Jennifer S. Labus, Ph.D.

Titles

Member, Brain Research Institute
Adjunct Associate Professor, Digestive Diseases/Gastroenterology

Contact Information

Email
jlabus@ucla.edu
Phone
Fax Number: (310) 825-1919Work Phone Number: (310) 2060738
Address
Mailing Address: 10833 Le Conte AvenueMC 737818Los Angeles, CA 90095UNITED STATES

Biography

Dr. Jennifer S Labus is an Adjunct Associate Professor in the David GeffenSchool of Medicine at University of California, Los Angeles. She is an investigator and Director for the Neuroimaging and Bioinformatics Core in the Oppenheimer Family Center for Neurobiology of Stress at UCLA. Her research is focused on the interface of stress, pain and emotions and its influence on the role of dysregulation in the pathophysiology of common chronic pain disorders. She has unique expertise in applying advanced statistical and computational technologies to analyze multimodal brain imaging data. She has made seminal contributions to mapping neural networks underlying visceral pain. Dr. Labus’s current research focus lies in applying a biological system based approach using bioinformatics, network analyses, supervised and unsupervised machine learning tools to integrate multimodal brain imaging data with other large scale biological data sets including genetics and metabolomics. This research provides the means to integrate and decipher large amounts of multivariate neuroimaging data to subgroup patients based on objective biological markers, and characterize central nervous system alterations for further pathophysiological investigations targeting treatment of chronic pain and obesity. She has been the recipient of a K08 Career Development award, “Effective connectivity of central response in irritable bowel disorder”, from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) as well as a RO3 award examining the role of altered attention and emotional arousal networks in IBS. Recently, acting as lead Co-Primary investigator she was awarded R01 funding by the National Institute of Childhood Health and Human Development (NICHD) to use brain imaging data, along with genetic, physiological and biological data, to extensively phenotype women with vulvodynia. Dr. Labus is a co-investigator on several NIH funded grants, international research collaborations, and is actively involved in mentoring graduate students and postdoctoral fellows. As a result of her work she was awarded the Master’s Award in Gastroenterology in 2010 for her outstanding achievements in Basic and Clinical Digestive Sciences. Dr. Labus was also the recipient of the American College of Neuropsychopharmacolgy Travel Award in 2013.

Publications:

Labus Jennifer S, Van Horn John D, Gupta Arpana, Alaverdyan Mher, Torgerson Carinna, Ashe-McNalley Cody, Irimia Andrei, Hong Jui-Yang, Naliboff Bruce, Tillisch Kirsten, Mayer Emeran A   Multivariate morphological brain signatures predict patients with chronic abdominal pain from healthy control subjects Pain, 2015; 156(8): 1545-54.
Gupta Arpana, Rapkin Andrea J, Gill Zafar, Kilpatrick Lisa, Fling Connor, Stains Jean, Masghati Salome, Tillisch Kirsten, Mayer Emeran A, Labus Jennifer S   Disease-related differences in resting-state networks: a comparison between localized provoked vulvodynia, irritable bowel syndrome, and healthy control subjects Pain, 2015; 156(5): 809-19.
Martucci Katherine T, Shirer William R, Bagarinao Epifanio, Johnson Kevin A, Farmer Melissa A, Labus Jennifer S, Apkarian A Vania, Deutsch Georg, Harris Richard E, Mayer Emeran A, Clauw Daniel J, Greicius Michael D, Mackey Sean C   The Posterior Medial Cortex in Urologic Chronic Pelvic Pain Syndrome: Detachment from Default Mode Network. A Resting-State Study from the MAPP Research Network Pain, 2015; 156(8): .
Labus Jennifer S, Naliboff Bruce, Kilpatrick Lisa, Liu Cathy, Ashe-McNalley Cody, Dos Santos Ivani R, Alaverdyan Mher, Woodworth Davis, Gupta Arpana, Ellingson Benjamin M, Tillisch Kirsten, Mayer Emeran A   Pain and Interoception Imaging Network (PAIN): A multimodal, multisite, brain-imaging repository for chronic somatic and visceral pain disorders NeuroImage, 2015; 156(5): .
