Claude G. Wasterlain, M.D.

Titles

Distinguished Professor, Neurology
Neurology, West LA Veterans Hospital
Member, Brain Research Institute

Contact Information

Email
wasterla@ucla.edu
Phone
Fax Number: 310-268-4611
Work Phone Number: 310-268-3595
Address

Work Address:

Laboratory
West LA VA Bldg 114
West Los Angeles, CA 90073
UNITED STATES
Office
West LA VA, Bldg 500, Rm 3257
11301 Wilshire Blvd
West Los Angeles, CA 90073
UNITED STATES

Biography

EDUCATION University of Liege (Belgium), M.D., 1961 Free University of Brussels, L.Sc., Molecular Biology, 1969 Cornell University Medical College: Neurology residency, research fellowship in Jerry Posner's lab POSITIONS Instructor, Department of Neurology, Cornell University Medical College, New York, NY,1969-70 Assistant Professor of Neurology, Cornell University Medical College, New York, NY, 1970-75. Associate Professor of Neurology, Cornell University Medical College, New York, NY, 1975-76. Associate Professor of Neurology, UCLA School of Medicine, Los Angeles, CA 1976-79. Vice-Chair, Department of Neurology, UCLA School of Medicine, 1976-present. Professor of Neurology, UCLA School of Medicine, 1979-present. Chief, Neurology Section, VA Medical Center, Sepulveda, CA 1976-79. Chief, Neurology Service, VA Medical Center, Sepulveda, CA 1979-98. Chair, Department of Neurology, VA Greater Los Angeles Healthcare System, 1998-present HONORS AND AWARDS M.D. with Distinction. L.Sc. in Molecular Biology Summa Cum Laude. Research Career Development Award, NIH, 1973-1976. Elected "Outstanding Faculty Member" (best clinical teacher) by the UCLA-SFVMP Interns & Residents Assoc. 1976-77. Grass Traveling Fellow, 1983. William Evans Fellow, Auckland Medical School, 1984. Visiting Professor, University of Otago, 1984. American Epilepsy Society-Milken Family Foundation Award for Basic Research in Epilepsy, 1992. Distinguished Lecturer in Neuroscience, LSU Center of Excellence, 1996. "Golden Hammer" teaching award, UCLA dpt of Neurology, 1996. "Ambassador for Epilepsy" award, International League Against Epilepsy, 2003. Distinguished Professor of Neurology, Geffen School of Medicine at UCLA, 2005. Pierre Gloor Award, American Clinical Neurophysiology Society, 2006.

Publications:

