Michael R. Irwin, M.D.

Titles

Director, Cousins Center for Psychoneuroimmunology
Mindful Awareness Research Center
Co-Leader, Clinical Immunology Research Laboratory (CIRL)
Pilot and Collaborative Translational Clinical Studies Program
Professor, Psychology
Psychiatry and Biobehavioral Sciences
Member, Adult Psychiatry
Brain Research Institute
CTSI
JCCC Patients and Survivors Program Area
Neuroscience GPB Home Area

Contact Information

Email
mirwin1@ucla.edu
Phone
Work Phone Number: (310) 825-8281
Address
Work Address: Medical Plaza 300, Room 3109Campus - 707624Los Angeles, CA 90095UNITED STATES

Biography

Michael Irwin, M.D. holds the Norman Cousins Chair for Psychoneuroimmunology at the UCLA Semel Institute for Neuroscience and Human Behavior and is a Professor of Psychiatry and Biobehavioral Sciences at the UCLA David Geffen School of Medicine. He is Director of the UCLA Cousins Center in Psychoneuroimmunology, Director of the Training Program in Psychoneuroimmunology and Mental Health, and Director of the Inflammatory Biology Core of the Older Adults for Independence Center.

Publications:

Patel Sunita K, Wong Andrew L, Wong F Lennie, Breen Elizabeth Crabb, Hurria Arti, Smith Mackenzie, Kinjo Christine, Paz I Benjamin, Kruper Laura, Somlo George, Mortimer Joanne E, Palomares Melanie R, Irwin Michael R, Bhatia Smita   Inflammatory Biomarkers, Comorbidity, and Neurocognition in Women With Newly Diagnosed Breast Cancer Journal of the National Cancer Institute, 2015; 107(8): .
Irwin Michael R, Witarama Tuff, Caudill Marissa, Olmstead Richard, Breen Elizabeth Crabb   Sleep loss activates cellular inflammation and signal transducer and activator of transcription (STAT) family proteins in humans Brain, behavior, and immunity, 2015; 47: 86-92.
Inagaki Tristen K, Irwin Michael R, Eisenberger Naomi I   Blocking Opioids Attenuates Physical Warmth-Induced Feelings of Social Connection Emotion (Washington, D.C.), 2015; 47: .
Doering Lynn V, McGuire Anthony, Eastwood Jo-Ann, Chen Belinda, Bodán Rebecca C, Czer Lawrence S, Irwin Michael R   Cognitive behavioral therapy for depression improves pain and perceived control in cardiac surgery patients European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology, 2015; 47: .
Bower Julienne E, Irwin Michael R   Mind-body therapies and control of inflammatory biology: A descriptive review Brain, behavior, and immunity, 2015; 47: .
Moieni Mona, Irwin Michael R, Jevtic Ivana, Olmstead Richard, Breen Elizabeth C, Eisenberger Naomi I   Sex differences in depressive and socioemotional responses to an inflammatory challenge: implications for sex differences in depression Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015; 40(7): 1709-16.
Irwin Michael R, Olmstead Richard, Carroll Judith E   Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation Biological psychiatry, 2015; 107(8): .
Inagaki Tristen K, Muscatell Keely A, Moieni Mona, Dutcher Janine M, Jevtic Ivana, Irwin Michael R, Eisenberger Naomi I   Yearning for connection? Loneliness is associated with increased ventral striatum activity to close others Social cognitive and affective neuroscience, 2015; 107(8): .
Carroll Judith E, Seeman Teresa E, Olmstead Richard, Melendez Gerson, Sadakane Ryan, Bootzin Richard, Nicassio Perry, Irwin Michael R   Improved sleep quality in older adults with insomnia reduces biomarkers of disease risk: pilot results from a randomized controlled comparative efficacy trial Psychoneuroendocrinology, 2015; 55(7): 184-92.
Cho Hyong Jin, Seeman Teresa E, Kiefe Catarina I, Lauderdale Diane S, Irwin Michael R   Sleep disturbance and longitudinal risk of inflammation: Moderating influences of social integration and social isolation in the Coronary Artery Risk Development in Young Adults (CARDIA) study Brain, behavior, and immunity, 2015; 46(7): 319-26.
Black David S, O'Reilly Gillian A, Olmstead Richard, Breen Elizabeth C, Irwin Michael R   Mindfulness meditation and improvement in sleep quality and daytime impairment among older adults with sleep disturbances: a randomized clinical trial JAMA internal medicine, 2015; 175(4): 494-501.
Bjurstrom Martin F, Irwin Michael R   Polysomnographic characteristics in nonmalignant chronic pain populations: A review of controlled studies Sleep medicine reviews, 2015; 55(7): .
Chiang Jessica J, Bower Julienne E, Almeida David M, Irwin Michael R, Seeman Teresa E, Fuligni Andrew J   Socioeconomic status, daily affective and social experiences, and inflammation during adolescence Psychosomatic medicine, 2015; 77(3): 256-66.
Campo Rebecca A, Light Kathleen C, O'Connor Kathleen, Nakamura Yoshio, Lipschitz David, LaStayo Paul C, Pappas Lisa M, Boucher Kenneth M, Irwin Michael R, Hill Harry R, Martins Thomas B, Agarwal Neeraj, Kinney Anita Y   Blood pressure, salivary cortisol, and inflammatory cytokine outcomes in senior female cancer survivors enrolled in a tai chi chih randomized controlled trial Journal of cancer survivorship : research and practice, 2015; 9(1): 115-25.
Moieni Mona, Irwin Michael R, Jevtic Ivana, Breen Elizabeth C, Eisenberger Naomi I   Inflammation impairs social cognitive processing: A randomized controlled trial of endotoxin Brain, behavior, and immunity, 2015; 77(3): .
Compton Peggy, Griffis Charles, Breen Elizabeth Crabb, Torrington Matthew, Sadakane Ryan, Tefera Eshetu, Irwin Michael R   Opioid treatment of experimental pain activates nuclear factor-κB Journal of opioid management, 2015; 11(2): 115-25.
