
David S. Williams, Ph.D.
Titles
Professor In-Residence, Ophthalmology
Contact Information
Email
dswilliams@ucla.edu Phone
Work Phone Number:
310-825-9546
Address
Mailing Address:
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UNITED STATES
Publications
A selected list of publications:
Esteve-Rudd Julian, Hazim Roni A, Diemer Tanja, Paniagua Antonio E, Volland Stefanie, Umapathy Ankita, Williams David S
Defective phagosome motility and degradation in cell nonautonomous RPE
pathogenesis of a dominant macular degeneration
Proceedings of the National Academy of Sciences of the United States of America,
2018; 115(21):
5468-5473.
Hazim Roni A, Williams David S
Cell Culture Analysis of the Phagocytosis of Photoreceptor Outer
Segments by Primary Mouse RPE Cells
Methods in molecular biology (Clifton, N.J.),
2018; 1753(3):
63-71.
Volland Stefanie, Williams David S
Preservation of Photoreceptor Nanostructure for Electron Tomography
Using Transcardiac Perfusion Followed by High-Pressure Freezing and
Freeze-Substitution
Advances in experimental medicine and biology,
2018; 1074(3):
603-607.
Hazim Roni A, Karumbayaram Saravanan, Jiang Mei, Dimashkie Anupama, Lopes Vanda S, Li Douran, Burgess Barry L, Vijayaraj Preethi, Alva-Ornelas Jackelyn A, Zack Jerome A, Kohn Donald B, Gomperts Brigitte N, Pyle April D, Lowry William E, Williams David S
Differentiation of RPE cells from integration-free iPS cells and their
cell biological characterization
Stem cell research & therapy,
2017; 8(1):
217.
Galloway Chad A, Dalvi Sonal, Hung Sandy S C, MacDonald Leslie A, Latchney Lisa R, Wong Raymond C B, Guymer Robyn H, Mackey David A, Williams David S, Chung Mina M, Gamm David M, Pébay Alice, Hewitt Alex W, Singh Ruchira
Drusen in patient-derived hiPSC-RPE models of macular dystrophies
Proceedings of the National Academy of Sciences of the United States of America,
2017; 114(39):
E8214-E8223.
Goldberg Andrew F X, Moritz Orson L, Williams David S
Molecular basis for photoreceptor outer segment architecture
Progress in retinal and eye research,
2016; 55(1):
52-81.
Hazim Roni, Jiang Mei, Esteve-Rudd Julian, Diemer Tanja, Lopes Vanda S, Williams David S
Live-Cell Imaging of Phagosome Motility in Primary Mouse RPE Cells
Advances in experimental medicine and biology,
2016; 854(30):
751-5.
Volland Stefanie, Hughes Louise C, Kong Christina, Burgess Barry L, Linberg Kenneth A, Luna Gabriel, Zhou Z Hong, Fisher Steven K, Williams David S
Three-dimensional organization of nascent rod outer segment disk
membranes
Proceedings of the National Academy of Sciences of the United States of America,
2015; 112(48):
14870-5.
Jiang Mei, Esteve-Rudd Julian, Lopes Vanda S, Diemer Tanja, Lillo Concepción, Rump Agrani, Williams David S
Microtubule motors transport phagosomes in the RPE, and lack of KLC1
leads to AMD-like pathogenesis
The Journal of cell biology,
2015; 210(4):
595-611.
Volland Stefanie, Esteve-Rudd Julian, Hoo Juyea, Yee Claudine, Williams David S
A comparison of some organizational characteristics of the mouse
central retina and the human macula
PloS one,
2015; 10(4):
e0125631.
Eblimit Aiden, Nguyen Thanh-Minh T, Chen Yiyun, Esteve-Rudd Julian, Zhong Hua, Letteboer Stef, Van Reeuwijk Jeroen, Simons David L, Ding Qian, Wu Ka Man, Li Yumei, Van Beersum Sylvia, Moayedi Yalda, Xu Huidan, Pickard Patrick, Wang Keqing, Gan Lin, Wu Samuel M, Williams David S, Mardon Graeme, Roepman Ronald, Chen Rui
Spata7 is a retinal ciliopathy gene critical for correct RPGRIP1
localization and protein trafficking in the retina
Human molecular genetics,
2015; 24(6):
1584-601.
