Douglas L. Black, Ph.D.

Titles

Professor, Microbiology, Immunology & Molecular Genetics
Member, Biochemistry, Biophysics & Structural Biology GPB Home Area
Brain Research Institute
Center for Duchenne Muscular Dystrophy
Gene Regulation GPB Home Area
JCCC Gene Regulation Program Area
Neuroscience GPB Home Area
Faculty, Biomedical Engineering IDP
Molecular Biology IDP
Investigator, Howard Hughes Medical Institute

Contact Information

Email
dougb@microbio.ucla.edu
Phone
Work Phone Number: (310) 794-7644
Address
Laboratory Address: LaboratoryMRL 6-567UNITED STATES Work Address: OfficeMRL 6-780CAMPUS - 166222 CA UNITED STATES

Biography

Dr. Black is a Professor in the Department of Microbiology, Immunology, and Molecular Genetics at the University of California, Los Angeles, and the David Geffen School of Medicine at UCLA. His B.A. degree is in chemistry from the University of California, Santa Cruz. He received his Ph.D. degree in molecular biochemistry and biophysics at Yale University, working with Joan Steitz. Prior to his appointment at UCLA, he worked with David Baltimore and Donald Rio at the Whitehead Institute for Biomedical Research as a Helen Hay Whitney and American Cancer Society fellow. He was also a fellow of the David and Lucile Packard Foundation.

Publications:

Shalini Sharma, Lori A. Kohlstaedt, Andrey Damianov, Donald C. Rio, and Douglas L. Black   Polypyrimidine tract binding protein controls the transition from exon definition to an intron defined spliceosome, Nature Structural and Molecular Biology, 2008; In Press.: .
Lee J, Xing Y, Nguyen D, Xie J, Lee C. and Douglas L. Black   Depolarization and CaM Kinase IV Modulate NMDA Receptor Splicing through Two Essential RNA Elements, PLoS Biology, 2007; 5(2): e40.
Boutz P, Chawla G, Stoilov P, and Douglas L. Black   MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development, Genes and Development, 2007; 21(1): 71-84.
Li, Qin, Lee, Ji-Ann, and Douglas L. Black   Neuronal Regulation of Alternative Pre-messenger RNA Splicing, Nature Reviews Neuroscience, 2007; 8(11): 819-31.
Boutz P, Stoilov P, Li Q, Lin C, Chawla G, Ostrow K, Shiue L, Manuel C. Ares and Douglas L. Black   Post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons, Genes and Development, 2007; 21(13): 1636-52.
Xie J, Jan C, Stoilov P, Park J, Black DL   A concensus CaMK IV-responsive RNA sequence mediates regulation of alternative exons in neurons, RNA, 2005; 11(12): 1825-1834.
Underwood J, Boutz P, Dougherty JD, Stoilov P, Black DL   Homologues of the C. Elegans Fox-1 Protein are neuronal splicing regulators in mammals, MCB, 2005; 25(22): 10005-16.
Black DL   Mechanisms of alternative pre-messenger RNA splicing Annual review of biochemistry. , 2003; 72: 291-336.
Grabowski PJ, Black DL   Alternative RNA splicing in the nervous system, Progress in Neurobiology, 2001; 65: 289-308.
Amir-Ahmady B, Boutz PL, Markovtsov V, Phillips ML, Black DL   Exon repression by polypyrimidine tract binding protein RNA (New York, N.Y.) , 2005; 11(5): 699-716.