Niquet Jerome, Baldwin Roger, Gezalian Michael, Wasterlain Claude G   Deep hypothermia for the treatment of refractory status epilepticus Epilepsy & behavior : E&B, 2015; 49: 313-7.
Benz Alexander Philipp, Niquet Jerôme, Wasterlain Claude Guy, Rami Abdelhaq   Status epilepticus in the immature rodent brain alters the dynamics of autophagy Current neurovascular research, 2014; 11(2): 125-35.
Wasterlain Claude G, Naylor David E, Liu Hantao, Niquet Jerome, Baldwin Roger   Trafficking of NMDA receptors during status epilepticus: therapeutic implications Epilepsia, 2013; 54 Suppl 6(2): 78-80.
Wasterlain Claude G, Gloss David S, Niquet Jerome, Wasterlain Amy S   Epileptogenesis in the developing brain Handbook of clinical neurology, 2013; 111(2): 427-39.
Wasterlain Claude G, Gloss David S, Niquet Jerome, Wasterlain Amy S   Epileptogenesis in the developing brain Handbook of clinical neurology, 2013; 111(2): 427-39.
Naylor David E, Liu Hantao, Niquet Jerome, Wasterlain Claude G   Rapid surface accumulation of NMDA receptors increases glutamatergic excitation during status epilepticus Neurobiology of disease, 2013; 54(2): 225-38.
Wasterlain Claude G, Baldwin Roger, Naylor David E, Thompson Kerry W, Suchomelova Lucie, Niquet Jerome   Rational polytherapy in the treatment of acute seizures and status epilepticus Epilepsia, 2011; 52 Suppl 8(2): 70-1.
Wasterlain Claude G, Stöhr Thomas, Matagne Alain   The acute and chronic effects of the novel anticonvulsant lacosamide in an experimental model of status epilepticus Epilepsy research, 2011; 94(1-2): 10-7.
Wasterlain Claude G, Thompson Kerry W, Suchomelova Lucie, Niquet Jerome   Brain energy metabolism during experimental neonatal seizures Neurochemical research, 2010; 35(12): 2193-8.
Lu Xiaoying, Roberts Edward, Xia Fengcheng, Sanchez-Alavez Manuel, Liu Tianyu, Baldwin Roger, Wu Stephanie, Chang James, Wasterlain Claude G, Bartfai Tamas   GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(34): 15229-34.
Lopez-Meraz Maria-Leonor, Niquet Jerome, Wasterlain Claude G   Distinct caspase pathways mediate necrosis and apoptosis in subpopulations of hippocampal neurons after status epilepticus Epilepsia, 2010; 51 Suppl 3(34): 56-60.
Pedersen Mikael E, Baldwin Roger A, Niquet Jerome, Stafford Gary I, van Staden Johannes, Wasterlain Claude G, Jäger Anna K   Anticonvulsant effects of Searsia dentata (Anacardiaceae) leaf extract in rats Phytotherapy research : PTR, 2010; 24(6): 924-7.
Lopez-Meraz Maria-Leonor, Wasterlain Claude G, Rocha Luisa L, Allen Suni, Niquet Jerome   Vulnerability of postnatal hippocampal neurons to seizures varies regionally with their maturational stage Neurobiology of disease, 2010; 37(2): 394-402.
Wasterlain Claude G, Liu Hantao, Naylor David E, Thompson Kerry W, Suchomelova Lucy, Niquet Jerome, Mazarati Audrey M, Baldwin Roger A   Molecular basis of self-sustaining seizures and pharmacoresistance during status epilepticus: The receptor trafficking hypothesis revisited Epilepsia, 2009; 50 Suppl 12(2): 16-8.
Seo Dae-Won, Lopez-Meraz Maria-Leonor, Allen Suni, Wasterlain Claude Guy, Niquet Jerome   Contribution of a mitochondrial pathway to excitotoxic neuronal necrosis Journal of neuroscience research, 2009; 87(9): 2087-94.
Rocha Luisa L, Lopez-Meraz Maria-Leonor, Niquet Jerome, Wasterlain Claude G   Do single seizures cause neuronal death in the human hippocampus? Epilepsy currents / American Epilepsy Society, 2009; 7(3): 77-81.
Chen James W Y, Ruff Robert L, Eavey Roland, Wasterlain Claude G   Posttraumatic epilepsy and treatment Journal of rehabilitation research and development, 2009; 46(6): 685-96.
Wasterlain Claude G, Chen James W Y   Mechanistic and pharmacologic aspects of status epilepticus and its treatment with new antiepileptic drugs Epilepsia, 2008; 49 Suppl 9(9): 63-73.
Niquet Jerome, Auvin Stphane, Archie Mark, Seo Dae-Won, Allen Suni, Sankar Raman, Wasterlain Claude G   Status epilepticus triggers caspase-3 activation and necrosis in the immature rat brain Epilepsia, 2007; 48(6): 1203-6.
Pereira de Vasconcelos Anne, Riban Véronique, Wasterlain Claude, Nehlig Astrid   Role of endothelial nitric oxide synthase in cerebral blood flow changes during kainate seizures: a genetic approach using knockout mice Neurobiology of disease, 2006; 23(1): 219-27.
Chen JWY, Wasterlain CG,   Status Epilepticus, Lancet Neurology , 2006; 5: 246-256.
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Claude G. Wasterlain and David M. Treiman (Editors)   Status Epilepticus: Mechanisms and Management, , 2006; .
Suchomelova Lucie, Baldwin Roger A, Kubova Hana, Thompson Kerry W, Sankar Raman, Wasterlain Claude G   Treatment of experimental status epilepticus in immature rats: dissociation between anticonvulsant and antiepileptogenic effects Pediatric research, 2006; 59(2): 237-43.
Naylor DE, Liu H, Wasterlain C.   Trafficking of GABAA receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus, J Neurosci, 2005; 25: 7724-7733.
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Niquet, J Baldwin, RA Allen, SG Fujikawa, DG Wasterlain, CG   Hypoxic neuronal necrosis: protein synthesis-independent activation of a cell death program Proceedings of the National Academy of Sciences of the United States of America. , 2003; 100(5): 2825-30.
Sankar, R Shin, D Mazarati, AM Liu, H Katsumori, H Lezama, R Wasterlain, CG   Epileptogenesis after status epilepticus reflects age- and model-dependent plasticity Annals of neurology. , 2000; 48(4): 580-9.
Mazarati, AM Hohmann, JG Bacon, A Liu, H Sankar, R Steiner, RA Wynick, D Wasterlain, CG   Modulation of hippocampal excitability and seizures by galanin The Journal of neuroscience : the official journal of the Society for Neuroscience. , 2000; 20(16): 6276-81.
Liu, H Cao, Y Basbaum, AI Mazarati, AM Sankar, R Wasterlain, CG   Resistance to excitotoxin-induced seizures and neuronal death in mice lacking the preprotachykinin A gene Proceedings of the National Academy of Sciences of the United States of America. , 1999; 96(21): 12096-101.
Liu, H Mazarati, AM Katsumori, H Sankar, R Wasterlain, CG   Substance P is expressed in hippocampal principal neurons during status epilepticus and plays a critical role in the maintenance of status epilepticus Proceedings of the National Academy of Sciences of the United States of America. , 1999; 96(9): 5286-91.
Mazarati, AM Liu, H Soomets, U Sankar, R Shin, D Katsumori, H Langel, U Wasterlain, CG   Galanin modulation of seizures and seizure modulation of hippocampal galanin in animal models of status epilepticus The Journal of neuroscience : the official journal of the Society for Neuroscience. , 1998; 18(23): 10070-7.
Sankar, R Shin, DH Liu, H Mazarati, A Pereira de Vasconcelos, A Wasterlain, CG   Patterns of status epilepticus-induced neuronal injury during development and long-term consequences The Journal of neuroscience : the official journal of the Society for Neuroscience. , 1998; 18(20): 8382-93.