Kutch Jason J, Yani Moheb S, Asavasopon Skulpan, Kirages Daniel J, Rana Manku, Cosand Louise, Labus Jennifer S, Kilpatrick Lisa A, Ashe-McNalley Cody, Farmer Melissa A, Johnson Kevin A, Ness Timothy J, Deutsch Georg, Harris Richard E, Apkarian A Vania, Clauw Daniel J, Mackey Sean C, Mullins Chris, Mayer Emeran A   Altered resting state neuromotor connectivity in men with chronic prostatitis/chronic pelvic pain syndrome: A MAPP: Research Network Neuroimaging Study NeuroImage. Clinical, 2015; 8(1): 493-502.
Kairys Anson E, Schmidt-Wilcke Tobias, Puiu Tudor, Ichesco Eric, Labus Jennifer S, Martucci Katherine, Farmer Melissa A, Ness Timothy J, Deutsch Georg, Mayer Emeran A, Mackey Sean, Apkarian A Vania, Maravilla Kenneth, Clauw Daniel J, Harris Richard E   Increased brain gray matter in the primary somatosensory cortex is associated with increased pain and mood disturbance in patients with interstitial cystitis/painful bladder syndrome The Journal of urology, 2015; 193(1): 131-7.
Gupta Arpana, Labus Jennifer, Kilpatrick Lisa A, Bonyadi Mariam, Ashe-McNalley Cody, Heendeniya Nuwanthi, Bradesi Sylvie, Chang Lin, Mayer Emeran A   Interactions of early adversity with stress-related gene polymorphisms impact regional brain structure in females Brain structure & function, 2015; 56(2 Suppl 2): .
Gupta Arpana, Mayer Emeran A, Sanmiguel Claudia P, Van Horn John D, Woodworth Davis, Ellingson Benjamin M, Fling Connor, Love Aubrey, Tillisch Kirsten, Labus Jennifer S   Patterns of brain structural connectivity differentiate normal weight from overweight subjects NeuroImage. Clinical, 2015; 7(1): 506-17.
Kilpatrick Lisa A, Mayer Emeran A, Labus Jennifer S, Gupta Arpana, Hamaguchi Toyohiro, Mizuno Tomoko, Komuro Hazuki, Kano Michiko, Kanazawa Motoyori, Aoki Masashi, Fukudo Shin   Serotonin Transporter Gene Polymorphism Modulates Activity and Connectivity within an Emotional Arousal Network of Healthy Men during an Aversive Visceral Stimulus PloS one, 2015; 10(4): e0123183.
Bagarinao Epifanio, Johnson Kevin A, Martucci Katherine T, Ichesco Eric, Farmer Melissa A, Labus Jennifer, Ness Timothy J, Harris Richard, Deutsch Georg, Apkarian A Vania, Mayer Emeran A, Clauw Daniel J, Mackey Sean   Preliminary structural MRI based brain classification of chronic pelvic pain: A MAPP network study Pain, 2014; 155(12): 2502-9.
Hong Jui-Yang, Kilpatrick Lisa A, Labus Jennifer S, Gupta Arpana, Katibian David, Ashe-McNalley Cody, Stains Jean, Heendeniya Nuwanthi, Smith Suzanne R, Tillisch Kirsten, Naliboff Bruce, Mayer Emeran A   Sex and disease-related alterations of anterior insula functional connectivity in chronic abdominal pain The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014; 34(43): 14252-9.
Kilpatrick Lisa A, Kutch Jason J, Tillisch Kirsten, Naliboff Bruce D, Labus Jennifer S, Jiang Zhiguo, Farmer Melissa A, Apkarian A Vania, Mackey Sean, Martucci Katherine T, Clauw Daniel J, Harris Richard E, Deutsch Georg, Ness Timothy J, Yang Claire C, Maravilla Kenneth, Mullins Chris, Mayer Emeran A   Alterations in resting state oscillations and connectivity in sensory and motor networks in women with interstitial cystitis/painful bladder syndrome The Journal of urology, 2014; 192(3): 947-55.
Gupta Arpana, Kilpatrick Lisa, Labus Jennifer, Tillisch Kirsten, Braun Adam, Hong Jui-Yang, Ashe-McNalley Cody, Naliboff Bruce, Mayer Emeran A   Early adverse life events and resting state neural networks in patients with chronic abdominal pain: evidence for sex differences Psychosomatic medicine, 2014; 76(6): 404-12.
