sensors Journal, IEEE, 2004; 4(4): 494-502.
Lan, E. H., Umali, T. A., Dunn, D., and Ho, C. M. "Reconfigurable Hydrophobic/Hydrophilic Surfaces in Microelectricalmechanical Systems (MEMS)" Journal of Micromechanics and Microengineering, 2004; 14: 91-95.
Mingming Wu, Thomas Cubaud, and Chih-Ming Ho. "Scaling law in liquid drop coalescence driven by surface tension" Physics of Fluids, 2004; 16(7): L51-L54.
T Cubaud, C-M Ho. "Transport of bubbles in square microchannels" Physics of Fluids, 2004; 16(12): 4575-4585.
Wong, P.K., Lee, Y.-K., and Ho, C.M. "Deformation of DNA Molecules by Hydrodynamic Focusing" Journal of Fluid Mechanics, 2003; 497: 55-65.
Xu, Y., Jiang, F. Newbern, S., Huang, P.H., Ho, C.M., and Tai, Y.C. "Flexible Shear-Stress Sensor Skin and its Application to Unmanned Aerial Vehicles" Sensors and Actuators A: Physical, 2003; 105(3): 321-329.
Xu, Y., Tai, Y.C., Huang, P.H. and Ho, C.M. "IC-Integrated Flexible Shear-Stress Sensor Skin" IEEE/ASME J. of Microelectromechanical Systems (J. MEMS), 2003; 12(5): 740-747.
Tony Jun Huang; Flood, A.; Chih-Wei Chu; Seogshin Kang; Tzung-Fang Guo; Yamamoto, T.; Hsian-Rong Tseng; Bi-Dan Yu; Yang Yang; Stoddart, J.F.; Chih-Ming Ho. "In Situ Infrared Spectroscopic Studies of Molecular Behavior in Nanoelectronic Devices" IEEE-NANO, 2003; 2(San Francisco, USA 12-14 Aug.): 698 - 701.
Hsiai T, Cho, S.K., Wong, P, Ing M., Salazar, A., Hama S., Navab, M., Demer, L., Ho, C. M. "Monocyte Recruitment to Endothelial Cells in Response to Oscillatory Shear Stress" The FASEB Journal, 2003; 17: 1648-1657.
Suzuki, H., Nakano, M., Kasagi, N. and Ho, C.M. "Particle Tracking Velocimetry Measurement of Chaotic Mixing in a Micro Mixer" JSME, 2003; 397-402.
S. Ho, H. Nassef, N. Pornsin-Sirirak, Y.-C. Tai, C.-M. Ho. "Unsteady Aerodynamics and Flow Control for Flapping Wing Flyers" Progress in Aerospace Science, 2003; 39(8): 635-681.
Huang, J., Liu, M., Knight, L. D., Grody, W. W. Miller, J. F., and Ho, C. M. "An Electrochemical Detection Scheme for Identifications of Single-Nucleotide Polymorphism Using Hairpin-forming Probes" Nucleic Acids Research, 2002; 30(12): e55.
Wang, T. H., Wong, P.K., and Ho, C. M. "Electrical Molecular Focusing For Laser Induced Fluorescence Based Single DNA Detection" Technical Digest of the 15th IEEE International Conference on MEMS, 2002; (MEMS 2002): .
T. K. Hsiai, S. K. Cho, J. M. Yang, X. Yang, Y. C. Tai and C. M. Ho. "Pressure Drops of Water Flow through Micromachined Particle Filters" ASME Journal of Fluids Engineering, 2002; 124(4): 1053-1056.
Tseng, F.G., Kim, C.J. and Ho, C.M. A high-resolution high-frequency monolithic top-shooting microinjector free of satellite drops - Part I: Concept, design, and model JMEMS, 2002; 11(5): 427-436.
T. K. Hsiai, S. K. Cho, H. M. Honda, S. Hama, M. Navab, L. L. Demer, A. M. Fogelman, and C. M. Ho. Endothelial Cell Dynamics under Pulsating Flows: Significance of High Versus Low Shear Stress Slew Rates (??/??) Annals of Biomedical Engineering, 2002; 30(5): 646-656.