Natik Piri, Ph.D.

Professor, Ophthalmology

Member, Stein Eye Institute

Brain Research Institute

Neuroscience GPB Home Area

Gu Lei, Bok Dean, Yu Fei, Caprioli Joseph, Piri Natik   Downregulation of splicing regulator RBFOX1 compromises visual depth perception PloS one, 2018; 13(7): e0200417.

Ye Linda, Gu Lei, Caprioli Joseph, Piri Natik   RNA-binding protein Rbpms is represented in human retinas by isoforms A and C and its transcriptional regulation involves Sp1-binding site Molecular genetics and genomics : MGG, 2018; 293(4): 819-830.

Gu Lei, Kwong Jacky M K, Yadegari Daniel, Yu Fei, Caprioli Joseph, Piri Natik   The effect of celastrol on the ocular hypertension-induced degeneration of retinal ganglion cells Neuroscience letters, 2018; 670(7): 89-93.

Piri Natik, Kwong Jacky M K, Gu Lei, Caprioli Joseph   Heat shock proteins in the retina: Focus on HSP70 and alpha crystallins in ganglion cell survival Progress in retinal and eye research, 2016; 52(7): 22-46.

Kyung Haksu, Kwong Jacky M K, Bekerman Vlad, Gu Lei, Yadegari Daniel, Caprioli Joseph, Piri Natik   Celastrol supports survival of retinal ganglion cells injured by optic nerve crush Brain research, 2015; 1609(7): 21-30.

Piri Natik, Kwong Jacky M K, Caprioli Joseph   Crystallins in retinal ganglion cell survival and regeneration Molecular neurobiology, 2013; 48(3): 819-28.

Kwong Jacky M K, Vo Nancy, Quan Ann, Nam Michael, Kyung Haksu, Yu Fei, Piri Natik, Caprioli Joseph   The dark phase intraocular pressure elevation and retinal ganglion cell degeneration in a rat model of experimental glaucoma Experimental eye research, 2013; 112(3): 21-8.

Munemasa Yasunari, Chang Chang-Sheng, Kwong Jacky M K, Kyung Haksu, Kitaoka Yasushi, Caprioli Joseph, Piri Natik   The neuronal EGF-related gene Nell2 interacts with Macf1 and supports survival of retinal ganglion cells after optic nerve injury PloS one, 2012; 7(4): e34810.

Kwong Jacky M K, Quan Ann, Kyung Haksu, Piri Natik, Caprioli Joseph   Quantitative analysis of retinal ganglion cell survival with Rbpms immunolabeling in animal models of optic neuropathies Investigative ophthalmology & visual science, 2011; 52(13): 9694-702.

Law Simon K, Sami Maha, Piri Natik, Coleman Anne L, Caprioli Joseph   Asymmetric phenotype of Axenfeld-Rieger anomaly and aniridia associated with a novel PITX2 mutation Molecular vision, 2011; 17(37): 1231-8.

Kao Liyo, Kurtz Lisa M, Shao Xuesi, Papadopoulos Marios C, Liu Li, Bok Dean, Nusinowitz Steven, Chen Bryan, Stella Salvatore L, Andre Mark, Weinreb Josh, Luong Serena S, Piri Natik, Kwong Jacky M K, Newman Debra, Kurtz Ira   Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene) The Journal of biological chemistry, 2011; 286(37): 32563-74.

Kwong Jacky M K, Caprioli Joseph, Piri Natik   RNA binding protein with multiple splicing: a new marker for retinal ganglion cells Investigative ophthalmology & visual science, 2010; 51(2): 1052-8.

Munemasa Yasunari, Kwong Jacky M K, Kim Seok H, Ahn Jae H, Caprioli Joseph, Piri Natik   Thioredoxins 1 and 2 protect retinal ganglion cells from pharmacologically induced oxidative stress, optic nerve transection and ocular hypertension Advances in experimental medicine and biology, 2010; 664(2): 355-63.

Caprioli Joseph, Munemasa Yasunari, Kwong Jacky M K, Piri Natik   Overexpression of thioredoxins 1 and 2 increases retinal ganglion cell survival after pharmacologically induced oxidative stress, optic nerve transection, and in experimental glaucoma Transactions of the American Ophthalmological Society, 2009; 107(2): 161-5.

Munemasa Yasunari, Kwong Jacky M K, Caprioli Joseph, Piri Natik   The role of alphaA- and alphaB-crystallins in the survival of retinal ganglion cells after optic nerve axotomy Investigative ophthalmology & visual science, 2009; 50(8): 3869-75.