Irwin Michael R, Olmstead Richard, Breen Elizabeth C, Witarama Tuff, Carrillo Carmen, Sadeghi Nina, Arevalo Jesusa M G, Ma Jeffrey, Nicassio Perry, Bootzin Richard, Cole Steve   Cognitive Behavioral Therapy and Tai Chi Reverse Cellular and Genomic Markers of Inflammation in Late Life Insomnia: A Randomized Controlled Trial Biological psychiatry, 2015; 11(2): .
Carroll Judith E, Carrillo Carmen, Olmstead Richard, Witarama Tuff, Breen Elizabeth C, Yokomizo Megumi, Seeman Teresa, Irwin Michael R   Sleep deprivation and divergent toll-like receptor-4 activation of cellular inflammation in aging Sleep, 2015; 38(2): 205-11.
Inagaki Tristen K, Muscatell Keely A, Irwin Michael R, Moieni Mona, Dutcher Janine M, Jevtic Ivana, Breen Elizabeth C, Eisenberger Naomi I   The role of the ventral striatum in inflammatory-induced approach toward support figures Brain, behavior, and immunity, 2015; 44(2): 247-52.
Muscatell Keely A, Dedovic Katarina, Slavich George M, Jarcho Michael R, Breen Elizabeth C, Bower Julienne E, Irwin Michael R, Eisenberger Naomi I   Greater amygdala activity and dorsomedial prefrontal-amygdala coupling are associated with enhanced inflammatory responses to stress Brain, behavior, and immunity, 2015; 43(2): 46-53.
Carroll Judith E, Irwin Michael R, Stein Merkin Sharon, Seeman Teresa E   Sleep and multisystem biological risk: a population-based study PloS one, 2015; 10(2): e0118467.
Tabak Benjamin A, Meyer Meghan L, Castle Elizabeth, Dutcher Janine M, Irwin Michael R, Han Jung H, Lieberman Matthew D, Eisenberger Naomi I   Vasopressin, but not oxytocin, increases empathic concern among individuals who received higher levels of paternal warmth: A randomized controlled trial Psychoneuroendocrinology, 2015; 51(2): 253-61.
Irwin Michael R   Why sleep is important for health: a psychoneuroimmunology perspective Annual review of psychology, 2015; 66(2): 143-72.
Hoyt Michael A, Marin-Chollom Amanda M, Bower Julienne E, Thomas KaMala S, Irwin Michael R, Stanton Annette L   Approach and avoidance coping: diurnal cortisol rhythm in prostate cancer survivors Psychoneuroendocrinology, 2014; 49(50): 182-6.
Ganz Patricia A, Petersen Laura, Castellon Steven A, Bower Julienne E, Silverman Daniel H S, Cole Steven W, Irwin Michael R, Belin Thomas R   Cognitive function after the initiation of adjuvant endocrine therapy in early-stage breast cancer: an observational cohort study Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014; 32(31): 3559-67.
Irwin Michael R, Olmstead Richard, Breen Elizabeth C, Witarama Tuff, Carrillo Carmen, Sadeghi Nina, Arevalo Jesusa M G, Ma Jeffrey, Nicassio Perry, Ganz Patricia A, Bower Julienne E, Cole Steve   Tai chi, cellular inflammation, and transcriptome dynamics in breast cancer survivors with insomnia: a randomized controlled trial Journal of the National Cancer Institute. Monographs, 2014; 2014(50): 295-301.
Irwin Michael R   Sleep and inflammation in resilient aging Interface focus, 2014; 4(5): 20140009.
Irwin Michael R, Olmstead Richard, Carrillo Carmen, Sadeghi Nina, Breen Elizabeth C, Witarama Tuff, Yokomizo Megumi, Lavretsky Helen, Carroll Judith E, Motivala Sarosh J, Bootzin Richard, Nicassio Perry   Cognitive behavioral therapy vs. Tai Chi for late life insomnia and inflammatory risk: a randomized controlled comparative efficacy trial Sleep, 2014; 37(9): 1543-52.
Black David S, O'Reilly Gillian A, Olmstead Richard, Breen Elizabeth C, Irwin Michael R   Mindfulness-based intervention for prodromal sleep disturbances in older adults: design and methodology of a randomized controlled trial Contemporary clinical trials, 2014; 39(1): 22-7.
Prasad Sandip M, Eggener Scott E, Lipsitz Stuart R, Irwin Michael R, Ganz Patricia A, Hu Jim C   Effect of depression on diagnosis, treatment, and mortality of men with clinically localized prostate cancer Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014; 32(23): 2471-8.
Doering Lynn V, Chen Belinda, McGuire Anthony, Bodán Rebecca Cross, Irwin Michael R   Persistent depressive symptoms and pain after cardiac surgery Psychosomatic medicine, 2014; 76(6): 437-44.
Burklund Lisa J, Creswell J David, Irwin Michael R, Lieberman Matthew D   The common and distinct neural bases of affect labeling and reappraisal in healthy adults Frontiers in psychology, 2014; 5(6): 221.
Bower Julienne E, Greendale Gail, Crosswell Alexandra D, Garet Deborah, Sternlieb Beth, Ganz Patricia A, Irwin Michael R, Olmstead Richard, Arevalo Jesusa, Cole Steve W   Yoga reduces inflammatory signaling in fatigued breast cancer survivors: a randomized controlled trial Psychoneuroendocrinology, 2014; 43(6): 20-9.
Dzierzewski Joseph M, Fung Constance H, Jouldjian Stella, Alessi Cathy A, Irwin Michael R, Martin Jennifer L   Decrease in daytime sleeping is associated with improvement in cognition after hospital discharge in older adults Journal of the American Geriatrics Society, 2014; 62(1): 47-53.
