
Ira Kurtz, M.D.
Titles
Chief, Nephrology
Professor, Medicine
Member, Brain Research Institute
Contact Information
Email
ikurtz@mednet.ucla.edu Phone
Work Phone Number:
(310) 206-7662
Address
Mailing Address:
UCLA Med-NephBOX 951689, 7-155 Factor
Los Angeles, CA 90095
UNITED STATES
Publications
A selected list of publications:
Zhu Quansheng, Liu Weixin, Kao Liyo, Azimov Rustam, Newman Debra, Abuladze Natalia, Kurtz Ira
Topology of NBCe1 Transmembrane Segment 1 and Structural Effect of
pRTA S427L Mutation
The Journal of biological chemistry,
2013;
.
Tsirulnikov Kirill, Abuladze Natalia, Vahi Ritu, Hasnain Huma, Phillips Martin, Ryan Christopher M, Atanasov Ivo, Faull Kym F, Kurtz Ira, Pushkin Alexander
Aminoacylase 3 binds to and cleaves the N-terminus of the hepatitis C
virus core protein
FEBS letters,
2012; 586(21):
3799-804.
Kao Liyo, Abuladze Natalia, Shao Xuesi M, McKeegan Kevin, Kurtz Ira
A new technique for multiple re-use of planar patch clamp chips
Journal of neuroscience methods,
2012; 208(2):
205-10.
Kurtz Lisa, Kao Liyo, Newman Debra, Kurtz Ira, Zhu Quansheng
Integrin ?IIb?3 inside-out activation: an in situ conformational
analysis reveals a new mechanism
The Journal of biological chemistry,
2012; 287(27):
23255-65.
Lacruz Rodrigo S, Smith Charles E, Bringas Pablo, Chen Yi-Bu, Smith Susan M, Snead Malcolm L, Kurtz Ira, Hacia Joseph G, Hubbard Michael J, Paine Michael L
Identification of novel candidate genes involved in mineralization of
dental enamel by genome-wide transcript profiling
Journal of cellular physiology,
2012; 227(5):
2264-75.
Burette Alain C, Weinberg Richard J, Sassani Patrick, Abuladze Natalia, Kao Liyo, Kurtz Ira
The sodium-driven chloride/bicarbonate exchanger in presynaptic
terminals
The Journal of comparative neurology,
2012; 520(7):
1481-92.
Sergeev Mikhail, Godin Antoine G, Kao Liyo, Abuladze Natalia, Wiseman Paul W, Kurtz Ira
Determination of membrane protein transporter oligomerization in
native tissue using spatial fluorescence intensity fluctuation
analysis
PloS one,
2012; 7(4):
e36215.
Hu Ping, Lacruz Rodrigo S, Smith Charles E, Smith Susan M, Kurtz Ira, Paine Michael L
Expression of the sodium/calcium/potassium exchanger, NCKX4, in
ameloblasts
Cells, tissues, organs,
2012; 196(6):
501-9.
Lacruz Rodrigo S, Smith Charles E, Moffatt Pierre, Chang Eugene H, Bromage Timothy G, Bringas Pablo, Nanci Antonio, Baniwal Sanjeev K, Zabner Joseph, Welsh Michael J, Kurtz Ira, Paine Michael L
Requirements for ion and solute transport, and pH regulation during
enamel maturation
Journal of cellular physiology,
2012; 227(4):
1776-85.
Snead Christian M, Smith Susan M, Sadeghein Negar, Lacruz Rodrigo S, Hu Ping, Kurtz Ira, Paine Michael L
Identification of a pH-responsive DNA region upstream of the
transcription start site of human NBCe1-B
European journal of oral sciences,
2011; 119 Suppl 1(4):
136-41.
Nguyen Minhtri K, Kao Liyo, Kurtz Ira
Defining the buffering process by a triprotic acid without relying on
Stewart-electroneutrality considerations
Theoretical biology & medical modelling,
2011; 8(37):
29.
