
Natik Piri, Ph.D.
Titles
Professor, Ophthalmology
Member, Stein Eye Institute
Brain Research Institute
Neuroscience GPB Home Area
Contact Information
Email
piri@jsei.ucla.edu Phone
Lab Number:
310-206-7900
Office Phone Number: 310-825-9850
Office Phone Number: 310-825-9850
Address
Work Address:
JSEILos Angeles, CA 90095
UNITED STATES
Publications
A selected list of publications:
Gu Lei, Bok Dean, Yu Fei, Caprioli Joseph, Piri Natik
Downregulation of splicing regulator RBFOX1 compromises visual depth
perception
PloS one,
2018; 13(7):
e0200417.
Ye Linda, Gu Lei, Caprioli Joseph, Piri Natik
RNA-binding protein Rbpms is represented in human retinas by isoforms
A and C and its transcriptional regulation involves Sp1-binding site
Molecular genetics and genomics : MGG,
2018; 293(4):
819-830.
Gu Lei, Kwong Jacky M K, Yadegari Daniel, Yu Fei, Caprioli Joseph, Piri Natik
The effect of celastrol on the ocular hypertension-induced
degeneration of retinal ganglion cells
Neuroscience letters,
2018; 670(7):
89-93.
Piri Natik, Kwong Jacky M K, Gu Lei, Caprioli Joseph
Heat shock proteins in the retina: Focus on HSP70 and alpha
crystallins in ganglion cell survival
Progress in retinal and eye research,
2016; 52(7):
22-46.
Kyung Haksu, Kwong Jacky M K, Bekerman Vlad, Gu Lei, Yadegari Daniel, Caprioli Joseph, Piri Natik
Celastrol supports survival of retinal ganglion cells injured by optic
nerve crush
Brain research,
2015; 1609(7):
21-30.
Piri Natik, Kwong Jacky M K, Caprioli Joseph
Crystallins in retinal ganglion cell survival and regeneration
Molecular neurobiology,
2013; 48(3):
819-28.
Kwong Jacky M K, Vo Nancy, Quan Ann, Nam Michael, Kyung Haksu, Yu Fei, Piri Natik, Caprioli Joseph
The dark phase intraocular pressure elevation and retinal ganglion
cell degeneration in a rat model of experimental glaucoma
Experimental eye research,
2013; 112(3):
21-8.
Munemasa Yasunari, Chang Chang-Sheng, Kwong Jacky M K, Kyung Haksu, Kitaoka Yasushi, Caprioli Joseph, Piri Natik
The neuronal EGF-related gene Nell2 interacts with Macf1 and supports
survival of retinal ganglion cells after optic nerve injury
PloS one,
2012; 7(4):
e34810.
Kwong Jacky M K, Quan Ann, Kyung Haksu, Piri Natik, Caprioli Joseph
Quantitative analysis of retinal ganglion cell survival with Rbpms
immunolabeling in animal models of optic neuropathies
Investigative ophthalmology & visual science,
2011; 52(13):
9694-702.
Law Simon K, Sami Maha, Piri Natik, Coleman Anne L, Caprioli Joseph
Asymmetric phenotype of Axenfeld-Rieger anomaly and aniridia
associated with a novel PITX2 mutation
Molecular vision,
2011; 17(37):
1231-8.
Kao Liyo, Kurtz Lisa M, Shao Xuesi, Papadopoulos Marios C, Liu Li, Bok Dean, Nusinowitz Steven, Chen Bryan, Stella Salvatore L, Andre Mark, Weinreb Josh, Luong Serena S, Piri Natik, Kwong Jacky M K, Newman Debra, Kurtz Ira
Severe neurologic impairment in mice with targeted disruption of the
electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene)
The Journal of biological chemistry,
2011; 286(37):
32563-74.
Kwong Jacky M K, Caprioli Joseph, Piri Natik
RNA binding protein with multiple splicing: a new marker for retinal
ganglion cells
Investigative ophthalmology & visual science,
2010; 51(2):
1052-8.
Munemasa Yasunari, Kwong Jacky M K, Kim Seok H, Ahn Jae H, Caprioli Joseph, Piri Natik
Thioredoxins 1 and 2 protect retinal ganglion cells from
pharmacologically induced oxidative stress, optic nerve transection
and ocular hypertension
Advances in experimental medicine and biology,
2010; 664(2):
355-63.
Caprioli Joseph, Munemasa Yasunari, Kwong Jacky M K, Piri Natik
Overexpression of thioredoxins 1 and 2 increases retinal ganglion cell
survival after pharmacologically induced oxidative stress, optic nerve
transection, and in experimental glaucoma
Transactions of the American Ophthalmological Society,
2009; 107(2):
161-5.