Black David S, Irwin Michael R, Olmstead Richard, Ji Ellen, Crabb Breen Elizabeth, Motivala Sarosh J   Tai chi meditation effects on nuclear factor-κB signaling in lonely older adults: a randomized controlled trial Psychotherapy and psychosomatics, 2014; 83(5): 315-7.
Morgan Nani, Irwin Michael R, Chung Mei, Wang Chenchen   The effects of mind-body therapies on the immune system: meta-analysis PloS one, 2014; 9(7): e100903.
O'Connor Mary-Frances, Schultze-Florey Christian R, Irwin Michael R, Arevalo Jesusa M G, Cole Steven W   Divergent gene expression responses to Complicated Grief and Non-complicated Grief Brain, behavior, and immunity, 2013; .
Pomykala K L, Ganz P A, Bower J E, Kwan L, Castellon S A, Mallam S, Cheng I, Ahn R, Breen E C, Irwin M R, Silverman D H S   The association between pro-inflammatory cytokines, regional cerebral metabolism, and cognitive complaints following adjuvant chemotherapy for breast cancer Brain imaging and behavior, 2013; 7(4): 511-23.
Irwin Michael R   Depression and insomnia in cancer: prevalence, risk factors, and effects on cancer outcomes Current psychiatry reports, 2013; 15(11): 404.
Lee Eun, Cho Hyong Jin, Olmstead Richard, Levin Myron J, Oxman Michael N, Irwin Michael R   Persistent sleep disturbance: a risk factor for recurrent depression in community-dwelling older adults Sleep, 2013; 36(11): 1685-91.
Barsevick Andrea M, Irwin Michael R, Hinds Pamela, Miller Andrew, Berger Ann, Jacobsen Paul, Ancoli-Israel Sonia, Reeve Bryce B, Mustian Karen, O'Mara Ann, Lai Jin-Shei, Fisch Michael, Cella David, Cella David   Recommendations for high-priority research on cancer-related fatigue in children and adults Journal of the National Cancer Institute, 2013; 105(19): 1432-40.
Youngstedt Shawn D, Jean-Louis Girardin, Bootzin Richard R, Kripke Daniel F, Cooper Jonnifer, Dean Lauren R, Catao Fabio, James Shelli, Vining Caitlin, Williams Natasha J, Irwin Michael R   Chronic moderate sleep restriction in older long sleepers and older average duration sleepers: a randomized controlled trial Contemporary clinical trials, 2013; 36(1): 175-86.
Dimsdale Joel E, Creed Francis, Escobar Javier, Sharpe Michael, Wulsin Lawson, Barsky Arthur, Lee Sing, Irwin Michael R, Levenson James   Somatic symptom disorder: an important change in DSM Journal of psychosomatic research, 2013; 75(3): 223-8.
Bower Julienne E, Ganz Patricia A, Irwin Michael R, Castellon Steven, Arevalo Jesusa, Cole Steven W   Cytokine genetic variations and fatigue among patients with breast cancer Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013; 31(13): 1656-61.
Ganz Patricia A, Kwan Lorna, Castellon Steven A, Oppenheim Amy, Bower Julienne E, Silverman Daniel H S, Cole Steve W, Irwin Michael R, Ancoli-Israel Sonia, Belin Thomas R   Cognitive Complaints After Breast Cancer Treatments: Examining the Relationship With Neuropsychological Test Performance Journal of the National Cancer Institute, 2013; 31(13): .
Campo Rebecca A, O'Connor Kathleen, Light Kathleen C, Nakamura Yoshio, Lipschitz David L, Lastayo Paul C, Pappas Lisa, Boucher Kenneth, Irwin Michael R, Agarwal Neeraj, Kinney Anita Y   Feasibility and Acceptability of a Tai Chi Chih Randomized Controlled Trial in Senior Female Cancer Survivors Integrative cancer therapies, 2013; 31(13): .
Hoyt Michael A, Stanton Annette L, Bower Julienne E, Thomas Kamala S, Litwin Mark S, Breen Elizabeth C, Irwin Michael R   Inflammatory Biomarkers and Emotional Approach Coping in Men with Prostate Cancer Brain, behavior, and immunity, 2013; 31(13): .
Irwin Michael R, Levin Myron J, Laudenslager Mark L, Olmstead Richard, Lucko Anne, Lang Nancy, Carrillo Carmen, Stanley Harold A, Caulfield Michael J, Weinberg Adriana, Chan Ivan S F, Clair Jim, Smith Jeff G, Marchese R D, Williams Heather M, Beck Danielle J, McCook Patricia T, Zhang Jane H, Johnson Gary, Oxman Michael N   Varicella zoster virus-specific immune responses to a herpes zoster vaccine in elderly recipients with major depression and the impact of antidepressant medications Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2013; 56(8): 1085-93.
Griffis Charles A, Crabb Breen Elizabeth, Compton Peggy, Goldberg Alyssa, Witarama Tuff, Kotlerman Jenny, Irwin Michael R   Acute Painful Stress and Inflammatory Mediator Production Neuroimmunomodulation, 2013; 20(3): 127-133.
Hoyt Michael A, Stanton Annette L, Irwin Michael R, Thomas KaMala S   Cancer-related masculine threat, emotional approach coping, and physical functioning following treatment for prostate cancer Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2013; 32(1): 66-74.
Cho H J, Kivimki M, Bower J E, Irwin M R   Association of C-reactive protein and interleukin-6 with new-onset fatigue in the Whitehall II prospective cohort study Psychological medicine, 2012; 32(1): 1-11.
Creswell J David, Irwin Michael R, Burklund Lisa J, Lieberman Matthew D, Arevalo Jesusa M G, Ma Jeffrey, Breen Elizabeth Crabb, Cole Steven W   Mindfulness-Based Stress Reduction training reduces loneliness and pro-inflammatory gene expression in older adults: A small randomized controlled trial Brain, behavior, and immunity, 2012; 26(7): 1095-101.
