Riccardo Olcese, Ph.D.

Titles

Professor, Anesthesiology

Physiology

Member, Molecular Medicine

Biochemistry, Biophysics & Structural Biology GPB Home Area

Brain Research Institute

Molecular, Cellular & Integrative Physiology GPB Home Area

Neuroscience GPB Home Area

Faculty, Cardiovascular Research Laboratory

Contact Information

Email
rolcese@ucla.edu
Phone
Fax Number: 310-206-1947
Lab Number: 310-206-2685
Office Phone Number: 310-206-2214
Address

Work Address:

Laboratory
CHS
Los Angeles, CA 90095
UNITED STATES
Office
CHS
100 Jules Stein Plaza
Division of Molecular Medicine, Dept. of Anesthesiology
Los Angeles, CA 90095
UNITED STATES

Publications

Prudat Yann, Madhvani Roshni V, Angelini Marina, Borgstom Nils P, Garfinkel Alan, Karagueuzian Hrayr S, Weiss James N, de Lange Enno, Olcese Riccardo, Kucera Jan P   Stochastic pacing reveals the propensity to cardiac action potential alternans and uncovers its underlying dynamics The Journal of physiology, 2015; .
Weiss James N, Garfinkel Alan, Karagueuzian Hrayr S, Nguyen Thao P, Olcese Riccardo, Chen Peng-Sheng, Qu Zhilin   Perspective: a dynamics-based classification of ventricular arrhythmias Journal of molecular and cellular cardiology, 2015; 82(5): 136-52.
Madhvani Roshni V, Angelini Marina, Xie Yuanfang, Pantazis Antonios, Suriany Silvie, Borgstrom Nils P, Garfinkel Alan, Qu Zhilin, Weiss James N, Olcese Riccardo   Targeting the late component of the cardiac L-type Ca2+ current to suppress early afterdepolarizations The Journal of general physiology, 2015; 145(5): 395-404.
Pantazis Antonios, Savalli Nicoletta, Sigg Daniel, Neely Alan, Olcese Riccardo   Functional heterogeneity of the four voltage sensors of a human L-type calcium channel Proceedings of the National Academy of Sciences of the United States of America, 2014; 111(51): 18381-6.
Qu Zhilin, Xie Lai-Hua, Olcese Riccardo, Karagueuzian Hrayr S, Chen Peng-Sheng, Garfinkel Alan, Weiss James N   Early afterdepolarizations in cardiac myocytes: beyond reduced repolarization reserve Cardiovascular research, 2013; 99(1): 6-15.
Pantazis Antonios, Olcese Riccardo   Relative transmembrane segment rearrangements during BK channel activation resolved by structurally assigned fluorophore-quencher pairing The Journal of general physiology, 2012; 140(2): 207-18.
Savalli Nicoletta, Pantazis Antonios, Yusifov Taleh, Sigg Daniel, Olcese Riccardo   The contribution of RCK domains to human BK channel allosteric activation The Journal of biological chemistry, 2012; 287(26): 21741-50.
Madhvani Roshni V, Xie Yuanfang, Pantazis Antonios, Garfinkel Alan, Qu Zhilin, Weiss James N, Olcese Riccardo   Shaping a new Ca²⁺ conductance to suppress early afterdepolarizations in cardiac myocytes The Journal of physiology, 2011; 589(Pt 24): 6081-92.
Javaherian Anoosh D, Yusifov Taleh, Pantazis Antonios, Franklin Sarah, Gandhi Chris S, Olcese Riccardo   Metal-driven operation of the human large-conductance voltage- and Ca2+-dependent potassium channel (BK) gating ring apparatus The Journal of biological chemistry, 2011; 286(23): 20701-9.
Olcese Riccardo   I(KACh) at the whim of a capricious M2R The Journal of physiology, 2011; 589(Pt 8): 1869-70.
Pantazis Antonios, Kohanteb Azadeh P, Olcese Riccardo   Relative motion of transmembrane segments S0 and S4 during voltage sensor activation in the human BK(Ca) channel The Journal of general physiology, 2010; 136(6): 645-57.
Yusifov Taleh, Javaherian Anoosh D, Pantazis Antonios, Gandhi Chris S, Olcese Riccardo   The RCK1 domain of the human BKCa channel transduces Ca2+ binding into structural rearrangements The Journal of general physiology, 2010; 136(2): 189-202.
Pantazis Antonios, Gudzenko Vadym, Savalli Nicoletta, Sigg Daniel, Olcese Riccardo   Operation of the voltage sensor of a human voltage- and Ca2+-activated K+ channel Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(9): 4459-64.
Olcese Riccardo   It's spring-time for slow inactivation The Journal of general physiology, 2009; 134(6): 457-9.
Gandhi Chris S, Olcese Riccardo   The voltage-clamp fluorometry technique Methods in molecular biology (Clifton, N.J.), 2008; 491(6): 213-31.
