Biography
Dr. Kornblum is a basic and translational researcher in the Intellectual and Developmental Disabilities Research Center of the Semel Research Institute. He is Professor of Psychiatry, Pharmacology and Pediatrics at the David Geffen School of Medicine at UCLA. He is also an attending Pediatric Neurologist at Mattel Children's Hospital at UCLA and the founding director of the Neural Stem Cell Research Center. He is a member of the Brain Research Institute, The Broad Stem Cell Research Center and the Molecular Biology Institute and serves on the Steering Committe of the Broad Stem Cell Research Center. Dr. Kornblum received his AB degree from Washington University in St. Louis and his MD and PhD degrees from UC Irvine. He trained as a Pediatrics Resident and Pediatric Neurology Fellow at UCLA. He did undergraduate research with Dr. Eugene M. Johnson and received his PhD in the laboratory of Frances M. Leslie. He pursued postdoctoral research with Dr. Christine M. Gall at UCI and Dr. Harry Chugani at UCLA. Dr. Kornblum is a frequent lecturer on the topics of neural stem cells and brain tumors at conferences and universities world-wide and has published over 100 research articles and book chapters. Dr. Kornblum is the recipient of numerous grants from the Federal Government as well as philanthropic foundations. He served as the Eleanor Leslie Professor of Pioneering Brain Research.
Publications
A selected list of publications:
Akhavan David, Pourzia Alexandra L, Nourian Alex A, Williams Kevin J, Nathanson David, Babic Ivan, Villa Genaro R, Tanaka Kazuhiro, Nael Ali, Yang Huijun, Dang Julie, Vinters Harry V, Yong William H, Flagg Mitchell, Tamanoi Fuyuhiko, Sasayama Takashi, James C David, Kornblum Harley I, Cloughesy Tim F, Cavenee Webster K, Bensinger Steven J, Mischel Paul S
De-repression of PDGFRβ transcription promotes acquired resistance to
EGFR tyrosine kinase inhibitors in glioblastoma patients
Cancer discovery,
2013; 3(5):
534-47.
Joshi Kaushal, Banasavadi-Siddegowda Yeshavanth, Mo Xiaokui, Kim Sung-Hak, Mao Ping, Kig Cenk, Nardini Diana, Sobol Robert W, Chow Lionel M L, Kornblum Harley I, Waclaw Ronald, Beullens Monique, Nakano Ichiro
MELK-dependent FOXM1 phosphorylation is essential for proliferation of
glioma stem cells
Stem cells (Dayton, Ohio),
2013; 31(6):
1051-63.
Chou Arthur P, Chowdhury Reshmi, Li Sichen, Chen Weidong, Kim Andrew J, Piccioni David E, Selfridge Julia M, Mody Reema R, Chang Stephen, Lalezari Shadi, Lin Jeffrey, Sanchez Desiree E, Wilson Ryan W, Garrett Matthew C, Harry Bret, Mottahedeh Jack, Nghiemphu Phioanh L, Kornblum Harley I, Mischel Paul S, Prins Robert M, Yong William H, Cloughesy Timothy, Nelson Stanley F, Liau Linda M, Lai Albert
Identification of retinol binding protein 1 promoter hypermethylation
in isocitrate dehydrogenase 1 and 2 mutant gliomas
Journal of the National Cancer Institute,
2012; 104(19):
1458-69.
Pope Whitney B, Prins Robert M, Albert Thomas M, Nagarajan Rajakumar, Yen Katharine E, Bittinger Mark A, Salamon Noriko, Chou Arthur P, Yong William H, Soto Horacio, Wilson Neil, Driggers Edward, Jang Hyun G, Su Shinsan M, Schenkein David P, Lai Albert, Cloughesy Timothy F, Kornblum Harley I, Wu Hong, Fantin Valeria R, Liau Linda M
Non-invasive detection of 2-hydroxyglutarate and other metabolites in
IDH1 mutant glioma patients using magnetic resonance spectroscopy
Journal of neuro-oncology,
2012; 107(1):
197-205.
Visnyei Koppany, Onodera Hideyuki, Damoiseaux Robert, Saigusa Kuniyasu, Petrosyan Syuzanna, De Vries David, Ferrari Denise, Saxe Jonathan, Panosyan Eduard H, Masterman-Smith Michael, Mottahedeh Jack, Bradley Kenneth A, Huang Jing, Sabatti Chiara, Nakano Ichiro, Kornblum Harley I
A molecular screening approach to identify and characterize inhibitors
of glioblastoma stem cells
Molecular cancer therapeutics,
2011; 10(10):
1818-28.
Liu Yue, Ye Fei, Yamada Kazunari, Tso Jonathan L, Zhang Yibei, Nguyen David H, Dong Qinghua, Soto Horacio, Choe Jinny, Dembo Anna, Wheeler Hayley, Eskin Ascia, Schmid Ingrid, Yong William H, Mischel Paul S, Cloughesy Timothy F, Kornblum Harley I, Nelson Stanley F, Liau Linda M, Tso Cho-Lea
Autocrine endothelin-3/endothelin receptor B signaling maintains
cellular and molecular properties of glioblastoma stem cells
Molecular cancer research : MCR,
2011; 9(12):
1668-85.
