Jeff M. Bronstein, M.D., Ph.D.

Titles

Professor of Molecular Toxicology, Neurology
Member, Brain Research Institute
Center for Neurodegenerative Disease Studies
Neuroengineering Training Program
Neuroscience GPB Home Area
Neuroscience IDP
Faculty, Molecular Toxicology IDP

Awards and Honors:

UCLA School of Medicine Harbor - UCLA Medical Center

Contact Information

Email
jbronste@ucla.edu
Phone
Work Phone Number: (310) 206-9799
Address
Mailing Address: UCLA neuroBOX 951769, A-153 RNRCLos Angeles, CA 90095UNITED STATES

Biography

Jeff Bronstein received his bachelor's degree from the University of California, Berkeley and M.D. and Ph.D. from UCLA as a recipient of the Medical Scientist Training Program Award. He completed a residency in Neurology and fellowship training in Movement Disorders at UCLA. Dr. Bronstein also completed a postdoctoral fellowship in molecular biology before being appointed an Assistant Professor of Neurology. He was later appointed Director of the Movement Disorders Program at UCLA. His interests and expertise include the management of Parkinson's disease (PD) and other movement disorders, surgical treatment of PD, and developing new therapies for patients. Dr. Bronstein was recently awarded one of 6 National Parkinson's Disease Centers at the Veterans Administration Medical Center with the goal of furthering research, education and clinical care in the Southwest US. His laboratory studies the cause of PD using cell models and a newly developed zebrafish model. His work supported by the NIH and private foundations. Dr. Bronstein also directs clinical trials in order to develop new therapies for PD that include transplantation and deep brain stimulation. He has received several awards and is widely published in the field.

Publications:

