Richard W. Olsen, Ph.D.

Titles

Distinguished Professor, Anesthesiology
Molecular & Medical Pharmacology
Professor, Neuroscience
Member, Biochemistry, Biophysics & Structural Biology GPB Home Area
Brain Research Institute
Molecular Pharmacology GPB Home Area
Neuroscience GPB Home Area

Contact Information

Email
rolsen@mednet.ucla.edu
Phone
Lab Number: 310-825-5748Office Phone Number: 310-825-5093
Address
Laboratory Address: Laboratory23-338 CHSLos Angeles, CA 90095UNITED STATES Office Address: Office23-316 CHSLos Angeles, CA 90095UNITED STATES

Publications:

Stewart Deirdre S, Hotta Mayo, Li Guo-Dong, Desai Rooma, Chiara David C, Olsen Richard W, Forman Stuart A   Cysteine Substitutions Define Etomidate Binding and Gating Linkages in the α-M1 Domain of γ-Aminobutyric Acid Type A (GABAA) Receptors The Journal of biological chemistry, 2013; .
Davies Daryl L, Bortolato Marco, Finn Deborah A, Ramaker Marcia J, Barak Segev, Ron Dorit, Liang Jing, Olsen Richard W   Recent advances in the discovery and preclinical testing of novel compounds for the prevention and/or treatment of alcohol use disorders Alcoholism, clinical and experimental research, 2013; 37(1): 8-15.
Shen Yi, Lindemeyer A Kerstin, Gonzalez Claudia, Shao Xuesi M, Spigelman Igor, Olsen Richard W, Liang Jing   Dihydromyricetin as a novel anti-alcohol intoxication medication The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012; 32(1): 390-401.
Tanaka Miyabi, Bailey Julia N, Bai Dongsheng, Ishikawa-Brush Yumiko, Delgado-Escueta Antonio V, Olsen Richard W   Effects on promoter activity of common SNPs in 5' region of GABRB3 exon 1A Epilepsia, 2012; 53(8): 1450-6.
Gonzalez Claudia, Moss Stephen J, Olsen Richard W   Ethanol promotes clathrin adaptor-mediated endocytosis via the intracellular domain of δ-containing GABAA receptors The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012; 32(49): 17874-81.
Cushman Jesse D, Moore Melissa D, Jacobs Nate S, Olsen Richard W, Fanselow Michael S   Behavioral pharmacogenetic analysis on the role of the α4 GABA(A) receptor subunit in the ethanol-mediated impairment of hippocampus-dependent contextual learning Alcoholism, clinical and experimental research, 2011; 35(11): 1948-59.
Olsen Richard W   Combining Ubiquitin Deficiency and GABA-Mediated Inhibition Equals Seizures? Epilepsy currents / American Epilepsy Society, 2011; 11(3): 96-8.
Tao Jifang, Wu Hao, Lin Quan, Wei Weizheng, Lu Xiao-Hong, Cantle Jeffrey P, Ao Yan, Olsen Richard W, Yang X William, Mody Istvan, Sofroniew Michael V, Sun Yi E   Deletion of astroglial Dicer causes non-cell-autonomous neuronal dysfunction and degeneration The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011; 31(22): 8306-19.
Olsen Richard W   Extrasynaptic GABAA receptors in the nucleus accumbens are necessary for alcohol drinking Proceedings of the National Academy of Sciences of the United States of America, 2011; 108(12): 4699-700.
Olsen Richard W, Li Guo-Dong   GABA(A) receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation Canadian journal of anaesthesia = Journal canadien d'anesthésie, 2011; 58(2): 206-15.
Lomenick Brett, Olsen Richard W, Huang Jing   Identification of direct protein targets of small molecules ACS chemical biology, 2011; 6(1): 34-46.
Shen Yi, Lindemeyer A Kerstin, Spigelman Igor, Sieghart Werner, Olsen Richard W, Liang Jing   Plasticity of GABAA receptors after ethanol pre-exposure in cultured hippocampal neurons Molecular pharmacology, 2011; 79(3): 432-42.