Kao Liyo, Kurtz Lisa M, Shao Xuesi, Papadopoulos Marios C, Liu Li, Bok Dean, Nusinowitz Steven, Chen Bryan, Stella Salvatore L, Andre Mark, Weinreb Josh, Luong Serena S, Piri Natik, Kwong Jacky M K, Newman Debra, Kurtz Ira
Severe neurologic impairment in mice with targeted disruption of the
electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene)
The Journal of biological chemistry,
2011; 286(37):
32563-74.
Zhu Quansheng, Kao Liyo, Azimov Rustam, Abuladze Natalia, Newman Debra, Pushkin Alexander, Liu Weixin, Chang Connie, Kurtz Ira
Structural and functional characterization of the C-terminal
transmembrane region of NBCe1-A
The Journal of biological chemistry,
2010; 285(48):
37178-87.
Hsieh Jennifer M, Tsirulnikov Kirill, Sawaya Michael R, Magilnick Nathaniel, Abuladze Natalia, Kurtz Ira, Abramson Jeff, Pushkin Alexander
Structures of aminoacylase 3 in complex with acetylated substrates
Proceedings of the National Academy of Sciences of the United States of America,
2010; 107(42):
17962-7.
Lacruz Rodrigo S, Nanci Antonio, White Shane N, Wen Xin, Wang Hongjun, Zalzal Sylvia F, Luong Vivian Q, Schuetter Verna L, Conti Peter S, Kurtz Ira, Paine Michael L
The sodium bicarbonate cotransporter (NBCe1) is essential for normal
development of mouse dentition
The Journal of biological chemistry,
2010; 285(32):
24432-8.
Zhu Quansheng, Kao Liyo, Azimov Rustam, Newman Debra, Liu Weixin, Pushkin Alexander, Abuladze Natalia, Kurtz Ira
Topological location and structural importance of the NBCe1-A residues
mutated in proximal renal tubular acidosis
The Journal of biological chemistry,
2010; 285(18):
13416-26.
Tsirulnikov Kirill, Abuladze Natalia, Koag Myong-Chul, Newman Debra, Scholz Karoline, Bondar Galyna, Zhu Quansheng, Avliyakulov Nuraly K, Dekant Wolfgang, Faull Kym, Kurtz Ira, Pushkin Alexander
Transport of N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine, a metabolite
of trichloroethylene, by mouse multidrug resistance associated protein
2 (Mrp2)
Toxicology and applied pharmacology,
2010; 244(2):
218-25.
Lacruz Rodrigo S, Hilvo Mika, Kurtz Ira, Paine Michael L
A survey of carbonic anhydrase mRNA expression in enamel cells
Biochemical and biophysical research communications,
2010; 393(4):
883-7.
Lacruz Rodrigo S, Nanci Antonio, Kurtz Ira, Wright J Timothy, Paine Michael L
Regulation of pH During Amelogenesis
Calcified tissue international,
2010; 86(2):
91-103.
Lopez Ivan A, Rosenblatt Mark I, Kim Charles, Galbraith Gary C, Jones Sherri M, Kao Liyo, Newman Debra, Liu Weixin, Yeh Stacey, Pushkin Alexander, Abuladze Natalia, Kurtz Ira
Slc4a11 gene disruption in mice: cellular targets of sensorineuronal
abnormalities
The Journal of biological chemistry,
2009; 284(39):
26882-96.
Tsirulnikov Kirill, Abuladze Natalia, Newman Debra, Ryazantsev Sergey, Wolak Talya, Magilnick Nathaniel, Koag Myong-Chul, Kurtz Ira, Pushkin Alexander
Mouse aminoacylase 3: a metalloenzyme activated by cobalt and nickel
Biochimica et biophysica acta,
2009; 1794(7):
1049-57.
Nguyen Minhtri K, Kao Liyo, Kurtz Ira
Calculation of the equilibrium pH in a multiple-buffered aqueous
solution based on partitioning of proton buffering: a new predictive
formula
American journal of physiology. Renal physiology,
2009; 296(6):
F1521-9.
