Joshua T. Trachtenberg, Ph.D.


Professor, Neurobiology

Member, Brain Research Institute

Cell & Developmental Biology GPB Home Area

Molecular, Cellular & Integrative Physiology GPB Home Area

Neuroengineering Training Program

Neuroscience GPB Home Area

Contact Information

Office Phone Number: (310) 825-0873

Office Address:

503 NRB
NRB 503
Los Angeles, CA 90095


Joshua Trachtenberg's research seeks to understand how sensory experiences are written into the fabric of our brains.  Genetics plays a dominant role in wiring together the connections between neurons that establish neural circuitry.  After we are born, our brains are bombarded with information from the world around us.  This sensory information changes neural circuitry, allowing us to learn a language, perform complex visual discrimination, obtain sophisticated motor skills, and learn the subtleties of social interactions.  How this external sensory information instructs neural circuitry is not known.  Given its centrality to complex thought, tackling this question is of some significance.  The Trachtenberg lab employs a sophisticated array of vital imaging and physiological tools to reveal the richness and mechanisms of this experience-dependent plasticity.


A selected list of publications:

Yaeger Courtney E, Ringach Dario L, Trachtenberg Joshua T   Neuromodulatory control of localized dendritic spiking in critical period cortex Nature, 2019; 567(7746): 100-104.
Garcia-Junco-Clemente Pablo, Tring Elaine, Ringach Dario L, Trachtenberg Joshua T   State-Dependent Subnetworks of Parvalbumin-Expressing Interneurons in Neocortex Cell reports, 2019; 26(9): 2282-2288.e3.
Garcia-Junco-Clemente Pablo, Ikrar Taruna, Tring Elaine, Xu Xiangmin, Ringach Dario L, Trachtenberg Joshua T   An inhibitory pull-push circuit in frontal cortex Nature neuroscience, 2017; 20(3): 389-392.
Baohan Amy, Ikrar Taruna, Tring Elaine, Xu Xiangmin, Trachtenberg Joshua T   Pten and EphB4 regulate the establishment of perisomatic inhibition in mouse visual cortex Nature communications, 2016; 7(3): 12829.
Ringach Dario L, Mineault Patrick J, Tring Elaine, Olivas Nicholas D, Garcia-Junco-Clemente Pablo, Trachtenberg Joshua T   Spatial clustering of tuning in mouse primary visual cortex Nature communications, 2016; 7(3): 12270.
Trachtenberg Joshua T   Competition, inhibition, and critical periods of cortical plasticity Current opinion in neurobiology, 2015; 35(24): 44-8.
Trachtenberg Joshua T   Parvalbumin Interneurons: All Forest, No Trees Neuron, 2015; 87(2): 247-8.
Kuhlman Sandra J, Olivas Nicholas D, Tring Elaine, Ikrar Taruna, Xu Xiangmin, Trachtenberg Joshua T   A disinhibitory microcircuit initiates critical-period plasticity in the visual cortex Nature, 2013; 501(7468): 543-6.
Gdalyahu Amos, Tring Elaine, Polack Pierre-Olivier, Gruver Robin, Golshani Peyman, Fanselow Michael S, Silva Alcino J, Trachtenberg Joshua T   Associative fear learning enhances sparse network coding in primary sensory cortex Neuron, 2012; 75(1): 121-32.
Wyatt Ryan M, Tring Elaine, Trachtenberg Joshua T   Pattern and not magnitude of neural activity determines dendritic spine stability in awake mice Nature neuroscience, 2012; 15(7): 949-51.
Kuhlman Sandra J, Tring Elaine, Trachtenberg Joshua T   Fast-spiking interneurons have an initial orientation bias that is lost with vision Nature neuroscience, 2011; 14(9): 1121-3.
Matter Cheryl, Pribadi Mochtar, Liu Xin, Trachtenberg Joshua T   Delta-catenin is required for the maintenance of neural structure and function in mature cortex in vivo Neuron, 2009; 64(3): 320-7.
Faguet J, Maranhao B, Smith SL, Trachtenberg JT   Ipsilateral eye cortical maps are uniquely sensitive to binocular plasticity, Journal of Neurophysiology, 2009; 101(2): 855-61.
Chow David K, Groszer Matthias, Pribadi Mochtar, Machniki Michal, Carmichael S Thomas, Liu Xin, Trachtenberg Joshua T   Laminar and compartmental regulation of dendritic growth in mature cortex Nature neuroscience, 2009; 12(2): 116-8.
Smith SL & Trachtenberg JT   Experience-dependent binocular competition in the visual cortex begins at eye opening, Nature Neuroscience, 2007; 10(3): 370-375.
Trachtenberg JT, Chen BE, Knott GW, Feng G, Sanes JR, Welker E, Svoboda K   Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex Nature. , 2002; 420(6917): 788-94.