Gary W. Mathern, M.D.

Titles

Director, Epilepsy Surgery
Pediatric Epilepsy Program
Professor, Neurosurgery
Professor in Residence, Surgery
Member, Brain Research Institute
Neuroscience GPB Home Area
Neuroscience IDP
Pediatric Neuro-oncology and Neural Tumors Center

Awards and Honors:

Harbor - UCLA Medical Center Cleveland Clinic Foundation UCLA School of Medicine

Contact Information

Email
gmathern@ucla.edu
Phone
Work Phone Number: (310) 825-7961
Address
Mailing Address: 710 Westwood PlazaLos Angeles, CA 90095UNITED STATES

Biography

Gary W. Mathern, M.D. Professor in Residence and Director of the Pediatric Epilepsy Surgery Program and Pediatric Neurosurgery Program. Dr. Mathern works in conjunction with the Epilepsy Program to provide surgical treatment for children with epilepsy. HOSPITAL POSITION * Professor in Residence, UCLA Medical Center, Department of Neurosurgery o American Association of Neurological Surgeons o American Association for the Advancement of Science o American Clinical Neurophysiology Society, Long Range Planning Committee o American Epilepsy Society o American Epilepsy Society Scientific Program Committee o Brain Research Institute o Mental Retardation Research Center, UCLA Center for Health Sciences o Society for Neuroscience o Trauma Care Committee, Olive View/UCLA Medical Center MEMBERSHIP, MEDICAL ORGANIZATIONS

Publications:

Cepeda, C. Andre, V. M. Vinters, H. V. Levine, M. S. Mathern, G. W.   Are cytomegalic neurons and balloon cells generators of epileptic activity in pediatric cortical dysplasia? Epilepsia, 2005; 46 Suppl 5: 82-8.
Cepeda, C. Andre, V. M. Flores-Hernandez, J. Nguyen, O. K. Wu, N. Klapstein, G. J. Nguyen, S. Koh, S. Vinters, H. V. Levine, M. S. Mathern, G. W.   Pediatric cortical dysplasia: correlations between neuroimaging, electrophysiology and location of cytomegalic neurons and balloon cells and glutamate/GABA synaptic circuits Dev Neurosci, 2005; 27(1): 59-76.
Jonas, R Asarnow, RF LoPresti, C Yudovin, S Koh, S Wu, JY Sankar, R Shields, WD Vinters, HV Mathern, GW   Surgery for symptomatic infant-onset epileptic encephalopathy with and without infantile spasms Neurology. , 2005; 64(4): 746-50.
Andres, M Andre, VM Nguyen, S Salamon, N Cepeda, C Levine, MS Leite, JP Neder, L Vinters, HV Mathern, GW   Human cortical dysplasia and epilepsy: an ontogenetic hypothesis based on volumetric MRI and NeuN neuronal density and size measurements Cerebral cortex (New York, N.Y. : 1991) , 2005; 15(2): 194-210.
de Bode, S Firestine, A Mathern, GW Dobkin, B   Residual motor control and cortical representations of function following hemispherectomy: effects of etiology Journal of child neurology. , 2005; 20(1): 64-75.
Koh, S. Nguyen, S. Asarnow, R. F. LoPresti, C. Yudovin, S. Shields, W. D. Vinters, H. V. Mathern, G. W.   Five or more acute postoperative seizures predict hospital course and long-term seizure control after hemispherectomy Epilepsia, 2004; 45(5): 527-33.
Andre, V. M. Flores-Hernandez, J. Cepeda, C. Starling, A. J. Nguyen, S. Lobo, M. K. Vinters, H. V. Levine, M. S. Mathern, G. W.   NMDA receptor alterations in neurons from pediatric cortical dysplasia tissue Cereb Cortex, 2004; 14(6): 634-46.
Jonas, R Nguyen, S Hu, B Asarnow, RF LoPresti, C Curtiss, S de Bode, S Yudovin, S Shields, WD Vinters, HV Mathern, GW   Cerebral hemispherectomy: hospital course, seizure, developmental, language, and motor outcomes Neurology. , 2004; 62(10): 1712-21.
Najm, I Ying, Z Babb, T Crino, PB Macdonald, R Mathern, GW Spreafico, R   Mechanisms of epileptogenicity in cortical dysplasias Neurology. , 2004; 62(6 Suppl 3): S9-13.
Cook, SW Nguyen, ST Hu, B Yudovin, S Shields, WD Vinters, HV Van de Wiele, BM Harrison, RE Mathern, GW   Cerebral hemispherectomy in pediatric patients with epilepsy: comparison of three techniques by pathological substrate in 115 patients Journal of neurosurgery. , 2004; 100(2 Suppl Pediatrics): 125-41.
Stables, JP Bertram, E Dudek, FE Holmes, G Mathern, G Pitkanen, A White, HS   Therapy discovery for pharmacoresistant epilepsy and for disease-modifying therapeutics: summary of the NIH/NINDS/AES models II workshop Epilepsia. , 2003; 44(12): 1472-8.
Handforth, A Ondo, WG Tatter, S Mathern, GW Simpson, RK Walker, F Sutton, JP Hubble, JP Jankovic, J   Vagus nerve stimulation for essential tremor: a pilot efficacy and safety trial Neurology. , 2003; 61(10): 1401-5.
Bender, RA Soleymani, SV Brewster, AL Nguyen, ST Beck, H Mathern, GW Baram, TZ   Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus The Journal of neuroscience : the official journal of the Society for Neuroscience. , 2003; 23(17): 6826-36.
Cepeda, C. Hurst, R. S. Flores-Hernandez, J. Hernandez-Echeagaray, E. Klapstein, G. J. Boylan, M. K. Calvert, C. R. Jocoy, E. L. Nguyen, O. K. Andre, V. M. Vinters, H. V. Ariano, M. A. Levine, M. S. Mathern, G. W.   Morphological and electrophysiological characterization of abnormal cell types in pediatric cortical dysplasia J Neurosci Res, 2003; 72(4): 472-86.
Caplan, R. Siddarth, P. Mathern, G. Vinters, H. Curtiss, S. Levitt, J. Asarnow, R. Shields, W. D.   Developmental outcome with and without successful intervention Int Rev Neurobiol, 2002; 49: 269-84.
Mathern, GW Adelson, PD Cahan, LD Leite, JP   Hippocampal neuron damage in human epilepsy: Meyer's hypothesis revisited Progress in brain research. , 2002; 135: 237-51.
Mathern, GW Leiphart, JL De Vera, A Adelson, PD Seki, T Neder, L Leite, JP   Seizures decrease postnatal neurogenesis and granule cell development in the human fascia dentata Epilepsia. , 2002; 43 Suppl 5: 68-73.
Shusta, E. V. Boado, R. J. Mathern, G. W. Pardridge, W. M.   Vascular genomics of the human brain J Cereb Blood Flow Metab, 2002; 22(3): 245-52.
Curtiss, S de Bode, S Mathern, GW   Spoken language outcomes after hemispherectomy: factoring in etiology Brain and language. , 2001; 79(3): 379-96.