Zhu Quansheng, Azimov Rustam, Kao Liyo, Newman Debra, Liu Weixin, Abuladze Natalia, Pushkin Alexander, Kurtz Ira
NBCe1-A Transmembrane Segment 1 Lines the Ion Translocation Pathway
The Journal of biological chemistry,
2009; 284(13):
8918-29.
Azimov Rustam, Abuladze Natalia, Sassani Pakan, Newman Debra, Kao Liyo, Liu Weixin, Orozco Nicholas, Ruchala Piotr, Pushkin Alexander, Kurtz Ira
G418-mediated ribosomal read-through of a nonsense mutation causing
autosomal recessive proximal renal tubular acidosis
American journal of physiology. Renal physiology,
2008; 295(3):
F633-41.
Kao Liyo, Sassani Pakan, Azimov Rustam, Pushkin Alexander, Abuladze Natalia, Peti-Peterdi Janos, Liu Weixin, Newman Debra, Kurtz Ira
Oligomeric structure and minimal functional unit of the electrogenic
sodium bicarbonate cotransporter NBCe1-A
The Journal of biological chemistry,
2008; 283(39):
26782-94.
Nguyen Minhtri K, Kurtz Ira
Correction of hypervolaemic hypernatraemia by inducing negative Na+
and K+ balance in excess of negative water balance: a new quantitative
approach
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
2008; 23(7):
2223-7.
Kurtz Ira, Kraut Jeffrey, Ornekian Vahram, Nguyen Minhtri K
Acid-base analysis: a critique of the Stewart and bicarbonate-centered
approaches
American journal of physiology. Renal physiology,
2008; 294(5):
F1009-31.
Messerli Mark A, Kurtz Ira, Smith Peter J S
Characterization of optimized Na+ and Cl- liquid membranes for use
with extracellular, self-referencing microelectrodes
Analytical and bioanalytical chemistry,
2008; 390(5):
1355-9.
Pushkin Alexander, Kurtz Ira
Measurement of aminoacylases
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.],
2008; Chapter 6(5):
Unit6.14.
Kraut Jeffrey A, Kurtz Ira
Toxic alcohol ingestions: clinical features, diagnosis, and
management
Clinical journal of the American Society of Nephrology : CJASN,
2008; 3(1):
208-25.
Aldave Anthony J, Yellore Vivek S, Bourla Nirit, Momi Rominder S, Khan M Ali, Salem Andrew K, Rayner Sylvia A, Glasgow Ben J, Kurtz Ira
Autosomal recessive CHED associated with novel compound heterozygous
mutations in SLC4A11
Cornea,
2007; 26(7):
896-900.
Nguyen Minhtri K, Ornekian Vahram, Butch Anthony W, Kurtz Ira
A new method for determining plasma water content: application in
pseudohyponatremia
American journal of physiology. Renal physiology,
2007; 292(5):
F1652-6.
Leung Kevin, Nielsen Ida M B, Kurtz Ira
Ab initio molecular dynamics study of carbon dioxide and bicarbonate
hydration and the nucleophilic attack of hydroxide on CO2
The journal of physical chemistry. B,
2007; 111(17):
4453-9.
Ryazantsev Sergey, Abuladze Natalia, Newman Debra, Bondar Galyna, Kurtz Ira, Pushkin Alexander
Structural characterization of dimeric murine aminoacylase III
FEBS letters,
2007; 581(9):
1898-902.
Suh William M, Wainberg Zev A, de Vos Sven, Cohen Arthur H, Kurtz Ira, Nguyen Minhtri K
Acute lymphoblastic leukemia presenting as acute renal failure
Nature clinical practice. Nephrology,
2007; 3(2):
106-10.
Nguyen Minhtri K, Kurtz Ira
Is the osmotically inactive sodium storage pool fixed or variable?
Journal of applied physiology (Bethesda, Md. : 1985),
2007; 102(1):
445-7.
