Wendy Walwyn, Ph.D.

Titles

Member, Brain Research Institute

Adjunct Professor, Psychiatry and Biobehavioral Sciences

Hatos Center for Neuropharmacology

Contact Information

Email
wwalwyn@g.ucla.edu
Phone
Fax Number: (310) 206-7067
Work Phone Number: (310) 206-3231
Address

Mailing Address:

MRL Building
675 Charles Young Drive
Los Angeles, CA 90095
UNITED STATES

Publications

Smith Wesley C, Rosenberg Matthew H, Claar Leslie D, Chang Victoria, Shah Sagar N, Walwyn Wendy M, Evans Christopher J, Masmanidis Sotiris C   Frontostriatal Circuit Dynamics Correlate with Cocaine Cue-Evoked Behavioral Arousal during Early Abstinence eNeuro, ; 3(3): .
Storey, G. P.; Gonzalez-Fernandez, G.; Bamford, I. J.; Hur, M.; McKinley, J. W.; Heimbigner, L.; Minasyan, A.; Walwyn, W. M.; Bamford, N. S.   Nicotine Modifies Corticostriatal Plasticity and Amphetamine Rewarding Behaviors in Mice(1,2,3) eNeuro, 2016; 3(1): .
Taylor, A. M.; Roberts, K. W.; Pradhan, A. A.; Akbari, H. A.; Walwyn, W.; Lutfy, K.; Carroll, F. I.; Cahill, C. M.; Evans, C. J.   Anti-nociception mediated by a kappa opioid receptor agonist is blocked by a delta receptor agonist Br J Pharmacol, 2015; 172(2): 691-703.
Marvizon, J. C.; Walwyn, W.; Minasyan, A.; Chen, W.; Taylor, B. K.   Latent sensitization: a model for stress-sensitive chronic pain Curr Protoc Neurosci, 2015; 71: 9 50 1-9 50 14.
Marvizon, J. C.; Walwyn, W.; Minasyan, A.; Chen, W.; Taylor, B. K.   Latent sensitization: a model for stress-sensitive chronic pain Curr Protoc Neurosci, 2015; 71: 9 50 1-9 50 14.
Gendron, L.; Mittal, N.; Beaudry, H.; Walwyn, W.   Recent advances on the delta opioid receptor: from trafficking to function Br J Pharmacol, 2015; 172(2): 403-19.
Chen, W.; Walwyn, W.; Ennes, H. S.; Kim, H.; McRoberts, J. A.; Marvizon, J. C.   BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals Eur J Neurosci, 2014; 39(9): 1439-54.
Cui, Y.; Ostlund, S. B.; James, A. S.; Park, C. S.; Ge, W.; Roberts, K. W.; Mittal, N.; Murphy, N. P.; Cepeda, C.; Kieffer, B. L.; Levine, M. S.; Jentsch, J. D.; Walwyn, W. M.; Sun, Y. E.; Evans, C. J.; Maidment, N. T.; Yang, X. W.   Targeted expression of mu-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward Nat Neurosci, 2014; 17(2): 254-61.
Pradhan, A.; Smith, M.; McGuire, B.; Evans, C.; Walwyn, W.   Chronic inflammatory injury results in increased coupling of delta opioid receptors to voltage-gated Ca2+ channels Mol Pain, 2013; 9: 8.
Weibel, R.; Reiss, D.; Karchewski, L.; Gardon, O.; Matifas, A.; Filliol, D.; Becker, J. A.; Wood, J. N.; Kieffer, B. L.; Gaveriaux-Ruff, C.   Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice PLoS One, 2013; 8(9): e74706.
Mittal, N.; Tan, M.; Egbuta, O.; Desai, N.; Crawford, C.; Xie, C. W.; Evans, C.; Walwyn, W.   Evidence that behavioral phenotypes of morphine in beta-arr2-/- mice are due to the unmasking of JNK signaling Neuropsychopharmacology, 2012; 37(8): 1953-62.
Lam, H.; Maga, M.; Pradhan, A.; Evans, C. J.; Maidment, N. T.; Hales, T. G.; Walwyn, W.   Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking beta-arrestin 2 Mol Pain, 2011; 7: 24.
Walwyn, W.; John, S.; Maga, M.; Evans, C. J.; Hales, T. G.   Delta receptors are required for full inhibitory coupling of mu-receptors to voltage-dependent Ca(2+) channels in dorsal root ganglion neurons Mol Pharmacol, 2009; 76(1): 134-43.