Dinov Ivo D, Petrosyan Petros, Liu Zhizhong, Eggert Paul, Zamanyan Alen, Torri Federica, Macciardi Fabio, Hobel Sam, Moon Seok Woo, Sung Young Hee, Jiang Zhiguo, Labus Jennifer, Kurth Florian, Ashe-McNalley Cody, Mayer Emeran, Vespa Paul M, Van Horn John D, Toga Arthur W, Toga Arthur W   The perfect neuroimaging-genetics-computation storm: collision of petabytes of data, millions of hardware devices and thousands of software tools Brain imaging and behavior, 2014; 8(2): 311-22.
Saigo Tatsuo, Tayama Jun, Hamaguchi Toyohiro, Nakaya Naoki, Tomiie Tadaaki, Bernick Peter J, Kanazawa Motoyori, Labus Jennifer S, Naliboff Bruce D, Shirabe Susumu, Fukudo Shin   Gastrointestinal specific anxiety in irritable bowel syndrome: validation of the Japanese version of the visceral sensitivity index for university students BioPsychoSocial medicine, 2014; 8(1): 10.
Kilpatrick Lisa A, Coveleskie Kristen, Connolly Lynn, Labus Jennifer S, Ebrat Bahar, Stains Jean, Jiang Zhiguo, Suyenobu Brandall Y, Raybould Helen E, Tillisch Kirsten, Mayer Emeran A   Influence of sucrose ingestion on brainstem and hypothalamic intrinsic oscillations in lean and obese women Gastroenterology, 2014; 146(5): 1212-21.
Tillisch Kirsten, Labus Jennifer S   Neuroimaging the microbiome-gut-brain axis Advances in experimental medicine and biology, 2014; 817(1): 405-16.
Labus Jennifer S, Dinov Ivo D, Jiang Zhiguo, Ashe-McNalley Cody, Zamanyan Alen, Shi Yonggang, Hong Jui-Yang, Gupta Arpana, Tillisch Kirsten, Ebrat Bahar, Hobel Sam, Gutman Boris A, Joshi Shantanu, Thompson Paul M, Toga Arthur W, Mayer Emeran A   Irritable bowel syndrome in female patients is associated with alterations in structural brain networks Pain, 2014; 155(1): 137-49.
Hong Jui-Yang, Labus Jennifer S, Jiang Zhiguo, Ashe-Mcnalley Cody, Dinov Ivo, Gupta Arpana, Shi Yonggang, Stains Jean, Heendeniya Nuwanthi, Smith Suzanne R, Tillisch Kirsten, Mayer Emeran A   Regional neuroplastic brain changes in patients with chronic inflammatory and non-inflammatory visceral pain PloS one, 2014; 9(1): e84564.
Labus Jennifer S, Hubbard Catherine S, Bueller Joshua, Ebrat Bahar, Tillisch Kirsten, Chen Michelle, Stains Jean, Dukes George E, Kelleher Dennis L, Naliboff Bruce D, Fanselow Michael, Mayer Emeran A   Impaired emotional learning and involvement of the corticotropin-releasing factor signaling system in patients with irritable bowel syndrome Gastroenterology, 2013; 145(6): 1253-61.e1-3.
Labus Jennifer S, Gupta Arpana, Coveleskie Kristen, Tillisch Kirsten, Kilpatrick Lisa, Jarcho Johanna, Feier Natasha, Bueller Joshua, Stains Jean, Smith Suzanne, Suyenobu Brandall, Naliboff Bruce, Mayer Emeran A   Sex differences in emotion-related cognitive processes in irritable bowel syndrome and healthy control subjects Pain, 2013; 154(10): 2088-99.
Ellingson Benjamin M, Mayer Emeran, Harris Robert J, Ashe-McNally Cody, Naliboff Bruce D, Labus Jennifer S, Tillisch Kirsten   Diffusion tensor imaging detects microstructural reorganization in the brain associated with chronic irritable bowel syndrome Pain, 2013; 154(9): 1528-41.
Jarcho Johanna M, Feier Natasha A, Bert Alberto, Labus Jennifer A, Lee Maunoo, Stains Jean, Ebrat Bahar, Groman Stephanie M, Tillisch Kirsten, Brody Arthur L, London Edythe D, Mandelkern Mark A, Mayer Emeran A   Diminished neurokinin-1 receptor availability in patients with two forms of chronic visceral pain Pain, 2013; 154(7): 987-96.