Schultze-Florey Christian R, Martínez-Maza Otoniel, Magpantay Larry, Breen Elizabeth Crabb, Irwin Michael R, Gündel Harald, O'Connor Mary-Frances   When grief makes you sick: Bereavement induced systemic inflammation is a question of genotype Brain, behavior, and immunity, 2012; 26(7): 1066-71.
Elderkin-Thompson Virginia, Irwin Michael R, Hellemann Gerhard, Kumar Anand   Interleukin-6 and memory functions of encoding and recall in healthy and depressed elderly adults The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2012; 20(9): 753-63.
Nicassio Perry M, Ormseth Sarah R, Custodio Mara K, Olmstead Richard, Weisman Michael H, Irwin Michael R   Confirmatory Factor Analysis of the Pittsburgh Sleep Quality Index in Rheumatoid Arthritis Patients Behavioral sleep medicine, 2012; 32(1): .
Kierlin Lara, Olmstead Richard, Yokomizo Megumi, Nicassio Perry, Irwin Michael R   Diagnostic and Statistical Manual criteria for insomnia related impairment in daytime functioning: polysomnographic correlates in older adults Sleep medicine, 2012; 13(7): 958-60.
Ganz Patricia A, Bower J E, Kwan L, Castellon S A, Silverman D H S, Geist C, Breen E C, Irwin M R, Cole S W   Does tumor necrosis factor-alpha (TNF-α) play a role in post-chemotherapy cerebral dysfunction? Brain, behavior, and immunity, 2012; .
Irwin Michael R   Sleep and infectious disease risk Sleep, 2012; 35(8): 1025-6.
Black David S, Cole Steve W, Irwin Michael R, Breen Elizabeth, St Cyr Natalie M, Nazarian Nora, Khalsa Dharma S, Lavretsky Helen   Yogic meditation reverses NF-κB and IRF-related transcriptome dynamics in leukocytes of family dementia caregivers in a randomized controlled trial Psychoneuroendocrinology, 2012; 13(7): .
Nicassio Perry M, Ormseth Sarah R, Custodio Mara K, Irwin Michael R, Olmstead Richard, Weisman Michael H   A Multidimensional Model of Fatigue in Patients with Rheumatoid Arthritis The Journal of rheumatology, 2012; .
O'Connor Mary-Frances, Wellisch David K, Stanton Annette L, Olmstead Richard, Irwin Michael R   Diurnal cortisol in Complicated and Non-Complicated Grief: slope differences across the day Psychoneuroendocrinology, 2012; 37(5): 725-8.
Doering Lynn V, Chen Belinda, Cross Bodán Rebecca, Magsarili Marise C, Nyamathi Adey, Irwin Michael R   Early Cognitive Behavioral Therapy for Depression After Cardiac Surgery The Journal of cardiovascular nursing, 2012; .
Irwin Michael R, Olmstead Richard E, Ganz Patricia A, Haque Reina   Sleep disturbance, inflammation and depression risk in cancer survivors Brain, behavior, and immunity, 2012; .
Cho Hyong Jin, Bower Julienne E, Kiefe Catarina I, Seeman Teresa E, Irwin Michael R   Early life stress and inflammatory mechanisms of fatigue in the Coronary Artery Risk Development in Young Adults (CARDIA) study Brain, behavior, and immunity, 2012; 37(5): .
Irwin Michael R, Olmstead Richard, Carrillo Carmen, Sadeghi Nina, Fitzgerald John D, Ranganath Veena K, Nicassio Perry M   Sleep loss exacerbates fatigue, depression, and pain in rheumatoid arthritis Sleep, 2012; 35(4): 537-43.
Lavretsky H, Epel E S, Siddarth P, Nazarian N, Cyr N St, Khalsa D S, Lin J, Blackburn E, Irwin M R   A pilot study of yogic meditation for family dementia caregivers with depressive symptoms: effects on mental health, cognition, and telomerase activity International journal of geriatric psychiatry, 2012; .
Irwin Michael R, Rothermundt Matthias   Clinical psychoneuroimmunology Handbook of clinical neurology / edited by P.J. Vinken and G.W. Bruyn, 2012; 106(4): 211-25.
Inagaki Tristen K, Muscatell Keely A, Irwin Michael R, Cole Steve W, Eisenberger Naomi I   Inflammation selectively enhances amygdala activity to socially threatening images NeuroImage, 2012; 59(4): 3222-6.
Ishii Shinya, Karlamangla Arun S, Bote Marcos, Irwin Michael R, Jacobs David R, Cho Hyong Jin, Seeman Teresa E   Gender, Obesity and Repeated Elevation of C-Reactive Protein: Data from the CARDIA Cohort PloS one, 2012; 7(4): e36062.
Nicassio Perry M, Ormseth Sarah R, Kay Morgan, Custodio Mara, Irwin Michael R, Olmstead Richard, Weisman Michael H   The contribution of pain and depression to self-reported sleep disturbance in patients with rheumatoid arthritis Pain, 2012; 153(1): 107-12.
Bower Julienne E, Garet Deborah, Sternlieb Beth, Ganz Patricia A, Irwin Michael R, Olmstead Richard, Greendale Gail   Yoga for persistent fatigue in breast cancer survivors: A randomized controlled trial Cancer, 2011; 7(4): .
Lavretsky Helen, Alstein Lily L, Olmstead Richard E, Ercoli Linda M, Riparetti-Brown Marquertie, Cyr Natalie St, Irwin Michael R   Complementary use of tai chi chih augments escitalopram treatment of geriatric depression: a randomized controlled trial The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2011; 19(10): 839-50.
Bower Julienne E, Ganz Patricia A, Irwin Michael R, Kwan Lorna, Breen Elizabeth C, Cole Steve W   Inflammation and behavioral symptoms after breast cancer treatment: do fatigue, depression, and sleep disturbance share a common underlying mechanism? Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011; 29(26): 3517-22.
Irwin Michael R   Inflammation at the intersection of behavior and somatic symptoms The Psychiatric clinics of North America, 2011; 34(3): 605-20.
