
William P. Melega, Ph.D.
Titles
Professor, Jane and Terry Semel Institute for Neuroscience and Human Behavior
Professor In-Residence, Molecular & Medical Pharmacology
Member, Brain Research Institute
Molecular Pharmacology GPB Home Area
Contact Information
Email
wmelega@mednet.ucla.edu Phone
Office Phone Number:
(310) 206-1797
Address
Work Address:
OfficeBRI
Los Angeles, CA 90095
UNITED STATES
Publications
A selected list of publications:
Lacan Goran, Dang Hoa, Middleton Blake, Horwitz Marcus A, Tian Jide, Melega William P, Kaufman Daniel L
Bacillus Calmette-Guerin vaccine-mediated neuroprotection is associated with regulatory T-cell induction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
Journal of neuroscience research,
2013; 91(10):
1292-302.
Lacan Goran, Hadamitzky Martin, Kuczenski Ronald, Melega William P
Alterations in the striatal dopamine system during intravenous methamphetamine exposure: effects of contingent and noncontingent administration
Synapse (New York, N.Y.),
2013; 67(8):
476-88.
Mulgaonkar Amit P, Singh Rahul S, Babakhanian Meghedi, Culjat Martin O, Grundfest Warren S, Gorgulho Alessandra, Lacan Goran, De Salles Antonio A F, Bystritsky Alexander, Melega William P
A prototype stimulator system for noninvasive Low Intensity Focused
Ultrasound delivery
Studies in health technology and informatics,
2012; 173(8):
297-303.
Melega WP, Lacan G, Gorgulho AA, Behnke EJ, De Salles AA
Hypothalamic deep brain stimulation reduces weight gain in an obesity-animal model
PLoS ONE ,
2012; 7(1):
e30672, 1-8.
Yong J, Lacan G, Dang H, Hsieh T, Middleton B, Wasserfall C, Tian J, Melega WP, Kaufman DL
BCG vaccine-induced neuroprotection in a mouse model of Parkinson's Disease
PLoS ONE,
2011; 6(1):
e16610.
Kuczenski R, Segal DS, Melega WP, Lacan G, McCunney SJ
Human methamphetamine pharmacokinetics simulated in the rat: behavioral and neurochemical effects of a 72-hour binge
Neuropsychopharmacology,
2009; 34:
24302441.
Lacan G, Plenevaux A, Rubins D, Way BM, Defraiteur C, Gillet S, Lemaire C, Aerts J, Luxen, A, Cherry SR, Melega WP.
Cyclosporine, a p-glycoprotein modulator, increases 18F-MPPF binding in rat brain and peripheral tissues: Micropet and ex vivo studies,
Eur. J. Nuc. Med. Mol. Imaging,
2008;
.
Chin MH, Qian W-J, Wang H, Petyuk VA, Bloom JS, Sforza DM, Lacan G, Liu D, Khan AH, Cantor RM, Bigelow DJ, Melega WP, Camp II DG, Richard D. Smith RD, Smith DJ.
miRNAs and codon usage regulate striatal gene and protein expression in two mouse models of Parkinson's disease,
J Proteome Res,
2008; 7:
666-677.
Melega WP, Cho AK, Harvey DC, Lacan G
Methamphetamine blood concentrations in human abusers: application to pharmacokinetic modeling,
Synapse,
2007; 61:
216-220.
O'Neil ML,Kuczenski R, Segal DS, Cho AK, Lacan G, Melega WP
Escalating dose pretreatment induces pharmacodynamic and not pharmacokinetic tolerance to a subsequent high-dose methamphetamine binge,
Synapse,
2006; 60:
465-473.
Segal, DS Kuczenski, R O'Neil, ML Melega, WP Cho, AK
Prolonged exposure of rats to intravenous methamphetamine: behavioral and neurochemical characterization
Psychopharmacology,
2005; 180(3):
501-12.
Segal DS, Kuczenski R, O'Neil ML, Melega WP, Cho AK
Prolonged exposure of rats to intravenous methamphetamine: behavioral and neurochemical characterization,
Psychopharmacology (Berl),
2005; 180:
501-512.
Rubins, DJ Melega, WP Lacan, G Way, B Plenevaux, A Luxen, A Cherry, SR
Development and evaluation of an automated atlas-based image analysis method for microPET studies of the rat brain
NeuroImage,
2003; 20(4):
2100-18.
Segal DS, Kuczenski R, ONeil ML, Melega WP, Cho AK.
Escalating dose methamphetamine pretreatment alters the behavioral and neurochemical profiles associated with exposure to a high dose methamphetamine binge,
Neuropsychopharmacology,
2003; 28:
1730-40.
Cho AK, Melega WP
Patterns of methamphetamine abuse and their consequences
Journal of addictive diseases ,
2002; 21(1):
21-34.
Brown, VM Ossadtchi, A Khan, AH Yee, S Lacan, G Melega, WP Cherry, SR Leahy, RM Smith, DJ
Multiplex three-dimensional brain gene expression mapping in a mouse model of Parkinson's disease
Genome research,
2002; 12(6):
868-84.
Cho, AK Melega, WP Kuczenski, R Segal, DS
Relevance of pharmacokinetic parameters in animal models of methamphetamine abuse
Synapse (New York, N.Y.) ,
2001; 39(2):
161-6.
Harvey, DC Lacan, G Tanious, SP Melega, WP
Recovery from methamphetamine induced long-term nigrostriatal dopaminergic deficits without substantia nigra cell loss
Brain research. ,
2000; 871(2):
259-70.
Cho, AK Melega, WP Kuczenski, R Segal, DS Schmitz, DA
Caudate-putamen dopamine and stereotypy response profiles after intravenous and subcutaneous amphetamine
Synapse (New York, N.Y.) ,
1999; 31(2):
125-33.
Melega, WP Cho, AK Schmitz, D Kuczenski, R Segal, DS
l-methamphetamine pharmacokinetics and pharmacodynamics for assessment of in vivo deprenyl-derived l-methamphetamine
The Journal of pharmacology and experimental therapeutics,
1999; 288(2):
752-8.