Geraldine A. Weinmaster, Ph.D.

Titles

Professor, Biological Chemistry
Member, Brain Research Institute
JCCC Cancer and Stem Cell Biology Program Area

Awards and Honors:

UCLA College of Letters and Science Dean's Recognition Award Jacob Javits Investigator Merit Award (NINDS) Stop Cancer Research Career Development Award March of Dimes Basil O'Conner Starter Award

Contact Information

Email
gweinmaster@mednet.ucla.edu
Phone
Work Phone Number: (310) 206-8400 (310) 206-9446
Address
Work Address: Laboratory354-06 BSRBLos Angeles, CA 90095UNITED STATES Office390A BSRBLos Angeles, CA 90095UNITED STATES

Biography

Geraldine (Gerry) Weinmaster is a molecular, developmental and cell biologist who has served on the UCLA School of Medicine faculty since joining the Biological Chemistry Department in 1992 as an assistant professor and advancing to a full professor in 2002. Dr. Weinmaster obtained her Ph.D. at the University of British Columbia working with Tony Pawson on oncogenic tyrosine kinases. In collaboration with Michael Smith, who won the 1993 Nobel prize in Chemistry for the use of oligonucleotides in the development of site-directed mutagenesis, they were the first to show that tyrosine phosphorylation is required for both tyrosine kinase and oncogenic activities. She continued her training as a post-doctoral fellow in Tony Hunter’s group at the Salk Institute, and later with Greg Lemke where she cloned the mammalian homolog of Drosophila Notch. Her studies also identified the closely related Notch2 providing the first evidence for a family of Notch genes, of which there are now four known members. In her own laboratory at UCLA she cloned the first vertebrate Notch ligand, Jagged1 that is mutated in the inherited developmental syndrome Alagille. Her group has developed an extensive battery of reagents to study mechanisms of ligand-induced Notch signaling using cell culture and mouse mutants. She has received the March of Dimes Basil O'Conner Starter Award, STOP Cancer Research Career Development Award, NIH/NINDS Javits Neuroscience Investigator Award and the UCLA College of Letters and Science Dean’s Recognition Award for her studies on Notch signaling in mammalian cells.

Publications:

Musse Abdiwahab A, Meloty-Kapella Laurence, Weinmaster Gerry   Notch ligand endocytosis: Mechanistic basis of signaling activity Seminars in cell & developmental biology, 2012; .
Weinmaster Gerry, Fischer Janice A   Notch ligand ubiquitylation: what is it good for? Developmental cell, 2011; 21(1): 134-44.
Hofmann Jennifer J, Zovein Ann C, Koh Huilin, Radtke Freddy, Weinmaster Gerry, Iruela-Arispe M Luisa   Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome Development (Cambridge, England), 2010; 137(23): 4061-72.
D'Souza Brendan, Meloty-Kapella Laurence, Weinmaster Gerry   Canonical and non-canonical Notch ligands Current topics in developmental biology, 2010; 92(4): 73-129.
Kim Woo-Kyun, Meliton Vicente, Tetradis Sotirios, Weinmaster Gerry, Hahn Theodore J, Carlson Marc, Nelson Stanley F, Parhami Farhad   Osteogenic oxysterol, 20(S)-hydroxycholesterol, induces notch target gene expression in bone marrow stromal cells Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2010; 25(4): 782-95.
Bozkulak Esra Cagavi, Weinmaster Gerry   Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling Molecular and cellular biology, 2009; 29(21): 5679-95.
Miyamoto A and Weinmaster G.   Notch Signal Transduction: Molecular and Cellular Mechanisms, In Larry R. Squire, Editor-in-Chief, Encyclopedia of Neuroscience, Academic Press, Oxford, 2008; .
Nichols JT and Weinmaster, G.   Proteolytic activation of Notch signaling: Roles for ligand endocytosis and mechanotransduction, In Handbook of Cell Signaling, Second Edition, Ed. Bradshaw RA and Dennis EA, 2008; .
D'Souza B, Miyamoto A and Weinmaster G.   The many facets of Notch ligands, Oncogene, 2008; .
Nichols J, Miyamoto A, Olsen S, D???Souza B, Yao C, and Weinmaster G.   DSL-ligand endocytosis physically dissociates Notch1 heterodimers prior to activating proteolysis. , Journal of Cell Biology, 2007; 176(4): 445-458.
Nichols JT, Miyamoto A, Weinmaster G.   Notch signaling--constantly on the move. , Traffic , 2007; 8: 959-69.
Weinmaster G. and Kopan R.   A garden of Notch-ly delights, , 2006; 133: 3277-82.
Miyamoto A, Lau R, Hein PW, Shipley JM, Weinmaster G.   Microfibrillar proteins MAGP-1 and MAGP-2 induce Notch1 extracellular domain dissociation and receptor activation. , JBC, 2006; 281(15): 10089-97.
Ladi, E., Nichols, J. T., Ge, W., Miyamoto, A., Yao, C., Yang, L-T, Boulter, J., Sun, Y. E., Kintner, C., Weinmaster, G.   The divergent DSL ligand Dll3 does not activate Notch signaling but cell-autonomously attenuates signaling induced by other DSL ligands, Jounal of Cell Biology , 2005; 170: 983-992.
Nehring LC, Miyamoto A, Hein PW, Weinmaster G, Shipley JM   The extracellular matrix protein MAGP-2 interacts with Jagged1 and induces its shedding from the cell surface The Journal of biological chemistry. , 2005; 280(21): 20349-55.
Yang LT, Nichols JT, Yao C, Manilay JO, Robey EA, Weinmaster G   Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1 Molecular biology of the cell. , 2005; 16(2): 927-42.
Patten BA, Peyrin JM, Weinmaster G, Corfas G   Sequential signaling through Notch1 and erbB receptors mediates radial glia differentiation The Journal of neuroscience : the official journal of the Society for Neuroscience. , 2003; 23(14): 6132-40.
Oakley F, Mann J, Ruddell RG, Pickford J, Weinmaster G, Mann DA   Basal expression of IkappaBalpha is controlled by the mammalian transcriptional repressor RBP-J (CBF1) and its activator Notch1 The Journal of biological chemistry. , 2003; 278(27): 24359-70.
Irvin DK, Dhaka A, Hicks C, Weinmaster G, Kornblum HI   Extrinsic and intrinsic factors governing cell fate in cortical progenitor cultures Developmental neuroscience. , 2003; 25(2-4): 162-72.
Weinmaster G, Kintner C   Modulation of notch signaling during somitogenesis Annual review of cell and developmental biology. , 2003; 19: 367-95.
Patten, B. A., Peyrin, J. M. Weinmaster, G. and Corfas, G.   Sequential signaling through Notch1 and erbB receptors mediate radial glia differentiation, J. Neuroscience, 2003; 23(14): 6132-6140.
Chojnacki A, Shimazaki T, Gregg C, Weinmaster G, Weiss S   Glycoprotein 130 signaling regulates Notch1 expression and activation in the self-renewal of mammalian forebrain neural stem cells The Journal of neuroscience : the official journal of the Society for Neuroscience. , 2003; 23(5): 1730-41.