Munemasa Yasunari, Kwong Jacky M K, Caprioli Joseph, Piri Natik
The role of alphaA- and alphaB-crystallins in the survival of retinal
ganglion cells after optic nerve axotomy
Investigative ophthalmology & visual science,
2009; 50(8):
3869-75.
Verardo Mark R, Viczian Andrea, Piri Natik, Akhmedov Novrouz B, Knox Barry E, Farber Debora B
Regulatory sequences in the 3' untranslated region of the human
cGMP-phosphodiesterase beta-subunit gene
Investigative ophthalmology & visual science,
2009; 50(6):
2591-8.
Kim Seok Hwan, Munemasa Yasunari, Kwong Jacky M K, Ahn Jae Hong, Mareninov Sergey, Gordon Lynn K, Caprioli Joseph, Piri Natik
Activation of autophagy in retinal ganglion cells
Journal of neuroscience research,
2008; 86(13):
2943-51.
Souied Eric H, Reid Silvia N M, Piri Natik I, Lerner Leonid E, Nusinowitz Steven, Farber Debora B
Non-invasive gene transfer by iontophoresis for therapy of an
inherited retinal degeneration
Experimental eye research,
2008; 87(3):
168-75.
Munemasa Yasunari, Kim Seok Hwan, Ahn Jae Hong, Kwong Jacky M K, Caprioli Joseph, Piri Natik
Protective effect of thioredoxins 1 and 2 in retinal ganglion cells
after optic nerve transection and oxidative stress
Investigative ophthalmology & visual science,
2008; 49(8):
3535-43.
Ahn Jaehong, Piri Natik, Caprioli Joseph, Munemasa Yasunari, Kim Seok Hwan, Kwong Jacky M K
Expression of heat shock transcription factors and heat shock protein
72 in rat retina after intravitreal injection of low dose
N-methyl-D-aspartate
Neuroscience letters,
2008; 433(1):
11-6.
Piri Natik, Song Min, Kwong Jacky M K, Caprioli Joseph
Modulation of alpha and beta crystallin expression in rat retinas with
ocular hypertension-induced ganglion cell degeneration
Brain research,
2007; 1141(1):
1-9.
Piri Natik, Kwong Jacky M K, Song Min, Elashoff David, Caprioli Joseph
Gene expression changes in the retina following optic nerve
transection
Molecular vision,
2006; 12(1):
1660-73.
Piri Natik, Mendoza Emmanuel, Shih Jennifer, Yamashita Clyde K, Akhmedov Novrouz B, Farber Debora B
Translational regulation of the rod photoreceptor
cGMP-phosphodiesterase: the role of the 5'- and 3'-untranslated
regions
Experimental eye research,
2006; 83(4):
841-8.
Kwong Jacky M K, Lalezary Maziar, Nguyen Jessica K, Yang Christine, Khattar Anuj, Piri Natik, Mareninov Sergey, Gordon Lynn K, Caprioli Joseph
Co-expression of heat shock transcription factors 1 and 2 in rat
retinal ganglion cells
Neuroscience letters,
2006; 405(3):
191-5.
Piri Natik, Kwong Jacky M K, Song Min, Caprioli Joseph
Expression of hermes gene is restricted to the ganglion cells in the
retina
Neuroscience letters,
2006; 405(1-2):
40-5.
Lerner Leonid E, Piri Natik, Farber Debora B
Transcriptional and post-transcriptional regulation of the rod
cGMP-phosphodiesterase beta-subunit gene. Recent advances and current
concepts
Advances in experimental medicine and biology,
2006; 572(1-2):
217-29.
Akhmedov Novrouz B, Yamashita Clyde K, Tran Dai, Piri Natik I, Aguirre Gustavo D, Farber Debora B
Two forms of the large tumor suppressor gene (Lats1) protein expressed
in the vertebrate retina
Biochimica et biophysica acta,
2005; 1728(1-2):
11-7.
Piri Natik, Gao Yong Qing, Danciger Michael, Mendoza Emmanuel, Fishman Gerald A, Farber Debora B
A substitution of G to C in the cone cGMP-phosphodiesterase gamma
subunit gene found in a distinctive form of cone dystrophy
Ophthalmology,
2005; 112(1):
159-66.
Piri Natik, Yamashita Clyde K, Shih Jennifer, Akhmedov Novrouz B, Farber Debora B
Differential expression of rod photoreceptor cGMP-phosphodiesterase
alpha and beta subunits: mRNA and protein levels
The Journal of biological chemistry,
2003; 278(39):
36999-7005.
Piriev Natik I, Yamashita Clyde K, Shih Jennifer, Farber Debora B
Expression of cone photoreceptor cGMP-phosphodiesterase alpha' subunit
in Chinese hamster ovary, 293 human embryonic kidney, and Y79
retinoblastoma cells
Molecular vision,
2003; 9:
80-6.
