Riccardo Olcese, Ph.D.

Titles

Professor, Physiology
Associate Professor, Anesthesiology
Member, Molecular Medicine
Biochemistry, Biophysics & Structural Biology GPB Home Area
Brain Research Institute
Molecular, Cellular & Integrative Physiology GPB Home Area
Neuroscience GPB Home Area
Neuroscience IDP
Faculty, Cardiovascular Research Laboratory
Molecular, Cellular, and Integrative Physiology IDP

Contact Information

Email
rolcese@ucla.edu
Phone
Fax Number: 310-206-1947Lab Number: 310-206-2685Office Phone Number: 310-206-2214
Address
Work Address: LaboratoryCHSLos Angeles, CA 90095UNITED STATES OfficeCHS100 Jules Stein PlazaDivision of Molecular Medicine, Dept. of AnesthesiologyLos Angeles, CA 90095UNITED STATES

Publications:

Mahajan A, Shiferaw Y, Sato D, Baher A, Olcese R, Xie LH, Yang MJ, Chen PS, Restrepo JG, Karma A, Garfinkel A, Qu Z, Weiss JN. 2008   A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates, Biophys J, 2008; 94(2): 392-410.
Mahajan A, Sato D, Shiferaw Y, Baher A, Xie LH, Peralta R, Olcese R, Garfinkel A, Qu Z, Weiss JN.   Modifying L-type calcium current kinetics: consequences for cardiac excitation and arrhythmia dynamics, Biophys J. , 2008; 94(2): 411-23. .
Yusifov T, Savalli N, Gandhi CS, Ottolia M, Olcese R.   The RCK2 domain of the human BKCa channel is a calcium sensor, Proc Natl Acad Sci U S A, 2008; 105(1): 376-81.
Olcese Riccardo   And yet it moves: conformational States of the Ca2+ channel pore, J Gen Physiol. , 2007; 129(6)((6)): 457-9..
Gudzenko V, Shiferaw Y, Savalli N, Vyas R, Weiss JN, Olcese R.   Influence of channel subunit composition on L-type Ca2+ current kinetics and cardiac wave stability, Am J Physiol Heart Circ Physiol, 2007; 293(3): H1805-15.
Savalli N, Kondratiev A, de Quintana SB, Toro L, Olcese R.   Modes of operation of the BKCa channel beta2 subunit, J Gen Physiol, 2007; 130((1)): 117-31.
Savalli N, Kondratiev A, Toro L, Olcese R.   Voltage-dependent conformational changes in human Ca(2+)- and voltage-activated K(+) channel, revealed by voltage-clamp fluorometry, Proc Natl Acad Sci U S A. , 2006; 103(33): 12619-24.
Chen ZW, Chang CS, Leil TA, Olcese R, Olsen RW.   GABAA receptor-associated protein regulates GABAA receptor cell-surface number in Xenopus laevis oocytes, Mol Pharmacol, 2005; 68(1): 152-9..
Haug T., Olcese, R., Ciani S, Toro L., Stefani, E.   Regulation of inward K flow by a negative residue in the outer vestibule of the MaxiK channel pore Part I, Journal of General Physiology, 2004; 124(2): 185-97.
Haug T, Ciani S, Toro L., Stefani, Olcese, R.   Regulation of inward K flow by a negative residue in the outer vestibule of the MaxiK channel pore Part II, Journal of General Physiology, 2004; 124(2): 173-184.
Chang CS., Olcese, R., and R. Olsen   A single M1 residue in the beta2 subunit alters channel gating of GAGAA receptor in anesthetic modulation and direct activation, Journal of Biological Chemistry, 2003; 278(44): 42821.
Latorre R.,Olcese R.,Basso C.,Gonzalez C., Munoz F.,Cosmelli D. and Osvaldo Alvarez.   Molecular coupling between voltage sensor and pore opening in the Arabidopis inward rectifier K+ channel KAT1, Journal of General Physiology, 2003; 122(4): 459-469.
Eghbali, M Olcese, R Zarei, MM Toro, L Stefani, E   External pore collapse as an inactivation mechanism for Kv4.3 K+ channels The Journal of membrane biology. , 2002; 188(1): 73-86.
Helguera G., Olcese, R., Song M., Toro L. and Stefani E.   Tissue-specific regulation of K+ and Ca2+ channel protein expression, Biochimica et Biophysica Acta, 2002; 1569(1-3): 59-66.
Olcese, R., Sigg D., Bezanilla F., Stefani E   A conducting state with properties of a slow inactivated state in Shaker K+ channel mutant, Journal of General Physiology , 2001; 117: 149-163.
Platano, D. Qin N., Birnbaumer L., Stefani, E. and Olcese, R.   Alpha-2-delta subunit interferes with prepulse facilitation in L-type Ca2+ channels, Biophysical Journal, 2000; 78: 2959-2972.
Qin, N Olcese, R Bransby, M Lin, T Birnbaumer, L   Ca2+-induced inhibition of the cardiac Ca2+ channel depends on calmodulin Proceedings of the National Academy of Sciences of the United States of America. , 1999; 96(5): 2435-8.
Noceti, F., Olcese, R., Qin, N., Birnbaumer, L., and Stefani, E.   Effect of Bay K 8644(-) and the b2a subunit on Ca2+ dependent inactivation in a1C Ca2+ channels: A model, , 1998; 111(3): 463-475.
Roux, M., Olcese, R., Toro, L., Bezanilla, F. and Stefani, E.   Fast inactivation in Shaker K+ channels: properties of ionic and gating currents, , 1998; 111: 625-638.
