Biography
Jeff Bronstein received his bachelor's degree from the University of California, Berkeley and M.D. and Ph.D. from UCLA as a recipient of the Medical Scientist Training Program Award. He completed a residency in Neurology and fellowship training in Movement Disorders at UCLA. Dr. Bronstein also completed a postdoctoral fellowship in molecular biology before being appointed an Assistant Professor of Neurology. He was later appointed Director of the Movement Disorders Program at UCLA.
His interests and expertise include the management of Parkinson's disease (PD) and other movement disorders, surgical treatment of PD, and developing new therapies for patients. Dr. Bronstein was recently awarded one of 6 National Parkinson's Disease Centers at the Veterans Administration Medical Center with the goal of furthering research, education and clinical care in the Southwest US. His laboratory studies the cause of PD using cell models and a newly developed zebrafish model. His work supported by the NIH and private foundations. Dr. Bronstein also directs clinical trials in order to develop new therapies for PD that include transplantation and deep brain stimulation. He has received several awards and is widely published in the field.
Publications
A selected list of publications:
Bronstein Jeff M, Tagliati Michele, McIntyre Cameron, Chen Robert, Cheung Tyler, Hargreaves Eric L, Israel Zvi, Moffitt Michael, Montgomery Erwin B, Stypulkowski Paul, Shils Jay, Denison Timothy, Vitek Jerrold, Volkman Jens, Wertheimer Jeffrey, Okun Michael S
The rationale driving the evolution of deep brain stimulation to
constant-current devices
Neuromodulation : journal of the International Neuromodulation Society,
2015; 18(2):
85-8; discussion 88-9.
Bronstein Jeff M, Fitzmaurice Arthur
Author response
Neurology,
2014; 83(20):
1879-80.
Rhodes Shannon L, Buchanan Daniel D, Ahmed Ismaïl, Taylor Kent D, Loriot Marie-Anne, Sinsheimer Janet S, Bronstein Jeff M, Elbaz Alexis, Mellick George D, Rotter Jerome I, Ritz Beate
Pooled analysis of iron-related genes in Parkinson's disease:
association with transferrin
Neurobiology of disease,
2014; 62(5):
172-8.
Fitzmaurice Arthur G, Rhodes Shannon L, Lulla Aaron, Murphy Niall P, Lam Hoa A, O'Donnell Kelley C, Barnhill Lisa, Casida John E, Cockburn Myles, Sagasti Alvaro, Stahl Mark C, Maidment Nigel T, Ritz Beate, Bronstein Jeff M
Aldehyde dehydrogenase inhibition as a pathogenic mechanism in
Parkinson disease
Proceedings of the National Academy of Sciences of the United States of America,
2013; 110(2):
636-41.
Weaver Frances M, Follett Kenneth A, Stern Matthew, Luo Ping, Harris Crystal L, Hur Kwan, Marks William J, Rothlind Johannes, Sagher Oren, Moy Claudia, Pahwa Rajesh, Burchiel Kim, Hogarth Penelope, Lai Eugene C, Duda John E, Holloway Kathryn, Samii Ali, Horn Stacy, Bronstein Jeff M, Stoner Gatana, Starr Philip A, Simpson Richard, Baltuch Gordon, De Salles Antonio, Huang Grant D, Reda Domenic J, Reda Domenic J
Randomized trial of deep brain stimulation for Parkinson disease:
thirty-six-month outcomes
Neurology,
2012; 79(1):
55-65.
Prabhudesai Shubhangi, Sinha Sharmistha, Attar Aida, Kotagiri Aswani, Fitzmaurice Arthur G, Lakshmanan Rajeswari, Lakshmanan Ravi, Ivanova Magdalena I, Loo Joseph A, Klärner Frank-Gerrit, Schrader Thomas, Stahl Mark, Bitan Gal, Bronstein Jeff M
A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in
vitro and in vivo
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics,
2012; 9(2):
464-76.
Bronstein Jeff M, Tagliati Michele, Alterman Ron L, Lozano Andres M, Volkmann Jens, Stefani Alessandro, Horak Fay B, Okun Michael S, Foote Kelly D, Krack Paul, Pahwa Rajesh, Henderson Jaimie M, Hariz Marwan I, Bakay Roy A, Rezai Ali, Marks William J, Moro Elena, Vitek Jerrold L, Weaver Frances M, Gross Robert E, DeLong Mahlon R
Deep brain stimulation for Parkinson disease: an expert consensus and
review of key issues
Archives of neurology,
2011; 68(2):
165.