Rhodes Shannon L, Fitzmaurice Arthur G, Cockburn Myles, Bronstein Jeff M, Sinsheimer Janet S, Ritz Beate   Pesticides that inhibit the ubiquitin-proteasome system: Effect measure modification by genetic variation in SKP1 in Parkinson׳s disease Environmental research, 2013; .
Lee Pei-Chen, Rhodes Shannon L, Sinsheimer Janet S, Bronstein Jeff, Ritz Beate   Functional paraoxonase 1 variants modify the risk of Parkinson's disease due to organophosphate exposure Environment international, 2013; 56: 42-7.
Fitzmaurice Arthur G, Rhodes Shannon L, Lulla Aaron, Murphy Niall P, Lam Hoa A, O'Donnell Kelley C, Barnhill Lisa, Casida John E, Cockburn Myles, Sagasti Alvaro, Stahl Mark C, Maidment Nigel T, Ritz Beate, Bronstein Jeff M   Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease Proceedings of the National Academy of Sciences of the United States of America, 2013; 110(2): 636-41.
Lee Pei-Chen, Bordelon Yvette, Bronstein Jeff, Ritz Beate   Traumatic brain injury, paraquat exposure, and their relationship to Parkinson disease Neurology, 2012; 79(20): 2061-6.
Prabhudesai Shubhangi, Sinha Sharmistha, Attar Aida, Kotagiri Aswani, Fitzmaurice Arthur G, Lakshmanan Rajeswari, Lakshmanan Ravi, Ivanova Magdalena I, Loo Joseph A, Klärner Frank-Gerrit, Schrader Thomas, Stahl Mark, Bitan Gal, Bronstein Jeff M   A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2012; 9(2): 464-76.
Chan Nora, Le Cindy, Shieh Perry, Mozaffar Tahseen, Khare Manaswitha, Bronstein Jeff, Kimonis Virginia   Valosin-containing protein mutation and Parkinson's disease Parkinsonism & related disorders, 2012; 18(1): 107-9.
Ritz Beate, Rhodes Shannon L, Bordelon Yvette, Bronstein Jeff   α-Synuclein genetic variants predict faster motor symptom progression in idiopathic Parkinson disease PloS one, 2012; 7(5): e36199.
Wang Anthony, Costello Sadie, Cockburn Myles, Zhang Xinbo, Bronstein Jeff, Ritz Beate   Parkinson's disease risk from ambient exposure to pesticides European journal of epidemiology, 2011; 26(7): 547-55.
Rhodes Shannon L, Sinsheimer Janet S, Bordelon Yvette, Bronstein Jeff M, Ritz Beate   Replication of GWAS associations for GAK and MAPT in Parkinson's disease Annals of human genetics, 2011; 75(2): 195-200.
Bronstein Jeff M, Tagliati Michele, Alterman Ron L, Lozano Andres M, Volkmann Jens, Stefani Alessandro, Horak Fay B, Okun Michael S, Foote Kelly D, Krack Paul, Pahwa Rajesh, Henderson Jaimie M, Hariz Marwan I, Bakay Roy A, Rezai Ali, Marks William J, Moro Elena, Vitek Jerrold L, Weaver Frances M, Gross Robert E, DeLong Mahlon R   Deep brain stimulation for Parkinson disease: an expert consensus and review of key issues Archives of neurology, 2011; 68(2): 165.
Bordelon Yvette M, Hays Ron D, Vassar Stefanie D, Diaz Natalie, Bronstein Jeff, Vickrey Barbara G   Medication responsiveness of motor symptoms in a population-based study of Parkinson disease Parkinson's disease, 2011; 2011(1): 967839.
Chou Arthur P, Li Sharon, Fitzmaurice Arthur G, Bronstein Jeff M   Mechanisms of rotenone-induced proteasome inhibition Neurotoxicology, 2010; 31(4): 367-72.
Manthripragada Angelika D, Costello Sadie, Cockburn Myles G, Bronstein Jeff M, Ritz Beate   Paraoxonase 1, agricultural organophosphate exposure, and Parkinson disease Epidemiology (Cambridge, Mass.), 2010; 21(1): 87-94.
Gatto Nicole M, Rhodes Shannon L, Manthripragada Angelika D, Bronstein Jeff, Cockburn Myles, Farrer Matt, Ritz Beate   α-Synuclein gene may interact with environmental factors in increasing risk of Parkinson's disease Neuroepidemiology, 2010; 35(3): 191-5.
Gatto Nicole M, Cockburn Myles, Bronstein Jeff, Manthripragada Angelika D, Ritz Beate   Well-water consumption and Parkinson's disease in rural California Environmental health perspectives, 2009; 117(12): 1912-8.
Farag Emad S, Vinters Harry V, Bronstein Jeff   Pathologic findings in retinal pigment epithelial cell implantation for Parkinson disease Neurology, 2009; 73(14): 1095-102.
Ritz Beate R, Manthripragada Angelika D, Costello Sadie, Lincoln Sarah J, Farrer Matthew J, Cockburn Myles, Bronstein Jeff   Dopamine transporter genetic variants and pesticides in Parkinson's disease Environmental health perspectives, 2009; 117(6): 964-9.
Costello Sadie, Cockburn Myles, Bronstein Jeff, Zhang Xinbo, Ritz Beate   Parkinson's disease and residential exposure to maneb and paraquat from agricultural applications in the central valley of California American journal of epidemiology, 2009; 169(8): 919-26.
Bronstein Jeff, Carvey Paul, Chen Honglei, Cory-Slechta Deborah, DiMonte Donato, Duda John, English Paul, Goldman Samuel, Grate Stephen, Hansen Johnni, Hoppin Jane, Jewell Sarah, Kamel Freya, Koroshetz Walter, Langston James W, Logroscino Giancarlo, Nelson Lorene, Ravina Bernard, Rocca Walter, Ross George W, Schettler Ted, Schwarzschild Michael, Scott Bill, Seegal Richard, Singleton Andrew, Steenland Kyle, Tanner Caroline M, Van Den Eeden Stephen, Weisskopf Marc   Meeting report: consensus statement-Parkinson's disease and the environment: collaborative on health and the environment and Parkinson's Action Network (CHE PAN) conference 26-28 June 2007 Environmental health perspectives, 2009; 117(1): 117-21.