Verardo Mark R, Viczian Andrea, Piri Natik, Akhmedov Novrouz B, Knox Barry E, Farber Debora B   Regulatory sequences in the 3' untranslated region of the human cGMP-phosphodiesterase beta-subunit gene Investigative ophthalmology & visual science, 2009; 50(6): 2591-8.

Kim Seok Hwan, Munemasa Yasunari, Kwong Jacky M K, Ahn Jae Hong, Mareninov Sergey, Gordon Lynn K, Caprioli Joseph, Piri Natik   Activation of autophagy in retinal ganglion cells Journal of neuroscience research, 2008; 86(13): 2943-51.

Souied Eric H, Reid Silvia N M, Piri Natik I, Lerner Leonid E, Nusinowitz Steven, Farber Debora B   Non-invasive gene transfer by iontophoresis for therapy of an inherited retinal degeneration Experimental eye research, 2008; 87(3): 168-75.

Munemasa Yasunari, Kim Seok Hwan, Ahn Jae Hong, Kwong Jacky M K, Caprioli Joseph, Piri Natik   Protective effect of thioredoxins 1 and 2 in retinal ganglion cells after optic nerve transection and oxidative stress Investigative ophthalmology & visual science, 2008; 49(8): 3535-43.

Ahn Jaehong, Piri Natik, Caprioli Joseph, Munemasa Yasunari, Kim Seok Hwan, Kwong Jacky M K   Expression of heat shock transcription factors and heat shock protein 72 in rat retina after intravitreal injection of low dose N-methyl-D-aspartate Neuroscience letters, 2008; 433(1): 11-6.

Piri Natik, Song Min, Kwong Jacky M K, Caprioli Joseph   Modulation of alpha and beta crystallin expression in rat retinas with ocular hypertension-induced ganglion cell degeneration Brain research, 2007; 1141(1): 1-9.

Piri Natik, Kwong Jacky M K, Song Min, Elashoff David, Caprioli Joseph   Gene expression changes in the retina following optic nerve transection Molecular vision, 2006; 12(1): 1660-73.

Piri Natik, Mendoza Emmanuel, Shih Jennifer, Yamashita Clyde K, Akhmedov Novrouz B, Farber Debora B   Translational regulation of the rod photoreceptor cGMP-phosphodiesterase: the role of the 5'- and 3'-untranslated regions Experimental eye research, 2006; 83(4): 841-8.

Kwong Jacky M K, Lalezary Maziar, Nguyen Jessica K, Yang Christine, Khattar Anuj, Piri Natik, Mareninov Sergey, Gordon Lynn K, Caprioli Joseph   Co-expression of heat shock transcription factors 1 and 2 in rat retinal ganglion cells Neuroscience letters, 2006; 405(3): 191-5.

Piri Natik, Kwong Jacky M K, Song Min, Caprioli Joseph   Expression of hermes gene is restricted to the ganglion cells in the retina Neuroscience letters, 2006; 405(1-2): 40-5.

Lerner Leonid E, Piri Natik, Farber Debora B   Transcriptional and post-transcriptional regulation of the rod cGMP-phosphodiesterase beta-subunit gene. Recent advances and current concepts Advances in experimental medicine and biology, 2006; 572(1-2): 217-29.

Akhmedov Novrouz B, Yamashita Clyde K, Tran Dai, Piri Natik I, Aguirre Gustavo D, Farber Debora B   Two forms of the large tumor suppressor gene (Lats1) protein expressed in the vertebrate retina Biochimica et biophysica acta, 2005; 1728(1-2): 11-7.

Piri Natik, Gao Yong Qing, Danciger Michael, Mendoza Emmanuel, Fishman Gerald A, Farber Debora B   A substitution of G to C in the cone cGMP-phosphodiesterase gamma subunit gene found in a distinctive form of cone dystrophy Ophthalmology, 2005; 112(1): 159-66.

Piri Natik, Yamashita Clyde K, Shih Jennifer, Akhmedov Novrouz B, Farber Debora B   Differential expression of rod photoreceptor cGMP-phosphodiesterase alpha and beta subunits: mRNA and protein levels The Journal of biological chemistry, 2003; 278(39): 36999-7005.

Piriev Natik I, Yamashita Clyde K, Shih Jennifer, Farber Debora B   Expression of cone photoreceptor cGMP-phosphodiesterase alpha' subunit in Chinese hamster ovary, 293 human embryonic kidney, and Y79 retinoblastoma cells Molecular vision, 2003; 9: 80-6.