Irwin Michael R, Olmstead Richard   Mitigating Cellular Inflammation in Older Adults: A Randomized Controlled Trial of Tai Chi Chih The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2011; 19(10): .
Irwin Michael R, Cole Steven W   Reciprocal regulation of the neural and innate immune systems Nature reviews. Immunology, 2011; 11(9): 625-32.
Nicassio Perry M, Kay Morgan A, Custodio Mara K, Irwin Michael R, Olmstead Richard, Weisman Michael H   An evaluation of a biopsychosocial framework for health-related quality of life and disability in rheumatoid arthritis Journal of psychosomatic research, 2011; 71(2): 79-85.
Cole Steven W, Arevalo Jesusa M G, Manu Kavya, Telzer Eva H, Kiang Lisa, Bower Julienne E, Irwin Michael R, Fuligni Andrew J   Antagonistic pleiotropy at the human IL6 promoter confers genetic resilience to the pro-inflammatory effects of adverse social conditions in adolescence Developmental psychology, 2011; 47(4): 1173-80.
Irwin Michael R, Levin Myron J, Carrillo Carmen, Olmstead Richard, Lucko Anne, Lang Nancy, Caulfield Michael J, Weinberg Adriana, Chan Ivan S F, Clair Jim, Smith Jeff G, Marchese R D, Williams Heather M, Beck Danielle J, McCook Patricia T, Johnson Gary, Oxman Michael N   Major depressive disorder and immunity to varicella-zoster virus in the elderly Brain, behavior, and immunity, 2011; 25(4): 759-66.
Bower Julienne E, Ganz Patricia A, Irwin Michael R, Arevalo Jesusa M G, Cole Steve W   Fatigue and gene expression in human leukocytes: increased NF-κB and decreased glucocorticoid signaling in breast cancer survivors with persistent fatigue Brain, behavior, and immunity, 2011; 25(1): 147-50.
Thomas KaMala S, Motivala S, Olmstead R, Irwin M R   Sleep depth and fatigue: role of cellular inflammatory activation Brain, behavior, and immunity, 2011; 25(1): 53-8.
Eisenberger Naomi I, Berkman Elliot T, Inagaki Tristen K, Rameson Lian T, Mashal Nehjla M, Irwin Michael R   Inflammation-induced anhedonia: endotoxin reduces ventral striatum responses to reward Biological psychiatry, 2010; 68(8): 748-54.
Eisenberger Naomi I, Inagaki Tristen K, Mashal Nehjla M, Irwin Michael R   Inflammation and social experience: an inflammatory challenge induces feelings of social disconnection in addition to depressed mood Brain, behavior, and immunity, 2010; 24(4): 558-63.
Cho Hyong Jin, Lavretsky Helen, Olmstead Richard, Levin Myron, Oxman Michael N, Irwin Michael R   Prior depression history and deterioration of physical health in community-dwelling older adults--a prospective cohort study The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2010; 18(5): 442-51.
O'Connor M-F, Irwin M R   Links between behavioral factors and inflammation Clinical pharmacology and therapeutics, 2010; 87(4): 479-82.
Lavretsky Helen, Siddarth Prabha, Irwin Michael R   Improving depression and enhancing resilience in family dementia caregivers: a pilot randomized placebo-controlled trial of escitalopram The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2010; 18(2): 154-62.
Irwin Michael R, Olmstead Richard, Valladares Edwin M, Breen Elizabeth Crabb, Ehlers Cindy L   In response to: Etanercept for sleep in patients with Alcohol use disorder - mechanisms need to be elucidated Biological psychiatry, 2010; 67(1): e3.
Frasure-Smith Nancy, Lespérance François, Irwin Michael R, Talajic Mario, Pollock Bruce G   The relationships among heart rate variability, inflammatory markers and depression in coronary heart disease patients Brain, behavior, and immunity, 2009; 23(8): 1140-7.
O'Connor Mary-Frances, Bower Julie E, Cho Hyong Jin, Creswell J David, Dimitrov Stoyan, Hamby Mary E, Hoyt Michael A, Martin Jennifer L, Robles Theodore F, Sloan Erica K, Thomas Kamala S, Irwin Michael R   To assess, to control, to exclude: effects of biobehavioral factors on circulating inflammatory markers Brain, behavior, and immunity, 2009; 23(7): 887-97.
Weinberg Adriana, Zhang Jane H, Oxman Michael N, Johnson Gary R, Hayward Anthony R, Caulfield Michael J, Irwin Michael R, Clair James, Smith Jeffrey G, Stanley Harold, Marchese Rocio D, Harbecke Ruth, Williams Heather M, Chan Ivan S F, Arbeit Robert D, Gershon Anne A, Schdel Florian, Morrison Vicki A, Kauffman Carol A, Straus Steve E, Schmader Kenneth E, Davis Larry E, Levin Myron J, Levin Myron J   Varicella-zoster virus-specific immune responses to herpes zoster in elderly participants in a trial of a clinically effective zoster vaccine The Journal of infectious diseases, 2009; 200(7): 1068-77.
Eisenberger Naomi I, Inagaki Tristen K, Rameson Lian T, Mashal Nehjla M, Irwin Michael R   An fMRI study of cytokine-induced depressed mood and social pain: the role of sex differences NeuroImage, 2009; 47(3): 881-90.
Dickerson SS, Gable SL, Irwin MR, Aziz N, Kemeny ME.   Social-Evaluative Threat and Proinflammatory Cytokine Regulation: An Experimental Laboratory Investigation Psychological science : a journal of the American Psychological Society / APS, 2009; 200(7): .
O'Connor Mary-Frances, Irwin Michael R, Wellisch David K   When grief heats up: pro-inflammatory cytokines predict regional brain activation NeuroImage, 2009; 47(3): 891-6.
Fuligni Andrew J, Telzer Eva H, Bower Julienne, Irwin Michael R, Kiang Lisa, Cole Steve W   Daily family assistance and inflammation among adolescents from Latin American and European backgrounds Brain, behavior, and immunity, 2009; 23(6): 803-9.
