Harley I. Kornblum, M.D., Ph.D.

Professor, Pediatrics

Psychiatry and Biobehavioral Sciences

Pediatric Neurology

Semel Institute for Neuroscience and Human Behavior

Molecular & Medical Pharmacology

Member, Brain Research Institute

Cell & Developmental Biology GPB Home Area

Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research

JCCC Cancer and Stem Cell Biology Program Area

Molecular Pharmacology GPB Home Area

Molecular, Cellular & Integrative Physiology GPB Home Area

Neuroscience GPB Home Area

Biography

Dr. Kornblum is a basic and translational researcher in the Intellectual and Developmental Disabilities Research Center of the Semel Research Institute. He is Professor of Psychiatry, Pharmacology and Pediatrics at the David Geffen School of Medicine at UCLA. He is also an attending Pediatric Neurologist at Mattel Children's Hospital at UCLA and the founding director of the Neural Stem Cell Research Center. He is a member of the Brain Research Institute, The Broad Stem Cell Research Center and the Molecular Biology Institute and serves on the Steering Committe of the Broad Stem Cell Research Center. Dr. Kornblum received his AB degree from Washington University in St. Louis and his MD and PhD degrees from UC Irvine. He trained as a Pediatrics Resident and Pediatric Neurology Fellow at UCLA. He did undergraduate research with Dr. Eugene M. Johnson and received his PhD in the laboratory of Frances M. Leslie. He pursued postdoctoral research with Dr. Christine M. Gall at UCI and Dr. Harry Chugani at UCLA. Dr. Kornblum is a frequent lecturer on the topics of neural stem cells and brain tumors at conferences and universities world-wide and has published over 100 research articles and book chapters. Dr. Kornblum is the recipient of numerous grants from the Federal Government as well as philanthropic foundations. He served as the Eleanor Leslie Professor of Pioneering Brain Research.

Akhavan David, Pourzia Alexandra L, Nourian Alex A, Williams Kevin J, Nathanson David, Babic Ivan, Villa Genaro R, Tanaka Kazuhiro, Nael Ali, Yang Huijun, Dang Julie, Vinters Harry V, Yong William H, Flagg Mitchell, Tamanoi Fuyuhiko, Sasayama Takashi, James C David, Kornblum Harley I, Cloughesy Tim F, Cavenee Webster K, Bensinger Steven J, Mischel Paul S   De-repression of PDGFRβ transcription promotes acquired resistance to EGFR tyrosine kinase inhibitors in glioblastoma patients Cancer discovery, 2013; 3(5): 534-47.

Joshi Kaushal, Banasavadi-Siddegowda Yeshavanth, Mo Xiaokui, Kim Sung-Hak, Mao Ping, Kig Cenk, Nardini Diana, Sobol Robert W, Chow Lionel M L, Kornblum Harley I, Waclaw Ronald, Beullens Monique, Nakano Ichiro   MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells Stem cells (Dayton, Ohio), 2013; 31(6): 1051-63.

Chou Arthur P, Chowdhury Reshmi, Li Sichen, Chen Weidong, Kim Andrew J, Piccioni David E, Selfridge Julia M, Mody Reema R, Chang Stephen, Lalezari Shadi, Lin Jeffrey, Sanchez Desiree E, Wilson Ryan W, Garrett Matthew C, Harry Bret, Mottahedeh Jack, Nghiemphu Phioanh L, Kornblum Harley I, Mischel Paul S, Prins Robert M, Yong William H, Cloughesy Timothy, Nelson Stanley F, Liau Linda M, Lai Albert   Identification of retinol binding protein 1 promoter hypermethylation in isocitrate dehydrogenase 1 and 2 mutant gliomas Journal of the National Cancer Institute, 2012; 104(19): 1458-69.