Jijiwa Mayumi, Demir Habibe, Gupta Snehalata, Leung Crystal, Joshi Kaushal, Orozco Nicholas, Huang Tiffany, Yildiz Vedat O, Shibahara Ichiyo, de Jesus Jason A, Yong William H, Mischel Paul S, Fernandez Soledad, Kornblum Harley I, Nakano Ichiro
CD44v6 regulates growth of brain tumor stem cells partially through
the AKT-mediated pathway
PloS one,
2011; 6(9):
e24217.
Nakano Ichiro, Joshi Kaushal, Visnyei Koppany, Hu Bin, Watanabe Momoko, Lam Diana, Wexler Eric, Saigusa Kuniyasu, Nakamura Yuko, Laks Dan R, Mischel Paul S, Viapiano Mariano, Kornblum Harley I
Siomycin A targets brain tumor stem cells partially through a
MELK-mediated pathway
Neuro-oncology,
2011; 13(6):
622-34.
Sun Jing, Masterman-Smith Michael D, Graham Nicholas A, Jiao Jing, Mottahedeh Jack, Laks Dan R, Ohashi Minori, DeJesus Jason, Kamei Ken-ichiro, Lee Ki-Bum, Wang Hao, Yu Zeta T F, Lu Yi-Tsung, Hou Shuang, Li Keyu, Liu Max, Zhang Nangang, Wang Shutao, Angenieux Brigitte, Panosyan Eduard, Samuels Eric R, Park Jun, Williams Dirk, Konkankit Vera, Nathanson David, van Dam R Michael, Phelps Michael E, Wu Hong, Liau Linda M, Mischel Paul S, Lazareff Jorge A, Kornblum Harley I, Yong William H, Graeber Thomas G, Tseng Hsian-Rong
A microfluidic platform for systems pathology: multiparameter
single-cell signaling measurements of clinical brain tumor specimens
Cancer research,
2010; 70(15):
6128-38.
Panosyan Eduard H, Laks Dan R, Masterman-Smith Michael, Mottahedeh Jack, Yong William H, Cloughesy Timothy F, Lazareff Jorge A, Mischel Paul S, Moore Theodore B, Kornblum Harley I
Clinical outcome in pediatric glial and embryonal brain tumors
correlates with in vitro multi-passageable neurosphere formation
Pediatric blood & cancer,
2010; 55(4):
644-51.
Neveu Pierre, Kye Min Jeong, Qi Shuping, Buchholz David E, Clegg Dennis O, Sahin Mustafa, Park In-Hyun, Kim Kwang-Soo, Daley George Q, Kornblum Harley I, Shraiman Boris I, Kosik Kenneth S
MicroRNA profiling reveals two distinct p53-related human pluripotent
stem cell states
Cell stem cell,
2010; 7(6):
671-81.
Karumbayaram Saravanan, Novitch Bennett G, Patterson Michaela, Umbach Joy A, Richter Laura, Lindgren Anne, Conway Anne E, Clark Amander T, Goldman Steve A, Plath Kathrin, Wiedau-Pazos Martina, Kornblum Harley I, Lowry William E
Directed differentiation of human-induced pluripotent stem cells
generates active motor neurons
Stem cells (Dayton, Ohio),
2009; 27(4):
806-11.
Lewerenz Jan, Albrecht Philipp, Tien Mai-Ly Tran, Henke Nadine, Karumbayaram Saravanan, Kornblum Harley I, Wiedau-Pazos Martina, Schubert Dave, Maher Pamela, Methner Axel
Induction of Nrf2 and xCT are involved in the action of the
neuroprotective antibiotic ceftriaxone in vitro
Journal of neurochemistry,
2009; 111(2):
332-43.
Laks Dan R, Masterman-Smith Michael, Visnyei Koppany, Angenieux Brigitte, Orozco Nicholas M, Foran Ian, Yong William H, Vinters Harry V, Liau Linda M, Lazareff Jorge A, Mischel Paul S, Cloughesy Timothy F, Horvath Steve, Kornblum Harley I
Neurosphere formation is an independent predictor of clinical outcome
in malignant glioma
Stem cells (Dayton, Ohio),
2009; 27(4):
980-7.
Gregorian Caroline, Nakashima Jonathan, Le Belle Janel, Ohab John, Kim Rachel, Liu Annie, Smith Kate Barzan, Groszer Matthias, Garcia A Denise, Sofroniew Michael V, Carmichael S Thomas, Kornblum Harley I, Liu Xin, Wu Hong
Pten deletion in adult neural stem/progenitor cells enhances
constitutive neurogenesis
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2009; 29(6):
1874-86.
Lelievre Vincent, Seksenyan Akop, Nobuta Hiroko, Yong William H, Chhith Seririthanar, Niewiadomski Pawel, Cohen Joseph R, Dong Hongmei, Flores Avegail, Liau Linda M, Kornblum Harley I, Scott Matthew P, Waschek James A
Disruption of the PACAP gene promotes medulloblastoma in ptc1 mutant
mice
Developmental biology,
2008; 313(1):
359-70.
