Thomas Otis, Ph.D.

Titles

Professor, and Chair, Neurobiology
Chair, Neurobiology

Contact Information

Email
otist@ucla.edu
Phone
Lab Number: (310) 206-5274Office Phone Number: (310) 206-0746
Address
Work Address: LaboratoryCHS 63-241Los Angeles, CA 90095UNITED STATES OfficeCHS 63-241Los Angeles, CA 90095UNITED STATES

Biography

Research Interest:

Publications:

Peng, Z.; Zhang, N.; Wei, W.; Huang, C. S.; Cetina, Y.; Otis, T. S.; Houser, C. R.   A reorganized GABAergic circuit in a model of epilepsy: evidence from optogenetic labeling and stimulation of somatostatin interneurons J Neurosci, 2013; 33(36): 14392-405.
Santhakumar, V.; Meera, P.; Karakossian, M. H.; Otis, T. S.   A Reinforcing Circuit Action of Extrasynaptic GABAA Receptor Modulators on Cerebellar Granule Cell Inhibition Plos One, 2013; 8(8): e72976.
Hansen, S. T.; Meera, P.; Otis, T. S.; Pulst, S. M.   Changes in Purkinje cell firing and gene expression precede behavioral pathology in a mouse model of SCA2, Human Molecular Genetics, 2013; 22(2): 271-283.
Mathews, P. J.; Lee, K. H.; Peng, Z. C.; Houser, C. R.; Otis, T. S.   Effects of Climbing Fiber Driven Inhibition on Purkinje Neuron Spiking, Journal of Neuroscience, 2012; 32(50): 17988-17997.
Dellal, S. S.; Luo, R.; Otis, T. S.   GABA(A) receptors increase excitability and conduction velocity of cerebellar parallel fiber axons, Journal of Neurophysiology, 2012; 107(11): 2958-2970.
Otis, T. S.; Mathews, P. J.; Lee, K. H.; Maiz, J.   How do climbing fibers teach?, Frontiers in Neural Circuits, 2012; 6: .
Maiz, J.; Karakossian, M. H.; Pakaprot, N.; Robleto, K.; Thompson, R. F.; Otis, T. S.   Prolonging the postcomplex spike pause speeds eyeblink conditioning, Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(41): 16726-16730.
Pulst, S. M.; Otis, T. S.   Repolarization Matters: Mutations in the Kv4.3 Potassium Channel Cause SCA19/22, Annals of Neurology, 2012; 72(6): 829-831.
Yue, L.; Pawlowski, M.; Dellal, S. S.; Xie, A.; Feng, F.; Otis, T. S.; Bruzik, K. S.; Qian, H. H.; Pepperberg, D. R.   Robust photoregulation of GABA(A) receptors by allosteric modulation with a propofol analogue, Nature Communications, 2012; 3: .
Gehman, L. T.; Meera, P.; Stoilov, P.; Shiue, L.; O'Brien, J. E.; Meisler, M. H.; Ares, M.; Otis, T. S.; Black, D. L.   The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function, Genes & Development, 2012; 26(5): 445-460.
Fink, A. E.; Bender, K. J.; Trussell, L. O.; Otis, T. S.; DiGregorio, D. A.   Two-Photon Compatibility and Single-Voxel, Single-Trial Detection of Subthreshold Neuronal Activity by a Two-Component Optical Voltage Sensor, Plos One, 2012; 7(8): .
Hansen, S. T.; Meera, P.; Otis, T. S.; Pulst, S. M.   Changes in Purkinje Cell Firing Accompany Biochemical and Behavioral Changes in a Mouse Model of SCA 2, Neurology, 2011; 76(9): A346-A347.
Kruger, L.; Otis, T. S.; Shtrahman, M.   Golgi in retrospect: A historiographic examination of contextual influence in tracing the constructs of neuronal organization, Brain Research Reviews, 2011; 66(1-2): 68-74.
Meera, P.; Wallner, M.; Otis, T. S.   Molecular basis for the high THIP/gaboxadol sensitivity of extrasynaptic GABA(A) receptors, Journal of Neurophysiology, 2011; 106(4): 2057-2064.
Meera, P.; Olsen, R. W.; Otis, T. S.; Wallner, M.   Alcohol- and Alcohol Antagonist-Sensitive Human GABA(A) Receptors: Tracking delta Subunit Incorporation into Functional Receptors, Molecular Pharmacology, 2010; 78(5): 918-924.
