Guido A. Zampighi, D.D.S., Ph.D.

Titles

Professor, Neurobiology

Collaborator, Vestibular Neuroscience Laboratory

Member, Brain Research Institute

Contact Information

Email
gzampighi@mednet.ucla.edu
Phone
Work Phone Number: 310-825-6430
310-825-6430
Address

Work Address:

Laboratory
JLNRC
Los Angeles, CA 90095
UNITED STATES
Office
JLNRC
Los Angeles, CA 90095
UNITED STATES

Biography

Intercellular junctions and communication

Publications

Zampighi GA, Fain N, Zampighi LM, Cantele F, Lanzavecchia S, Wright EM.   Conical electron tomography of a chemical synapse: polyhedral cages dock vesicles to the active zone, J Neurosci, 2008; 28(16): 4151-60.
Salvi E, Cantele F, Zampighi L, Fain N, Pigino G, Zampighi G, Lanzavecchia S.   JUST (Java User Segmentation Tool) for semi-automatic segmentation of tomographic maps, J Struct Biol, 2008; 161(3): 287-97.
Cantele F, Zampighi L, Radermacher M, Zampighi G, Lanzavecchia S.   Local refinement: an attempt to correct for shrinkage and distortion in electron tomography, J Struct Biol, 2007; 158(1): 59-70.
Lin D, Harris R, Stutzman R, Zampighi GA, Davidson H, Takemoto DJ.   Protein kinase C-gamma activation in the early streptozotocin diabetic rat lens, Curr Eye Res, 2007; 32(6): 523-32.
Zampighi GA, Zampighi LM, Fain N, Lanzavecchia S, Simon SA, Wright EM.   Conical electron tomography of a chemical synapse: vesicles docked to the active zone are hemi-fused, Biophys J, 2006; 91(8): 2910-8.
Lin D, Barnett M, Lobell S, Madgwick D, Shanks D, Willard L, Zampighi GA, Takemoto DJ.   PKCgamma knockout mouse lenses are more susceptible to oxidative stress damage, J Exp Biol, 2006; 209(Pt 21): 4371-8.
Zampighi GA, Zampighi L, Fain N, Wright EM, Cantele F, Lanzavecchia S.   Conical tomography II: A method for the study of cellular organells in thin sections, J Struct Biol, 2005; 151(3): 263-74.
Lanzavecchia S, Cantele F, Bellon PL, Zampighi L, Kreman M, Wright E, Zampighi GA.   Conical tomography of freeze-fracture replicas: a method for the study of integral membrane proteins inserted in phospholipid bilayers, J Struct Biol, 2005; 149(1): 87-98.
Zampighi GA, Planells AM, Lin D, Takemoto D.   Regulation of lens cell-to-cell communication by activation of PKCgamma and disassembly of Cx50 channels, Invest Ophthalmol Vis Sci, 2005; 46(9): 3247-55.
Diez-Sampedro A, Loo DD, Wright EM, Zampighi GA, Hirayama BA.   Coupled sodium/glucose cotransport by SGLT1 requires a negative charge at position 454, Biochemistry, 2004; 43(41): 13175-84.
Zampighi LM, Kavanau CL, Zampighi GA.   The Kohonen self-organizing map: a tool for the clustering and alignment of single particles imaged using random conical tilt, J Struct Biol, 2004; 146(3): 368-80.
Zampighi GA.   Distribution of connexin50 channels and hemichannels in lens fibers: a structural approach, Cell Commun Adhes, 2003; 10(4-6): 265-70.
Zampighi, GA Kreman, M Lanzavecchia, S Turk, E Eskandari, S Zampighi, L Wright, EM   Structure of functional single AQP0 channels in phospholipid membranes Journal of molecular biology. , 2003; 325(1): 201-10.
Eskandari, S Kreman, M Kavanaugh, MP Wright, EM Zampighi, GA   Pentameric assembly of a neuronal glutamate transporter Proceedings of the National Academy of Sciences of the United States of America. , 2000; 97(15): 8641-6.
Zampighi, GA Loo, DD Kreman, M Eskandari, S Wright, EM   Functional and morphological correlates of connexin50 expressed in Xenopus laevis oocytes The Journal of general physiology. , 1999; 113(4): 507-24.
Konig, N Zampighi, GA   Purification of bovine lens cell-to-cell channels composed of connexin44 and connexin50 Journal of cell science. , 1995; 108 ( Pt 9): 3091-8.
Mandel, LJ Bacallao, R Zampighi, G   Uncoupling of the molecular 'fence' and paracellular 'gate' functions in epithelial tight junctions Nature. , 1993; 361(6412): 552-5.