S. Lawrence Zipursky, Ph.D.


Distinguished Professor, Biological Chemistry

Member, Bioinformatics GPB Home Area

Brain Research Institute

Cell & Developmental Biology GPB Home Area

JCCC Cancer and Stem Cell Biology Program Area

Molecular, Cellular & Integrative Physiology GPB Home Area

Neuroscience GPB Home Area

Investigator, Howard Hughes Medical Institute

Contact Information

Lab Number: 310-206-3750
Office Phone Number: (310) 825-2834

Work Address:

5619, 5629 MRL
675 Charles E. Young Dr. South
Los Angeles, CA 90095
5784 MRL
675 Charles E. Young Dr. South
Los Angeles, CA 90095


A selected list of publications:

Pecot Matthew Y, Tadros Wael, Nern Aljoscha, Bader Maya, Chen Yi, Zipursky S Lawrence   Multiple interactions control synaptic layer specificity in the Drosophila visual system Neuron, 2013; 77(2): 299-310.
Wu Wei, Ahlsen Goran, Baker David, Shapiro Lawrence, Zipursky S Lawrence   Complementary chimeric isoforms reveal Dscam1 binding specificity in vivo Neuron, 2012; 74(2): 261-8.
Pappu Kartik S, Morey Marta, Nern Aljoscha, Spitzweck Bettina, Dickson Barry J, Zipursky S L   Robo-3--mediated repulsive interactions guide R8 axons during Drosophila visual system development Proceedings of the National Academy of Sciences of the United States of America, 2011; 108(18): 7571-6.
Pappu Kartik S, Zipursky S Lawrence   Axon guidance: repulsion and attraction in roundabout ways Current biology : CB, 2010; 20(9): R400-2.
Zipursky S Lawrence, Sanes Joshua R   Chemoaffinity revisited: dscams, protocadherins, and neural circuit assembly Cell, 2010; 143(3): 343-53.
Sanes Joshua R, Zipursky S Lawrence   Design principles of insect and vertebrate visual systems Neuron, 2010; 66(1): 15-36.
Millard S Sean, Lu Zhiyuan, Zipursky S Lawrence, Meinertzhagen Ian A   Drosophila dscam proteins regulate postsynaptic specificity at multiple-contact synapses Neuron, 2010; 67(5): 761-8.
Zhu Yan, Nern Aljoscha, Zipursky S Lawrence, Frye Mark A   Peripheral visual circuits functionally segregate motion and phototaxis behaviors in the fly Current biology : CB, 2009; 19(7): 613-9.
Hattori Daisuke, Chen Yi, Matthews Benjamin J, Salwinski Lukasz, Sabatti Chiara, Grueber Wesley B, Zipursky S Lawrence   Robust discrimination between self and non-self neurites requires thousands of Dscam1 isoforms Nature, 2009; 461(7264): 644-8.
Millard S Sean, Zipursky S Lawrence   Dscam-mediated repulsion controls tiling and self-avoidance Current opinion in neurobiology, 2008; 18(1): 84-9.
Cayirlioglu Pelin, Kadow Ilona Grunwald, Zhan Xiaoli, Okamura Katsutomo, Suh Greg S B, Gunning Dorian, Lai Eric C, Zipursky S Lawrence   Hybrid neurons in a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systems Science (New York, N.Y.), 2008; 319(5867): 1256-60.
Nern Aljoscha, Zhu Yan, Zipursky S Lawrence   Local N-cadherin interactions mediate distinct steps in the targeting of lamina neurons Neuron, 2008; 58(1): 34-41.
Wojtowicz Woj M, Wu Wei, Andre Ingemar, Qian Bin, Baker David, Zipursky S Lawrence   A vast repertoire of Dscam binding specificities arises from modular interactions of variable Ig domains Cell, 2007; 130(6): 1134-45.
Matthews Benjamin J, Kim Michelle E, Flanagan John J, Hattori Daisuke, Clemens James C, Zipursky S Lawrence, Grueber Wesley B   Dendrite self-avoidance is controlled by Dscam Cell, 2007; 129(3): 593-604.
Hattori Daisuke, Demir Ebru, Kim Ho Won, Viragh Erika, Zipursky S Lawrence, Dickson Barry J   Dscam diversity is essential for neuronal wiring and self-recognition Nature, 2007; 449(7159): 223-7.