Hong Jui-Yang, Kilpatrick Lisa A, Labus Jennifer, Gupta Arpana, Jiang Zhiguo, Ashe-McNalley Cody, Stains Jean, Heendeniya Nuwanthi, Ebrat Bahar, Smith Suzanne, Tillisch Kirsten, Naliboff Bruce, Mayer Emeran A   Patients with chronic visceral pain show sex-related alterations in intrinsic oscillations of the resting brain The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013; 33(29): 11994-2002.
Tillisch Kirsten, Labus Jennifer, Kilpatrick Lisa, Jiang Zhiguo, Stains Jean, Ebrat Bahar, Guyonnet Denis, Legrain-Raspaud Sophie, Trotin Beatrice, Naliboff Bruce, Mayer Emeran A   Consumption of fermented milk product with probiotic modulates brain activity Gastroenterology, 2013; 144(7): 1394-401, 1401.e1-4.
Jiang Zhiguo, Dinov Ivo D, Labus Jennifer, Shi Yonggang, Zamanyan Alen, Gupta Arpana, Ashe-McNalley Cody, Hong Jui-Yang, Tillisch Kirsten, Toga Arthur W, Mayer Emeran A   Sex-related differences of cortical thickness in patients with chronic abdominal pain PloS one, 2013; 8(9): e73932.
Berman Steven, Suyenobu Brandall, Naliboff Bruce D, Bueller Joshua, Stains Jean, Wong Heng, Mandelkern Mark, Fitzgerald Leah, Ohning Gordon, Gupta Arpana, Labus Jennifer S, Tillisch Kirsten, Mayer Emeran A   Evidence for alterations in central noradrenergic signaling in irritable bowel syndrome NeuroImage, 2012; 63(4): 1854-63.
Wolitzky-Taylor Kate, Craske Michelle G, Labus Jennifer S, Mayer Emeran A, Naliboff Bruce D   Visceral sensitivity as a mediator of outcome in the treatment of irritable bowel syndrome Behaviour research and therapy, 2012; 50(10): 647-50.
Larsson Mats B O, Tillisch Kirsten, Craig A D, Engström Maria, Labus Jennifer, Naliboff Bruce, Lundberg Peter, Ström Magnus, Mayer Emeran A, Walter Susanna A   Brain responses to visceral stimuli reflect visceral sensitivity thresholds in patients with irritable bowel syndrome Gastroenterology, 2012; 142(3): 463-472.e3.
Hubbard Catherine S, Labus Jennifer S, Bueller Joshua, Stains Jean, Suyenobu Brandall, Dukes George E, Kelleher Dennis L, Tillisch Kirsten, Naliboff Bruce D, Mayer Emeran A   Corticotropin-releasing factor receptor 1 antagonist alters regional activation and effective connectivity in an emotional-arousal circuit during expectation of abdominal pain The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011; 31(35): 12491-500.
Hubbard Catherine S, Ornitz Edward, Gaspar John X, Smith Suzanne, Amin Jenny, Labus Jennifer S, Kilpatrick Lisa A, Rhudy Jamie L, Mayer Emeran A, Naliboff Bruce D   Modulation of nociceptive and acoustic startle responses to an unpredictable threat in men and women Pain, 2011; 152(7): 1632-40.
Craske Michelle G, Wolitzky-Taylor Kate B, Labus Jennifer, Wu Stephen, Frese Michael, Mayer Emeran A, Naliboff Bruce D   A cognitive-behavioral treatment for irritable bowel syndrome using interoceptive exposure to visceral sensations Behaviour research and therapy, 2011; 49(6-7): 413-21.
Kilpatrick Lisa A, Labus Jennifer S, Coveleskie Kristen, Hammer Christian, Rappold Gudrun, Tillisch Kirsten, Bueller Joshua A, Suyenobu Brandall, Jarcho Johana M, McRoberts Jim A, Niesler Beate, Mayer Emeran A   The HTR3A polymorphism c. -42C>T is associated with amygdala responsiveness in patients with irritable bowel syndrome Gastroenterology, 2011; 140(7): 1943-51.