Haritunians, T., Boulter, J., Hicks, C., Buhrman, J., diSibio, G., Shawber, C., Weinmaster, G., Nofziger, D., and Schanen, N. C. ().   CADASIL Notch3 mutant proteins localize to the cell surface and bind ligand. , Circulation Res. , 2002; 90(5): 506-8..
Hicks C, Ladi E, Lindsell C, Hsieh JJ, Hayward SD, Collazo A, Weinmaster G   A secreted Delta1-Fc fusion protein functions both as an activator and inhibitor of Notch1 signaling Journal of neuroscience research. , 2002; 68(6): 655-67.
Hicks, C., Ladi, E., Lindsell, C., Hsieh, J.-D., Hayward, S.D, Collazo, A., and Weinmaster, G. (2002). J. Neurosc. Res. 68 (6): 655-667.   A secreted Delta1-Fc fusion protein functions both as an activator and inhibitor of Notch1 signaling, , 2002; .
Ge W, Martinowich K, Wu X, He F, Miyamoto A, Fan G, Weinmaster G, Sun YE.   Notch signaling promotes astrogliogenesis via direct CSL-mediated glial gene activation, J Neurosci Res, 2002; 69(6): 848-60.
Kubu CJ, Orimoto K, Morrison SJ, Weinmaster G, Anderson DJ, Verdi JM   Developmental changes in Notch1 and numb expression mediated by local cell-cell interactions underlie progressively increasing delta sensitivity in neural crest stem cells Developmental biology. , 2002; 244(1): 199-214.
Haritunians T, Boulter J, Hicks C, Buhrman J, DiSibio G, Shawber C, Weinmaster G, Nofziger D, Schanen C   CADASIL Notch3 mutant proteins localize to the cell surface and bind ligand Circulation research. , 2002; 90(5): 506-8.
Yamamoto S, Nagao M, Sugimori M, Kosako H, Nakatomi H, Yamamoto N, Takebayashi H, Nabeshima Y, Kitamura T, Weinmaster G, Nakamura K, Nakafuku M   Transcription factor expression and Notch-dependent regulation of neural progenitors in the adult rat spinal cord The Journal of neuroscience : the official journal of the Society for Neuroscience. , 2001; 21(24): 9814-23.
Villa N, Walker L, Lindsell CE, Gasson J, Iruela-Arispe ML, Weinmaster G   Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels Mechanisms of development. , 2001; 108(1-2): 161-4.
Irvin DK, Zurcher SD, Nguyen T, Weinmaster G, Kornblum HI   Expression patterns of Notch1, Notch2, and Notch3 suggest multiple functional roles for the Notch-DSL signaling system during brain development The Journal of comparative neurology. , 2001; 436(2): 167-81.
McCright, B., X. Gao, L. Shen, J. Lozier, Y. Lan, M. Maguire, D. Herzlinger, G. Weinmaster, R. Jiang and T. Gridley.   Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation, Development, 2001; 128: 491-502.
JimEnez E, Vicente A, SacedUn R, MuOoz JJ, Weinmaster G, Zapata AG, and Varas A   Distinct Mechanisms Contribute to Generate and Change the CD4:CD8 Cell Ratio During Thymus Development: A Role for the Notch Ligand, Jagged1, , 2001; 166: 5898-5908.
Irvin DK, Zurcher SD, Nguyen T, Weinmaster G., and Kornblum HI.   Expression patterns of Notch1, Notch2, and Notch3 suggest multiple functional roles for the Notch-DSL signaling system during brain development. , J Comp Neurol, 2001; 436: 167-181.
Bush, G., diSibio, G., Miyamoto, A., Denault, J-B., Leduc, R., and Weinmaster, G.   Ligand-induced signaling in the absence of furin processing of Notch1. , Developmental Biology, 2001; 229(2): 494-502.
Yamamoto N, Yamamoto Si S, Inagaki F, Kawaichi M, Fukamizu A, Kishi N, Matsuno K, Nakamura K, Weinmaster G, Okano H, Nakafuku M.   Role of Deltex-1 as a transcriptional regulator downstream of the notch receptor, , 2001; 276 (48) : 45031-45040.
Walker L, Carlson A, Tan-Pertel HT, Weinmaster G, Gasson J   The notch receptor and its ligands are selectively expressed during hematopoietic development in the mouse Stem cells (Dayton, Ohio) , 2001; 19(6): 543-52.
Villa, N., Walker, L., Lindsell, C.E., Gasson, J., Iruela-Arispe, M. L., and Weinmaster, G.   Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels, Mech. Dev, 2001; 108: 161-164..
Imai T, Tokunaga A, Yoshida T, Hashimoto M, Mikoshiba K, Weinmaster G, Nakafuku M, Okano H   The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA Molecular and cellular biology. , 2001; 21(12): 3888-900.