Pope Whitney B, Prins Robert M, Albert Thomas M, Nagarajan Rajakumar, Yen Katharine E, Bittinger Mark A, Salamon Noriko, Chou Arthur P, Yong William H, Soto Horacio, Wilson Neil, Driggers Edward, Jang Hyun G, Su Shinsan M, Schenkein David P, Lai Albert, Cloughesy Timothy F, Kornblum Harley I, Wu Hong, Fantin Valeria R, Liau Linda M   Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy Journal of neuro-oncology, 2012; 107(1): 197-205.

Visnyei Koppany, Onodera Hideyuki, Damoiseaux Robert, Saigusa Kuniyasu, Petrosyan Syuzanna, De Vries David, Ferrari Denise, Saxe Jonathan, Panosyan Eduard H, Masterman-Smith Michael, Mottahedeh Jack, Bradley Kenneth A, Huang Jing, Sabatti Chiara, Nakano Ichiro, Kornblum Harley I   A molecular screening approach to identify and characterize inhibitors of glioblastoma stem cells Molecular cancer therapeutics, 2011; 10(10): 1818-28.

Liu Yue, Ye Fei, Yamada Kazunari, Tso Jonathan L, Zhang Yibei, Nguyen David H, Dong Qinghua, Soto Horacio, Choe Jinny, Dembo Anna, Wheeler Hayley, Eskin Ascia, Schmid Ingrid, Yong William H, Mischel Paul S, Cloughesy Timothy F, Kornblum Harley I, Nelson Stanley F, Liau Linda M, Tso Cho-Lea   Autocrine endothelin-3/endothelin receptor B signaling maintains cellular and molecular properties of glioblastoma stem cells Molecular cancer research : MCR, 2011; 9(12): 1668-85.

Jijiwa Mayumi, Demir Habibe, Gupta Snehalata, Leung Crystal, Joshi Kaushal, Orozco Nicholas, Huang Tiffany, Yildiz Vedat O, Shibahara Ichiyo, de Jesus Jason A, Yong William H, Mischel Paul S, Fernandez Soledad, Kornblum Harley I, Nakano Ichiro   CD44v6 regulates growth of brain tumor stem cells partially through the AKT-mediated pathway PloS one, 2011; 6(9): e24217.

Le Belle Janel E, Orozco Nicolas M, Paucar Andres A, Saxe Jonathan P, Mottahedeh Jack, Pyle April D, Wu Hong, Kornblum Harley I   Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner Cell stem cell, 2011; 8(1): 59-71.

Nakano Ichiro, Joshi Kaushal, Visnyei Koppany, Hu Bin, Watanabe Momoko, Lam Diana, Wexler Eric, Saigusa Kuniyasu, Nakamura Yuko, Laks Dan R, Mischel Paul S, Viapiano Mariano, Kornblum Harley I   Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway Neuro-oncology, 2011; 13(6): 622-34.

Sun Jing, Masterman-Smith Michael D, Graham Nicholas A, Jiao Jing, Mottahedeh Jack, Laks Dan R, Ohashi Minori, DeJesus Jason, Kamei Ken-ichiro, Lee Ki-Bum, Wang Hao, Yu Zeta T F, Lu Yi-Tsung, Hou Shuang, Li Keyu, Liu Max, Zhang Nangang, Wang Shutao, Angenieux Brigitte, Panosyan Eduard, Samuels Eric R, Park Jun, Williams Dirk, Konkankit Vera, Nathanson David, van Dam R Michael, Phelps Michael E, Wu Hong, Liau Linda M, Mischel Paul S, Lazareff Jorge A, Kornblum Harley I, Yong William H, Graeber Thomas G, Tseng Hsian-Rong   A microfluidic platform for systems pathology: multiparameter single-cell signaling measurements of clinical brain tumor specimens Cancer research, 2010; 70(15): 6128-38.

Kornblum Harley I   A multipronged approach to the identification and study of an important oncogene in GBM Cancer cell, 2010; 17(5): 417-8.