Akhmedov N B, Piriev N I, Chang B, Rapoport A L, Hawes N L, Nishina P M, Nusinowitz S, Heckenlively J R, Roderick T H, Kozak C A, Danciger M, Davisson M T, Farber D B   A deletion in a photoreceptor-specific nuclear receptor mRNA causes retinal degeneration in the rd7 mouse Proceedings of the National Academy of Sciences of the United States of America, 2000; 97(10): 5551-6.

Guillonneau X, Piriev N I, Danciger M, Kozak C A, Cideciyan A V, Jacobson S G, Farber D B   A nonsense mutation in a novel gene is associated with retinitis pigmentosa in a family linked to the RP1 locus Human molecular genetics, 1999; 8(8): 1541-6.

Gao Y Q, Danciger M, Longmuir R, Piriev N I, Zhao D Y, Heckenlively J R, Fishman G A, Weleber R G, Jacobson S G, Stone E M, Farber D B   Screening of the gene encoding the alpha'-subunit of cone cGMP-PDE in patients with retinal degenerations Investigative ophthalmology & visual science, 1999; 40(8): 1818-22.

Reid S N, Akhmedov N B, Piriev N I, Kozak C A, Danciger M, Farber D B   The mouse X-linked juvenile retinoschisis cDNA: expression in photoreceptors Gene, 1999; 227(2): 257-66.

Akhmedov N B, Piriev N I, Pearce-Kelling S, Acland G M, Aguirre G D, Farber D B   Canine cone transducin-gamma gene and cone degeneration in the cd dog Investigative ophthalmology & visual science, 1998; 39(10): 1775-81.

Piriev N I, Shih J M, Farber D B   Defective RNA splicing resulting from a mutation in the cyclic guanosine monophosphate-phosphodiesterase beta-subunit gene Investigative ophthalmology & visual science, 1998; 39(3): 463-70.

Akhmedov N B, Piriev N I, Ray K, Acland G M, Aguirre G D, Farber D B   Structure and analysis of the transducin beta3-subunit gene, a candidate for inherited cone degeneration (cd) in the dog Gene, 1997; 194(1): 47-56.

Gao Y Q, Danciger M, Zhao D Y, Blaney J, Piriev N I, Shih J, Jacobson S G, Heckenlively J H, Farber D B   Screening of the PDE6B gene in patients with autosomal dominant retinitis pigmentosa Experimental eye research, 1996; 62(2): 149-54.

Viczian A S, Piriev N I, Farber D B   Isolation and characterization of a cDNA encoding the alpha' subunit of human cone cGMP-phosphodiesterase Gene, 1995; 166(2): 205-11.

Piriev N I, Viczian A S, Ye J, Kerner B, Korenberg J R, Farber D B   Gene structure and amino acid sequence of the human cone photoreceptor cGMP-phosphodiesterase alpha' subunit (PDEA2) and its chromosomal localization to 10q24 Genomics, 1995; 28(3): 429-35.

Piriev N I, Khramtsov N V, Lipkin V M   Cloning and characterization of the gene encoding the cGMP-phosphodiesterase gamma-subunit of human rod photoreceptor cells Gene, 1994; 151(1-2): 297-301.

Piriev N I, Yamashita C, Samuel G, Farber D B   Rod photoreceptor cGMP-phosphodiesterase: analysis of alpha and beta subunits expressed in human kidney cells Proceedings of the National Academy of Sciences of the United States of America, 1993; 90(20): 9340-4.

Piriev N I, Purishko V A, Khramtsov N V, Lipkin V M   [The organization of the gamma-subunit gene of human photoreceptor cyclic GMP phosphodiesterase] Doklady Akademii nauk SSSR, 1990; 315(1): 229-31.

Limb GA, Martin K, Di Polo A, Harvey AR, Morrison JC, Reh T, Bainbridge J, Benowitz L, Coleman M, Dahlmann-Noor AH, Fischer A, Fischer D, Goldberg JL, Gonzales P, Grus F, Hauck SM, Johnson EC, Kaufman P, Lingor P, Morgan JE, Piri N, Quigley H, Sendtner M, Tezel G, Weber AJ, Chao MV, Behar-Cohen FF, Mitra A, Ferrari D.   Current prospects in optic nerve protection and regeneration: sixth ARVO/Pfizer Ophthalmics Research Institute conference, Invest Ophthalmol Vis Sci, 2011; 52(8): 5941-54.

Klionsky DJ, ..., Piri N et al.   Guidelines for the use and interpretation of assays for monitoring autophagy. , Autophagy, 2012; 8(4): 445-544.