Guido A. Zampighi, D.D.S., Ph.D.

Titles

Professor, Neurobiology
Collaborator, Vestibular Neuroscience Laboratory
Member, Brain Research Institute
Faculty, Molecular, Cellular, and Integrative Physiology IDP

Contact Information

Email
gzampighi@mednet.ucla.edu
Phone
Work Phone Number: 310-825-6430 310-825-6430
Address
Work Address: LaboratoryJLNRCLos Angeles, CA 90095UNITED STATES OfficeJLNRCLos Angeles, CA 90095UNITED STATES

Biography

Intercellular junctions and communication

Publications:

Zampighi GA, Fain N, Zampighi LM, Cantele F, Lanzavecchia S, Wright EM.   Conical electron tomography of a chemical synapse: polyhedral cages dock vesicles to the active zone, J Neurosci, 2008; 28(16): 4151-60.
Salvi E, Cantele F, Zampighi L, Fain N, Pigino G, Zampighi G, Lanzavecchia S.   JUST (Java User Segmentation Tool) for semi-automatic segmentation of tomographic maps, J Struct Biol, 2008; 161(3): 287-97.
Cantele F, Zampighi L, Radermacher M, Zampighi G, Lanzavecchia S.   Local refinement: an attempt to correct for shrinkage and distortion in electron tomography, J Struct Biol, 2007; 158(1): 59-70.
Lin D, Harris R, Stutzman R, Zampighi GA, Davidson H, Takemoto DJ.   Protein kinase C-gamma activation in the early streptozotocin diabetic rat lens, Curr Eye Res, 2007; 32(6): 523-32.
Zampighi GA, Zampighi LM, Fain N, Lanzavecchia S, Simon SA, Wright EM.   Conical electron tomography of a chemical synapse: vesicles docked to the active zone are hemi-fused, Biophys J, 2006; 91(8): 2910-8.
Lin D, Barnett M, Lobell S, Madgwick D, Shanks D, Willard L, Zampighi GA, Takemoto DJ.   PKCgamma knockout mouse lenses are more susceptible to oxidative stress damage, J Exp Biol, 2006; 209(Pt 21): 4371-8.
Zampighi GA, Zampighi L, Fain N, Wright EM, Cantele F, Lanzavecchia S.   Conical tomography II: A method for the study of cellular organells in thin sections, J Struct Biol, 2005; 151(3): 263-74.
Lanzavecchia S, Cantele F, Bellon PL, Zampighi L, Kreman M, Wright E, Zampighi GA.   Conical tomography of freeze-fracture replicas: a method for the study of integral membrane proteins inserted in phospholipid bilayers, J Struct Biol, 2005; 149(1): 87-98.
Zampighi GA, Planells AM, Lin D, Takemoto D.   Regulation of lens cell-to-cell communication by activation of PKCgamma and disassembly of Cx50 channels, Invest Ophthalmol Vis Sci, 2005; 46(9): 3247-55.
Diez-Sampedro A, Loo DD, Wright EM, Zampighi GA, Hirayama BA.   Coupled sodium/glucose cotransport by SGLT1 requires a negative charge at position 454, Biochemistry, 2004; 43(41): 13175-84.
Zampighi LM, Kavanau CL, Zampighi GA.   The Kohonen self-organizing map: a tool for the clustering and alignment of single particles imaged using random conical tilt, J Struct Biol, 2004; 146(3): 368-80.
Zampighi GA.   Distribution of connexin50 channels and hemichannels in lens fibers: a structural approach, Cell Commun Adhes, 2003; 10(4-6): 265-70.
Zampighi, GA Kreman, M Lanzavecchia, S Turk, E Eskandari, S Zampighi, L Wright, EM   Structure of functional single AQP0 channels in phospholipid membranes Journal of molecular biology. , 2003; 325(1): 201-10.
Eskandari, S Kreman, M Kavanaugh, MP Wright, EM Zampighi, GA   Pentameric assembly of a neuronal glutamate transporter Proceedings of the National Academy of Sciences of the United States of America. , 2000; 97(15): 8641-6.
Zampighi, GA Loo, DD Kreman, M Eskandari, S Wright, EM   Functional and morphological correlates of connexin50 expressed in Xenopus laevis oocytes The Journal of general physiology. , 1999; 113(4): 507-24.
Konig, N Zampighi, GA   Purification of bovine lens cell-to-cell channels composed of connexin44 and connexin50 Journal of cell science. , 1995; 108 ( Pt 9): 3091-8.
Mandel, LJ Bacallao, R Zampighi, G   Uncoupling of the molecular 'fence' and paracellular 'gate' functions in epithelial tight junctions Nature. , 1993; 361(6412): 552-5.