Leiphart, JW Peacock, WJ Mathern, GW   Lobar and multilobar resections for medically intractable pediatric epilepsy Pediatric neurosurgery. , 2001; 34(6): 311-8.
Mathern, GW Cepeda, C Hurst, RS Flores-Hernandez, J Mendoza, D Levine, MS   Neurons recorded from pediatric epilepsy surgery patients with cortical dysplasia Epilepsia. , 2000; 41 Suppl 6: S162-7.
Mathern, GW Giza, CC Yudovin, S Vinters, HV Peacock, WJ Shewmon, DA Shields, WD   Postoperative seizure control and antiepileptic drug use in pediatric epilepsy surgery patients: the UCLA experience, 1986-1997 Epilepsia. , 1999; 40(12): 1740-9.
Kerfoot, C Vinters, HV Mathern, GW   Cerebral cortical dysplasia: giant neurons show potential for increased excitation and axonal plasticity Developmental neuroscience. , 1999; 21(3-5): 260-70.
Cepeda, C Li, Z Cromwell, HC Altemus, KL Crawford, CA Nansen, EA Ariano, MA Sibley, DR Peacock, WJ Mathern, GW Levine, MS   Electrophysiological and morphological analyses of cortical neurons obtained from children with catastrophic epilepsy: dopamine receptor modulation of glutamatergic responses Developmental neuroscience. , 1999; 21(3-5): 223-35.
Bragin, A Engel, J Wilson, CL Vizentin, E Mathern, GW   Electrophysiologic analysis of a chronic seizure model after unilateral hippocampal KA injection Epilepsia. , 1999; 40(9): 1210-21.
Mathern, GW Pretorius, JK Mendoza, D Leite, JP Chimelli, L Born, DE Fried, I Assirati, JA Ojemann, GA Adelson, PD Cahan, LD Kornblum, HI   Hippocampal N-methyl-D-aspartate receptor subunit mRNA levels in temporal lobe epilepsy patients Annals of neurology. , 1999; 46(3): 343-58.
Mathern, GW Mendoza, D Lozada, A Pretorius, JK Dehnes, Y Danbolt, NC Nelson, N Leite, JP Chimelli, L Born, DE Sakamoto, AC Assirati, JA Fried, I Peacock, WJ Ojemann, GA Adelson, PD   Hippocampal GABA and glutamate transporter immunoreactivity in patients with temporal lobe epilepsy Neurology. , 1999; 52(3): 453-72.
Mathern, GW Pretorius, JK Mendoza, D Lozada, A Kornblum, HI   Hippocampal AMPA and NMDA mRNA levels correlate with aberrant fascia dentata mossy fiber sprouting in the pilocarpine model of spontaneous limbic epilepsy Journal of neuroscience research. , 1998; 54(6): 734-53.
Mathern, GW Pretorius, JK Kornblum, HI Mendoza, D Lozada, A Leite, JP Chimelli, L Born, DE Fried, I Sakamoto, AC Assirati, JA Peacock, WJ Ojemann, GA Adelson, PD   Altered hippocampal kainate-receptor mRNA levels in temporal lobe epilepsy patients Neurobiology of disease. , 1998; 5(3): 151-76.
Mathern, GW Pretorius, JK Leite, JP Kornblum, HI Mendoza, D Lozada, A Bertram, EH   Hippocampal AMPA and NMDA mRNA levels and subunit immunoreactivity in human temporal lobe epilepsy patients and a rodent model of chronic mesial limbic epilepsy Epilepsy research. , 1998; 32(1-2): 154-71.
Mathern, GW Pretorius, JK Mendoza, D Lozada, A Leite, JP Chimelli, L Fried, I Sakamoto, AC Assirati, JA Adelson, PD   Increased hippocampal AMPA and NMDA receptor subunit immunoreactivity in temporal lobe epilepsy patients Journal of neuropathology and experimental neurology. , 1998; 57(6): 615-34.
Mathern, GW Price, G Rosales, C Pretorius, JK Lozada, A Mendoza, D   Anoxia during kainate status epilepticus shortens behavioral convulsions but generates hippocampal neuron loss and supragranular mossy fiber sprouting Epilepsy research. , 1998; 30(2): 133-51.
Mathern, GW Pretorius, JK Kornblum, HI Mendoza, D Lozada, A Leite, JP Chimelli, LM Fried, I Sakamoto, AC Assirati, JA Lévesque, MF Adelson, PD Peacock, WJ   Human hippocampal AMPA and NMDA mRNA levels in temporal lobe epilepsy patients Brain : a journal of neurology. , 1997; 120 ( Pt 11): 1937-59.
Mathern, GW Babb, TL Micevych, PE Blanco, CE Pretorius, JK   Granule cell mRNA levels for BDNF, NGF, and NT-3 correlate with neuron losses or supragranular mossy fiber sprouting in the chronically damaged and epileptic human hippocampus Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid. , 1997; 30(1-2): 53-76.
Mathern, GW Kuhlman, PA Mendoza, D Pretorius, JK   Human fascia dentata anatomy and hippocampal neuron densities differ depending on the epileptic syndrome and age at first seizure Journal of neuropathology and experimental neurology. , 1997; 56(2): 199-212.
Babb, TL Mathern, GW Leite, JP Pretorius, JK Yeoman, KM Kuhlman, PA   Glutamate AMPA receptors in the fascia dentata of human and kainate rat hippocampal epilepsy Epilepsy research. , 1996; 26(1): 193-205.
