Varghese John, Ph.D.

Titles

Visiting Assistant Professor, Neurology

Contact Information

Email
vjohn@mednet.ucla.edu

Publications

Ellerby H Michael, Bredesen Dale E, Fujimura Satoshi, John Varghese   Correction to hunter-killer peptide (HKP) for targeted therapy Journal of medicinal chemistry, 2015; 58(4): 2045.
Zhang Qiang, Descamps Olivier, Hart Matthew J, Poksay Karen S, Spilman Patricia, Kane Darci J, Gorostiza Olivia, John Varghese, Bredesen Dale E   Paradoxical effect of TrkA inhibition in Alzheimer's disease models Journal of Alzheimer's disease : JAD, 2014; 40(3): 605-17.
Spilman Patricia, Descamps Olivier, Gorostiza Olivia, Peters-Libeu Clare, Poksay Karen S, Matalis Alexander, Campagna Jesus, Patent Alexander, Rao Rammohan, John Varghese, Bredesen Dale E   The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model Brain research, 2014; 1551(4): 25-44.
Theendakara Veena, Patent Alexander, Peters Libeu Clare A, Philpot Brittany, Flores Sonia, Descamps Olivier, Poksay Karen S, Zhang Qiang, Cailing Gabriellee, Hart Matthew, John Varghese, Rao Rammohan V, Bredesen Dale E   Neuroprotective Sirtuin ratio reversed by ApoE4 Proceedings of the National Academy of Sciences of the United States of America, 2013; 110(45): 18303-8.
Ng Raymond A, Sun Minghua, Bowers Simeon, Hom Roy K, Probst Gary D, John Varghese, Fang Lawrence Y, Maillard Michel, Gailunas Andrea, Brogley Louis, Neitz R Jeffrey, Tung Jay S, Pleiss Michael A, Konradi Andrei W, Sham Hing L, Dappen Michael S, Adler Marc, Yao Nanhua, Zmolek Wes, Nakamura David, Quinn Kevin P, Sauer John-Michael, Bova Michael P, Ruslim Lany, Artis Dean R, Yednock Ted A   Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitors Bioorganic & medicinal chemistry letters, 2013; 23(16): 4674-9.
Descamps Olivier, Spilman Patricia, Zhang Qiang, Libeu Clare P, Poksay Karen, Gorostiza Olivia, Campagna Jesus, Jagodzinska Barbara, Bredesen Dale E, John Varghese   AβPP-selective BACE inhibitors (ASBI): novel class of therapeutic agents for alzheimer's disease Journal of Alzheimer's disease : JAD, 2013; 37(2): 343-55.
Bredesen Dale E, John Varghese   Next generation therapeutics for Alzheimer's disease EMBO molecular medicine, 2013; 5(6): 795-8.
Libeu Clare A Peters, Descamps Olivier, Zhang Qiang, John Varghese, Bredesen Dale E   Altering APP proteolysis: increasing sAPPalpha production by targeting dimerization of the APP ectodomain PloS one, 2012; 7(6): e40027.
Rao Rammohan V, Descamps Olivier, John Varghese, Bredesen Dale E   Ayurvedic medicinal plants for Alzheimer's disease: a review Alzheimer's research & therapy, 2012; 4(3): 22.
Maccecchini Maria L, Chang Mee Young, Pan Catherine, John Varghese, Zetterberg Henrik, Greig Nigel H   Posiphen as a candidate drug to lower CSF amyloid precursor protein, amyloid-β peptide and τ levels: target engagement, tolerability and pharmacokinetics in humans Journal of neurology, neurosurgery, and psychiatry, 2012; 83(9): 894-902.
Hollingworth Samantha A, Nissen Lisa M, Stathis Stephen S, Siskind Dan J, Varghese John M N, Scott James G   Australian national trends in stimulant dispensing: 2002-2009 The Australian and New Zealand journal of psychiatry, 2011; 45(4): 332-6.
Descamps Olivier, Zhang Qiang, John Varghese, Bredesen Dale E   Induction of the C-terminal proteolytic cleavage of AβPP by statins Journal of Alzheimer's disease : JAD, 2011; 25(1): 51-7.
Jin Kunlin, Mao Xiao Ou, Xie Lin, John Varghese, Greenberg David A   Pharmacological induction of neuroglobin expression Pharmacology, 2011; 87(1-2): 81-4.
Libeu Clare Peters, Poksay Karen S, John Varghese, Bredesen Dale E   Structural and functional alterations in amyloid-β precursor protein induced by amyloid-β peptides Journal of Alzheimer's disease : JAD, 2011; 25(3): 547-66.