McCright B, Gao X, Shen L, Lozier J, Lan Y, Maguire M, Herzlinger D, Weinmaster G, Jiang R, Gridley T   Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation Development (Cambridge, England) , 2001; 128(4): 491-502.
Bush G, diSibio G, Miyamoto A, Denault JB, Leduc R, Weinmaster G   Ligand-induced signaling in the absence of furin processing of Notch1 Developmental biology. , 2001; 229(2): 494-502.
Tan-Pertel HT, Walker L, Browning D, Miyamoto A, Weinmaster G, Gasson JC   Notch signaling enhances survival and alters differentiation of 32D myeloblasts Journal of immunology (Baltimore, Md. : 1950) , 2000; 165(8): 4428-36.
Hicks C, Johnston SH, diSibio G, Collazo A, Vogt TF, Weinmaster G   Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2 Nature cell biology. , 2000; 2(8): 515-20.
Weinmaster G   Notch signal transduction: a real rip and more Current opinion in genetics & development. , 2000; 10(4): 363-9.
Hicks C., Johnston S. H., diSibio G., Collazo A., Vogt T. F., & Weinmaster G.   Fringe differentially modulates Jagged1 and Delta1 signaling through Notch1 and Notch2 receptors in mammalian cells. , Nature Cell Biology, 2000; 2: 515-520.
Jensen J, Heller RS, Pedersen EE, Funder-Nielsen T, Lindsell C, Weinmaster G, Madsen OD, and erup P   Independent development of pancreatic a- and b-cells from neurogenin3 expressing precursors: A role for the Notch pathway in repression of premature differentiation, Diabetes, 2000; 49: 163-176.
Uyttendaele H, Closson V, Wu G, Roux F, Weinmaster G & Kitajewski J   Notch4 and Jagged1 induce microvessel differentiation of rat brain endothelial cells, Microvascular Res, 2000; 60 (2): 91-103.
Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Taylor Kimberly W, Weinmaster G, Selkoe D & Hyman BT   Two transmembrane aspartate mutationin presenilin impair Notch1 proteolysis and nuclear translocation with relative preservation of Notch signaling, J. Neurochem, 2000; 75(2): 583-593.
Morrison SJ, Perez SE, Qiao Z, Verdi JM, Hicks C, Weinmaster G, Anderson DJ   Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells Cell. , 2000; 101(5): 499-510.
Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD   SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function Molecular and cellular biology. , 2000; 20(7): 2400-10.
Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD   SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function Molecular and cellular biology. , 2000; 20(7): 2400-10.
Redmond L, Oh SR, Hicks C, Weinmaster G, Ghosh A   Nuclear Notch1 signaling and the regulation of dendritic development Nature neuroscience. , 2000; 3(1): 30-40.
Louis AA, Van Eyken P, Haber BA, Hicks C, Weinmaster G, Taub R, Rand EB   Hepatic jagged1 expression studies Hepatology (Baltimore, Md.) , 1999; 30(5): 1269-75.
Nofziger D, Miyamoto A, Lyons KM, and Weinmaster G   Notch signaling imposes two distinct blocks in the diffentiation of C2C12 myoblasts, Development, 1999; 126: 1689-1702..
Lanford PJ, Lan Y, Jiang R, Lindsell C, Weinmaster G, Gridley T, and Kelley MW   Regulation of hair cell development in the mammalian cochlea by the Notch ligand Jagged2, Nature Genetics, 1999; 21 (3): 289-292.
Walker L, Lynch M, Silverman S, Fraser J, Boulter J, Weinmaster G, Gasson JC   The Notch/Jagged pathway inhibits proliferation of human hematopoietic progenitors in vitro Stem cells (Dayton, Ohio) , 1999; 17(3): 162-71.
Xue Y, Gao X, Lindsell CE, Norton CR, Chang B, Hicks C, Gendron-Maguire M, Rand EB, Weinmaster G, Gridley T   Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1 Human molecular genetics. , 1999; 8(5): 723-30.
Wang S, Sdrulla AD, diSibio G, Bush G, Nofziger D, Hicks C, Weinmaster G, Barres BA   Notch receptor activation inhibits oligodendrocyte differentiation Neuron. , 1998; 21(1): 63-75.
Weinmaster G   Notch Signaling: Direct or what?, Curr. Opin Genetics and Development, 1998; 8: 436-442...
Jiang R, Lan Y, Chapman HD, Shawber C, Norton CR, Serreze DV, Weinmaster G, Gridley T   Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice Genes & development. , 1998; 12(7): 1046-57.
Weinmaster G   Reprolysins and astacins...alive, alive-o Science. , 1998; 279(5349): 336-7.
Hsieh J, J-D Nofziger D, Weinmaster G, and Hayward D   EBV Immortalization: Notch2 interacts with CBF1, J. Virology, 1997; 71 (3): 1616-1625.