Mahajan A, Shiferaw Y, Sato D, Baher A, Olcese R, Xie LH, Yang MJ, Chen PS, Restrepo JG, Karma A, Garfinkel A, Qu Z, Weiss JN. 2008   A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates, Biophys J, 2008; 94(2): 392-410.
Mahajan A, Sato D, Shiferaw Y, Baher A, Xie LH, Peralta R, Olcese R, Garfinkel A, Qu Z, Weiss JN.   Modifying L-type calcium current kinetics: consequences for cardiac excitation and arrhythmia dynamics, Biophys J. , 2008; 94(2): 411-23. .
Yusifov T, Savalli N, Gandhi CS, Ottolia M, Olcese R.   The RCK2 domain of the human BKCa channel is a calcium sensor, Proc Natl Acad Sci U S A, 2008; 105(1): 376-81.
Olcese Riccardo   And yet it moves: conformational States of the Ca2+ channel pore, J Gen Physiol. , 2007; 129(6)((6)): 457-9..
Gudzenko V, Shiferaw Y, Savalli N, Vyas R, Weiss JN, Olcese R.   Influence of channel subunit composition on L-type Ca2+ current kinetics and cardiac wave stability, Am J Physiol Heart Circ Physiol, 2007; 293(3): H1805-15.
Savalli N, Kondratiev A, de Quintana SB, Toro L, Olcese R.   Modes of operation of the BKCa channel beta2 subunit, J Gen Physiol, 2007; 130((1)): 117-31.
Savalli N, Kondratiev A, Toro L, Olcese R.   Voltage-dependent conformational changes in human Ca(2+)- and voltage-activated K(+) channel, revealed by voltage-clamp fluorometry, Proc Natl Acad Sci U S A. , 2006; 103(33): 12619-24.
Chen ZW, Chang CS, Leil TA, Olcese R, Olsen RW.   GABAA receptor-associated protein regulates GABAA receptor cell-surface number in Xenopus laevis oocytes, Mol Pharmacol, 2005; 68(1): 152-9..
Haug T., Olcese, R., Ciani S, Toro L., Stefani, E.   Regulation of inward K flow by a negative residue in the outer vestibule of the MaxiK channel pore Part I, Journal of General Physiology, 2004; 124(2): 185-97.
Haug T, Ciani S, Toro L., Stefani, Olcese, R.   Regulation of inward K flow by a negative residue in the outer vestibule of the MaxiK channel pore Part II, Journal of General Physiology, 2004; 124(2): 173-184.
Chang CS., Olcese, R., and R. Olsen   A single M1 residue in the beta2 subunit alters channel gating of GAGAA receptor in anesthetic modulation and direct activation, Journal of Biological Chemistry, 2003; 278(44): 42821.
Latorre R.,Olcese R.,Basso C.,Gonzalez C., Munoz F.,Cosmelli D. and Osvaldo Alvarez.   Molecular coupling between voltage sensor and pore opening in the Arabidopis inward rectifier K+ channel KAT1, Journal of General Physiology, 2003; 122(4): 459-469.
Eghbali, M Olcese, R Zarei, MM Toro, L Stefani, E   External pore collapse as an inactivation mechanism for Kv4.3 K+ channels The Journal of membrane biology. , 2002; 188(1): 73-86.
Helguera G., Olcese, R., Song M., Toro L. and Stefani E.   Tissue-specific regulation of K+ and Ca2+ channel protein expression, Biochimica et Biophysica Acta, 2002; 1569(1-3): 59-66.
Olcese, R., Sigg D., Bezanilla F., Stefani E   A conducting state with properties of a slow inactivated state in Shaker K+ channel mutant, Journal of General Physiology , 2001; 117: 149-163.
Platano, D. Qin N., Birnbaumer L., Stefani, E. and Olcese, R.   Alpha-2-delta subunit interferes with prepulse facilitation in L-type Ca2+ channels, Biophysical Journal, 2000; 78: 2959-2972.
Qin, N Olcese, R Bransby, M Lin, T Birnbaumer, L   Ca2+-induced inhibition of the cardiac Ca2+ channel depends on calmodulin Proceedings of the National Academy of Sciences of the United States of America. , 1999; 96(5): 2435-8.
Noceti, F., Olcese, R., Qin, N., Birnbaumer, L., and Stefani, E.   Effect of Bay K 8644(-) and the b2a subunit on Ca2+ dependent inactivation in a1C Ca2+ channels: A model, , 1998; 111(3): 463-475.
Roux, M., Olcese, R., Toro, L., Bezanilla, F. and Stefani, E.   Fast inactivation in Shaker K+ channels: properties of ionic and gating currents, , 1998; 111: 625-638.
Qin N, Olcese, R., Stefani, E., and Birnbaumer L.   Modulation of human neuronal a1E calcium channel by a2d ?subunit, , 1998; 274: C1324-1331.
Birnbaumer. L., Qin N., Olcese, R., Tareilus E., Platano, D., Costantin J. and Stefani, E.   Structures and functions of calcium channel b subunits, J. of Bioenergy and Biomembrane, 1998; 30(4): 357-375.