Suryanarayanan Asha, Liang Jing, Meyer Edward M, Lindemeyer A Kerstin, Chandra Dev, Homanics Gregg E, Sieghart Werner, Olsen Richard W, Spigelman Igor   Subunit Compensation and Plasticity of Synaptic GABA(A) Receptors Induced by Ethanol in α4 Subunit Knockout Mice Frontiers in neuroscience, 2011; 5(1): 110.
Meera Pratap, Olsen Richard W, Otis Thomas S, Wallner Martin   Alcohol- and alcohol antagonist-sensitive human GABAA receptors: tracking δ subunit incorporation into functional receptors Molecular pharmacology, 2010; 78(5): 918-24.
Li Guo-Dong, Chiara David C, Cohen Jonathan B, Olsen Richard W   Numerous classes of general anesthetics inhibit etomidate binding to gamma-aminobutyric acid type A (GABAA) receptors The Journal of biological chemistry, 2010; 285(12): 8615-20.
Husain S Shaukat, Stewart Deirdre, Desai Rooma, Hamouda Ayman K, Li S Guo-Dong, Kelly Elizabeth, Dostalova Zuzana, Zhou Xiaojuan, Cotten Joseph F, Raines Douglas E, Olsen Richard W, Cohen Jonathan B, Forman Stuart A, Miller Keith W   p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels Journal of medicinal chemistry, 2010; 53(17): 6432-44.
Olsen Richard W, Sieghart Werner   GABA A receptors: subtypes provide diversity of function and pharmacology Neuropharmacology, 2009; 56(1): 141-8.
Collingridge Graham L, Olsen Richard, Peters John A, Spedding Michael   Ligand gated ion channels Neuropharmacology, 2009; 56(1): 1.
Li Guo-Dong, Chiara David C, Cohen Jonathan B, Olsen Richard W   Neurosteroids allosterically modulate binding of the anesthetic etomidate to gamma-aminobutyric acid type A receptors The Journal of biological chemistry, 2009; 284(18): 11771-5.
Liang Jing, Suryanarayanan Asha, Chandra Dev, Homanics Gregg E, Olsen Richard W, Spigelman Igor   Functional consequences of GABAA receptor alpha 4 subunit deletion on synaptic and extrasynaptic currents in mouse dentate granule cells Alcoholism, clinical and experimental research, 2008; 32(1): 19-26.
Tanaka Miyabi, Olsen Richard W, Medina Marco T, Schwartz Emily, Alonso Maria Elisa, Duron Reyna M, Castro-Ortega Ramon, Martinez-Juarez Iris E, Pascual-Castroviejo Ignacio, Machado-Salas Jesus, Silva Rene, Bailey Julia N, Bai Dongsheng, Ochoa Adriana, Jara-Prado Aurelio, Pineda Gregorio, Macdonald Robert L, Delgado-Escueta Antonio V   Hyperglycosylation and reduced GABA currents of mutated GABRB3 polypeptide in remitting childhood absence epilepsy American journal of human genetics, 2008; 82(6): 1249-61.
Chen Zi-Wei, Chang Chang-Sheng S, Leil Tarek A, Olsen Richard W   C-terminal modification is required for GABARAP-mediated GABA(A) receptor trafficking The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007; 27(25): 6655-63.
Chen Zi-Wei, Olsen Richard W   GABAA receptor associated proteins: a key factor regulating GABAA receptor function Journal of neurochemistry, 2007; 100(2): 279-94.
Olsen Richard W, Hanchar Harry J, Meera Pratap, Wallner Martin   GABAA receptor subtypes: the "one glass of wine" receptors Alcohol (Fayetteville, N.Y.), 2007; 41(3): 201-9.
Liang Jing, Suryanarayanan Asha, Abriam Alana, Snyder Bradley, Olsen Richard W, Spigelman Igor   Mechanisms of reversible GABAA receptor plasticity after ethanol intoxication The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007; 27(45): 12367-77.
