Ira Kurtz, M.D.

Login to edit your profile page

Titles

Chief, Nephrology

Professor, Medicine

Member, Brain Research Institute


Awards and Honors:

Toronto Hospital, General Division

Sunnybrook Health Science Center

Moffitt Hospital

National Institutes of Health, The Clinical Center

Contact Information

Email
ikurtz@mednet.ucla.edu
Phone
Work Phone Number: (310) 206-7662
Address

Mailing Address:

UCLA Med-Neph
BOX 951689, 7-155 Factor
Los Angeles, CA 90095
UNITED STATES

Website
http://www.uclahealth.org/IraKurtz

Publications

A selected list of publications:

Zhu Quansheng, Liu Weixin, Kao Liyo, Azimov Rustam, Newman Debra, Abuladze Natalia, Kurtz Ira   Topology of NBCe1 Transmembrane Segment 1 and Structural Effect of pRTA S427L Mutation The Journal of biological chemistry, 2013; .
Tsirulnikov Kirill, Abuladze Natalia, Vahi Ritu, Hasnain Huma, Phillips Martin, Ryan Christopher M, Atanasov Ivo, Faull Kym F, Kurtz Ira, Pushkin Alexander   Aminoacylase 3 binds to and cleaves the N-terminus of the hepatitis C virus core protein FEBS letters, 2012; 586(21): 3799-804.
Kao Liyo, Abuladze Natalia, Shao Xuesi M, McKeegan Kevin, Kurtz Ira   A new technique for multiple re-use of planar patch clamp chips Journal of neuroscience methods, 2012; 208(2): 205-10.
Kurtz Lisa, Kao Liyo, Newman Debra, Kurtz Ira, Zhu Quansheng   Integrin ?IIb?3 inside-out activation: an in situ conformational analysis reveals a new mechanism The Journal of biological chemistry, 2012; 287(27): 23255-65.
Lacruz Rodrigo S, Smith Charles E, Bringas Pablo, Chen Yi-Bu, Smith Susan M, Snead Malcolm L, Kurtz Ira, Hacia Joseph G, Hubbard Michael J, Paine Michael L   Identification of novel candidate genes involved in mineralization of dental enamel by genome-wide transcript profiling Journal of cellular physiology, 2012; 227(5): 2264-75.
Burette Alain C, Weinberg Richard J, Sassani Patrick, Abuladze Natalia, Kao Liyo, Kurtz Ira   The sodium-driven chloride/bicarbonate exchanger in presynaptic terminals The Journal of comparative neurology, 2012; 520(7): 1481-92.
Sergeev Mikhail, Godin Antoine G, Kao Liyo, Abuladze Natalia, Wiseman Paul W, Kurtz Ira   Determination of membrane protein transporter oligomerization in native tissue using spatial fluorescence intensity fluctuation analysis PloS one, 2012; 7(4): e36215.
Hu Ping, Lacruz Rodrigo S, Smith Charles E, Smith Susan M, Kurtz Ira, Paine Michael L   Expression of the sodium/calcium/potassium exchanger, NCKX4, in ameloblasts Cells, tissues, organs, 2012; 196(6): 501-9.
Lacruz Rodrigo S, Smith Charles E, Moffatt Pierre, Chang Eugene H, Bromage Timothy G, Bringas Pablo, Nanci Antonio, Baniwal Sanjeev K, Zabner Joseph, Welsh Michael J, Kurtz Ira, Paine Michael L   Requirements for ion and solute transport, and pH regulation during enamel maturation Journal of cellular physiology, 2012; 227(4): 1776-85.
Snead Christian M, Smith Susan M, Sadeghein Negar, Lacruz Rodrigo S, Hu Ping, Kurtz Ira, Paine Michael L   Identification of a pH-responsive DNA region upstream of the transcription start site of human NBCe1-B European journal of oral sciences, 2011; 119 Suppl 1(4): 136-41.
Nguyen Minhtri K, Kao Liyo, Kurtz Ira   Defining the buffering process by a triprotic acid without relying on Stewart-electroneutrality considerations Theoretical biology & medical modelling, 2011; 8(37): 29.
Kao Liyo, Kurtz Lisa M, Shao Xuesi, Papadopoulos Marios C, Liu Li, Bok Dean, Nusinowitz Steven, Chen Bryan, Stella Salvatore L, Andre Mark, Weinreb Josh, Luong Serena S, Piri Natik, Kwong Jacky M K, Newman Debra, Kurtz Ira   Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene) The Journal of biological chemistry, 2011; 286(37): 32563-74.