Qin, N., Platano, D., Olcese, R., Constantin J.L., Stefani, E., and Birnbaumer, L.   Unique regulatory properties of type 2a Ca2+ channel b ?subunit due to palmitoylation, , 1998; 95: 4690-4695.
Olcese, R Latorre, R Toro, L Bezanilla, F Stefani, E   Correlation between charge movement and ionic current during slow inactivation in Shaker K+ channels The Journal of general physiology. , 1997; 110(5): 579-89.
Stefani, E., Ottolia, M., Noceti, F., Olcese, R., Wallner, M., and Latorre, R.   Calcium independent and voltage-controlled gating in a Ca2+-sensitive K+ channel (hslo). Proceedings of National Academy of Science USA, , 1997; 94: 5427-5431.
Olcese, R., Neely, A.,Qin, N., Wei, X., Birnbaumer, L., and Stefani, E.   Coupling between charge movement and pore opening in type-E Ca2+ channel, Journal of Physiology, 1997; 497: 675-686.
Qin, N., Platano, D., Olcese, R., Stefani, E., and Birnbaumer, L.   Direct interaction of Gbg with a novel C-terminal Gbg binding domain of a1 is responsible for inhibition of presynaptic Ca2+ channels by G-protein-coupled receptors, Proceedings of National Academy of Science USA, 1997; 94: 8866-8871.
Nobile, M., Olcese, R., Toro, L., and Stefani, E.   Fast inactivation of Shaker K+ channels is highly temperature dependent, Experimental Brain Research, 1997; 114 (1):: 138-142.
Zhou, J., Olcese, R., Qin, N., Birnbaumer, L. and Stefani, E.   Feedback inhibition of calcium channels by calcium depends on a short sequence of carboxy terminus that does not include the calcium binding function of a motif with similarity to calcium binding domains, , 1997; 94: 2301-2305.
Olcese, R., Noceti, F., Baldelli, P., Qin, N., Birnbaumer, L. and Stefani, E.   beta subunit modulation of the coupling between charge movement and pore opening in calcium channels, From ion channels to cell to cell conversation, 1997; 91-104.
Tareilus, E. Roux, M., Qin, N., Olcese, R., Zhou, J., Stefani, E. and Birnbaumer, L.   A Xenopus Oocytes b subunit: evidence for a role in Assembly/expression of voltage-gated calcium channels that is separated from a role as a regulatory subunit, Proceedings of National Academy of Science USA, 1996; 94: 1703-170.
Qin, N., Olcese, R., Zhou, J., Cabello, O.A., Birnbaumer, L. and Stefani E.   Identification of a second region of the b subunit involved in the regulation of calcium channel inactivation, American Journal of Physiology, 1996; 271: C1539-C1545.
Wei, X., Neely, A., Olcese, R., Stefani, E., and Birnbaumer, L.   Increase in Ca2+ channel expression by deletions at the amino terminus of the cardiac a1 subunit. Receptors and channels, , 1996; 4 (4):: 205-215.
Neely, A., Olcese, R., Wei, X., Baldelli, P., Birnbaumer, L. and Stefani E.   Dual activation kinetic in cloned calcium channel and its modulation by the b subunit, American Journal of Physiology, 1995; 268: C732-C740.
Olcese, R Qin, N Schneider, T Neely, A Wei, X Stefani, E Birnbaumer, L   The amino terminus of a calcium channel beta subunit sets rates of channel inactivation independently of the subunit's effect on activation Neuron. , 1994; 13(6): 1433-8.
Neely, A., Olcese, R., Wei, X., Birnbaumer, L. and Stefani E.   Calcium-dependent inactivation of cardiac calcium channels expressed in Xenopus oocytes, Biophysical J, 1994; 66 (6): 1895-1903.
Wei, X., Neely, A., Lacerda, A.E., Olcese, R., Stefani, E., and Birnbaumer, L.   Modification of Ca2+ channel activity by deletions at the carboxyl terminus of the cardiac a1 subunit, J. Biol. Chem, 1994; 239 (3):: 1635-40.
Schneider, T., Wei, X., Olcese, R., Costantin J.L., Neely, A., Palade, P., Perez-Reyes, E.; Pan, S., Qin, N., Zhou, J., Crawford, G.D., Smith, R.G., Appel, S.H., Stefani, E., and Birnbaumer, L.   Molecular analysis and functional expression of the human type E neuronal Ca2+ channel a1 subunit, Receptors and Channels, 1994; 2: 255-270.
Olcese, R Usai, C Maestrone, E Nobile, M   The general anesthetic propofol inhibits transmembrane calcium current in chick sensory neurons Anesthesia and analgesia. , 1994; 78(5): 955-60.
Neely, A., Wei, X., Olcese, R., Birnbaumer, L., and Stefani E.   Potentiation by the b subunit of the ratio of the ionic current to charge movement in the cardiac calcium channel, Science, 1993; 262: 575-578.