Jie Zheng, Ph.D.

Titles

Professor, Ophthalmology

Member, CTSI

Contact Information

Email
jzheng@jsei.ucla.edu
Phone
Work Phone Number: (310) 206-2173
Address

Office Address:

CHS BH-973B
Los Angeles, CA 90095
UNITED STATES

Publications

Tran Freddi Huan, Zheng Jie J   Modulating the Wnt signaling pathway with small molecules Protein science : a publication of the Protein Society, 2017; .
Young Alejandra, Dandekar Uma, Pan Calvin, Sader Avery, Zheng Jie J, Lewis Richard A, Farber Debora B   GNAI3: Another Candidate Gene to Screen in Persons with Ocular Albinism PloS one, 2016; 11(9): e0162273.
Bao Ju, Marathe Bindumadhav, Govorkova Elena A, Zheng Jie J   Drug Repurposing Identifies Inhibitors of Oseltamivir-Resistant Influenza Viruses Angewandte Chemie (International ed. in English), 2016; 128(10): 3499–3502.
Bari Rafijul, Thapa Rajoo, Bao Ju, Li Ying, Zheng Jie, Leung Wing   KIR2DL2/2DL3-E(35) alleles are functionally stronger than -Q(35) alleles Scientific reports, 2016; 6(1): 23689.
Vanarotti Murugendra S, Finkelstein David B, Guibao Cristina D, Nourse Amanda, Miller Darcie J, Zheng Jie J   Structural basis for the interaction between Pyk2-FAT domain and Leupaxin LD repeats Biochemistry, 2016; 146: .
Morgan Jessica A, Lynch John, Panetta John C, Wang Yao, Frase Sharon, Bao Ju, Zheng Jie, Opferman Joseph T, Janke Laura, Green Daniel M, Chemaitilly Wassim, Schuetz John D   Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death Scientific reports, 2015; 5: 16488.
Lee Ho-Jin, Shi De-Li, Zheng Jie J   Conformational change of Dishevelled plays a key regulatory role in the Wnt signaling pathways eLife, 2015; 4: e08142.
Lee Ho-Jin, Bao Ju, Miller Ami, Zhang Chi, Wu Jibo, Baday Yiressy C, Guibao Cristina, Li Lin, Wu Dianqing, Zheng Jie J   Structure-based discovery of novel small molecule Wnt signaling inhibitors by targeting the cysteine rich domain of Frizzled The Journal of biological chemistry, 2015; 290(51): 30596-606.
Diouf Barthelemy, Crews Kristine R, Lew Glen, Pei Deqing, Cheng Cheng, Bao Ju, Zheng Jie J, Yang Wenjian, Fan Yiping, Wheeler Heather E, Wing Claudia, Delaney Shannon M, Komatsu Masaaki, Paugh Steven W, McCorkle Joseph Robert, Lu Xiaomin, Winick Naomi J, Carroll William L, Loh Mignon L, Hunger Stephen P, Devidas Meenakshi, Pui Ching-Hon, Dolan M Eileen, Relling Mary V, Evans William E   Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia JAMA, 2015; 313(8): 815-23.
Vanarotti Murugendra S, Miller Darcie J, Guibao Cristina D, Nourse Amanda, Zheng Jie J   Structural and mechanistic insights into the interaction between Pyk2 and paxillin LD motifs Journal of molecular biology, 2014; 426(24): 3985-4001.
Brown Nicholas G, Watson Edmond R, Weissmann Florian, Jarvis Marc A, VanderLinden Ryan, Grace Christy R R, Frye Jeremiah J, Qiao Renping, Dube Prakash, Petzold Georg, Cho Shein Ei, Alsharif Omar, Bao Ju, Davidson Iain F, Zheng Jie J, Nourse Amanda, Kurinov Igor, Peters Jan-Michael, Stark Holger, Schulman Brenda A   Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly Molecular cell, 2014; 56(2): 246-60.
Bao Ju, Lee Ho-Jin, Zheng Jie J   Genome-wide network analysis of Wnt signaling in three pediatric cancers Scientific reports, 2013; 3(2): 2969.
Rana Rajashree, Carroll Candace E, Lee Ho-Jin, Bao Ju, Marada Suresh, Grace Christy R R, Guibao Cristina D, Ogden Stacey K, Zheng Jie J   Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling Nature communications, 2013; 4(2): 2965.
Li Xiaofeng, Shan Jufang, Chang Woochul, Kim Ingyu, Bao Ju, Lee Ho-Jin, Zhang Xinxin, Samuel Varman T, Shulman Gerald I, Liu Dakai, Zheng Jie J, Wu Dianqing   Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(28): 11402-7.
Bao Ju, Zheng Jie J, Wu Dianqing   The structural basis of DKK-mediated inhibition of Wnt/LRP signaling Science signaling, 2012; 5(224): pe22.
Shan Jufang, Zhang Xinxin, Bao Ju, Cassell Robert, Zheng Jie J   Synthesis of potent dishevelled PDZ domain inhibitors guided by virtual screening and NMR studies Chemical biology & drug design, 2012; 79(4): 376-83.