Qin N, Olcese, R., Stefani, E., and Birnbaumer L.   Modulation of human neuronal a1E calcium channel by a2d ?subunit, , 1998; 274: C1324-1331.
Birnbaumer. L., Qin N., Olcese, R., Tareilus E., Platano, D., Costantin J. and Stefani, E.   Structures and functions of calcium channel b subunits, J. of Bioenergy and Biomembrane, 1998; 30(4): 357-375.
Qin, N., Platano, D., Olcese, R., Constantin J.L., Stefani, E., and Birnbaumer, L.   Unique regulatory properties of type 2a Ca2+ channel b ?subunit due to palmitoylation, , 1998; 95: 4690-4695.
Olcese, R Latorre, R Toro, L Bezanilla, F Stefani, E   Correlation between charge movement and ionic current during slow inactivation in Shaker K+ channels The Journal of general physiology. , 1997; 110(5): 579-89.
Stefani, E., Ottolia, M., Noceti, F., Olcese, R., Wallner, M., and Latorre, R.   Calcium independent and voltage-controlled gating in a Ca2+-sensitive K+ channel (hslo). Proceedings of National Academy of Science USA, , 1997; 94: 5427-5431.
Olcese, R., Neely, A.,Qin, N., Wei, X., Birnbaumer, L., and Stefani, E.   Coupling between charge movement and pore opening in type-E Ca2+ channel, Journal of Physiology, 1997; 497: 675-686.
Qin, N., Platano, D., Olcese, R., Stefani, E., and Birnbaumer, L.   Direct interaction of Gbg with a novel C-terminal Gbg binding domain of a1 is responsible for inhibition of presynaptic Ca2+ channels by G-protein-coupled receptors, Proceedings of National Academy of Science USA, 1997; 94: 8866-8871.
Nobile, M., Olcese, R., Toro, L., and Stefani, E.   Fast inactivation of Shaker K+ channels is highly temperature dependent, Experimental Brain Research, 1997; 114 (1):: 138-142.
Zhou, J., Olcese, R., Qin, N., Birnbaumer, L. and Stefani, E.   Feedback inhibition of calcium channels by calcium depends on a short sequence of carboxy terminus that does not include the calcium binding function of a motif with similarity to calcium binding domains, , 1997; 94: 2301-2305.
Olcese, R., Noceti, F., Baldelli, P., Qin, N., Birnbaumer, L. and Stefani, E.   beta subunit modulation of the coupling between charge movement and pore opening in calcium channels, From ion channels to cell to cell conversation, 1997; 91-104.
Tareilus, E. Roux, M., Qin, N., Olcese, R., Zhou, J., Stefani, E. and Birnbaumer, L.   A Xenopus Oocytes b subunit: evidence for a role in Assembly/expression of voltage-gated calcium channels that is separated from a role as a regulatory subunit, Proceedings of National Academy of Science USA, 1996; 94: 1703-170.
Qin, N., Olcese, R., Zhou, J., Cabello, O.A., Birnbaumer, L. and Stefani E.   Identification of a second region of the b subunit involved in the regulation of calcium channel inactivation, American Journal of Physiology, 1996; 271: C1539-C1545.
Wei, X., Neely, A., Olcese, R., Stefani, E., and Birnbaumer, L.   Increase in Ca2+ channel expression by deletions at the amino terminus of the cardiac a1 subunit. Receptors and channels, , 1996; 4 (4):: 205-215.
Neely, A., Olcese, R., Wei, X., Baldelli, P., Birnbaumer, L. and Stefani E.   Dual activation kinetic in cloned calcium channel and its modulation by the b subunit, American Journal of Physiology, 1995; 268: C732-C740.
Olcese, R Qin, N Schneider, T Neely, A Wei, X Stefani, E Birnbaumer, L   The amino terminus of a calcium channel beta subunit sets rates of channel inactivation independently of the subunit's effect on activation Neuron. , 1994; 13(6): 1433-8.
Neely, A., Olcese, R., Wei, X., Birnbaumer, L. and Stefani E.   Calcium-dependent inactivation of cardiac calcium channels expressed in Xenopus oocytes, Biophysical J, 1994; 66 (6): 1895-1903.
Wei, X., Neely, A., Lacerda, A.E., Olcese, R., Stefani, E., and Birnbaumer, L.   Modification of Ca2+ channel activity by deletions at the carboxyl terminus of the cardiac a1 subunit, J. Biol. Chem, 1994; 239 (3):: 1635-40.
Schneider, T., Wei, X., Olcese, R., Costantin J.L., Neely, A., Palade, P., Perez-Reyes, E.; Pan, S., Qin, N., Zhou, J., Crawford, G.D., Smith, R.G., Appel, S.H., Stefani, E., and Birnbaumer, L.   Molecular analysis and functional expression of the human type E neuronal Ca2+ channel a1 subunit, Receptors and Channels, 1994; 2: 255-270.
Olcese, R Usai, C Maestrone, E Nobile, M   The general anesthetic propofol inhibits transmembrane calcium current in chick sensory neurons Anesthesia and analgesia. , 1994; 78(5): 955-60.
Neely, A., Wei, X., Olcese, R., Birnbaumer, L., and Stefani E.   Potentiation by the b subunit of the ratio of the ionic current to charge movement in the cardiac calcium channel, Science, 1993; 262: 575-578.