Newman Debra, Abuladze Natalia, Scholz Karoline, Dekant Wolfgang, Tsuprun Vladimir, Ryazantsev Sergey, Bondar Galyna, Sassani Pakan, Kurtz Ira, Pushkin Alexander
Specificity of aminoacylase III-mediated deacetylation of mercapturic
acids
Drug metabolism and disposition: the biological fate of chemicals,
2007; 35(1):
43-50.
Galbraith Gary, Waschek James, Armstrong Brian, Edmond John, Lopez Ivan, Liu Weixin, Kurtz Ira
Murine auditory brainstem evoked response: putative two-channel
differentiation of peripheral and central neural pathways
Journal of neuroscience methods,
2006; 153(2):
214-20.
Nguyen Minhtri K, Rastogi Anjay, Kurtz Ira
True hyponatremia secondary to intravenous immunoglobulin
Clinical and experimental nephrology,
2006; 10(2):
124-6.
Kraut Jeffrey A, Kurtz Ira
Use of base in the treatment of acute severe organic acidosis by
nephrologists and critical care physicians: results of an online
survey
Clinical and experimental nephrology,
2006; 10(2):
111-7.
Kalantar-Zadeh Kamyar, Nguyen Minhtri K, Chang Roger, Kurtz Ira
Fatal hyponatremia in a young woman after ecstasy ingestion
Nature clinical practice. Nephrology,
2006; 2(5):
283-8, quiz 289.
Nguyen Minhtri Khac, Kurtz Ira
Physiologic Interrelationships between Gibbs-Donnan Equilibrium,
Osmolality of Body Fluid Compartments, and Plasma Water Sodium
Concentration
Journal of applied physiology (Bethesda, Md. : 1985),
2006; 10(2):
.
Nguyen Minhtri K, Kurtz Ira
Quantitative interrelationship between Gibbs-Donnan equilibrium,
osmolality of body fluid compartments, and plasma water sodium
concentration
Journal of applied physiology (Bethesda, Md. : 1985),
2006; 100(4):
1293-300.
Pushkin Alexander, Kurtz Ira
SLC4 base (HCO3 -, CO3 2-) transporters: classification, function,
structure, genetic diseases, and knockout models
American journal of physiology. Renal physiology,
2006; 290(3):
F580-99.
Nguyen Minhtri K, Kurtz Ira
Whole-body electrolyte-free water clearance: derivation and clinical
utility in analyzing the pathogenesis of the dysnatremias
Clinical and experimental nephrology,
2006; 10(1):
19-24.
Kim Young-Hee, Verlander Jill W, Matthews Sharon W, Kurtz Ira, Shin Wonkyong, Weiner I David, Everett Lorraine A, Green Eric D, Nielsen Søren, Wall Susan M
Intercalated cell H+/OH- transporter expression is reduced in Slc26a4
null mice
American journal of physiology. Renal physiology,
2005; 289(6):
F1262-72.
Kurtz Ira, Nguyen Minhtri K
Evolving concepts in the quantitative analysis of the determinants of
the plasma water sodium concentration and the pathophysiology and
treatment of the dysnatremias
Kidney international,
2005; 68(5):
1982-93.
Lopez Ivan A, Acuna Dora, Galbraith Gary, Bok Dean, Ishiyama Akira, Liu Weixin, Kurtz Ira
Time course of auditory impairment in mice lacking the electroneutral
sodium bicarbonate cotransporter NBC3 (slc4a7)
Brain research. Developmental brain research,
2005; 160(1):
63-77.
Nguyen Minhtri K, Kurtz Ira
A new formula for predicting alterations in plasma sodium
concentration in peritoneal dialysis
American journal of physiology. Renal physiology,
2005; 288(6):
F1113-7.