Laks Dan Richard, Visnyei Koppany, Kornblum Harley Ian   Brain tumor stem cells as therapeutic targets in models of glioma Yonsei medical journal, 2010; 51(5): 633-40.

Panosyan Eduard H, Laks Dan R, Masterman-Smith Michael, Mottahedeh Jack, Yong William H, Cloughesy Timothy F, Lazareff Jorge A, Mischel Paul S, Moore Theodore B, Kornblum Harley I   Clinical outcome in pediatric glial and embryonal brain tumors correlates with in vitro multi-passageable neurosphere formation Pediatric blood & cancer, 2010; 55(4): 644-51.

Zhong Jin, Chan Albert, Morad Leeron, Kornblum Harley I, Fan Guoping, Carmichael S Thomas   Hydrogel Matrix to Support Stem Cell Survival After Brain Transplantation in Stroke Neurorehabilitation and neural repair, 2010; .

Shoemaker Lorelei D, Orozco Nicholas M, Geschwind Daniel H, Whitelegge Julian P, Faull Kym F, Kornblum Harley I   Identification of differentially expressed proteins in murine embryonic and postnatal cortical neural progenitors PloS one, 2010; 5(2): e9121.

Neveu Pierre, Kye Min Jeong, Qi Shuping, Buchholz David E, Clegg Dennis O, Sahin Mustafa, Park In-Hyun, Kim Kwang-Soo, Daley George Q, Kornblum Harley I, Shraiman Boris I, Kosik Kenneth S   MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states Cell stem cell, 2010; 7(6): 671-81.

Kelly Theresa K, Karsten Stanislav L, Geschwind Daniel H, Kornblum Harley I   Cell lineage and regional identity of cultured spinal cord neural stem cells and comparison to brain-derived neural stem cells PloS one, 2009; 4(1): e4213.

Karumbayaram Saravanan, Novitch Bennett G, Patterson Michaela, Umbach Joy A, Richter Laura, Lindgren Anne, Conway Anne E, Clark Amander T, Goldman Steve A, Plath Kathrin, Wiedau-Pazos Martina, Kornblum Harley I, Lowry William E   Directed differentiation of human-induced pluripotent stem cells generates active motor neurons Stem cells (Dayton, Ohio), 2009; 27(4): 806-11.

Wexler Eric M, Paucer Andres, Kornblum Harley I, Palmer Theodore D, Plamer Theodore D, Geschwind Daniel H   Endogenous Wnt signaling maintains neural progenitor cell potency Stem cells (Dayton, Ohio), 2009; 27(5): 1130-41.

Karumbayaram Saravanan, Kelly Theresa K, Paucar Andres A, Roe Anne J T, Umbach Joy A, Charles Andrew, Goldman Steven A, Kornblum Harley I, Wiedau-Pazos Martina   Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS Disease models & mechanisms, 2009; 2(3-4): 189-95.

Lewerenz Jan, Albrecht Philipp, Tien Mai-Ly Tran, Henke Nadine, Karumbayaram Saravanan, Kornblum Harley I, Wiedau-Pazos Martina, Schubert Dave, Maher Pamela, Methner Axel   Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro Journal of neurochemistry, 2009; 111(2): 332-43.

Nakano Ichiro, Kornblum Harley I   Methods for analysis of brain tumor stem cell and neural stem cell self-renewal Methods in molecular biology (Clifton, N.J.), 2009; 568(6): 37-56.

Laks Dan R, Masterman-Smith Michael, Visnyei Koppany, Angenieux Brigitte, Orozco Nicholas M, Foran Ian, Yong William H, Vinters Harry V, Liau Linda M, Lazareff Jorge A, Mischel Paul S, Cloughesy Timothy F, Horvath Steve, Kornblum Harley I   Neurosphere formation is an independent predictor of clinical outcome in malignant glioma Stem cells (Dayton, Ohio), 2009; 27(4): 980-7.