Otoshi, C. K.; Walwyn, W. M.; Tillakaratne, N. J.; Zhong, H.; Roy, R. R.; Edgerton, V. R.   Distribution and localization of 5-HT(1A) receptors in the rat lumbar spinal cord after transection and deafferentation J Neurotrauma, 2009; 26(4): 575-84.
Walwyn, W. M.; Matsuka, Y.; Arai, D.; Bloom, D. C.; Lam, H.; Tran, C.; Spigelman, I.; Maidment, N. T.   HSV-1-mediated NGF delivery delays nociceptive deficits in a genetic model of diabetic neuropathy Exp Neurol, 2006; 198(1): 260-70.
Walwyn, W.; Maidment, N. T.; Sanders, M.; Evans, C. J.; Kieffer, B. L.; Hales, T. G.   Induction of delta opioid receptor function by up-regulation of membrane receptors in mouse primary afferent neurons Mol Pharmacol, 2005; 68(6): 1688-98.
Walwyn, W. M.; Keith, D. E., Jr.; Wei, W.; Tan, A. M.; Xie, C. W.; Evans, C. J.; Kieffer, B. L.; Maidment, N. T.   Functional coupling, desensitization and internalization of virally expressed mu opioid receptors in cultured dorsal root ganglion neurons from mu opioid receptor knockout mice Neuroscience, 2004; 123(1): 111-21.
Irnaten, M.; Walwyn, W. M.; Wang, J.; Venkatesan, P.; Evans, C.; Chang, K. S.; Andresen, M. C.; Hales, T. G.; Mendelowitz, D.   Pentobarbital enhances GABAergic neurotransmission to cardiac parasympathetic neurons, which is prevented by expression of GABA(A) epsilon subunit Anesthesiology, 2002; 97(3): 717-24.
Skoubis, P. D.; Matthes, H. W.; Walwyn, W. M.; Kieffer, B. L.; Maidment, N. T.   Naloxone fails to produce conditioned place aversion in mu-opioid receptor knock-out mice Neuroscience, 2001; 106(4): 757-63.
Walwyn, W. M.; Ta-Haung, J.; Ackerson, L.; Maidment, N. T.; Edgerton, V. R.   Extracellular glutamate in the dorsal horn of the lumbar spinal cord in the freely moving rat during hindlimb stepping Pharmacol Biochem Behav, 1999; 63(4): 581-8.
Pradhan Amynah A, Perroy Julie, Walwyn Wendy M, Smith Monique L, Vicente-Sanchez Ana, Segura Laura, Bana Alia, Kieffer Brigitte L, Evans Christopher J   Agonist-Specific Recruitment of Arrestin Isoforms Differentially Modify Delta Opioid Receptor Function The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016; 36(12): 3541-51.
Walwyn, W. M.; Chen, W.; Kim, H.; Minasyan, A.; Ennes, H. S.; McRoberts, J. A.; Marvizon, J. C.   Sustained Suppression of Hyperalgesia during Latent Sensitization by mu-, delta-, and kappa-opioid receptors and alpha2A Adrenergic Receptors: Role of Constitutive Activity J Neurosci, 2016; 36(1): 204-21.
Mittal, N.; Roberts, K.; Pal, K.; Bentolila, L. A.; Fultz, E.; Minasyan, A.; Cahill, C.; Pradhan, A.; Conner, D.; DeFea, K.; Evans, C.; Walwyn, W.   Select G-protein-coupled receptors modulate agonist-induced signaling via a ROCK, LIMK, and beta-arrestin 1 pathway Cell Rep, 2013; 5(4): 1010-21.
James, A. S.; Chen, J. Y.; Cepeda, C.; Mittal, N.; Jentsch, J. D.; Levine, M. S.; Evans, C. J.; Walwyn, W.   Opioid self-administration results in cell-type specific adaptations of striatal medium spiny neurons Behav Brain Res, 2013; 256: 279-83.
