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Douglas L. Black, Ph.D.
Professor, Microbiology, Immunology & Molecular Genetics
Member, Biochemistry, Biophysics & Structural Biology GPB Home Area
Brain Research Institute
Center for Duchenne Muscular Dystrophy
Gene Regulation GPB Home Area
JCCC Gene Regulation Program Area
Investigator, Howard Hughes Medical Institute
Work Phone Number: (310) 794-7644
CAMPUS - 166222
BiographyDr. Black is a Professor in the Department of Microbiology, Immunology, and Molecular Genetics at the University of California, Los Angeles, and the David Geffen School of Medicine at UCLA. His B.A. degree is in chemistry from the University of California, Santa Cruz. He received his Ph.D. degree in molecular biochemistry and biophysics at Yale University, working with Joan Steitz. Prior to his appointment at UCLA, he worked with David Baltimore and Donald Rio at the Whitehead Institute for Biomedical Research as a Helen Hay Whitney and American Cancer Society fellow. He was also a fellow of the David and Lucile Packard Foundation.
Shalini Sharma, Lori A. Kohlstaedt, Andrey Damianov, Donald C. Rio, and Douglas L. Black Polypyrimidine tract binding protein controls the transition from exon definition to an intron defined spliceosome, Nature Structural and Molecular Biology, 2008; In Press.: .
Lee J, Xing Y, Nguyen D, Xie J, Lee C. and Douglas L. Black Depolarization and CaM Kinase IV Modulate NMDA Receptor Splicing through Two Essential RNA Elements, PLoS Biology, 2007; 5(2): e40.
Boutz P, Chawla G, Stoilov P, and Douglas L. Black MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development, Genes and Development, 2007; 21(1): 71-84.
Li, Qin, Lee, Ji-Ann, and Douglas L. Black Neuronal Regulation of Alternative Pre-messenger RNA Splicing, Nature Reviews Neuroscience, 2007; 8(11): 819-31.
Boutz P, Stoilov P, Li Q, Lin C, Chawla G, Ostrow K, Shiue L, Manuel C. Ares and Douglas L. Black Post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons, Genes and Development, 2007; 21(13): 1636-52.
Xie J, Jan C, Stoilov P, Park J, Black DL A concensus CaMK IV-responsive RNA sequence mediates regulation of alternative exons in neurons, RNA, 2005; 11(12): 1825-1834.
Underwood J, Boutz P, Dougherty JD, Stoilov P, Black DL Homologues of the C. Elegans Fox-1 Protein are neuronal splicing regulators in mammals, MCB, 2005; 25(22): 10005-16.
Black DL Mechanisms of alternative pre-messenger RNA splicing Annual review of biochemistry. , 2003; 72: 291-336.
Grabowski PJ, Black DL Alternative RNA splicing in the nervous system, Progress in Neurobiology, 2001; 65: 289-308.
Sharma S, Falick AM, Black DL Polypyrimidine tract binding protein blocks the 5' splice site-dependent assembly of U2AF and the prespliceosomal E complex Molecular Cell , 2005; 19(4): 485-96.
Amir-Ahmady B, Boutz PL, Markovtsov V, Phillips ML, Black DL Exon repression by polypyrimidine tract binding protein RNA (New York, N.Y.) , 2005; 11(5): 699-716.
Xie J, Black DL A CaMK IV responsive RNA element mediates depolarization-induced alternative splicing of ion channels Nature. , 2001; 410(6831): 936-9.