Chou Arthur P, Maidment Nigel, Klintenberg Rebecka, Casida John E, Li Sharon, Fitzmaurice Arthur G, Fernagut Pierre-Olivier, Mortazavi Farzad, Chesselet Marie-Francoise, Bronstein Jeff M   Ziram causes dopaminergic cell damage by inhibiting E1 ligase of the proteasome The Journal of biological chemistry, 2008; 283(50): 34696-703.
Wahner Angelika D, Bronstein Jeff M, Bordelon Yvette M, Ritz Beate   Statin use and the risk of Parkinson disease Neurology, 2008; 70(16 Pt 2): 1418-22.
Wahner Angelika D, Bronstein Jeff M, Bordelon Yvette M, Ritz Beate   Nonsteroidal anti-inflammatory drugs may protect against Parkinson disease Neurology, 2007; 69(19): 1836-42.
Wahner Angelika D, Sinsheimer Janet S, Bronstein Jeff M, Ritz Beate   Inflammatory cytokine gene polymorphisms and increased risk of Parkinson disease Archives of neurology, 2007; 64(6): 836-40.
Wahner Angelika D, Glatt Charles E, Bronstein Jeff M, Ritz Beate   Glutathione S-transferase mu, omega, pi, and theta class variants and smoking in Parkinson's disease Neuroscience letters, 2007; 413(3): 274-8.
Tiwari-Woodruff Seema, Beltran-Parrazal Luis, Charles Andrew, Keck Thomas, Vu Trung, Bronstein Jeff   K+ channel KV3.1 associates with OSP/claudin-11 and regulates oligodendrocyte development American journal of physiology. Cell physiology, 2006; 291(4): C687-98.
Wang Xue-Feng, Li Sharon, Chou Arthur P, Bronstein Jeff M   Inhibitory effects of pesticides on proteasome activity: implication in Parkinson's disease Neurobiology of disease, 2006; 23(1): 198-205.
Bronstein Jeff M, Chou Arthur P   Peripheral proteasome and caspase activity in Parkinson disease and Alzheimer disease Neurology, 2006; 67(1): 182; author reply 182.
Follett Kenneth, Weaver Frances, Stern Matthew, Marks William, Hogarth Penelope, Holloway Katherine, Bronstein Jeff, Duda John, Horn Stacy, Lai Eugene, Samii Ali   Multisite randomized trial of deep brain stimulation Archives of neurology, 2005; 62(10): 1643-4; author reply 1644-5.
Kang Gail A, Bronstein Jeff M, Masterman Donna L, Redelings Matthew, Crum Jarrod A, Ritz Beate   Clinical characteristics in early Parkinson's disease in a central California population-based study Movement disorders : official journal of the Movement Disorder Society, 2005; 20(9): 1133-42.
Bhidayasiri Roongroj, Bronstein Jeff M, Sinha Shantanu, Krahl Scott E, Ahn Sinyeob, Behnke Eric J, Cohen Mark S, Frysinger Robert, Shellock Frank G   Bilateral neurostimulation systems used for deep brain stimulation: in vitro study of MRI-related heating at 1.5 T and implications for clinical imaging of the brain Magnetic resonance imaging, 2005; 23(4): 549-55.
Bhidayasiri Roongroj, Bronstein Jeff M   Improvement of cervical dystonia: possible role of transcranial magnetic stimulation simulating sensory tricks effect Medical hypotheses, 2005; 64(5): 941-5.
Diaz Natalie, Bronstein Jeff M   Parkinson's Disease Research Education and Clinical Centers (PADRECC): background and overview NeuroRehabilitation, 2005; 20(3): 153-60.
Bhidayasiri Roongroj, Miyata Hajime, Bronstein Jeff M, Schweitzer Jeffrey, Saber Peter A, Vinters Harry V   Postmortem analysis of pallidotomy in Parkinson's disease Journal of neurology, 2005; 252(1): 100-2.
Tiwari-Woodruff Seema K, Kaplan Roman, Kornblum Harley I, Bronstein Jeff M   Developmental expression of OAP-1/Tspan-3, a member of the tetraspanin superfamily Journal of neuroscience research, 2004; 77(2): 166-73.
Kang Gail A, Bronstein Jeff M   Psychosis in nursing home patients with Parkinson's disease Journal of the American Medical Directors Association, 2004; 5(3): 167-73.
Sage Jennifer R, Anagnostaras Stephan G, Mitchell Shawn, Bronstein Jeff M, De Salles Antonio, Masterman Donna, Knowlton Barbara J   Analysis of probabilistic classification learning in patients with Parkinson's disease before and after pallidotomy surgery Learning & memory (Cold Spring Harbor, N.Y.), 2003; 10(3): 226-36.
Bryant Joshua A, De Salles Antonio, Cabatan Cynthia, Frysinger Robert, Behnke Eric, Bronstein Jeff   The impact of thalamic stimulation on activities of daily living for essential tremor Surgical neurology, 2003; 59(6): 479-84; discussion 484-5.
Subramanian Indu, Vanek Zeba F, Bronstein Jeff M   Diagnosis and treatment of Wilson's disease Current neurology and neuroscience reports, 2002; 2(4): 317-23.
Liau Linda M, Jensen Eric R, Kremen Thomas J, Odesa Sylvia K, Sykes Steven N, Soung Michael C, Miller Jeff F, Bronstein Jeff M   Tumor immunity within the central nervous system stimulated by recombinant Listeria monocytogenes vaccination Cancer research, 2002; 62(8): 2287-93.