Abuladze Natalia, Azimov Rustam, Newman Debra, Sassani Pakan, Liu Weixin, Tatishchev Sergei, Pushkin Alexander, Kurtz Ira
Critical amino acid residues involved in the electrogenic
sodium-bicarbonate cotransporter kNBC1-mediated transport
The Journal of physiology,
2005; 565(Pt 3):
717-30.
Kraut Jeffrey A, Kurtz Ira
Metabolic acidosis of CKD: diagnosis, clinical characteristics, and
treatment
American journal of kidney diseases : the official journal of the National Kidney Foundation,
2005; 45(6):
978-93.
Nguyen Minhtri K, Kurtz Ira
An analysis of current quantitative approaches to the treatment of
severe symptomatic SIADH with intravenous saline therapy
Clinical and experimental nephrology,
2005; 9(1):
1-4.
Nguyen Minhtri K, Kurtz Ira
Derivation of a new formula for calculating urinary electrolyte-free
water clearance based on the Edelman equation
American journal of physiology. Renal physiology,
2005; 288(1):
F1-7.
Abuladze Natalia, Pushkin Alexander, Tatishchev Sergei, Newman Debra, Sassani Pakan, Kurtz Ira
Expression and localization of rat NBC4c in liver and renal
uroepithelium
American journal of physiology. Cell physiology,
2004; 287(3):
C781-9.
Pushkin Alexander, Abuladze Natalia, Gross Eitan, Newman Debra, Tatishchev Sergei, Lee Ivan, Fedotoff Olga, Bondar Galyna, Azimov Rustam, Ngyuen Matt, Kurtz Ira
Molecular mechanism of kNBC1-carbonic anhydrase II interaction in
proximal tubule cells
The Journal of physiology,
2004; 559(Pt 1):
55-65.
Nguyen Minhtri K, Kurtz Ira
New insights into the pathophysiology of the dysnatremias: a
quantitative analysis
American journal of physiology. Renal physiology,
2004; 287(2):
F172-80.
Nguyen Minhtri K, Kurtz Ira
Role of potassium in hypokalemia-induced hyponatremia: lessons learned
from the Edelman equation
Clinical and experimental nephrology,
2004; 8(2):
98-102.
Nguyen Minhtri K, Kurtz Ira
Determinants of plasma water sodium concentration as reflected in the
Edelman equation: role of osmotic and Gibbs-Donnan equilibrium
American journal of physiology. Renal physiology,
2004; 286(5):
F828-37.
Pushkin Alexander, Carpenito Gerardo, Abuladze Natalia, Newman Debra, Tsuprun Vladimir, Ryazantsev Sergey, Motemoturu Srilakshmi, Sassani Pakan, Solovieva Nadezhda, Dukkipati Ramnath, Kurtz Ira
Structural characterization, tissue distribution, and functional
expression of murine aminoacylase III
American journal of physiology. Cell physiology,
2004; 286(4):
C848-56.
Nguyen Minhtri K, Kurtz Ira
Analysis of current formulas used for treatment of the dysnatremias
Clinical and experimental nephrology,
2004; 8(1):
12-6.
Woo David D L, Kurtz Ira
Mapping blood pressure loci in (A/J x B6)F2 mice
Physiological genomics,
2003; 15(3):
236-42.
Nguyen Minhtri K, Kurtz Ira
An unusual case of pseudohyperkalaemia
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
2003; 18(8):
1657-9.
Nguyen Minhtri K, Kurtz Ira
Are the total exchangeable sodium, total exchangeable potassium and
total body water the only determinants of the plasma water sodium
concentration?
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
2003; 18(7):
1266-71.
Bok Dean, Galbraith Gary, Lopez Ivan, Woodruff Michael, Nusinowitz Steven, BeltrandelRio Hector, Huang Wenhu, Zhao Shulei, Geske Robert, Montgomery Charles, Van Sligtenhorst Isaac, Friddle Carl, Platt Kenneth, Sparks Mary Jean, Pushkin Alexander, Abuladze Natalia, Ishiyama Akira, Dukkipati Ramanath, Liu Weixin, Kurtz Ira
Blindness and auditory impairment caused by loss of the sodium
bicarbonate cotransporter NBC3
Nature genetics,
2003; 34(3):
313-9.