Zhu Quansheng, Kao Liyo, Azimov Rustam, Abuladze Natalia, Newman Debra, Pushkin Alexander, Liu Weixin, Chang Connie, Kurtz Ira   Structural and functional characterization of the C-terminal transmembrane region of NBCe1-A The Journal of biological chemistry, 2010; 285(48): 37178-87.
Hsieh Jennifer M, Tsirulnikov Kirill, Sawaya Michael R, Magilnick Nathaniel, Abuladze Natalia, Kurtz Ira, Abramson Jeff, Pushkin Alexander   Structures of aminoacylase 3 in complex with acetylated substrates Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(42): 17962-7.
Lacruz Rodrigo S, Nanci Antonio, White Shane N, Wen Xin, Wang Hongjun, Zalzal Sylvia F, Luong Vivian Q, Schuetter Verna L, Conti Peter S, Kurtz Ira, Paine Michael L   The sodium bicarbonate cotransporter (NBCe1) is essential for normal development of mouse dentition The Journal of biological chemistry, 2010; 285(32): 24432-8.
Zhu Quansheng, Kao Liyo, Azimov Rustam, Newman Debra, Liu Weixin, Pushkin Alexander, Abuladze Natalia, Kurtz Ira   Topological location and structural importance of the NBCe1-A residues mutated in proximal renal tubular acidosis The Journal of biological chemistry, 2010; 285(18): 13416-26.
Tsirulnikov Kirill, Abuladze Natalia, Koag Myong-Chul, Newman Debra, Scholz Karoline, Bondar Galyna, Zhu Quansheng, Avliyakulov Nuraly K, Dekant Wolfgang, Faull Kym, Kurtz Ira, Pushkin Alexander   Transport of N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine, a metabolite of trichloroethylene, by mouse multidrug resistance associated protein 2 (Mrp2) Toxicology and applied pharmacology, 2010; 244(2): 218-25.
Lacruz Rodrigo S, Hilvo Mika, Kurtz Ira, Paine Michael L   A survey of carbonic anhydrase mRNA expression in enamel cells Biochemical and biophysical research communications, 2010; 393(4): 883-7.
Lacruz Rodrigo S, Nanci Antonio, Kurtz Ira, Wright J Timothy, Paine Michael L   Regulation of pH During Amelogenesis Calcified tissue international, 2010; 86(2): 91-103.
Lopez Ivan A, Rosenblatt Mark I, Kim Charles, Galbraith Gary C, Jones Sherri M, Kao Liyo, Newman Debra, Liu Weixin, Yeh Stacey, Pushkin Alexander, Abuladze Natalia, Kurtz Ira   Slc4a11 gene disruption in mice: cellular targets of sensorineuronal abnormalities The Journal of biological chemistry, 2009; 284(39): 26882-96.
Tsirulnikov Kirill, Abuladze Natalia, Newman Debra, Ryazantsev Sergey, Wolak Talya, Magilnick Nathaniel, Koag Myong-Chul, Kurtz Ira, Pushkin Alexander   Mouse aminoacylase 3: a metalloenzyme activated by cobalt and nickel Biochimica et biophysica acta, 2009; 1794(7): 1049-57.
Nguyen Minhtri K, Kao Liyo, Kurtz Ira   Calculation of the equilibrium pH in a multiple-buffered aqueous solution based on partitioning of proton buffering: a new predictive formula American journal of physiology. Renal physiology, 2009; 296(6): F1521-9.
Zhu Quansheng, Azimov Rustam, Kao Liyo, Newman Debra, Liu Weixin, Abuladze Natalia, Pushkin Alexander, Kurtz Ira   NBCe1-A Transmembrane Segment 1 Lines the Ion Translocation Pathway The Journal of biological chemistry, 2009; 284(13): 8918-29.
Azimov Rustam, Abuladze Natalia, Sassani Pakan, Newman Debra, Kao Liyo, Liu Weixin, Orozco Nicholas, Ruchala Piotr, Pushkin Alexander, Kurtz Ira   G418-mediated ribosomal read-through of a nonsense mutation causing autosomal recessive proximal renal tubular acidosis American journal of physiology. Renal physiology, 2008; 295(3): F633-41.
Kao Liyo, Sassani Pakan, Azimov Rustam, Pushkin Alexander, Abuladze Natalia, Peti-Peterdi Janos, Liu Weixin, Newman Debra, Kurtz Ira   Oligomeric structure and minimal functional unit of the electrogenic sodium bicarbonate cotransporter NBCe1-A The Journal of biological chemistry, 2008; 283(39): 26782-94.
Nguyen Minhtri K, Kurtz Ira   Correction of hypervolaemic hypernatraemia by inducing negative Na+ and K+ balance in excess of negative water balance: a new quantitative approach Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2008; 23(7): 2223-7.