Lopes Vanda S, Williams David S
Gene Therapy for the Retinal Degeneration of Usher Syndrome Caused by
Mutations in MYO7A
Cold Spring Harbor perspectives in medicine,
2015; 5(6):
1584-601.
Frost Laura S, Lopes Vanda S, Bragin Alvina, Reyes-Reveles Juan, Brancato Jennifer, Cohen Art, Mitchell Claire H, Williams David S, Boesze-Battaglia Kathleen
The Contribution of Melanoregulin to Microtubule-Associated Protein 1
Light Chain 3 (LC3) Associated Phagocytosis in Retinal Pigment
Epithelium
Molecular neurobiology,
2014;
.
Crouse Jacquelin A, Lopes Vanda S, Sanagustin Jovenal T, Keady Brian T, Williams David S, Pazour Gregory J
Distinct functions for IFT140 and IFT20 in opsin transport
Cytoskeleton (Hoboken, N.J.),
2014; 71(5):
302-10.
Almenar-Queralt Angels, Falzone Tomas L, Shen Zhouxin, Lillo Concepcion, Killian Rhiannon L, Arreola Angela S, Niederst Emily D, Ng Kheng S, Kim Sonia N, Briggs Steven P, Williams David S, Goldstein Lawrence S B
UV irradiation accelerates amyloid precursor protein (APP) processing
and disrupts APP axonal transport
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2014; 34(9):
3320-39.
Lopes VS, Boye SE, Louie CM, Boye S, Dyka F, Chiodo V, Fofo H, Hauswirth WW, Williams DS
Retinal gene therapy with a large MYO7A cDNA using Adeno-associated virus
Gene Therapy,
2013;
.
Harkewicz R, Du H, Tong Z, Alkuraya H, Bedell M, Sun W, Wang X, Hsu YH, Esteve-Rudd J, Hughes G, Su Z, Zhang M, Lopes VS, Molday RS, Williams DS, Dennis EA, Zhang K
Essential role of ELOVL4 in very long chain fatty acid synthesis and retinal function
Journal of Biological Chemistry ,
2012; 287:
11469-11480.
Engelhardt M, Tosha C, Lopes VS, Chen B, Nguyen L, Nusinowitz S, Williams DS
Functional and morphological analysis of the subretinal injection of RPE cells
Visual Neuroscience,
2012; 29:
83-93.
Trivedi D, Colin E, Louie CM, Williams DS
Live-cell imaging evidence for the ciliary transport of rod photoreceptor opsin by heterotrimeric kinesin-2
Journal of Neuroscience,
2012; 32:
10587-10593.
Da Cruz Sandrine, Parone Philippe A, Lopes Vanda S, Lillo Concepción, McAlonis-Downes Melissa, Lee Sandra K, Vetto Anne P, Petrosyan Susanna, Marsala Martin, Murphy Anne N, Williams David S, Spiegelman Bruce M, Cleveland Don W
Elevated PGC-1α activity sustains mitochondrial biogenesis and muscle
function without extending survival in a mouse model of inherited ALS
Cell metabolism,
2012; 15(5):
778-86.
Phillips JB, Blanco-Sanchez B, Lentz JJ, Tallafuss A, Khanobdee K, Sampath S, Jacobs ZG, Han PF, Mishra M, Williams DS, Keats BJ, Washbourne P, Westerfield M
Harmonin (Ush1c) is required in zebrafish Muller glial cells for photoreceptor synaptic development and function
Disease Models & Mechanisms ,
2011; 4:
786-800.
Jacobson SG, Cideciyan AV, Gibbs D, Sumaroka A, Roman AJ, Aleman TS, Schwartz SB, Olivares MB, Russell RC, Steinberg JD, Kenna MA, Kimberling WJ, Rehm HL, Williams DS
Retinal Disease Course in Usher Syndrome 1B due to MYO7A Mutations
Investigative Ophthalmology & Visual Science,
2011; 52:
7924-7936.
Lopes VS, Gibbs D, Libby RT, Aleman TS, Welch DL, Lillo C, Jacobson SG, Radu RA, Steel KP, Williams DS
The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65
Human Molecular Genetics,
2011; 20:
2560-2570.