Gregorian Caroline, Nakashima Jonathan, Le Belle Janel, Ohab John, Kim Rachel, Liu Annie, Smith Kate Barzan, Groszer Matthias, Garcia A Denise, Sofroniew Michael V, Carmichael S Thomas, Kornblum Harley I, Liu Xin, Wu Hong   Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009; 29(6): 1874-86.

Nakano Ichiro, Saigusa Kuniyasu, Kornblum Harley I   BMPing off glioma stem cells Cancer cell, 2008; 13(1): 3-4.

Lelievre Vincent, Seksenyan Akop, Nobuta Hiroko, Yong William H, Chhith Seririthanar, Niewiadomski Pawel, Cohen Joseph R, Dong Hongmei, Flores Avegail, Liau Linda M, Kornblum Harley I, Scott Matthew P, Waschek James A   Disruption of the PACAP gene promotes medulloblastoma in ptc1 mutant mice Developmental biology, 2008; 313(1): 359-70.

Nakano Ichiro, Masterman-Smith Michael, Saigusa Kuniyasu, Paucar Andres A, Horvath Steve, Shoemaker Lorelei, Watanabe Momoko, Negro Alejandra, Bajpai Ruchi, Howes Amy, Lelievre Vincent, Waschek James A, Lazareff Jorge A, Freije William A, Liau Linda M, Gilbertson Richard J, Cloughesy Timothy F, Geschwind Daniel H, Nelson Stanley F, Mischel Paul S, Terskikh Alexey V, Kornblum Harley I   Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells Journal of neuroscience research, 2008; 86(1): 48-60.

Erickson Rebecca I, Paucar Andres A, Jackson Robert L, Visnyei Koppany, Kornblum Harley   Roles of insulin and transferrin in neural progenitor survival and proliferation Journal of neuroscience research, 2008; 86(8): 1884-94.

Ratan Rajiv R, Siddiq Ambreena, Aminova Leila, Langley Brett, McConoughey Stephen, Karpisheva Ksenia, Lee Hsin-Hwa, Carmichael Thomas, Kornblum Harley, Coppola Giovanni, Geschwind Daniel H, Hoke Ahmet, Smirnova Natalya, Rink Cameron, Roy Sashwati, Sen Chandan, Beattie Michael S, Hart Ron P, Grumet Martin, Sun Dongming, Freeman Robert S, Semenza Gregg L, Gazaryan Irina   Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury Annals of the New York Academy of Sciences, 2008; 1147(6): 383-94.

Saxe Jonathan P, Wu Hao, Kelly Theresa K, Phelps Michael E, Sun Yi E, Kornblum Harley I, Huang Jing   A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation Chemistry & biology, 2007; 14(9): 1019-30.

Liu Tsunglin, Papagiannakopoulos Thales, Puskar Kathy, Qi Shuping, Santiago Fernando, Clay William, Lao Kaiqin, Lee Yohan, Nelson Stanley F, Kornblum Harley I, Doyle Frank, Petzold Linda, Shraiman Boris, Kosik Kenneth S   Detection of a microRNA signal in an in vivo expression set of mRNAs PloS one, 2007; 2(8): e804.

Kornblum Harley I   Introduction to neural stem cells Stroke; a journal of cerebral circulation, 2007; 38(2 Suppl): 810-6.

Nakano Ichiro, Dougherty Joseph D, Kim Kevin, Klement Ivan, Geschwind Daniel H, Kornblum Harley I   Phosphoserine phosphatase is expressed in the neural stem cell niche and regulates neural stem and progenitor cell proliferation Stem cells (Dayton, Ohio), 2007; 25(8): 1975-84.

Cheng Jerry C, Horwitz Edwin M, Karsten Stanislav L, Shoemaker Lorelei, Kornblum Harley I, Malik Punam, Sakamoto Kathleen M   Report on the workshop "New Technologies in Stem Cell Research," Society for Pediatric Research, San Francisco, California, April 29, 2006 Stem cells (Dayton, Ohio), 2007; 25(4): 1070-88.