Meera, P.; Olsen, R. W.; Otis, T. S.; Wallner, M.   GABA(A) RECEPTOR Delta SUBUNITS NOT ONLY CONFER HIGH SENSITIVITY TO ALCOHOL, BUT ALSO DRAMATICALLY INCREASE THIP/GABOXADOL SENSITIVITY, Alcoholism-Clinical and Experimental Research, 2010; 34(6): 194A-194A.
Wallner, M.; Meera, P.; Olsen, R. W.; Otis, T. S.   HIGH SENSITIVITY TO GABOXADOL AND ETHANOL OF delta SUBUNIT-CONTAINING GABA(A) RECEPTORS, Alcoholism-Clinical and Experimental Research, 2010; 34(8): 56A-56A.
Meera, P.; Olsen, R. W.; Otis, T. S.; Wallner, M.   THE GABA(A) RECEPTOR DELTA SUBUNIT NOT ONLY CONFERS HIGH SENSITIVITY TO ETOH, BUT ALSO DRAMATICALLY INCREASES THIP/GABOXADOL SENSITIVITY, Alcoholism-Clinical and Experimental Research, 2010; 34(8): 157A-157A.
Meera, P.; Olsen, R. W.; Otis, T. S.; Wallner, M.   Etomidate, propofol and the neurosteroid THDOC increase the GABA efficacy of recombinant alpha 4 beta 3 delta and alpha 4 beta 3 GABA(A) receptors expressed in HEK cells, Neuropharmacology, 2009; 56(1): 155-160.
Bradley, J.; Luo, R.; Otis, T. S.; DiGregorio, D. A.   Submillisecond Optical Reporting of Membrane Potential In Situ Using a Neuronal Tracer Dye, Journal of Neuroscience, 2009; 29(29): 9197-9209.
Otis, T. S.   Comments on "Ethanol sensitivity of GABAergic currents in cerebellar granule neurons is not increased by a single amino acid change (R100Q) in the alpha(6) GABA(A) receptor subunit", Journal of Pharmacology and Experimental Therapeutics, 2008; 324(1): 399-400.
Otis, T. S.; Sofroniew, M. V.   Glia get excited, Nature Neuroscience, 2008; 11(4): 379-380.
Lutz, C.; Otis, T. S.; DeSars, V.; Charpak, S.; DiGregorio, D. A.; Emiliani, V.   Holographic photolysis of caged neurotransmitters, Nature Methods, 2008; 5(9): 821-827.
Fortin, D. L.; Banghart, M. R.; Dunn, T. W.; Borges, K.; Wagenaar, D. A.; Gaudry, Q.; Karakossian, M. H.; Otis, T. S.; Kristan, W. B.; Trauner, D.; Kramer, R. H.   Photochemical control of endogenous ion channels and cellular excitability, Nature Methods, 2008; 5(4): 331-338.
Santhakumar, V.; Wallner, M.; Otis, T. S.   Ethanol acts directly on extrasynaptic subtypes of GABA(A) receptors to increase tonic inhibition, Alcohol, 2007; 41(3): 211-221.
Santhakumar, V.; Wallner, M.; Otis, T. S.   Ethanol acts directly on extrasynaptic subtypes of GABA(A) receptors to increase tonic inhibition (vol 41, pg 211, 2007), Alcohol, 2007; 41(6): 461-461.
Santhakumar, V.; Karakossian, M. H.; Otis, T. S.   Ethanol enhancement of GABA(A) receptor function in cerebellum, Alcoholism-Clinical and Experimental Research, 2007; 31(6): 290A-290A.
Kruger, L.; Otis, T. S.   Whither withered Golgi? A retrospective evaluation of reticularist and synaptic constructs, Brain Research Bulletin, 2007; 72(4-6): 201-207.
Breese, G. R.; Criswell, H. E.; Carta, M.; Dodson, P. D.; Hanchar, H. J.; Khisti, R. T.; Mameli, M.; Ming, Z.; Morrow, A. L.; Olsen, R. W.; Otis, T. S.; Parsons, L. H.; Penland, S. N.; Roberto, M.; Siggins, G. R.; Valenzuela, C. F.; Wallner, M.   Basis of the gabamimetic profile of ethanol, Alcoholism-Clinical and Experimental Research, 2006; 30(4): 731-744.
Otis, T. S.; Jen, J. C.   Blessed are the pacemakers, Nature Neuroscience, 2006; 9(3): 297-298.
Santhakumar, V.; Hanchar, H. J.; Wallner, M.; Olsen, R. W.; Otis, T. S.   Contributions of the GABA(A) receptor alpha 6 subunit to phasic and tonic inhibition revealed by a naturally occurring polymorphism in the alpha 6 gene, Journal of Neuroscience, 2006; 26(12): 3357-3364.
Hanchar, H. J.; Dodson, P. D.; Olsen, R. W.; Otis, T. S.; Wallner, M.   Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activity, Nature Neuroscience, 2005; 8(3): 339-345.