Cho HJ, Seeman TE, Bower JE, Kiefe CI, Irwin MR.   Prospective Association Between C-Reactive Protein and Fatigue in the Coronary Artery Risk Development in Young Adults Study Biological psychiatry, 2009; 23(6): .
Irwin Michael R, Olmstead Richard, Valladares Edwin M, Breen Elizabeth Crabb, Ehlers Cindy L   Tumor necrosis factor antagonism normalizes rapid eye movement sleep in alcohol dependence Biological psychiatry, 2009; 66(2): 191-5.
Irwin MR, Carrillo C, Olmstead R.   Sleep loss activates cellular markers of inflammation: Sex differences Brain, behavior, and immunity, 2009; 122(12): .
Gold Stefan M, Irwin Michael R   Depression and immunity: inflammation and depressive symptoms in multiple sclerosis Immunology and allergy clinics of North America, 2009; 29(2): 309-20.
Motivala Sarosh J, Tomiyama A Janet, Ziegler Michael, Khandrika Srikrishna, Irwin Michael R   Nocturnal levels of ghrelin and leptin and sleep in chronic insomnia Psychoneuroendocrinology, 2009; 34(4): 540-5.
Fuligni Andrew J, Telzer Eva H, Bower Julienne, Cole Steve W, Kiang Lisa, Irwin Michael R   A preliminary study of daily interpersonal stress and C-reactive protein levels among adolescents from Latin American and European backgrounds Psychosomatic medicine, 2009; 71(3): 329-33.
Creswell J David, Myers Hector F, Cole Steven W, Irwin Michael R   Mindfulness meditation training effects on CD4+ T lymphocytes in HIV-1 infected adults: a small randomized controlled trial Brain, behavior, and immunity, 2009; 23(2): 184-8.
Cho Hyong Jin, Lavretsky Helen, Olmstead Richard, Levin Myron J, Oxman Michael N, Irwin Michael R   Sleep disturbance and depression recurrence in community-dwelling older adults: a prospective study The American journal of psychiatry, 2008; 165(12): 1543-50.
Collado-Hidalgo Alicia, Bower Julienne E, Ganz Patricia A, Irwin Michael R, Cole Steve W   Cytokine gene polymorphisms and fatigue in breast cancer survivors: early findings Brain, behavior, and immunity, 2008; 22(8): 1197-200.
Irwin Michael R, Wang Minge, Ribeiro Denise, Cho Hyong Jin, Olmstead Richard, Breen Elizabeth Crabb, Martinez-Maza Otoniel, Cole Steve   Sleep loss activates cellular inflammatory signaling Biological psychiatry, 2008; 64(6): 538-40.
Irwin Michael R, Davis Mary, Zautra Alex   Behavioral Comorbidities in Rheumatoid Arthritis: A Psychoneuroimmunological Perspective The Psychiatric times, 2008; 25(9): 1.
O'Connor Mary-Frances, Wellisch David K, Stanton Annette L, Eisenberger Naomi I, Irwin Michael R, Lieberman Matthew D   Craving love? Enduring grief activates brain's reward center NeuroImage, 2008; 42(2): 969-72.
Irwin Michael R, Olmstead Richard, Motivala Sarosh J   Improving sleep quality in older adults with moderate sleep complaints: A randomized controlled trial of Tai Chi Chih Sleep, 2008; 31(7): 1001-8.
Zautra Alex J, Davis Mary C, Reich John W, Nicassario Perry, Tennen Howard, Finan Patrick, Kratz Anna, Parrish Brendt, Irwin Michael R   Comparison of cognitive behavioral and mindfulness meditation interventions on adaptation to rheumatoid arthritis for patients with and without history of recurrent depression Journal of consulting and clinical psychology, 2008; 76(3): 408-21.
Irwin Matthew R, Downey Donald B, Gardi Lori, Fenster Aaron   Registered 3-D ultrasound and digital stereotactic mammography for breast biopsy guidance IEEE transactions on medical imaging, 2008; 27(3): 391-401.
Valladares Edwin M, Eljammal Sam M, Motivala Sarosh, Ehlers Cindy L, Irwin Michael R   Sex differences in cardiac sympathovagal balance and vagal tone during nocturnal sleep Sleep medicine, 2008; 9(3): 310-6.
Levin M J, Oxman M N, Zhang J H, Johnson G R, Stanley H, Hayward A R, Caulfield M J, Irwin M R, Smith J G, Clair J, Chan I S F, Williams H, Harbecke R, Marchese R, Straus S E, Gershon A, Weinberg A, Weinberg A   Varicella-zoster virus-specific immune responses in elderly recipients of a herpes zoster vaccine The Journal of infectious diseases, 2008; 197(6): 825-35.
Irwin Michael R   Human psychoneuroimmunology: 20 years of discovery Brain, behavior, and immunity, 2008; 22(2): 129-39.
Miller Andrew H, Ancoli-Israel Sonia, Bower Julienne E, Capuron Lucile, Irwin Michael R   Neuroendocrine-immune mechanisms of behavioral comorbidities in patients with cancer Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008; 26(6): 971-82.
Motivala Sarosh J, Khanna Dinesh, FitzGerald John, Irwin Michael R   Stress activation of cellular markers of inflammation in rheumatoid arthritis: protective effects of tumor necrosis factor alpha antagonists Arthritis and rheumatism, 2008; 58(2): 376-83.
Klumpp Klaus, Kalayanov Genadiy, Ma Han, Le Pogam Sophie, Leveque Vincent, Jiang Wen-Rong, Inocencio Nicole, De Witte Anniek, Rajyaguru Sonal, Tai Ezra, Chanda Sushmita, Irwin Michael R, Sund Christian, Winqist Anna, Maltseva Tatiana, Eriksson Staffan, Usova Elena, Smith Mark, Alker Andre, Najera Isabel, Cammack Nick, Martin Joseph A, Johansson Nils Gunnar, Smith David B   2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups The Journal of biological chemistry, 2008; 283(4): 2167-75.