Akhmedov N B, Piriev N I, Chang B, Rapoport A L, Hawes N L, Nishina P M, Nusinowitz S, Heckenlively J R, Roderick T H, Kozak C A, Danciger M, Davisson M T, Farber D B
A deletion in a photoreceptor-specific nuclear receptor mRNA causes
retinal degeneration in the rd7 mouse
Proceedings of the National Academy of Sciences of the United States of America,
2000; 97(10):
5551-6.
Guillonneau X, Piriev N I, Danciger M, Kozak C A, Cideciyan A V, Jacobson S G, Farber D B
A nonsense mutation in a novel gene is associated with retinitis
pigmentosa in a family linked to the RP1 locus
Human molecular genetics,
1999; 8(8):
1541-6.
Gao Y Q, Danciger M, Longmuir R, Piriev N I, Zhao D Y, Heckenlively J R, Fishman G A, Weleber R G, Jacobson S G, Stone E M, Farber D B
Screening of the gene encoding the alpha'-subunit of cone cGMP-PDE in
patients with retinal degenerations
Investigative ophthalmology & visual science,
1999; 40(8):
1818-22.
Reid S N, Akhmedov N B, Piriev N I, Kozak C A, Danciger M, Farber D B
The mouse X-linked juvenile retinoschisis cDNA: expression in
photoreceptors
Gene,
1999; 227(2):
257-66.
Akhmedov N B, Piriev N I, Pearce-Kelling S, Acland G M, Aguirre G D, Farber D B
Canine cone transducin-gamma gene and cone degeneration in the cd dog
Investigative ophthalmology & visual science,
1998; 39(10):
1775-81.
Piriev N I, Shih J M, Farber D B
Defective RNA splicing resulting from a mutation in the cyclic
guanosine monophosphate-phosphodiesterase beta-subunit gene
Investigative ophthalmology & visual science,
1998; 39(3):
463-70.
Akhmedov N B, Piriev N I, Ray K, Acland G M, Aguirre G D, Farber D B
Structure and analysis of the transducin beta3-subunit gene, a
candidate for inherited cone degeneration (cd) in the dog
Gene,
1997; 194(1):
47-56.
Gao Y Q, Danciger M, Zhao D Y, Blaney J, Piriev N I, Shih J, Jacobson S G, Heckenlively J H, Farber D B
Screening of the PDE6B gene in patients with autosomal dominant
retinitis pigmentosa
Experimental eye research,
1996; 62(2):
149-54.
Viczian A S, Piriev N I, Farber D B
Isolation and characterization of a cDNA encoding the alpha' subunit
of human cone cGMP-phosphodiesterase
Gene,
1995; 166(2):
205-11.
Piriev N I, Viczian A S, Ye J, Kerner B, Korenberg J R, Farber D B
Gene structure and amino acid sequence of the human cone photoreceptor
cGMP-phosphodiesterase alpha' subunit (PDEA2) and its chromosomal
localization to 10q24
Genomics,
1995; 28(3):
429-35.
Piriev N I, Khramtsov N V, Lipkin V M
Cloning and characterization of the gene encoding the
cGMP-phosphodiesterase gamma-subunit of human rod photoreceptor cells
Gene,
1994; 151(1-2):
297-301.
Piriev N I, Yamashita C, Samuel G, Farber D B
Rod photoreceptor cGMP-phosphodiesterase: analysis of alpha and beta
subunits expressed in human kidney cells
Proceedings of the National Academy of Sciences of the United States of America,
1993; 90(20):
9340-4.
Piriev N I, Purishko V A, Khramtsov N V, Lipkin V M
[The organization of the gamma-subunit gene of human photoreceptor
cyclic GMP phosphodiesterase]
Doklady Akademii nauk SSSR,
1990; 315(1):
229-31.
Limb GA, Martin K, Di Polo A, Harvey AR, Morrison JC, Reh T, Bainbridge J, Benowitz L, Coleman M, Dahlmann-Noor AH, Fischer A, Fischer D, Goldberg JL, Gonzales P, Grus F, Hauck SM, Johnson EC, Kaufman P, Lingor P, Morgan JE, Piri N, Quigley H, Sendtner M, Tezel G, Weber AJ, Chao MV, Behar-Cohen FF, Mitra A, Ferrari D.
Current prospects in optic nerve protection and regeneration: sixth ARVO/Pfizer Ophthalmics Research Institute conference,
Invest Ophthalmol Vis Sci,
2011; 52(8):
5941-54.
Klionsky DJ, ..., Piri N et al.
Guidelines for the use and interpretation of assays for monitoring autophagy. ,
Autophagy,
2012; 8(4):
445-544.