Meera, P.; Dodson, P. D.; Karakossian, M. H.; Otis, T. S.   Expression of GFP-tagged neuronal glutamate transporters in cerebellar Purkinje neurons, Neuropharmacology, 2005; 49(6): 883-889.
Otis, T. S.; Hanchar, H. J.; Dodson, P. D.; Olsen, R. W.; Wallner, M.   Letters to the Editor, Alcoholism-Clinical and Experimental Research, 2005; 29(7): 1358-1358.
Wallner, M.; Hanchar, H. J.; Dodson, P. D.; Otis, T. S.; Olsen, R. W.   Molecular actions of alcohol on extrasynaptic GABA(A) receptors, Journal of Neurochemistry, 2005; 94: 21-21.
Smith, S. L.; Otis, T. S.   Pattern-dependent, simultaneous plasticity differentially transforms the input-output relationship of a feedforward circuit, Proceedings of the National Academy of Sciences of the United States of America, 2005; 102(41): 14901-14906.
Wallner, M.; Hanchar, H. J.; Dodson, P.; Otis, T. S.; Olsen, R. W.   Role of 8 subunit-containing GABA(A) receptors in acute ethanol actions, Alcoholism-Clinical and Experimental Research, 2005; 29(5): 173A-173A.
Smith, S. L.; Judy, J. W.; Otis, T. S.   An ultra small array of electrodes for stimulating multiple inputs into a single neuron, Journal of Neuroscience Methods, 2004; 133(1-2): 109-114.
Karakossian, M. H.; Otis, T. S.   Excitation of cerebellar interneurons by group I metabotropic glutamate receptors, Journal of Neurophysiology, 2004; 92(3): 1558-1565.
Wallner, M.; Hanchar, H. J.; Otis, T. S.; Olsen, R. W.   Extrasynpatic GABA(A) receptors as mediators of low concentration ethanol effects, Alcoholism-Clinical and Experimental Research, 2004; 28(5): 92A-92A.
Otis, T. S.; Brasnjo, G.; Dzubay, J. A.; Pratap, M.   Interactions between glutamate transporters and metabotropic glutamate receptors at excitatory synapses in the cerebellar cortex, Neurochemistry International, 2004; 45(4): 537-544.
Brasnjo, G.; Otis, T. S.   Isolation of glutamate transport-coupled charge flux and estimation of glutamate uptake at the climbing fiber-Purkinje cell synapse, Proceedings of the National Academy of Sciences of the United States of America, 2004; 101(16): 6273-6278.
Hausser, M.; Raman, I. M.; Otis, T.; Smith, S. L.; Nelson, A.; du Lac, S.; Loewenstein, Y.; Mahon, S.; Pennartz, C.; Cohen, I.; Yarom, Y.   The beat goes on: Spontaneous firing in mammalian neuronal microcircuits, Journal of Neuroscience, 2004; 24(42): 9215-9219.
Brasnjo, G.; Otis, T. S.   Glycine transporters not only take out the garbage, they recycle, Neuron, 2003; 40(4): 667-669.
Smith, S. L.; Otis, T. S.   Persistent changes in spontaneous firing of Purkinje neurons triggered by the nitric oxide signaling cascade, Journal of Neuroscience, 2003; 23(2): 367-372.
Dzubay, J. A.; Otis, T. S.   Climbing fiber activation of metabotropic glutamate receptors on cerebellar Purkinje neurons, Neuron, 2002; 36(6): 1159-1167.
Otis, T. S.   Helping thy neighbors: Spillover at the mossy fiber glomerulus, Neuron, 2002; 35(3): 412-414.
Brasnjo, G.; Otis, T. S.   Neuronal glutamate transporters control activation of postsynaptic metabotropic glutamate receptors and influence cerebellar long-term depression, Neuron, 2001; 31(4): 607-616.
Otis, T. S.   Vesicular glutamate transporters in cognito, Neuron, 2001; 29(1): 11-14.
Otis, T. S.; Kavanaugh, M. P.   Isolation of current components and partial reaction cycles in the glial glutamate transporter EAAT2, Journal of Neuroscience, 2000; 20(8): 2749-2757.