Nguyen Minhtri K, Kurtz Ira
A new quantitative approach to the treatment of the dysnatremias
Clinical and experimental nephrology,
2003; 7(2):
125-37.
Kurtz Ira, Nguyen Minhtri K
A simple quantitative approach to analyzing the generation of the
dysnatremias
Clinical and experimental nephrology,
2003; 7(2):
138-43.
Nguyen Minhtri K, Nielsen Søren, Kurtz Ira
Molecular pathogenesis of nephrogenic diabetes insipidus
Clinical and experimental nephrology,
2003; 7(1):
9-17.
Pushkin Alexander, Abuladze Natalia, Newman Debra, Muronets Vladimir, Sassani Pejvak, Tatishchev Sergei, Kurtz Ira
The COOH termini of NBC3 and the 56-kDa H+-ATPase subunit are PDZ
motifs involved in their interaction
American journal of physiology. Cell physiology,
2003; 284(3):
C667-73.
Tatishchev Sergei, Abuladze Natalia, Pushkin Alexander, Newman Debra, Liu Weixin, Weeks David, Sachs George, Kurtz Ira
Identification of membrane topography of the electrogenic sodium
bicarbonate cotransporter pNBC1 by in vitro transcription/translation
Biochemistry,
2003; 42(3):
755-65.
Park Meeyoung, Ko Shigeru B H, Choi Joo Young, Muallem Gaia, Thomas Philip J, Pushkin Alexander, Lee Myeong-Sok, Kim Joo Young, Lee Min Goo, Muallem Shmuel, Kurtz Ira
The cystic fibrosis transmembrane conductance regulator interacts with
and regulates the activity of the HCO3- salvage transporter human
Na+-HCO3- cotransport isoform 3
The Journal of biological chemistry,
2002; 277(52):
50503-9.
Yip Kay-Pong, Tsuruoka Shuichi, Schwartz George J, Kurtz Ira
Apical H(+)/base transporters mediating bicarbonate absorption and
pH(i) regulation in the OMCD
American journal of physiology. Renal physiology,
2002; 283(5):
F1098-104.
Gross Eitan, Pushkin Alexander, Abuladze Natalia, Fedotoff Olga, Kurtz Ira
Regulation of the sodium bicarbonate cotransporter kNBC1 function:
role of Asp(986), Asp(988) and kNBC1-carbonic anhydrase II binding
The Journal of physiology,
2002; 544(Pt 3):
679-85.
Gross Eitan, Kurtz Ira
Structural determinants and significance of regulation of electrogenic
Na(+)-HCO(3)(-) cotransporter stoichiometry
American journal of physiology. Renal physiology,
2002; 283(5):
F876-87.
Carpenito Gerardo, Kurtz Ira
Green urine in a critically ill patient
American journal of kidney diseases : the official journal of the National Kidney Foundation,
2002; 39(4):
E20.
Kwon Tae-Hwan, Fulton Christiaan, Wang Weidong, Kurtz Ira, Frøkiaer Jørgen, Aalkjaer Christian, Nielsen Søren
Chronic metabolic acidosis upregulates rat kidney Na-HCO
cotransporters NBCn1 and NBC3 but not NBC1
American journal of physiology. Renal physiology,
2002; 282(2):
F341-51.
Yip Kay-Pong, Kurtz Ira
Confocal fluorescence microscopy measurements of pH and calcium in
living cells
Methods in cell biology,
2002; 70(2):
417-27.
Sassani Pejvak, Pushkin Alexander, Gross Eitan, Gomer Alla, Abuladze Natalia, Dukkipati Ramanath, Carpenito Gerardo, Kurtz Ira
Functional characterization of NBC4: a new electrogenic
sodium-bicarbonate cotransporter
American journal of physiology. Cell physiology,
2002; 282(2):
C408-16.