Nakano Ichiro, Kornblum Harley I   Brain tumor stem cells Pediatric research, 2006; 59(4 Pt 2): 54R-8R.

Visnyei Koppany, Tatsukawa Keith J, Erickson Rebecca I, Simonian Sharis, Oknaian Nareg, Carmichael S Thomas, Kornblum Harley I   Neural progenitor implantation restores metabolic deficits in the brain following striatal quinolinic acid lesion Experimental neurology, 2006; 197(2): 465-74.

Groszer Matthias, Erickson Rebecca, Scripture-Adams Deirdre D, Dougherty Joseph D, Le Belle Janel, Zack Jerome A, Geschwind Daniel H, Liu Xin, Kornblum Harley I, Wu Hong   PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry Proceedings of the National Academy of Sciences of the United States of America, 2006; 103(1): 111-6.

Imura Tetsuya, Nakano Ichiro, Kornblum Harley I, Sofroniew Michael V   Phenotypic and functional heterogeneity of GFAP-expressing cells in vitro: differential expression of LeX/CD15 by GFAP-expressing multipotent neural stem cells and non-neurogenic astrocytes Glia, 2006; 53(3): 277-93.

Fox Irina J, Kornblum Harley I   Developmental profile of ErbB receptors in murine central nervous system: implications for functional interactions Journal of neuroscience research, 2005; 79(5): 584-97.

Nakano Ichiro, Paucar Andres A, Bajpai Ruchi, Dougherty Joseph D, Zewail Amani, Kelly Theresa K, Kim Kevin J, Ou Jing, Groszer Matthias, Imura Tetsuya, Freije William A, Nelson Stanley F, Sofroniew Michael V, Wu Hong, Liu Xin, Terskikh Alexey V, Geschwind Daniel H, Kornblum Harley I   Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation The Journal of cell biology, 2005; 170(3): 413-27.

Tiwari-Woodruff Seema K, Kaplan Roman, Kornblum Harley I, Bronstein Jeff M   Developmental expression of OAP-1/Tspan-3, a member of the tetraspanin superfamily Journal of neuroscience research, 2004; 77(2): 166-73.

Fox Irina J, Paucar Andres A, Nakano Ichiro, Mottahedeh Jack, Dougherty Joseph D, Kornblum Harley I   Developmental expression of glial fibrillary acidic protein mRNA in mouse forebrain germinal zones--implications for stem cell biology Brain research. Developmental brain research, 2004; 153(1): 121-5.

Carmichael S Thomas, Tatsukawa Keith, Katsman Diana, Tsuyuguchi Naohiro, Kornblum Harley I   Evolution of diaschisis in a focal stroke model Stroke; a journal of cerebral circulation, 2004; 35(3): 758-63.

Mir Halleh M, Tatsukawa Keith J, Carmichael S Thomas, Chesselet Marie-Francoise, Kornblum Harley I   Metabolic correlates of lesion-specific plasticity: an in vivo imaging study Brain research, 2004; 1002(1-2): 28-34.

Irvin Dwain K, Nakano Ichiro, Paucar Andreas, Kornblum Harley I   Patterns of Jagged1, Jagged2, Delta-like 1 and Delta-like 3 expression during late embryonic and postnatal brain development suggest multiple functional roles in progenitors and differentiated cells Journal of neuroscience research, 2004; 75(3): 330-43.

Nakano Ichiro, Hemmati Houman D, Kornblum Harley I   [Cancer stem cells in pediatric brain tumors] No shinkei geka. Neurological surgery, 2004; 32(8): 827-34.

Hemmati HD, Nakano I, Lazareff JA, Masterman-Smith M, Geschwind DH, Bronner-Fraser M, Kornblum HI   Cancerous stem cells can arise from pediatric brain tumors Proceedings of the National Academy of Sciences of the United States of America. , 2003; 100(25): 15178-83.