Otis, T. S.; Jahr, C. E.   Anion currents and predicted glutamate flux through a neuronal glutamate transporter, Journal of Neuroscience, 1998; 18(18): 7099-7110.
Otis, T. S.; Kavanaugh, M. P.; Jahr, C. E.   Postsynaptic glutamate transport at the climbing fiber Purkinje cell synapse, Science, 1997; 277(5331): 1515-1518.
Otis, T. S.; Wu, Y. C.; Trussell, L. O.   Delayed clearance of transmitter and the role of glutamate transporters at synapses with multiple release sites, Journal of Neuroscience, 1996; 16(5): 1634-1644.
Otis, T.; Zhang, S.; Trussell, L. O.   Direct measurement of AMPA receptor desensitization induced by glutamatergic synaptic transmission, Journal of Neuroscience, 1996; 16(23): 7496-7504.
Otis, T. S.; Trussell, L. O.   Inhibition of transmitter release shortens the duration of the excitatory synaptic current at a calyceal synapse, Journal of Neurophysiology, 1996; 76(5): 3584-3588.
Buhl, E. H.; Otis, T. S.; Mody, I.   Zinc-induced collapse of augmented inhibition by GABA in a temporal lobe epilepsy model, Science, 1996; 271(5247): 369-373.
Otis, T. S.; Raman, I. M.; Trussell, L. O.   AMPA RECEPTORS WITH HIGH CA2+ PERMEABILITY MEDIATE SYNAPTIC TRANSMISSION IN THE AVIAN AUDITORY PATHWAY, Journal of Physiology-London, 1995; 482(2): 309-315.
Mody, I.; Otis, T. S.; Bragin, A.; Hsu, M.; Buzsaki, G.   GABAERGIC INHIBITION OF GRANULE CELLS AND HILAR NEURONAL SYNCHRONY FOLLOWING ISCHEMIA-INDUCED HILAR NEURONAL LOSS, Neuroscience, 1995; 69(1): 139-150.
Mody, I.; De Koninck, Y.; Otis, T. S.; Soltesz, I.   BRIDGING THE CLEFT AT GABA SYNAPSES IN THE BRAIN, Trends in Neurosciences, 1994; 17(12): 517-525.
Otis, T. S.; De Koninck, Y.; Mody, I.   LASTING POTENTIATION OF INHIBITION IS ASSOCIATED WITH AN INCREASED NUMBER OF GAMMA-AMINOBUTYRIC-ACID TYPE-A RECEPTORS ACTIVATED DURING MINIATURE INHIBITORY POSTSYNAPTIC CURRENTS, Proceedings of the National Academy of Sciences of the United States of America, 1994; 91(16): 7698-7702.
Otis, T. S.; De Koninck, Y.; Mody, I.   CHARACTERIZATION OF SYNAPTICALLY ELICITED GABA-B RESPONSES USING PATCH-CLAMP RECORDINGS IN RAT HIPPOCAMPAL SLICES, Journal of Physiology-London, 1993; 463: 391-407.
Otis, T. S.; Mody, I.   DIFFERENTIAL ACTIVATION OF GABA-A AND GABA-B RECEPTORS BY SPONTANEOUSLY RELEASED TRANSMITTER, Journal of Neurophysiology, 1992; 67(1): 227-235.
Staley, K. J.; Otis, T. S.; Mody, I.   MEMBRANE-PROPERTIES OF DENTATE GYRUS GRANULE CELLS - COMPARISON OF SHARP MICROELECTRODE AND WHOLE-CELL RECORDINGS, Journal of Neurophysiology, 1992; 67(5): 1346-1358.
Otis, T. S.; Mody, I.   MODULATION OF DECAY KINETICS AND FREQUENCY OF GABA-A RECEPTOR-MEDIATED SPONTANEOUS INHIBITORY POSTSYNAPTIC CURRENTS IN HIPPOCAMPAL-NEURONS, Neuroscience, 1992; 49(1): 13-32.
Mody, I.; Otis, T. S.; Staley, K. J.; Kohr, G.; Macdonald, R. L.; Wasterlain, C. G.; Ticku, M. K.   THE BALANCE BETWEEN EXCITATION AND INHIBITION IN DENTATE GRANULE CELLS AND ITS ROLE IN EPILEPSY, Epilepsy Research, 1992; 331-339.
Mody, I.; Kohr, G.; Otis, T. S.; Staley, K. J.   THE ELECTROPHYSIOLOGY OF DENTATE GYRUS GRANULE CELLS IN WHOLE-CELL RECORDINGS, Epilepsy Research, 1992; 159-168.
Otis, T. S.; Staley, K. J.; Mody, I.   PERPETUAL INHIBITORY ACTIVITY IN MAMMALIAN BRAIN-SLICES GENERATED BY SPONTANEOUS GABA RELEASE, Brain Research, 1991; 545(1-2): 142-150.
Otis, T. S.; Gilly, W. F.   JET-PROPELLED ESCAPE IN THE SQUID LOLIGO-OPALESCENS - CONCERTED CONTROL BY GIANT AND NON-GIANT MOTOR AXON PATHWAYS, Proceedings of the National Academy of Sciences of the United States of America, 1990; 87(8): 2911-2915.