Rosenbloom Barry, Balwani Manisha, Bronstein Jeff M, Kolodny Edwin, Sathe Swati, Gwosdow Andrea R, Taylor John S, Cole J Alexander, Zimran Ari, Weinreb Neal J
The incidence of Parkinsonism in patients with type 1 Gaucher disease:
data from the ICGG Gaucher Registry
Blood cells, molecules & diseases,
2011; 46(1):
95-102.
Follett Kenneth A, Weaver Frances M, Stern Matthew, Hur Kwan, Harris Crystal L, Luo Ping, Marks William J, Rothlind Johannes, Sagher Oren, Moy Claudia, Pahwa Rajesh, Burchiel Kim, Hogarth Penelope, Lai Eugene C, Duda John E, Holloway Kathryn, Samii Ali, Horn Stacy, Bronstein Jeff M, Stoner Gatana, Starr Philip A, Simpson Richard, Baltuch Gordon, De Salles Antonio, Huang Grant D, Reda Domenic J, Reda Domenic J
Pallidal versus subthalamic deep-brain stimulation for Parkinson's
disease
The New England journal of medicine,
2010; 362(22):
2077-91.
Plaitakis Andreas, Latsoudis Helen, Kanavouras Konstantinos, Ritz Beate, Bronstein Jeff M, Skoula Irene, Mastorodemos Vasileios, Papapetropoulos Spyridon, Borompokas Nikolas, Zaganas Ioannis, Xiromerisiou Georgia, Hadjigeorgiou George M, Spanaki Cleanthe
Gain-of-function variant in GLUD2 glutamate dehydrogenase modifies
Parkinson's disease onset
European journal of human genetics : EJHG,
2010; 18(3):
336-41.
Weaver Frances M, Follett Kenneth, Stern Matthew, Hur Kwan, Harris Crystal, Marks William J, Rothlind Johannes, Sagher Oren, Reda Domenic, Moy Claudia S, Pahwa Rajesh, Burchiel Kim, Hogarth Penelope, Lai Eugene C, Duda John E, Holloway Kathryn, Samii Ali, Horn Stacy, Bronstein Jeff, Stoner Gatana, Heemskerk Jill, Huang Grant D, Huang Grant D
Bilateral deep brain stimulation vs best medical therapy for patients
with advanced Parkinson disease: a randomized controlled trial
JAMA,
2009; 301(1):
63-73.
Bronstein Jeff, Carvey Paul, Chen Honglei, Cory-Slechta Deborah, DiMonte Donato, Duda John, English Paul, Goldman Samuel, Grate Stephen, Hansen Johnni, Hoppin Jane, Jewell Sarah, Kamel Freya, Koroshetz Walter, Langston James W, Logroscino Giancarlo, Nelson Lorene, Ravina Bernard, Rocca Walter, Ross George W, Schettler Ted, Schwarzschild Michael, Scott Bill, Seegal Richard, Singleton Andrew, Steenland Kyle, Tanner Caroline M, Van Den Eeden Stephen, Weisskopf Marc
Meeting report: consensus statement-Parkinson's disease and the
environment: collaborative on health and the environment and
Parkinson's Action Network (CHE PAN) conference 26-28 June 2007
Environmental health perspectives,
2009; 117(1):
117-21.
Chou Arthur P, Maidment Nigel, Klintenberg Rebecka, Casida John E, Li Sharon, Fitzmaurice Arthur G, Fernagut Pierre-Olivier, Mortazavi Farzad, Chesselet Marie-Francoise, Bronstein Jeff M
Ziram causes dopaminergic cell damage by inhibiting E1 ligase of the
proteasome
The Journal of biological chemistry,
2008; 283(50):
34696-703.
Follett Kenneth, Weaver Frances, Stern Matthew, Marks William, Hogarth Penelope, Holloway Katherine, Bronstein Jeff, Duda John, Horn Stacy, Lai Eugene, Samii Ali
Multisite randomized trial of deep brain stimulation
Archives of neurology,
2005; 62(10):
1643-4; author reply 1644-5.