Kurtz Ira, Kraut Jeffrey, Ornekian Vahram, Nguyen Minhtri K   Acid-base analysis: a critique of the Stewart and bicarbonate-centered approaches American journal of physiology. Renal physiology, 2008; 294(5): F1009-31.
Messerli Mark A, Kurtz Ira, Smith Peter J S   Characterization of optimized Na+ and Cl- liquid membranes for use with extracellular, self-referencing microelectrodes Analytical and bioanalytical chemistry, 2008; 390(5): 1355-9.
Pushkin Alexander, Kurtz Ira   Measurement of aminoacylases Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.], 2008; Chapter 6(5): Unit6.14.
Kraut Jeffrey A, Kurtz Ira   Toxic alcohol ingestions: clinical features, diagnosis, and management Clinical journal of the American Society of Nephrology : CJASN, 2008; 3(1): 208-25.
Aldave Anthony J, Yellore Vivek S, Bourla Nirit, Momi Rominder S, Khan M Ali, Salem Andrew K, Rayner Sylvia A, Glasgow Ben J, Kurtz Ira   Autosomal recessive CHED associated with novel compound heterozygous mutations in SLC4A11 Cornea, 2007; 26(7): 896-900.
Nguyen Minhtri K, Ornekian Vahram, Butch Anthony W, Kurtz Ira   A new method for determining plasma water content: application in pseudohyponatremia American journal of physiology. Renal physiology, 2007; 292(5): F1652-6.
Leung Kevin, Nielsen Ida M B, Kurtz Ira   Ab initio molecular dynamics study of carbon dioxide and bicarbonate hydration and the nucleophilic attack of hydroxide on CO2 The journal of physical chemistry. B, 2007; 111(17): 4453-9.
Ryazantsev Sergey, Abuladze Natalia, Newman Debra, Bondar Galyna, Kurtz Ira, Pushkin Alexander   Structural characterization of dimeric murine aminoacylase III FEBS letters, 2007; 581(9): 1898-902.
Suh William M, Wainberg Zev A, de Vos Sven, Cohen Arthur H, Kurtz Ira, Nguyen Minhtri K   Acute lymphoblastic leukemia presenting as acute renal failure Nature clinical practice. Nephrology, 2007; 3(2): 106-10.
Nguyen Minhtri K, Kurtz Ira   Is the osmotically inactive sodium storage pool fixed or variable? Journal of applied physiology (Bethesda, Md. : 1985), 2007; 102(1): 445-7.
Newman Debra, Abuladze Natalia, Scholz Karoline, Dekant Wolfgang, Tsuprun Vladimir, Ryazantsev Sergey, Bondar Galyna, Sassani Pakan, Kurtz Ira, Pushkin Alexander   Specificity of aminoacylase III-mediated deacetylation of mercapturic acids Drug metabolism and disposition: the biological fate of chemicals, 2007; 35(1): 43-50.
Galbraith Gary, Waschek James, Armstrong Brian, Edmond John, Lopez Ivan, Liu Weixin, Kurtz Ira   Murine auditory brainstem evoked response: putative two-channel differentiation of peripheral and central neural pathways Journal of neuroscience methods, 2006; 153(2): 214-20.
Nguyen Minhtri K, Rastogi Anjay, Kurtz Ira   True hyponatremia secondary to intravenous immunoglobulin Clinical and experimental nephrology, 2006; 10(2): 124-6.
Kalantar-Zadeh Kamyar, Nguyen Minhtri K, Chang Roger, Kurtz Ira   Fatal hyponatremia in a young woman after ecstasy ingestion Nature clinical practice. Nephrology, 2006; 2(5): 283-8, quiz 289.
Nguyen Minhtri Khac, Kurtz Ira   Physiologic Interrelationships between Gibbs-Donnan Equilibrium, Osmolality of Body Fluid Compartments, and Plasma Water Sodium Concentration Journal of applied physiology (Bethesda, Md. : 1985), 2006; 10(2): .
Nguyen Minhtri K, Kurtz Ira   Quantitative interrelationship between Gibbs-Donnan equilibrium, osmolality of body fluid compartments, and plasma water sodium concentration Journal of applied physiology (Bethesda, Md. : 1985), 2006; 100(4): 1293-300.
Pushkin Alexander, Kurtz Ira   SLC4 base (HCO3 -, CO3 2-) transporters: classification, function, structure, genetic diseases, and knockout models American journal of physiology. Renal physiology, 2006; 290(3): F580-99.