Millard S Sean, Flanagan John J, Pappu Kartik S, Wu Wei, Zipursky S Lawrence   Dscam2 mediates axonal tiling in the Drosophila visual system Nature, 2007; 447(7145): 720-4.
Ting Chun-Yuan, Herman Tory, Yonekura Shinichi, Gao Shuying, Wang Jian, Serpe Mihaela, O'Connor Michael B, Zipursky S Lawrence, Lee Chi-Hon   Tiling of r7 axons in the Drosophila visual system is mediated both by transduction of an activin signal to the nucleus and by mutual repulsion Neuron, 2007; 56(5): 793-806.
Zhu Haitao, Hummel Thomas, Clemens James C, Berdnik Daniela, Zipursky S Lawrence, Luo Liqun   Dendritic patterning by Dscam and synaptic partner matching in the Drosophila antennal lobe Nature neuroscience, 2006; 9(3): 349-55.
Zipursky S Lawrence, Wojtowicz Woj M, Hattori Daisuke   Got diversity? Wiring the fly brain with Dscam Trends in biochemical sciences, 2006; 31(10): 581-8.
Nern Aljoscha, Nguyen Louis-Vu T, Herman Tory, Prakash Saurabh, Clandinin Thomas R, Zipursky S Lawrence   An isoform-specific allele of Drosophila N-cadherin disrupts a late step of R7 targeting Proceedings of the National Academy of Sciences of the United States of America, 2005; 102(36): 12944-9.
Hummel T, Zipursky SL   Afferent induction of olfactory glomeruli requires N-cadherin Neuron. , 2004; 42(1): 77-88.
Wojtowicz WM, Flanagan JJ, Millard SS, Zipursky SL, Clemens JC   Alternative splicing of Drosophila Dscam generates axon guidance receptors that exhibit isoform-specific homophilic binding Cell. , 2004; 118(5): 619-33.
Zhan XL, Clemens JC, Neves G, Hattori D, Flanagan JJ, Hummel T, Vasconcelos ML, Chess A, Zipursky SL   Analysis of Dscam diversity in regulating axon guidance in Drosophila mushroom bodies Neuron. , 2004; 43(5): 673-86.
Hummel T, Vasconcelos ML, Clemens JC, Fishilevich Y, Vosshall LB, Zipursky SL   Axonal targeting of olfactory receptor neurons in Drosophila is controlled by Dscam Neuron. , 2003; 37(2): 221-31.
Lee RC, Clandinin TR, Lee CH, Chen PL, Meinertzhagen IA, Zipursky SL   The protocadherin Flamingo is required for axon target selection in the Drosophila visual system Nature neuroscience. , 2003; 6(6): 557-63.
Lee, CH Herman, T Clandinin, TR Lee, R Zipursky, SL   N-cadherin regulates target specificity in the Drosophila visual system Neuron. , 2001; 30(2): 437-50.
Schmucker D, Clemens JC, Shu H, Worby CA, Xiao J, Muda M, Dixon JE, and Zipursky SL   Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity, Cell, 2000; 101: 671-684.
Pecot Matthew Y, Chen Yi, Akin Orkun, Chen Zhenqing, Tsui C Y Kimberly, Zipursky S Lawrence   Sequential axon-derived signals couple target survival and layer specificity in the Drosophila visual system Neuron, 2014; 82(2): 320-33.
Tan Liming, Zhang Kelvin Xi, Pecot Matthew Y, Nagarkar-Jaiswal Sonal, Lee Pei-Tseng, Takemura Shin-Ya, McEwen Jason M, Nern Aljoscha, Xu Shuwa, Tadros Wael, Chen Zhenqing, Zinn Kai, Bellen Hugo J, Morey Marta, Zipursky S Lawrence   Ig Superfamily Ligand and Receptor Pairs Expressed in Synaptic Partners in Drosophila Cell, 2015; 163(7): 1756-69.
Zhang Kelvin Xi, Tan Liming, Pellegrini Matteo, Zipursky S Lawrence, McEwen Jason M   Rapid Changes in the Translatome during the Conversion of Growth Cones to Synaptic Terminals Cell reports, 2016; 14(5): 1258-71.
Tadros Wael, Xu Shuwa, Akin Orkun, Yi Caroline H, Shin Grace Ji-Eun, Millard S Sean, Zipursky S Lawrence   Dscam Proteins Direct Dendritic Targeting through Adhesion Neuron, 2016; 89(3): 480-93.