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Karen H. Gylys, Ph.D., R.N.
Professor, School of Nursing
Member, Brain Research Institute
Molecular Pharmacology GPB Home Area
Neuroscience GPB Home Area
Lab Number: 310 794-5472
Office Phone Number: 310-206-3840
Office Phone Number: 310-206-3840
Factor Building 6-266
Los Angeles, CA 90095
BiographyKaren Hoppens Gylys is a neuroscientist who joined the faculty of the School of Nursing and the Brain Research Institute in 1998. Dr. Gylys earned a B.S. degree in Nursing and a M.S. degree in Human Development at the University of Texas, Dallas. She received her Ph.D. in Neuroscience, with a major in neuropharmacology, at UCLA in 1993, and did postdoctoral work on molecular mechanisms of opioid tolereance in the NPI. Since joining the faculty of the School of Nursing, she has taught pharmacology and research in the School of Nursing and is actively involved in the BRI. Her laboratory research is focused on understanding the dysfunction and loss of synapses that occurs in Alzheimer's disease, which is thought to underlie the earliest cognitive impairments.
Sokolow Sophie, Henkins Kristen M, Bilousova Tina, Miller Carol A, Vinters Harry V, Poon Wayne, Cole Gregory M, Gylys Karen Hoppens AD synapses contain abundant AÎ² monomer and multiple soluble oligomers, including a 56-kDa assembly Neurobiology of aging, 2012; 33(8): 1545-55.
Arold Stephen, Sullivan Patrick, Bilousova Tina, Teng Edmond, Miller Carol A, Poon Wayne W, Vinters Harry V, Cornwell Lindsey B, Saing Tommy, Cole Gregory M, Gylys Karen Hoppens Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer's disease and apoE TR mouse cortex Acta neuropathologica, 2012; 123(1): 39-52.
Ringman John M, Coppola Giovanni, Elashoff David, Rodriguez-Agudelo Yaneth, Medina Luis D, Gylys Karen, Cummings Jeffrey L, Cole Greg M Cerebrospinal fluid biomarkers and proximity to diagnosis in preclinical familial Alzheimer's disease Dementia and geriatric cognitive disorders, 2012; 33(1): 1-5.
Ringman John M, Tomic Jennifer L, Coppola Giovanni, Elashoff David, Gylys Karen H, Glabe Charles G Conformation-dependent oligomers in cerebrospinal fluid of presymptomatic familial Alzheimer's disease mutation carriers Dementia and geriatric cognitive disorders extra, 2012; 2(1): 652-7.
Henkins Kristen M, Sokolow Sophie, Miller Carol A, Vinters Harry V, Poon Wayne W, Cornwell Lindsey B, Saing Tommy, Gylys Karen Hoppens Extensive p-tau pathology and SDS-stable p-tau oligomers in Alzheimer's cortical synapses Brain pathology (Zurich, Switzerland), 2012; 22(6): 826-33.
Sokolow Sophie, Henkins Kristen M, Williams Iris A, Vinters Harry V, Schmid Ingrid, Cole Gregory M, Gylys Karen H Isolation of synaptic terminals from Alzheimer's disease cortex Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2012; 81(3): 248-54.
Ringman John M, Frautschy Sally A, Teng Edmond, Begum Aynun N, Bardens Jenny, Beigi Maryam, Gylys Karen H, Badmaev Vladimir, Heath Dennis D, Apostolova Liana G, Porter Verna, Vanek Zeba, Marshall Gad A, Hellemann Gerhard, Sugar Catherine, Masterman Donna L, Montine Thomas J, Cummings Jeffrey L, Cole Greg M Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study Alzheimer's research & therapy, 2012; 4(5): 43.
Ringman John M, Elashoff David, Geschwind Daniel H, Welsh Brian T, Gylys Karen H, Lee Cathy, Cummings Jeffrey L, Cole Greg M Plasma signaling proteins in persons at genetic risk for Alzheimer disease: influence of APOE genotype Archives of neurology, 2012; 69(6): 757-64.
Sokolow Sophie, Luu Sanh H, Nandy Karabi, Miller Carol A, Vinters Harry V, Poon Wayne W, Gylys Karen H Preferential accumulation of amyloid-beta in presynaptic glutamatergic terminals (VGluT1 and VGluT2) in Alzheimer's disease cortex Neurobiology of disease, 2012; 45(1): 381-7.
Ringman John M, Schulman Howard, Becker Chris, Jones Ted, Bai Yuchen, Immermann Fred, Cole Gregory, Sokolow Sophie, Gylys Karen, Geschwind Daniel H, Cummings Jeffrey L, Wan Hong I Proteomic changes in cerebrospinal fluid of presymptomatic and affected persons carrying familial Alzheimer disease mutations Archives of neurology, 2012; 69(1): 96-104.
Ringman John M, Gylys Karen H, Medina Luis D, Fox Michelle, Kepe Vladimir, Flores Deborah L, Apostolova Liana G, Barrio Jorge R, Small Gary, Silverman Daniel H, Siu Erin, Cederbaum Stephen, Hecimovic Silva, Malnar Martina, Chakraverty Suma, Goate Alison M, Bird Thomas D, Leverenz James B Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation Neuroscience letters, 2011; 487(3): 287-92.
Sokolow Sophie, Luu Sanh H, Headley Alison J, Hanson Alecia Y, Kim Taeree, Miller Carol A, Vinters Harry V, Gylys Karen H High levels of synaptosomal Na(+)-Ca(2+) exchangers (NCX1, NCX2, NCX3) co-localized with amyloid-beta in human cerebral cortex affected by Alzheimer's disease Cell calcium, 2011; 49(4): 208-16.
10. Sokolow S, Henkins KM, Bilousova , Williams IA, Vinters HV, Cole GM, Schmid I, Gylys KH. Isolation of synaptic terminals from Alzheimers disease cortex, Brain Pathology, 2012; 81((3)): 248-254.
Tai Leon M, Bilousova Tina, Jungbauer Lisa, Roeske Stephen K, Youmans Katherine L, Yu Chunjiang, Poon Wayne W, Cornwell Lindsey B, Miller Carol A, Vinters Harry V, Van Eldik Linda J, Fardo David W, Estus Steve, Bu Guojun, Gylys Karen Hoppens, Ladu Mary Jo Levels of soluble apolipoprotein E/amyloid-Î² (AÎ²) complex are reduced and oligomeric AÎ² increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples The Journal of biological chemistry, 2013; 288(8): 5914-26.
Sokolow Sophie, Henkins Kristen M, Bilousova Tina, Gonzalez Bianca, Vinters Harry V, Miller Carol A, Cornwell Lindsey, Poon Wayne W, Gylys Karen H Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's disease Journal of neurochemistry, 2015; 133(3): 368-79.
Ringman John M, Fithian Andrew T, Gylys Karen, Cummings Jeffrey L, Coppola Giovanni, Elashoff David, Pratico Domenico, Moskovitz Jackob, Bitan Gal Plasma methionine sulfoxide in persons with familial Alzheimer's disease mutations Dementia and geriatric cognitive disorders, 2012; 33(4): 219-25.