Williams DS, Lopes VS
The many different cellular functions of MYO7A in the retina
Biochemical Society transactions,
2011; 39:
1207-10.
Louie CM, Caridi G, Lopes VS, Brancati F, Kispert A, Lancaster MA, Schlossman AM, Otto EA, Leitges M, Grone HJ, Lopez I, Gudiseva HV, O'Toole JF, Vallespin E, Ayyagari R, Ayuso C, Cremers FP, den Hollander Al, Koenekoop RK, Dallapiccola B, Ghiggeri GM, Hildebrandt F, Valente EM, Williams DS, Gleeson JG
AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis
Nature Genetics ,
2010; 42:
175-180.
Lopes VS, Jimeno D, Khanobdee K, Song X, Chen B, Nusinowitz S, Williams DS
Dysfunction of Heterotrimeric Kinesin-2 in Rod Photoreceptor Cells and the Role of Opsin Mislocalization in Rapid Cell Death
Molecular Biology of the Cell,
2010; 21:
4076-4088.
Gibbs D, Diemer T, Khanobdee K, Hu J, Bok D, Williams DS
Function of MYO7A in the human RPE and the validity of shaker1 mice as a model for Usher syndrome 1B
Investigative Ophthalmology and Visual Science,
2010; 51:
1130-1135.
Liao JL,Yu J, Huang K, Hu J, Diemer T, Ma Z, Dvash T, Yang XJ, Travis GH, Williams DS, Bok D, Fan G
Molecular signature of primary retinal pigment epithelium and stem-cell-derived RPE cells
Human Molecular Genetics ,
2010; 19:
4229-4238.
Louie Carrie M, Caridi Gianluca, Lopes Vanda S, Brancati Francesco, Kispert Andreas, Lancaster Madeline A, Schlossman Andrew M, Otto Edgar A, Leitges Michael, Gröne Hermann-Josef, Lopez Irma, Gudiseva Harini V, O'Toole John F, Vallespin Elena, Ayyagari Radha, Ayuso Carmen, Cremers Frans P M, den Hollander Anneke I, Koenekoop Robert K, Dallapiccola Bruno, Ghiggeri Gian Marco, Hildebrandt Friedhelm, Valente Enza Maria, Williams David S, Gleeson Joseph G
AHI1 is required for photoreceptor outer segment development and is a
modifier for retinal degeneration in nephronophthisis
Nature genetics,
2010; 42(2):
175-80.
Williams David S, Cash Alan, Hamadani Lara, Diemer Tanja
Oxaloacetate supplementation increases lifespan in Caenorhabditis
elegans through an AMPK/FOXO-dependent pathway
Aging cell,
2009; 8(6):
765-8.
Gibbs Daniel, Cideciyan Artur V, Jacobson Samuel G, Williams David S
Retinal pigment epithelium defects in humans and mice with mutations
in MYO7A: imaging melanosome-specific autofluorescence
Investigative ophthalmology & visual science,
2009; 50(9):
4386-93.
Schwander M, Lopes V, Sczaniecka A, Gibbs D, Lillo C, Delano D, Tarantino LM, Wiltshire T, Williams DS, Müller U
A novel allele of myosin VIIa reveals a critical function for the C-terminal FERM domain for melanosome transport in retinal pigment epithelial cells
Journal of Neuroscience,
2009; 29:
15810-15818.
Falzone Tomás L, Stokin Gorazd B, Lillo Concepción, Rodrigues Elizabeth M, Westerman Eileen L, Williams David S, Goldstein Lawrence S B
Axonal stress kinase activation and tau misbehavior induced by
kinesin-1 transport defects
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2009; 29(18):
5758-67.
Damek-Poprawa Monika, Diemer Tanja, Lopes Vanda S, Lillo Concepción, Harper Dawn C, Marks Michael S, Wu Yalin, Sparrow Janet R, Rachel Rivka A, Williams David S, Boesze-Battaglia Kathleen
Melanoregulin (MREG) modulates lysosome function in pigment epithelial
cells
The Journal of biological chemistry,
2009; 284(16):
10877-89.