Hemmati Houman D, Nakano Ichiro, Lazareff Jorge A, Masterman-Smith Michael, Geschwind Daniel H, Bronner-Fraser Marianne, Kornblum Harley I   Cancerous stem cells can arise from pediatric brain tumors Proceedings of the National Academy of Sciences of the United States of America, 2003; 100(25): 15178-83.

Bruce Laura L, Kornblum Harley I, Seroogy Kim B   Comparison of thalamic populations in mammals and birds: expression of ErbB4 mRNA Brain research bulletin, 2003; 57(3-4): 455-61.

Fu Lijuan, Abu-Khalil Amir, Morrison Richard S, Geschwind Daniel H, Kornblum Harley I   Expression patterns of epidermal growth factor receptor and fibroblast growth factor receptor 1 mRNA in fetal human brain The Journal of comparative neurology, 2003; 462(2): 265-73.

Irvin Dwain K, Dhaka Ajay, Hicks Carol, Weinmaster Gerry, Kornblum Harley I   Extrinsic and intrinsic factors governing cell fate in cortical progenitor cultures Developmental neuroscience, 2003; 25(2-4): 162-72.

Karsten Stanislav L, Kudo Lili C, Jackson Robert, Sabatti Chiara, Kornblum Harley I, Geschwind Daniel H   Global analysis of gene expression in neural progenitors reveals specific cell-cycle, signaling, and metabolic networks Developmental biology, 2003; 261(1): 165-82.

Easterday Mathew C, Dougherty Joseph D, Jackson Robert L, Ou Jing, Nakano Ichiro, Paucar Andres A, Roobini Babak, Dianati Mehrnoosh, Irvin Dwain K, Weissman Irving L, Terskikh Alexey V, Geschwind Daniel H, Kornblum Harley I   Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations Developmental biology, 2003; 264(2): 309-22.

Easterday MC, Dougherty JD, Jackson RL, Ou J, Nakano I, Paucar AA, Roobini B, Dianati M, Irvin DK, Weissman IL, Terskikh AV, Geschwind DH, Kornblum HI   Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations Developmental biology. , 2003; 264(2): 309-22.

Dhaka Ajay, Costa Rui M, Hu Hailiang, Irvin Dwain K, Patel Apoor, Kornblum Harley I, Silva Alcino J, O'Dell Thomas J, Colicelli John   The RAS effector RIN1 modulates the formation of aversive memories The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003; 23(3): 748-57.

Imura Tetsuya, Kornblum Harley I, Sofroniew Michael V   The predominant neural stem cell isolated from postnatal and adult forebrain but not early embryonic forebrain expresses GFAP The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003; 23(7): 2824-32.

Caplan Rochelle, Guthrie Donald, Komo Scott, Siddarth Prabha, Chayasirisobhon Sirichai, Kornblum Harley, Sankar Ramen, Hansen Rebecca, Mitchell Wendy, Shields W Donald   Social communication in children with epilepsy Journal of child psychology and psychiatry, and allied disciplines, 2002; 43(2): 245-53.

Geschwind DH, Ou J, Easterday M, Trerskikh A, Weissman I, Chen Z, Nelson S, Kornblum HI   A genetic analysis of neural progenitor differentiation, Neuron, 2001; 29: 325-339.

Groszer M, Erickson R, Scripture-Adams DD, Lesche R, Trumpp A, Zack JA, Kornblum HI, Liu X, Wu H   Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo Science. , 2001; 294(5549): 2186-9.

Kornblum HI, Araujo DM, Annala AJ, Tatsukawa KJ, Phelps ME, Cherry SR   In vivo imaging of neuronal activation and plasticity in the rat brain by high resolution positron emission tomography (microPET) Nature biotechnology. , 2000; 18(6): 655-60.