Nguyen Minhtri K, Kurtz Ira   Whole-body electrolyte-free water clearance: derivation and clinical utility in analyzing the pathogenesis of the dysnatremias Clinical and experimental nephrology, 2006; 10(1): 19-24.
Kim Young-Hee, Verlander Jill W, Matthews Sharon W, Kurtz Ira, Shin Wonkyong, Weiner I David, Everett Lorraine A, Green Eric D, Nielsen Søren, Wall Susan M   Intercalated cell H+/OH- transporter expression is reduced in Slc26a4 null mice American journal of physiology. Renal physiology, 2005; 289(6): F1262-72.
Lopez Ivan A, Acuna Dora, Galbraith Gary, Bok Dean, Ishiyama Akira, Liu Weixin, Kurtz Ira   Time course of auditory impairment in mice lacking the electroneutral sodium bicarbonate cotransporter NBC3 (slc4a7) Brain research. Developmental brain research, 2005; 160(1): 63-77.
Nguyen Minhtri K, Kurtz Ira   A new formula for predicting alterations in plasma sodium concentration in peritoneal dialysis American journal of physiology. Renal physiology, 2005; 288(6): F1113-7.
Abuladze Natalia, Azimov Rustam, Newman Debra, Sassani Pakan, Liu Weixin, Tatishchev Sergei, Pushkin Alexander, Kurtz Ira   Critical amino acid residues involved in the electrogenic sodium-bicarbonate cotransporter kNBC1-mediated transport The Journal of physiology, 2005; 565(Pt 3): 717-30.
Kraut Jeffrey A, Kurtz Ira   Metabolic acidosis of CKD: diagnosis, clinical characteristics, and treatment American journal of kidney diseases : the official journal of the National Kidney Foundation, 2005; 45(6): 978-93.
Nguyen Minhtri K, Kurtz Ira   An analysis of current quantitative approaches to the treatment of severe symptomatic SIADH with intravenous saline therapy Clinical and experimental nephrology, 2005; 9(1): 1-4.
Nguyen Minhtri K, Kurtz Ira   Derivation of a new formula for calculating urinary electrolyte-free water clearance based on the Edelman equation American journal of physiology. Renal physiology, 2005; 288(1): F1-7.
Abuladze Natalia, Pushkin Alexander, Tatishchev Sergei, Newman Debra, Sassani Pakan, Kurtz Ira   Expression and localization of rat NBC4c in liver and renal uroepithelium American journal of physiology. Cell physiology, 2004; 287(3): C781-9.
Pushkin Alexander, Abuladze Natalia, Gross Eitan, Newman Debra, Tatishchev Sergei, Lee Ivan, Fedotoff Olga, Bondar Galyna, Azimov Rustam, Ngyuen Matt, Kurtz Ira   Molecular mechanism of kNBC1-carbonic anhydrase II interaction in proximal tubule cells The Journal of physiology, 2004; 559(Pt 1): 55-65.
Nguyen Minhtri K, Kurtz Ira   New insights into the pathophysiology of the dysnatremias: a quantitative analysis American journal of physiology. Renal physiology, 2004; 287(2): F172-80.
Nguyen Minhtri K, Kurtz Ira   Role of potassium in hypokalemia-induced hyponatremia: lessons learned from the Edelman equation Clinical and experimental nephrology, 2004; 8(2): 98-102.
Nguyen Minhtri K, Kurtz Ira   Determinants of plasma water sodium concentration as reflected in the Edelman equation: role of osmotic and Gibbs-Donnan equilibrium American journal of physiology. Renal physiology, 2004; 286(5): F828-37.
Pushkin Alexander, Carpenito Gerardo, Abuladze Natalia, Newman Debra, Tsuprun Vladimir, Ryazantsev Sergey, Motemoturu Srilakshmi, Sassani Pakan, Solovieva Nadezhda, Dukkipati Ramnath, Kurtz Ira   Structural characterization, tissue distribution, and functional expression of murine aminoacylase III American journal of physiology. Cell physiology, 2004; 286(4): C848-56.
Nguyen Minhtri K, Kurtz Ira   Analysis of current formulas used for treatment of the dysnatremias Clinical and experimental nephrology, 2004; 8(1): 12-6.
Woo David D L, Kurtz Ira   Mapping blood pressure loci in (A/J x B6)F2 mice Physiological genomics, 2003; 15(3): 236-42.