Shan Jufang, Zheng Jie J   Virtual ligand screening combined with NMR to identify Dvl PDZ domain inhibitors targeting the Wnt signaling Methods in molecular biology (Clifton, N.J.), 2012; 928(4): 17-28.
Alli Rajshekhar, Zhang Ziwei M, Nguyen Phuong, Zheng Jie J, Geiger Terrence L   Rational design of T cell receptors with enhanced sensitivity for antigen PloS one, 2011; 6(3): e18027.
Bari Rafijul, Guo Qiusha, Xia Bing, Zhang Yanhui H, Giesert Eldon E, Levy Shoshana, Zheng Jie J, Zhang Xin A   Tetraspanins regulate the protrusive activities of cell membrane Biochemical and biophysical research communications, 2011; 415(4): 619-26.
Lee Ho-Jin, Finkelstein David, Li Xiaofeng, Wu Dianqing, Shi De-Li, Zheng Jie J   Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein The Journal of biological chemistry, 2010; 285(53): 41549-56.
Lee Ho-Jin, Zheng Jie J   PDZ domains and their binding partners: structure, specificity, and modification Cell communication and signaling : CCS, 2010; 8(53): 8.
Lin Shuei-Liong, Li Bing, Rao Sujata, Yeo Eun-Jin, Hudson Thomas E, Nowlin Brian T, Pei Huaying, Chen Lijun, Zheng Jie J, Carroll Thomas J, Pollard Jeffrey W, McMahon Andrew P, Lang Richard A, Duffield Jeremy S   Macrophage Wnt7b is critical for kidney repair and regeneration Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(9): 4194-9.
Grandy David, Shan Jufang, Zhang Xinxin, Rao Sujata, Akunuru Shailaja, Li Hongyan, Zhang Yanhui, Alpatov Ivan, Zhang Xin A, Lang Richard A, Shi De-Li, Zheng Jie J   Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled The Journal of biological chemistry, 2009; 284(24): 16256-63.
Wang Nick X, Zheng Jie J   Computational studies of H5N1 influenza virus resistance to oseltamivir Protein science : a publication of the Protein Society, 2009; 18(4): 707-15.
Lee Ho-Jin, Wang Nick X, Shao Youming, Zheng Jie J   Identification of tripeptides recognized by the PDZ domain of Dishevelled Bioorganic & medicinal chemistry, 2009; 17(4): 1701-8.
Lee Ho-Jin, Wang Nick X, Shi De-Li, Zheng Jie J   Sulindac inhibits canonical Wnt signaling by blocking the PDZ domain of the protein Dishevelled Angewandte Chemie (International ed. in English), 2009; 48(35): 6448-52.
Bari Rafijul, Zhang Yanhui H, Zhang Feng, Wang Nick X, Stipp Christopher S, Zheng Jie J, Zhang Xin A   Transmembrane interactions are needed for KAI1/CD82-mediated suppression of cancer invasion and metastasis The American journal of pathology, 2009; 174(2): 647-60.
Shan Jufang, Zheng Jie J   Optimizing Dvl PDZ domain inhibitor by exploring chemical space Journal of computer-aided molecular design, 2009; 23(1): 37-47.
Wu Bai-Nan, Zhang Yong-Mei, Rock Charles O, Zheng Jie J   Structural modification of acyl carrier protein by butyryl group Protein science : a publication of the Protein Society, 2009; 18(1): 240-6.
Chen Lijun, Wang Ke, Shao Youming, Huang Jin, Li Xiaofeng, Shan Jufang, Wu Dianqing, Zheng Jie J   Structural insight into the mechanisms of Wnt signaling antagonism by Dkk The Journal of biological chemistry, 2008; 283(34): 23364-70.
Zhang Ziwei M, Simmerman Joseph A, Guibao Cristina D, Zheng Jie J   GIT1 paxillin-binding domain is a four-helix bundle, and it binds to both paxillin LD2 and LD4 motifs The Journal of biological chemistry, 2008; 283(27): 18685-93.
Wang Nick X, Lee Ho-Jin, Zheng Jie J   Therapeutic use of PDZ protein-protein interaction antagonism Drug news & perspectives, 2008; 21(3): 137-41.
Xing Yi, Takemaru Ken-Ichi, Liu Jing, Berndt Jason D, Zheng Jie J, Moon Randall T, Xu Wenqing   Crystal structure of a full-length beta-catenin Structure (London, England : 1993), 2008; 16(3): 478-87.
Bertolucci Craig M, Guibao Cristina D, Zheng Jie J   Phosphorylation of paxillin LD4 destabilizes helix formation and inhibits binding to focal adhesion kinase Biochemistry, 2008; 47(2): 548-54.
Qi Jing, Lee Ho-Jin, Saquet Audrey, Cheng Xiao-Ning, Shao Ming, Zheng Jie J, Shi De-Li   Auto-inhibition of Dishevelled regulated by its extreme C-terminus plays a distinct role in Wnt/beta-catenin and Wnt/PCP signaling pathways The Journal of biological chemistry, 2017; 167: 26-30.