Liang Jing, Zhang Nianhui, Cagetti Elisabetta, Houser Carolyn R, Olsen Richard W, Spigelman Igor   Chronic intermittent ethanol-induced switch of ethanol actions from extrasynaptic to synaptic hippocampal GABAA receptors The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006; 26(6): 1749-58.
Santhakumar Vijayalakshmi, Hanchar H Jacob, Wallner Martin, Olsen Richard W, Otis Thomas S   Contributions of the GABAA receptor alpha6 subunit to phasic and tonic inhibition revealed by a naturally occurring polymorphism in the alpha6 gene The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006; 26(12): 3357-64.
Hanchar H Jacob, Chutsrinopkun Panida, Meera Pratap, Supavilai Porntip, Sieghart Werner, Wallner Martin, Olsen Richard W   Ethanol potently and competitively inhibits binding of the alcohol antagonist Ro15-4513 to alpha4/6beta3delta GABAA receptors Proceedings of the National Academy of Sciences of the United States of America, 2006; 103(22): 8546-51.
Li G-D, Chiara DC, Sawyer GW, Husain SS, Olsen RW, and Cohen JB   GABA-A receptor anesthetic binding sites identified at subunit interfaces by photolabeling. , J Neurosci, 2006; 26: 11599-11605..
Li Guo-Dong, Chiara David C, Sawyer Gregory W, Husain S Shaukat, Olsen Richard W, Cohen Jonathan B   Identification of a GABAA receptor anesthetic binding site at subunit interfaces by photolabeling with an etomidate analog The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006; 26(45): 11599-605.
Wallner Martin, Hanchar H Jacob, Olsen Richard W   Low dose acute alcohol effects on GABA A receptor subtypes Pharmacology & therapeutics, 2006; 112(2): 513-28.
Olsen Richard W   Picrotoxin-like channel blockers of GABAA receptors Proceedings of the National Academy of Sciences of the United States of America, 2006; 103(16): 6081-2.
Olsen Richard W   When is hot not so hot? Fever reduces brain inhibition Epilepsy currents / American Epilepsy Society, 2006; 6(5): 167-9.
Hanchar, HJ Dodson, PD Olsen, RW Otis, TS Wallner, M   Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activity Nature neuroscience. , 2005; 8(3): 339-45.
Liljelund Patricia, Handforth Adrian, Homanics Gregg E, Olsen Richard W   GABAA receptor beta3 subunit gene-deficient heterozygous mice show parent-of-origin and gender-related differences in beta3 subunit levels, EEG, and behavior Brain research. Developmental brain research, 2005; 157(2): 150-61.
Chen Zi-Wei, Chang Chang-Sheng S, Leil Tarek A, Olcese Riccardo, Olsen Richard W   GABAA receptor-associated protein regulates GABAA receptor cell-surface number in Xenopus laevis oocytes Molecular pharmacology, 2005; 68(1): 152-9.
Liljelund Patricia, Ferguson Carolyn, Homanics Gregg, Olsen Richard W   Long-term effects of diazepam treatment of epileptic GABAA receptor beta3 subunit knockout mouse in early life Epilepsy research, 2005; 66(1-3): 99-115.
Handforth Adrian, Delorey Timothy M, Homanics Gregg E, Olsen Richard W   Pharmacologic evidence for abnormal thalamocortical functioning in GABA receptor beta3 subunit-deficient mice, a model of Angelman syndrome Epilepsia, 2005; 46(12): 1860-70.
Olsen Richard W, Liang Jing, Cagetti Elisabetta, Spigelman Igor   Plasticity of GABAA receptors in brains of rats treated with chronic intermittent ethanol Neurochemical research, 2005; 30(12): 1579-88.
Hanchar H Jacob, Wallner Martin, Olsen Richard W   Alcohol effects on gamma-aminobutyric acid type A receptors: are extrasynaptic receptors the answer? Life sciences, 2004; 76(1): 1-8.
