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Rebecca A. Stockton, Ph.D.
Assistant Professor of Pediatrics, Brain Research Institute
PhoneWork Phone Number: 424-201-3005
AddressMailing Address: 1123 West Carson StCHRC #119Torrance, CA 90502UNITED STATES Child Health Research Center, Rm 1191124 West Carson Street Torrance, CA 90502UNITED STATES
BiographyDr. Stockton is a vascular biologist and specialist in endothelial cell signaling. She earned a PhD in Molecular and Cellular Biology from the University of Massachusetts Amherst, and trained as a postdoctoral fellow at the University of Virginia. She was Assistant Adjunct Professor at University of California San Diego, and established a lab at Harbor-UCLA Medical Center Dept of Pediatrics in 2012 as Assistant Professor of Pediatrics. She has extensive experience in the biology of vascular endothelial RhoGTPase signaling, conducting structure/function studies of in vitro and in vivo endothelial permeability and vascular barrier function, and assessing the basic mechanisms of vascular development and dysfunction in disease. Her work has been funded by NIH and the American Heart Association. She is a contributor to multiple groundbreaking studies defining aberrant endothelial signaling in Cerebral Cavernous Malformations (CCM) produced by mutations of the KRIT1, CCM2 and PDCD10 (CCM3) genes. As a junior faculty member at UC San Diego, her group reported the first endothelial expression and biological function regulating endothelial junctional stability of CCM gene product protein KRIT1. Ensuing collaborations with colleagues at University of Chicago and Duke University subsequently reported evidence for disrupted Rho/Rho-kinase signaling driving endothelial pathology producing brain lesions in this disease, identified a potential therapy, and reported in model mouse studies the first successful reduction of CCM brain lesion formation through a drug treatment. The Stockton Labs current studies focus on identifying additional protein signaling participants in multiple cerebrovascular pathologies.
Shenkar Robert, Shi Changbin, Rebeiz Tania, Stockton Rebecca A, McDonald David A, Mikati Abdul Ghani, Zhang Lingjiao, Austin Cecilia, Akers Amy L, Gallione Carol J, Rorrer Autumn, Gunel Murat, Min Wang, Marcondes de Souza Jorge, Lee Connie, Marchuk Douglas A, Awad Issam A Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations Genetics in medicine : official journal of the American College of Medical Genetics, 2015; 17(3): 188-96.
McDonald David A, Shi Changbin, Shenkar Robert, Stockton Rebecca A, Liu Feifei, Ginsberg Mark H, Marchuk Douglas A, Awad Issam A Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease Stroke; a journal of cerebral circulation, 2012; 43(2): 571-4.
Liu Jian J, Stockton Rebecca A, Gingras Alexandre R, Ablooglu Ararat J, Han Jaewon, Bobkov Andrey A, Ginsberg Mark H A mechanism of Rap1-induced stabilization of endothelial cell--cell junctions Molecular biology of the cell, 2011; 22(14): 2509-19.
McDonald David A, Shenkar Robert, Shi Changbin, Stockton Rebecca A, Akers Amy L, Kucherlapati Melanie H, Kucherlapati Raju, Brainer James, Ginsberg Mark H, Awad Issam A, Marchuk Douglas A A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease Human molecular genetics, 2011; 20(2): 211-22.
Stockton Rebecca A, Shenkar Robert, Awad Issam A, Ginsberg Mark H Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity The Journal of experimental medicine, 2010; 207(4): 881-96.
Goldfinger Lawrence E, Tzima Eleni, Stockton Rebecca, Kiosses William B, Kinbara Kayoko, Tkachenko Eugene, Gutierrez Edgar, Groisman Alex, Nguyen Phu, Chien Shu, Ginsberg Mark H Localized alpha4 integrin phosphorylation directs shear stress-induced endothelial cell alignment Circulation research, 2008; 103(2): 177-85.
Jones Christopher A, London Nyall R, Chen Haoyu, Park Kye Won, Sauvaget Dominique, Stockton Rebecca A, Wythe Joshua D, Suh Wonhee, Larrieu-Lahargue Frederic, Mukouyama Yoh-Suke, Lindblom Per, Seth Pankaj, Frias Antonio, Nishiya Naoyuki, Ginsberg Mark H, Gerhardt Holger, Zhang Kang, Li Dean Y Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability Nature medicine, 2008; 14(4): 448-53.
Glading Angela, Han Jaewon, Stockton Rebecca A, Ginsberg Mark H KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions The Journal of cell biology, 2007; 179(2): 247-54.
Stockton Rebecca, Reutershan Jörg, Scott David, Sanders John, Ley Klaus, Schwartz Martin Alexander Induction of vascular permeability: beta PIX and GIT1 scaffold the activation of extracellular signal-regulated kinase by PAK Molecular biology of the cell, 2007; 18(6): 2346-55.
Reutershan Jörg, Stockton Rebecca, Zarbock Alexander, Sullivan Gail W, Chang Daniel, Scott David, Schwartz Martin A, Ley Klaus Blocking p21-activated kinase reduces lipopolysaccharide-induced acute lung injury by preventing polymorphonuclear leukocyte infiltration American journal of respiratory and critical care medicine, 2007; 175(10): 1027-35.
Orr A Wayne, Stockton Rebecca, Simmers Michael B, Sanders John M, Sarembock Ian J, Blackman Brett R, Schwartz Martin Alexander Matrix-specific p21-activated kinase activation regulates vascular permeability in atherogenesis The Journal of cell biology, 2007; 176(5): 719-27.
Tsai Irene Y, Kimura Masahiro, Stockton Rebecca, Green J Angelo, Puig Ricardo, Jacobson Bruce, Russell Thomas P Fibroblast adhesion to micro- and nano-heterogeneous topography using diblock copolymers and homopolymers Journal of biomedical materials research. Part A, 2004; 71(3): 462-9.
Stockton Rebecca A, Schaefer Erik, Schwartz Martin Alexander p21-activated kinase regulates endothelial permeability through modulation of contractility The Journal of biological chemistry, 2004; 279(45): 46621-30.
Green J Angelo, Stockton Rebecca A, Johnson Christopher, Jacobson Bruce S 5-lipoxygenase and cyclooxygenase regulate wound closure in NIH/3T3 fibroblast monolayers American journal of physiology. Cell physiology, 2004; 287(2): C373-83.