Davis Mary C, Zautra Alex J, Younger Jarred, Motivala Sarosh J, Attrep Jeanne, Irwin Michael R   Chronic stress and regulation of cellular markers of inflammation in rheumatoid arthritis: implications for fatigue Brain, behavior, and immunity, 2008; 22(1): 24-32.
Dantzer Robert, Capuron Lucile, Irwin Michael R, Miller Andrew H, Ollat Helene, Perry Victor Hugh, Rousey Sarah, Yirmiya Raz   Identification and treatment of symptoms associated with inflammation in medically ill patients Psychoneuroendocrinology, 2008; 33(1): 18-29.
Meeks Thomas W, Wetherell Julie L, Irwin Michael R, Redwine Laura S, Jeste Dilip V   Complementary and alternative treatments for late-life depression, anxiety, and sleep disturbance: a review of randomized controlled trials The Journal of clinical psychiatry, 2007; 68(10): 1461-71.
Frasure-Smith Nancy, Lespérance François, Irwin Michael R, Sauvé Claude, Lespérance Jacques, Théroux Pierre   Depression, C-reactive protein and two-year major adverse cardiac events in men after acute coronary syndromes Biological psychiatry, 2007; 62(4): 302-8.
O'Connor Mary-Frances, Motivala Sarosh J, Valladares Edwin M, Olmstead Richard, Irwin Michael R   Sex differences in monocyte expression of IL-6: role of autonomic mechanisms American journal of physiology. Regulatory, integrative and comparative physiology, 2007; 293(1): R145-51.
Irwin Michael R   Depression and risk of cancer progression: an elusive link Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007; 25(17): 2343-4.
Irwin Michael R, Miller Andrew H   Depressive disorders and immunity: 20 years of progress and discovery Brain, behavior, and immunity, 2007; 21(4): 374-83.
O'Connor Mary-Frances, Irwin Michael R, Seldon Joyce, Kwan Lorna, Ganz Patricia A   Pro-inflammatory cytokines and depression in a familial cancer registry Psycho-oncology, 2007; 16(5): 499-501.
Irwin Michael R, Olmstead Richard, Oxman Michael N   Augmenting immune responses to varicella zoster virus in older adults: a randomized, controlled trial of Tai Chi Journal of the American Geriatrics Society, 2007; 55(4): 511-7.
Valladares Edwin M, Eljammal Sam M, Iyer Anand V, Irwin Michael R   EEG and vagal tone degradation during nocturnal sleep in abstinent alcohol dependence Sleep medicine, 2007; 8(3): 284-5.
Bower Julienne E, Ganz Patricia A, Aziz Najib, Olmstead Richard, Irwin Michael R, Cole Steve W   Inflammatory responses to psychological stress in fatigued breast cancer survivors: relationship to glucocorticoids Brain, behavior, and immunity, 2007; 21(3): 251-8.
Irwin Michael R, Olmos Luis, Wang Minge, Valladares Edwin M, Motivala Sarosh J, Fong Tim, Newton Tom, Butch Anthony, Olmstead Richard, Cole Steve W   Cocaine dependence and acute cocaine induce decreases of monocyte proinflammatory cytokine expression across the diurnal period: autonomic mechanisms The Journal of pharmacology and experimental therapeutics, 2007; 320(2): 507-15.
Griffis Charles A, Irwin Michael R, Martinez-Maza Otoniel, Doering Lynn, Nyamathi Adeline, Kaufman Robert, Elashoff David, Aziz Najib, Compton Peggy   Pain-related activation of leukocyte cellular adhesion molecules: preliminary findings Neuroimmunomodulation, 2007; 14(5): 224-8.
Redwine Laura S, Mills Paul J, Hong Suzi, Rutledge Thomas, Reis Veronica, Maisel Alan, Irwin Michael R   Cardiac-related hospitalization and/or death associated with immune dysregulation and symptoms of depression in heart failure patients Psychosomatic medicine, 2007; 69(1): 23-9.
Valladares Edwin M, Irwin Michael R   Polysomnographic sleep dysregulation in cocaine dependence TheScientificWorldJournal, 2007; 7(1): 213-6.
Motivala Sarosh J, Sollers John, Thayer Julian, Irwin Michael R   Tai Chi Chih acutely decreases sympathetic nervous system activity in older adults The journals of gerontology. Series A, Biological sciences and medical sciences, 2006; 61(11): 1177-80.
Cole Jason C, Khanna Dinesh, Clements Philip J, Seibold James R, Tashkin Donald P, Paulus Harold E, Irwin Michael R, Motivala Sarosh J, Furst Daniel E   Single-factor scoring validation for the Health Assessment Questionnaire-Disability Index (HAQ-DI) in patients with systemic sclerosis and comparison with early rheumatoid arthritis patients Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2006; 15(8): 1383-94.
Irwin Michael R, Wang Minge, Campomayor Capella O, Collado-Hidalgo Alicia, Cole Steve   Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation Archives of internal medicine, 2006; 166(16): 1756-62.
Gold Stefan M, Irwin Michael R   Depression and immunity: inflammation and depressive symptoms in multiple sclerosis Neurologic clinics, 2006; 24(3): 507-19.
Motivala Sarosh J, Levin Myron J, Oxman Michael N, Irwin Michael R   Impairments in health functioning and sleep quality in older adults with a history of depression Journal of the American Geriatrics Society, 2006; 54(8): 1184-91.
Collado-Hidalgo Alicia, Bower Julienne E, Ganz Patricia A, Cole Steve W, Irwin Michael R   Inflammatory biomarkers for persistent fatigue in breast cancer survivors Clinical cancer research : an official journal of the American Association for Cancer Research, 2006; 12(9): 2759-66.
Eljammal Sam M, Valladares Edwin M, Irwin Michael R   Loss of slow-wave sleep Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2006; 2(2): 213-4.