Probst Gary D, Bowers Simeon, Sealy Jennifer M, Stupi Brian, Dressen Darren, Jagodzinska Barbara M, Aquino Jose, Gailunas Andrea, Truong Anh P, Tso Luke, Xu Ying-Zi, Hom Roy K, John Varghese, Tung Jay S, Pleiss Michael A, Tucker John A, Konradi Andrei W, Sham Hing L, Jagodzinski Jacek, Toth Gergely, Brecht Eric, Yao Nanhua, Pan Hu, Lin May, Artis Dean R, Ruslim Lany, Bova Michael P, Sinha Sukanto, Yednock Ted A, Gauby Shawn, Zmolek Wes, Quinn Kevin P, Sauer John-Michael   Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region Bioorganic & medicinal chemistry letters, 2010; 20(20): 6034-9.
Bredesen Dale E, John Varghese, Galvan Veronica   Importance of the caspase cleavage site in amyloid-β protein precursor Journal of Alzheimer's disease : JAD, 2010; 22(1): 57-63.
Truong Anh P, Probst Gary D, Aquino Jose, Fang Larry, Brogley Louis, Sealy Jennifer M, Hom Roy K, Tucker John A, John Varghese, Tung Jay S, Pleiss Michael A, Konradi Andrei W, Sham Hing L, Dappen Michael S, Tóth Gergley, Yao Nanhua, Brecht Eric, Pan Hu, Artis Dean R, Ruslim Lany, Bova Michael P, Sinha Sukanto, Yednock Ted A, Zmolek Wes, Quinn Kevin P, Sauer John-Michael   Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: structure-activity relationship of P2' substituents Bioorganic & medicinal chemistry letters, 2010; 20(16): 4789-94.
Sealy Jennifer M, Truong Anh P, Tso Luke, Probst Gary D, Aquino Jose, Hom Roy K, Jagodzinska Barbara M, Dressen Darren, Wone David W G, Brogley Louis, John Varghese, Tung Jay S, Pleiss Michael A, Tucker John A, Konradi Andrei W, Dappen Michael S, Toth Gergely, Pan Hu, Ruslim Lany, Miller Jim, Bova Michael P, Sinha Sukanto, Quinn Kevin P, Sauer John-Michael   Design and synthesis of cell potent BACE-1 inhibitors: structure-activity relationship of P1' substituents Bioorganic & medicinal chemistry letters, 2009; 19(22): 6386-91.
Ellerby H Michael, Bredesen Dale E, Fujimura Satoshi, John Varghese   Hunter-killer peptide (HKP) for targeted therapy Journal of medicinal chemistry, 2008; 51(19): 5887-92.
Chung Alfred, Varghese John   Treatment of catatonia with electroconvulsive therapy in an 11-year-old girl The Australian and New Zealand journal of psychiatry, 2008; 42(3): 251-3.
Maillard Michel C, Hom Roy K, Benson Timothy E, Moon Joseph B, Mamo Shumeye, Bienkowski Michael, Tomasselli Alfredo G, Woods Danielle D, Prince D Bryan, Paddock Donna J, Emmons Thomas L, Tucker John A, Dappen Michael S, Brogley Louis, Thorsett Eugene D, Jewett Nancy, Sinha Sukanto, John Varghese   Design, synthesis, and crystal structure of hydroxyethyl secondary amine-based peptidomimetic inhibitors of human beta-secretase Journal of medicinal chemistry, 2007; 50(4): 776-81.
Kozlowska Kasia, Nunn Kenneth P, Rose Donna, Morris Anne, Ouvrier Robert A, Varghese John   Conversion disorder in Australian pediatric practice Journal of the American Academy of Child and Adolescent Psychiatry, 2007; 46(1): 68-75.
John Varghese   Human beta-secretase (BACE) and BACE inhibitors: progress report Current topics in medicinal chemistry, 2006; 6(6): 569-78.
Hom Roy K, Gailunas Andrea F, Mamo Shumeye, Fang Larry Y, Tung Jay S, Walker Donald E, Davis David, Thorsett Eugene D, Jewett Nancy E, Moon Joseph B, John Varghese   Design and synthesis of hydroxyethylene-based peptidomimetic inhibitors of human beta-secretase Journal of medicinal chemistry, 2004; 47(1): 158-64.
John Varghese, Beck James P, Bienkowski Michael J, Sinha Sukanto, Heinrikson Robert L   Human beta-secretase (BACE) and BACE inhibitors Journal of medicinal chemistry, 2003; 46(22): 4625-30.
Hom Roy K, Fang Larry Y, Mamo Shumeye, Tung Jay S, Guinn Ashley C, Walker Don E, Davis David L, Gailunas Andrea F, Thorsett Eugene D, Sinha Sukanto, Knops Jeroen E, Jewett Nancy E, Anderson John P, John Varghese   Design and synthesis of statine-based cell-permeable peptidomimetic inhibitors of human beta-secretase Journal of medicinal chemistry, 2003; 46(10): 1799-802.
Tung Jay S, Davis David L, Anderson John P, Walker Don E, Mamo Shumeye, Jewett Nancy, Hom Roy K, Sinha Sukanto, Thorsett Eugene D, John Varghese   Design of substrate-based inhibitors of human beta-secretase Journal of medicinal chemistry, 2002; 45(2): 259-62.