Nakano Ichiro, Masterman-Smith Michael, Saigusa Kuniyasu, Paucar Andres A, Horvath Steve, Shoemaker Lorelei, Watanabe Momoko, Negro Alejandra, Bajpai Ruchi, Howes Amy, Lelievre Vincent, Waschek James A, Lazareff Jorge A, Freije William A, Liau Linda M, Gilbertson Richard J, Cloughesy Timothy F, Geschwind Daniel H, Nelson Stanley F, Mischel Paul S, Terskikh Alexey V, Kornblum Harley I
Maternal embryonic leucine zipper kinase is a key regulator of the
proliferation of malignant brain tumors, including brain tumor stem
cells
Journal of neuroscience research,
2008; 86(1):
48-60.
Ratan Rajiv R, Siddiq Ambreena, Aminova Leila, Langley Brett, McConoughey Stephen, Karpisheva Ksenia, Lee Hsin-Hwa, Carmichael Thomas, Kornblum Harley, Coppola Giovanni, Geschwind Daniel H, Hoke Ahmet, Smirnova Natalya, Rink Cameron, Roy Sashwati, Sen Chandan, Beattie Michael S, Hart Ron P, Grumet Martin, Sun Dongming, Freeman Robert S, Semenza Gregg L, Gazaryan Irina
Small molecule activation of adaptive gene expression: tilorone or its
analogs are novel potent activators of hypoxia inducible factor-1 that
provide prophylaxis against stroke and spinal cord injury
Annals of the New York Academy of Sciences,
2008; 1147(6):
383-94.
Liu Tsunglin, Papagiannakopoulos Thales, Puskar Kathy, Qi Shuping, Santiago Fernando, Clay William, Lao Kaiqin, Lee Yohan, Nelson Stanley F, Kornblum Harley I, Doyle Frank, Petzold Linda, Shraiman Boris, Kosik Kenneth S
Detection of a microRNA signal in an in vivo expression set of mRNAs
PloS one,
2007; 2(8):
e804.
Cheng Jerry C, Horwitz Edwin M, Karsten Stanislav L, Shoemaker Lorelei, Kornblum Harley I, Malik Punam, Sakamoto Kathleen M
Report on the workshop "New Technologies in Stem Cell Research,"
Society for Pediatric Research, San Francisco, California, April 29,
2006
Stem cells (Dayton, Ohio),
2007; 25(4):
1070-88.
Groszer Matthias, Erickson Rebecca, Scripture-Adams Deirdre D, Dougherty Joseph D, Le Belle Janel, Zack Jerome A, Geschwind Daniel H, Liu Xin, Kornblum Harley I, Wu Hong
PTEN negatively regulates neural stem cell self-renewal by modulating
G0-G1 cell cycle entry
Proceedings of the National Academy of Sciences of the United States of America,
2006; 103(1):
111-6.
Nakano Ichiro, Paucar Andres A, Bajpai Ruchi, Dougherty Joseph D, Zewail Amani, Kelly Theresa K, Kim Kevin J, Ou Jing, Groszer Matthias, Imura Tetsuya, Freije William A, Nelson Stanley F, Sofroniew Michael V, Wu Hong, Liu Xin, Terskikh Alexey V, Geschwind Daniel H, Kornblum Harley I
Maternal embryonic leucine zipper kinase (MELK) regulates multipotent
neural progenitor proliferation
The Journal of cell biology,
2005; 170(3):
413-27.
Hemmati Houman D, Nakano Ichiro, Lazareff Jorge A, Masterman-Smith Michael, Geschwind Daniel H, Bronner-Fraser Marianne, Kornblum Harley I
Cancerous stem cells can arise from pediatric brain tumors
Proceedings of the National Academy of Sciences of the United States of America,
2003; 100(25):
15178-83.
Easterday Mathew C, Dougherty Joseph D, Jackson Robert L, Ou Jing, Nakano Ichiro, Paucar Andres A, Roobini Babak, Dianati Mehrnoosh, Irvin Dwain K, Weissman Irving L, Terskikh Alexey V, Geschwind Daniel H, Kornblum Harley I
Neural progenitor genes. Germinal zone expression and analysis of
genetic overlap in stem cell populations
Developmental biology,
2003; 264(2):
309-22.
Easterday MC, Dougherty JD, Jackson RL, Ou J, Nakano I, Paucar AA, Roobini B, Dianati M, Irvin DK, Weissman IL, Terskikh AV, Geschwind DH, Kornblum HI
Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations
Developmental biology. ,
2003; 264(2):
309-22.
Caplan Rochelle, Guthrie Donald, Komo Scott, Siddarth Prabha, Chayasirisobhon Sirichai, Kornblum Harley, Sankar Ramen, Hansen Rebecca, Mitchell Wendy, Shields W Donald
Social communication in children with epilepsy
Journal of child psychology and psychiatry, and allied disciplines,
2002; 43(2):
245-53.
Geschwind DH, Ou J, Easterday M, Trerskikh A, Weissman I, Chen Z, Nelson S, Kornblum HI
A genetic analysis of neural progenitor differentiation,
Neuron,
2001; 29:
325-339.