Anderson Ariana, Labus Jennifer S, Vianna Eduardo P, Mayer Emeran A, Cohen Mark S   Common component classification: what can we learn from machine learning? NeuroImage, 2011; 56(2): 517-24.
Tillisch Kirsten, Labus Jennifer S   Advances in imaging the brain-gut axis: functional gastrointestinal disorders Gastroenterology, 2011; 140(2): 407-411.e1.
Tillisch Kirsten, Mayer Emeran A, Labus Jennifer S   Quantitative meta-analysis identifies brain regions activated during rectal distension in irritable bowel syndrome Gastroenterology, 2011; 140(1): 91-100.
Seminowicz David A, Labus Jennifer S, Bueller Joshua A, Tillisch Kirsten, Naliboff Bruce D, Bushnell M Catherine, Mayer Emeran A   Regional gray matter density changes in brains of patients with irritable bowel syndrome Gastroenterology, 2010; 139(1): 48-57.e2.
Labus Jennifer S, Naliboff Bruce D, Berman Steve M, Suyenobu Brandall, Vianna Eduardo P, Tillisch Kirsten, Mayer Emeran A   Brain networks underlying perceptual habituation to repeated aversive visceral stimuli in patients with irritable bowel syndrome NeuroImage, 2009; 47(3): 952-60.
Wang Zhuo, Guo Yumei, Bradesi Sylvie, Labus Jennifer S, Maarek Jean-Michel I, Lee Kevin, Winchester Wendy J, Mayer Emeran A, Holschneider Daniel P   Sex differences in functional brain activation during noxious visceral stimulation in rats Pain, 2009; 145(1-2): 120-8.
Naliboff Bruce D, Waters Allison M, Labus Jennifer S, Kilpatrick Lisa, Craske Michelle G, Chang Lin, Negoro Hideki, Ibrahimovic Hana, Mayer Emeran A, Ornitz Edward   Increased acoustic startle responses in IBS patients during abdominal and nonabdominal threat Psychosomatic medicine, 2008; 70(8): 920-7.
Berman Steven M, Naliboff Bruce D, Suyenobu Brandall, Labus Jennifer S, Stains Jean, Ohning Gordon, Kilpatrick Lisa, Bueller Joshua A, Ruby Kim, Jarcho Johanna, Mayer Emeran A   Reduced brainstem inhibition during anticipated pelvic visceral pain correlates with enhanced brain response to the visceral stimulus in women with irritable bowel syndrome The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008; 28(2): 349-59.
Labus Jennifer S, Mayer Emeran A, Chang Lin, Bolus Roger, Naliboff Bruce D   The central role of gastrointestinal-specific anxiety in irritable bowel syndrome: further validation of the visceral sensitivity index Psychosomatic medicine, 2007; 69(1): 89-98.
Chang Lin, Mayer Emeran A, Labus Jennifer S, Schmulson Max, Lee Oh Young, Olivas Teresa I, Stains Jean, Naliboff Bruce D   Effect of sex on perception of rectosigmoid stimuli in irritable bowel syndrome American journal of physiology. Regulatory, integrative and comparative physiology, 2006; 291(2): R277-84.
Naliboff Bruce D, Berman Steve, Suyenobu Brandall, Labus Jennifer S, Chang Lin, Stains Jean, Mandelkern Mark A, Mayer Emeran A   Longitudinal change in perceptual and brain activation response to visceral stimuli in irritable bowel syndrome patients Gastroenterology, 2006; 131(2): 352-65.
Mayer Emeran A, Berman Steven, Suyenobu Brandall, Labus Jennifer, Mandelkern Mark A, Naliboff Bruce D, Chang Lin   Differences in brain responses to visceral pain between patients with irritable bowel syndrome and ulcerative colitis Pain, 2005; 115(3): 398-409.
Tillisch Kirsten, Labus Jennifer S, Naliboff Bruce D, Bolus Roger, Shetzline Michael, Mayer Emeran A, Chang Lin   Characterization of the alternating bowel habit subtype in patients with irritable bowel syndrome The American journal of gastroenterology, 2005; 100(4): 896-904.
Labus Jennifer S, Keefe Francis J, Jensen Mark P   Self-reports of pain intensity and direct observations of pain behavior: when are they correlated? Pain, 2003; 102(1-2): 109-24.