Liang Jing, Cagetti Elisabetta, Olsen Richard W, Spigelman Igor   Altered pharmacology of synaptic and extrasynaptic GABAA receptors on CA1 hippocampal neurons is consistent with subunit changes in a model of alcohol withdrawal and dependence The Journal of pharmacology and experimental therapeutics, 2004; 310(3): 1234-45.
Cagetti Elisabetta, Pinna Graziano, Guidotti Alessandro, Baicy Kate, Olsen Richard W   Chronic intermittent ethanol (CIE) administration in rats decreases levels of neurosteroids in hippocampus, accompanied by altered behavioral responses to neurosteroids and memory function Neuropharmacology, 2004; 46(4): 570-9.
Olsen Richard W, Chang Chang-Sheng S, Li Guodong, Hanchar H Jacob, Wallner Martin   Fishing for allosteric sites on GABA(A) receptors Biochemical pharmacology, 2004; 68(8): 1675-84.
Leil Tarek A, Chen Zi-Wei, Chang Chang-Sheng S, Olsen Richard W   GABAA receptor-associated protein traffics GABAA receptors to the plasma membrane in neurons The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004; 24(50): 11429-38.
Bowery Norman, Enna S J, Olsen Richard W   Six decades of GABA Biochemical pharmacology, 2004; 68(8): 1477-8.
Cagetti Elisabetta, Baicy Kate J, Olsen Richard W   Topiramate attenuates withdrawal signs after chronic intermittent ethanol in rats Neuroreport, 2004; 15(1): 207-10.
Chang Chang-sheng S, Olcese Riccardo, Olsen Richard W   A single M1 residue in the beta2 subunit alters channel gating of GABAA receptor in anesthetic modulation and direct activation The Journal of biological chemistry, 2003; 278(44): 42821-8.
Spigelman Igor, Li Zhiwei, Liang Jing, Cagetti Elisabetta, Samzadeh Sepideh, Mihalek Robert M, Homanics Gregg E, Olsen Richard W   Reduced inhibition and sensitivity to neurosteroids in hippocampus of mice lacking the GABA(A) receptor delta subunit Journal of neurophysiology, 2003; 90(2): 903-10.
Spigelman Igor, Li Zhiwei, Banerjee Pradeep K, Mihalek Robert M, Homanics Gregg E, Olsen Richard W   Behavior and physiology of mice lacking the GABAA-receptor delta subunit Epilepsia, 2002; 43 Suppl 5(5): 3-8.
Nymann-Andersen Jesper, Wang Hongbing, Olsen Richard W   Biochemical identification of the binding domain in the GABA(A) receptor-associated protein (GABARAP) mediating dimer formation Neuropharmacology, 2002; 43(4): 476-81.
Peng Zechun, Hauer Birgit, Mihalek Robert M, Homanics Gregg E, Sieghart Werner, Olsen Richard W, Houser Carolyn R   GABA(A) receptor changes in delta subunit-deficient mice: altered expression of alpha4 and gamma2 subunits in the forebrain The Journal of comparative neurology, 2002; 446(2): 179-97.
Sawyer Gregory W, Chiara David C, Olsen Richard W, Cohen Jonathan B   Identification of the bovine gamma-aminobutyric acid type A receptor alpha subunit residues photolabeled by the imidazobenzodiazepine [3H]Ro15-4513 The Journal of biological chemistry, 2002; 277(51): 50036-45.
Nymann-Andersen Jesper, Sawyer Gregory W, Olsen Richard W   Interaction between GABAA receptor subunit intracellular loops: implications for higher order complex formation Journal of neurochemistry, 2002; 83(5): 1164-71.
Nymann-Andersen Jesper, Wang Hongbing, Chen Li, Kittler Josef T, Moss Stephen J, Olsen Richard W   Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors Journal of neurochemistry, 2002; 80(5): 815-23.