Pike Jennifer L, Irwin Michael R   Dissociation of inflammatory markers and natural killer cell activity in major depressive disorder Brain, behavior, and immunity, 2006; 20(2): 169-74.
Irwin Michael R, Valladares Edwin M, Motivala Sarosh, Thayer Julian F, Ehlers Cindy L   Association between nocturnal vagal tone and sleep depth, sleep quality, and fatigue in alcohol dependence Psychosomatic medicine, 2006; 68(1): 159-66.
Irwin Michael R, Cole Jason C, Nicassio Perry M   Comparative meta-analysis of behavioral interventions for insomnia and their efficacy in middle-aged adults and in older adults 55+ years of age Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2006; 25(1): 3-14.
Cole Jason C, Motivala Sarosh J, Buysse Daniel J, Oxman Michael N, Levin Myron J, Irwin Michael R   Validation of a 3-factor scoring model for the Pittsburgh sleep quality index in older adults Sleep, 2006; 29(1): 112-6.
Motivala Sarosh J, Sarfatti Avishay, Olmos Luis, Irwin Michael R   Inflammatory markers and sleep disturbance in major depression Psychosomatic medicine, 2005; 67(2): 187-94.
Cole Jason C, Motivala Sarosh J, Khanna Dinesh, Lee Jessica Y, Paulus Harold E, Irwin Michael R   Validation of single-factor structure and scoring protocol for the Health Assessment Questionnaire-Disability Index Arthritis and rheumatism, 2005; 53(4): 536-42.
Motivala SJ, Sarfatti A, Olmos L, Irwin MR   Inflammatory markers and sleep disturbance in major depression Psychosomatic medicine. , 2005; 67(2): 187-94.
Oxman M N, Levin M J, Johnson G R, Schmader K E, Straus S E, Gelb L D, Arbeit R D, Simberkoff M S, Gershon A A, Davis L E, Weinberg A, Boardman K D, Williams H M, Zhang J Hongyuan, Peduzzi P N, Beisel C E, Morrison V A, Guatelli J C, Brooks P A, Kauffman C A, Pachucki C T, Neuzil K M, Betts R F, Wright P F, Griffin M R, Brunell P, Soto N E, Marques A R, Keay S K, Goodman R P, Cotton D J, Gnann J W, Loutit J, Holodniy M, Keitel W A, Crawford G E, Yeh S-S, Lobo Z, Toney J F, Greenberg R N, Keller P M, Harbecke R, Hayward A R, Irwin M R, Kyriakides T C, Chan C Y, Chan I S F, Wang W W B, Annunziato P W, Silber J L, Silber J L   A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults The New England journal of medicine, 2005; 352(22): 2271-84.
Aziz Najib, Irwin Michael R, Dickerson Sally S, Butch Anthony W   Spurious tumor necrosis factor-alpha and interleukin-6 production by human monocytes from blood collected in endotoxin-contaminated vacutainer blood collection tubes Clinical chemistry, 2004; 50(11): 2215-6.
Redwine L, Dang J, Irwin M   Cellular adhesion molecule expression, nocturnal sleep, and partial night sleep deprivation Brain, behavior, and immunity. , 2004; 18(4): 333-40.
Irwin M, Rinetti G, Redwine L, Motivala S, Dang J, Ehlers C   Nocturnal proinflammatory cytokine-associated sleep disturbances in abstinent African American alcoholics Brain, behavior, and immunity. , 2004; 18(4): 349-60.
Zautra AJ, Yocum DC, Villanueva I, Smith B, Davis MC, Attrep J, Irwin M   Immune activation and depression in women with rheumatoid arthritis The Journal of rheumatology. , 2004; 31(3): 457-63.
Irwin Michael R, Rinetti Gina   Disordered sleep, nocturnal cytokines, and immunity: interactions between alcohol dependence and African-American ethnicity Alcohol (Fayetteville, N.Y.), 2004; 32(1): 53-61.
Kuhlwein E, Hauger RL, Irwin MR   Abnormal nocturnal melatonin secretion and disordered sleep in abstinent alcoholics Biol Psychiatry, 2003; 54(12): 1437-43.
Kühlwein Eva, Hauger Richard L, Irwin Michael R   Abnormal nocturnal melatonin secretion and disordered sleep in abstinent alcoholics Biological psychiatry, 2003; 54(12): 1437-43.
Irwin Michael R, Pike Jennifer L, Cole Jason C, Oxman Michael N   Effects of a behavioral intervention, Tai Chi Chih, on varicella-zoster virus specific immunity and health functioning in older adults Psychosomatic medicine, 2003; 65(5): 824-30.
Grant Igor, Adler Karen A, Patterson Thomas L, Dimsdale Joel E, Ziegler Michael G, Irwin Michael R   Health consequences of Alzheimer's caregiving transitions: effects of placement and bereavement Psychosomatic medicine, 2003; 64(3): 477-86.
Motivala Sarosh J, Dang Jeff, Obradovic Tanja, Meadows Gary G, Butch Anthony W, Irwin Michael R   Leptin and cellular and innate immunity in abstinent alcoholics and controls Alcoholism, clinical and experimental research, 2003; 27(11): 1819-24.
Motivala SJ, Dang J, Obradovic T, Meadows GG, Butch AW, Irwin MR   Leptin and cellular and innate immunity in abstinent alcoholics and controls Alcoholism, clinical and experimental research. , 2003; 27(11): 1819-24.
Irwin M, Clark C, Kennedy B, Christian Gillin J, Ziegler M   Nocturnal catecholamines and immune function in insomniacs, depressed patients, and control subjects Brain, behavior, and immunity. , 2003; 17(5): 365-72.
Redwine L, Snow S, Mills P, Irwin M   Acute psychological stress: effects on chemotaxis and cellular adhesion molecule expression Psychosomatic medicine. , 2003; 65(4): 598-603.
Redwine L, Dang J, Hall M, Irwin M   Disordered sleep, nocturnal cytokines, and immunity in alcoholics Psychosomatic medicine. , 2003; 65(1): 75-85.