Pradhan, A. A.; Walwyn, W.; Nozaki, C.; Filliol, D.; Erbs, E.; Matifas, A.; Evans, C.; Kieffer, B. L.   Ligand-directed trafficking of the delta-opioid receptor in vivo: two paths toward analgesic tolerance J Neurosci, 2010; 30(49): 16459-68.
Walwyn, W. M.; Miotto, K. A.; Evans, C. J.   Opioid pharmaceuticals and addiction: the issues, and research directions seeking solutions Drug Alcohol Depend, 2010; 108(3): 156-65.
Tan, M.; Walwyn, W. M.; Evans, C. J.; Xie, C. W.   p38 MAPK and beta-arrestin 2 mediate functional interactions between endogenous micro-opioid and alpha2A-adrenergic receptors in neurons J Biol Chem, 2009; 284(10): 6270-81.
Walwyn Wendy, Evans Christopher J, Hales Tim G   Beta-arrestin2 and c-Src regulate the constitutive activity and recycling of mu opioid receptors in dorsal root ganglion neurons The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007; 27(19): 5092-104.
Walwyn, W. M. Wei, W. Xie, C. W. Chiu, K. Kieffer, B. L. Evans, C. J. Maidment, N. T.   Mu opioid receptor-effector coupling and trafficking in dorsal root ganglia neurons Neuroscience, 2006; 142(2): 493-503.
Walwyn, W. M.; Wei, W.; Xie, C. W.; Chiu, K.; Kieffer, B. L.; Evans, C. J.; Maidment, N. T.   Mu opioid receptor-effector coupling and trafficking in dorsal root ganglia neurons Neuroscience, 2006; 142(2): 493-503.
Walwyn, W. M. Matsuka, Y. Arai, D. Bloom, D. C. Lam, H. Tran, C. Spigelman, I. Maidment, N. T.   HSV-1-mediated NGF delivery delays nociceptive deficits in a genetic model of diabetic neuropathy Exp Neurol, 2006; 198(1): 260-70.
Walwyn, W. Maidment, N. T. Sanders, M. Evans, C. J. Kieffer, B. L. Hales, T. G.   Induction of delta opioid receptor function by up-regulation of membrane receptors in mouse primary afferent neurons Mol Pharmacol, 2005; 68(6): 1688-98.
Walwyn, W. M. Keith, D. E., Jr. Wei, W. Tan, A. M. Xie, C. W. Evans, C. J. Kieffer, B. L. Maidment, N. T.   Functional coupling, desensitization and internalization of virally expressed mu opioid receptors in cultured dorsal root ganglion neurons from mu opioid receptor knockout mice Neuroscience, 2004; 123(1): 111-21.
Lutfy, K. Eitan, S. Bryant, C. D. Yang, Y. C. Saliminejad, N. Walwyn, W. Kieffer, B. L. Takeshima, H. Carroll, F. I. Maidment, N. T. Evans, C. J.   Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors J Neurosci, 2003; 23(32): 10331-7.
Lutfy, K.; Eitan, S.; Bryant, C. D.; Yang, Y. C.; Saliminejad, N.; Walwyn, W.; Kieffer, B. L.; Takeshima, H.; Carroll, F. I.; Maidment, N. T.; Evans, C. J.   Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors J Neurosci, 2003; 23(32): 10331-7.
Irnaten, M. Walwyn, W. M. Wang, J. Venkatesan, P. Evans, C. Chang, K. S. Andresen, M. C. Hales, T. G. Mendelowitz, D.   Pentobarbital enhances GABAergic neurotransmission to cardiac parasympathetic neurons, which is prevented by expression of GABA(A) epsilon subunit Anesthesiology, 2002; 97(3): 717-24.
Skoubis, P. D. Matthes, H. W. Walwyn, W. M. Kieffer, B. L. Maidment, N. T.   Naloxone fails to produce conditioned place aversion in mu-opioid receptor knock-out mice Neuroscience, 2001; 106(4): 757-63.
Walwyn, W. M. Ta-Haung, J. Ackerson, L. Maidment, N. T. Edgerton, V. R.   Extracellular glutamate in the dorsal horn of the lumbar spinal cord in the freely moving rat during hindlimb stepping Pharmacol Biochem Behav, 1999; 63(4): 581-8.