Leite, JP Babb, TL Pretorius, JK Kuhlman, PA Yeoman, KM Mathern, GW   Neuron loss, mossy fiber sprouting, and interictal spikes after intrahippocampal kainate in developing rats Epilepsy research. , 1996; 26(1): 219-31.
Mathern, GW Babb, TL Leite, JP Pretorius, K Yeoman, KM Kuhlman, PA   The pathogenic and progressive features of chronic human hippocampal epilepsy Epilepsy research. , 1996; 26(1): 151-61.
Babb, TL Mathern, GW Pretorius, JK Cifuentes, F   Astrocytes may contribute to the latent period in progressive neuron loss, axon sprouting, and chronic seizures in rat kainate hippocampal epilepsy Epilepsy research. Supplement. , 1996; 12: 343-54.
Mathern, G. W. Leite, J. P. Pretorius, J. K. Quinn, B. Peacock, W. J. Babb, T. L.   Severe seizures in young children are associated with hippocampal neuron losses and aberrant mossy fiber sprouting during fascia dentata postnatal development Epilepsy Res Suppl, 1996; 12: 33-43.
Mathern, GW Babb, TL Mischel, PS Vinters, HV Pretorius, JK Leite, JP Peacock, WJ   Childhood generalized and mesial temporal epilepsies demonstrate different amounts and patterns of hippocampal neuron loss and mossy fibre synaptic reorganization Brain : a journal of neurology. , 1996; 119 ( Pt 3): 965-87.
Mathern, GW Leite, JP Babb, TL Pretorius, JK Kuhlman, PA Mendoza, D Fried, I Sakamoto, AC Assirati, JA Adelson, PD Peacock, WJ   Aberrant hippocampal mossy fiber sprouting correlates with greater NMDAR2 receptor staining Neuroreport. , 1996; 7(5): 1029-35.
Babb, TL Pereira-Leite, J Mathern, GW Pretorius, JK   Kainic acid induced hippocampal seizures in rats: comparisons of acute and chronic seizures using intrahippocampal versus systemic injections Italian journal of neurological sciences. , 1995; 16(1-2): 39-44.
Mathern, G. W. Babb, T. L. Pretorius, J. K. Melendez, M. Levesque, M. F.   The pathophysiologic relationships between lesion pathology, intracranial ictal EEG onsets, and hippocampal neuron losses in temporal lobe epilepsy Epilepsy Res, 1995; 21(2): 133-47.
Mathern, GW Babb, TL Pretorius, JK Leite, JP   Reactive synaptogenesis and neuron densities for neuropeptide Y, somatostatin, and glutamate decarboxylase immunoreactivity in the epileptogenic human fascia dentata The Journal of neuroscience : the official journal of the Society for Neuroscience. , 1995; 15(5 Pt 2): 3990-4004.
Mathern, GW Pretorius, JK Babb, TL   Quantified patterns of mossy fiber sprouting and neuron densities in hippocampal and lesional seizures Journal of neurosurgery. , 1995; 82(2): 211-9.
Mathern, GW Babb, TL Vickrey, BG Melendez, M Pretorius, JK   The clinical-pathogenic mechanisms of hippocampal neuron loss and surgical outcomes in temporal lobe epilepsy Brain : a journal of neurology. , 1995; 118 ( Pt 1): 105-18.
Mathern, GW Pretorius, JK Babb, TL Quinn, B   Unilateral hippocampal mossy fiber sprouting and bilateral asymmetric neuron loss with episodic postictal psychosis Journal of neurosurgery. , 1995; 82(2): 228-33.
Mathern, GW Babb, TL Vickrey, BG Melendez, M Pretorius, JK   Traumatic compared to non-traumatic clinical-pathologic associations in temporal lobe epilepsy Epilepsy research. , 1994; 19(2): 129-39.
Mathern, GW Leite, JP Pretorius, JK Quinn, B Peacock, WJ Babb, TL   Children with severe epilepsy: evidence of hippocampal neuron losses and aberrant mossy fiber sprouting during postnatal granule cell migration and differentiation Brain research. Developmental brain research. , 1994; 78(1): 70-80.
Mathern, GW Cifuentes, F Leite, JP Pretorius, JK Babb, TL   Hippocampal EEG excitability and chronic spontaneous seizures are associated with aberrant synaptic reorganization in the rat intrahippocampal kainate model Electroencephalography and clinical neurophysiology. , 1993; 87(5): 326-39.
Babb, TL Pretorius, JK Mello, LE Mathern, GW Levesque, MF   Synaptic reorganizations in epileptic human and rat kainate hippocampus may contribute to feedback and feedforward excitation Epilepsy research. Supplement. , 1992; 9: 193-202; discussion 203.
Schell, RE Mathern, GW   Complication in nasogastric tube placement after a gunshot wound to the face Oral surgery, oral medicine, and oral pathology. , 1990; 70(4): 525-6.
Mathern, GW Batzdorf, U   Grisel's syndrome. Cervical spine clinical, pathologic, and neurologic manifestations Clinical orthopaedics and related research. , 1989; (244): 131-46.