Lan Y, Jiang R, Shawber C, Weinmaster G, Gridley T   The Jagged2 gene maps to chromosome 12 and is a candidate for the lgl and sm mutations Mammalian genome : official journal of the International Mammalian Genome Society. , 1997; 8(11): 875-6.
Weinmaster G   The ins and outs of notch signaling Molecular and cellular neurosciences. , 1997; 9(2): 91-102.
Zhong W, Jiang MM, Weinmaster G, Jan LY, Jan YN   Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis Development (Cambridge, England) , 1997; 124(10): 1887-97.
Robey E, Chang D, Itano A, Cado D, Alexander H, Lans D, Weinmaster G, Salmon P   An activated form of Notch influences the choice between CD4 and CD8 T cell lineages Cell. , 1996; 87(3): 483-92.
Lindsell CE, Boulter J, diSibio G, Gossler A, Weinmaster G   Expression patterns of Jagged, Delta1, Notch1, Notch2, and Notch3 genes identify ligand-receptor pairs that may function in neural development Molecular and cellular neurosciences. , 1996; 8(1): 14-27.
Shawber CJ, Boulter J, Lindsell CE, and Weinmaster G   Jagged2: A Serrate-related gene expressed during rat embryogenesis, Developmental Biology , 1996; 180: 370-376.
Shawber C, Nofziger D, Lindsell C, Hsieh J, J-D Bogler O, Hayward D, and Weinmaster G   Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway, Development , 1996; 122: 3775-3784.
Lindsell CE, Shawber CJ, Boulter J, Weinmaster G   Jagged: a mammalian ligand that activates Notch1 Cell. , 1995; 80(6): 909-17.
Swiatek PJ, Lindsell CE, del Amo FF, Weinmaster G, Gridley T   Notch1 is essential for postimplantation development in mice Genes & development. , 1994; 8(6): 707-19.
Feinstein DL, Weinmaster GA and Milner RJ   Isolation of cDNA clones encoding rat glial fibrillary acidic protein: Expression in astrocytes and in Schwann cells, J. Neurosci. Res, 1992; 31: 110-124.
Weinmaster G, Roberts V and Lemke G   Notch 2: a second mammalian Notch gene, Development , 1992; 116: 931-941.
Weinmaster, G Roberts, VJ Lemke, G   A homolog of Drosophila Notch expressed during mammalian development Development (Cambridge, England) , 1991; 113(1): 199-205.
Lemke G, Kuhn R, Monuki ES, Weinmaster G   Expression and activity of the transcription factor SCIP during glial differentiation and myelination Annals of the New York Academy of Sciences. , 1991; 633: 189-95.
Monuki ES, Kuhn R, Weinmaster G, Trapp BD and Lemke G   Novel expression and activity of the POU transcription factor SCIP, Science, 1990; 249: 1300-1303.
Lemke G, Weinmaster G and Monuki ES   The myelination cascade, Cellular and Molecular Biology of Myelination, 1990; 533-541.
Lemke G, Kuhn R, Monuki ES, Weinmaster G   Transcriptional controls underlying Schwann cell differentiation and myelination Annals of the New York Academy of Sciences. , 1990; 605: 248-53.
Weinmaster G, Lemke G   Cell-specific cyclic AMP-mediated induction of the PDGF receptor The EMBO journal. , 1990; 9(3): 915-20.
Monuki ES, Weinmaster G, Kuhn R, Lemke G   SCIP: a glial POU domain gene regulated by cyclic AMP Neuron. , 1989; 3(6): 783-93.
Weinmaster GA, Middlemas DA, and Hunter T   A major site of tyrosine phosphorylation within the SH2 domain of FSV P130gag-fps is not required for protein-tyrosine kinase activity or transforming potential, J. Virol, 1988; 62: 2016-2025.
Auersperg N, Pawson T, Worth A, Weinmaster G   Modifications of tumor histology by point mutations in the v-fps oncogene: possible role of extracellular matrix Cancer research. , 1987; 47(23): 6341-8.
Weinmaster G, Pawson T   Protein kinase activity of FSV (Fujinami sarcoma virus) P130gag-fps shows a strict specificity for tyrosine residues The Journal of biological chemistry. , 1986; 261(1): 328-33.
Weinmaster G, Zoller MJ, Pawson T   A lysine in the ATP-binding site of P130gag-fps is essential for protein-tyrosine kinase activity The EMBO journal. , 1986; 5(1): 69-76.
Weinmaster G, Zoller MJ, Smith M, Hinze E, Pawson T   Mutagenesis of Fujinami sarcoma virus: evidence that tyrosine phosphorylation of P130gag-fps modulates its biological activity Cell. , 1984; 37(2): 559-68.
Weinmaster GA, Misra V, McGuire R, Babiuk LA, and DeClerq E   Bovid Herpesvirus Type I-Induced Thymidine Kinase, Virology , 1982; 118: 191-201.