Nguyen Minhtri K, Kurtz Ira   An unusual case of pseudohyperkalaemia Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2003; 18(8): 1657-9.
Nguyen Minhtri K, Kurtz Ira   Are the total exchangeable sodium, total exchangeable potassium and total body water the only determinants of the plasma water sodium concentration? Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2003; 18(7): 1266-71.
Bok Dean, Galbraith Gary, Lopez Ivan, Woodruff Michael, Nusinowitz Steven, BeltrandelRio Hector, Huang Wenhu, Zhao Shulei, Geske Robert, Montgomery Charles, Van Sligtenhorst Isaac, Friddle Carl, Platt Kenneth, Sparks Mary Jean, Pushkin Alexander, Abuladze Natalia, Ishiyama Akira, Dukkipati Ramanath, Liu Weixin, Kurtz Ira   Blindness and auditory impairment caused by loss of the sodium bicarbonate cotransporter NBC3 Nature genetics, 2003; 34(3): 313-9.
Nguyen Minhtri K, Kurtz Ira   A new quantitative approach to the treatment of the dysnatremias Clinical and experimental nephrology, 2003; 7(2): 125-37.
Kurtz Ira, Nguyen Minhtri K   A simple quantitative approach to analyzing the generation of the dysnatremias Clinical and experimental nephrology, 2003; 7(2): 138-43.
Nguyen Minhtri K, Nielsen Søren, Kurtz Ira   Molecular pathogenesis of nephrogenic diabetes insipidus Clinical and experimental nephrology, 2003; 7(1): 9-17.
Pushkin Alexander, Abuladze Natalia, Newman Debra, Muronets Vladimir, Sassani Pejvak, Tatishchev Sergei, Kurtz Ira   The COOH termini of NBC3 and the 56-kDa H+-ATPase subunit are PDZ motifs involved in their interaction American journal of physiology. Cell physiology, 2003; 284(3): C667-73.
Tatishchev Sergei, Abuladze Natalia, Pushkin Alexander, Newman Debra, Liu Weixin, Weeks David, Sachs George, Kurtz Ira   Identification of membrane topography of the electrogenic sodium bicarbonate cotransporter pNBC1 by in vitro transcription/translation Biochemistry, 2003; 42(3): 755-65.
Park Meeyoung, Ko Shigeru B H, Choi Joo Young, Muallem Gaia, Thomas Philip J, Pushkin Alexander, Lee Myeong-Sok, Kim Joo Young, Lee Min Goo, Muallem Shmuel, Kurtz Ira   The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3- cotransport isoform 3 The Journal of biological chemistry, 2002; 277(52): 50503-9.
Yip Kay-Pong, Tsuruoka Shuichi, Schwartz George J, Kurtz Ira   Apical H(+)/base transporters mediating bicarbonate absorption and pH(i) regulation in the OMCD American journal of physiology. Renal physiology, 2002; 283(5): F1098-104.
Gross Eitan, Pushkin Alexander, Abuladze Natalia, Fedotoff Olga, Kurtz Ira   Regulation of the sodium bicarbonate cotransporter kNBC1 function: role of Asp(986), Asp(988) and kNBC1-carbonic anhydrase II binding The Journal of physiology, 2002; 544(Pt 3): 679-85.
Gross Eitan, Kurtz Ira   Structural determinants and significance of regulation of electrogenic Na(+)-HCO(3)(-) cotransporter stoichiometry American journal of physiology. Renal physiology, 2002; 283(5): F876-87.
Carpenito Gerardo, Kurtz Ira   Green urine in a critically ill patient American journal of kidney diseases : the official journal of the National Kidney Foundation, 2002; 39(4): E20.
Kwon Tae-Hwan, Fulton Christiaan, Wang Weidong, Kurtz Ira, Frøkiaer Jørgen, Aalkjaer Christian, Nielsen Søren   Chronic metabolic acidosis upregulates rat kidney Na-HCO cotransporters NBCn1 and NBC3 but not NBC1 American journal of physiology. Renal physiology, 2002; 282(2): F341-51.
Yip Kay-Pong, Kurtz Ira   Confocal fluorescence microscopy measurements of pH and calcium in living cells Methods in cell biology, 2002; 70(2): 417-27.
Sassani Pejvak, Pushkin Alexander, Gross Eitan, Gomer Alla, Abuladze Natalia, Dukkipati Ramanath, Carpenito Gerardo, Kurtz Ira   Functional characterization of NBC4: a new electrogenic sodium-bicarbonate cotransporter American journal of physiology. Cell physiology, 2002; 282(2): C408-16.