Xin Liu, M.D., Ph.D.


Director, Embryonic Stem Cells

Assistant Professor, Pathology and Laboratory Medicine

Member, Brain Research Institute

JCCC Cancer and Stem Cell Biology Program Area

Molecular Biology Institute

Neuroengineering Training Program

Faculty, Cellular and Molecular Pathology PhD Program

Contact Information

Work Phone Number: (310) 794-5880

Work Address:

1P-217 CHS
CAMPUS - 173216


Hideaki Tsutsui*, Bahram Valamehr*, Antreas Hindoyan, Rong Qiao, Xianting Ding, Shuling Guo, Owen N. Witte, Xin Liu, Chih-Ming Ho & Hong Wu.   An optimized small molecule inhibitor cocktail supports long-term maintenance of human embryonic stem cells, Nat Commun, 2011; 2:167: 1-8.
Goebbels, S., Oltrogge, J., Kemper, R., Heilmann, I., Wichert, S., Bormuth, I., Wolfer, S., Liu, X., Lappe-Siefke, C., Rossner, M., Groszer, M., Suter, U., Frahm, J., Boretius, S., and Nave, K.   Elevated phosphatidylinositol 3,4,5 trisphosphate in glia triggers cell autonomous membrane wrapping and myelination, J. Neuroscience , 2010; 30(26): 8953-64.
Matter Cheryl, Pribadi Mochtar, Liu Xin, Trachtenberg Joshua T   Delta-catenin is required for the maintenance of neural structure and function in mature cortex in vivo Neuron, 2009; 64(3): 320-7.
Gregorian Caroline, Nakashima Jonathan, Dry Sarah M, Nghiemphu P Leia, Smith Kate Barzan, Ao Yan, Dang Julie, Lawson Gregory, Mellinghoff Ingo K, Mischel Paul S, Phelps Michael, Parada Luis F, Liu Xin, Sofroniew Michael V, Eilber Fritz C, Wu Hong   PTEN dosage is essential for neurofibroma development and malignant transformation Proceedings of the National Academy of Sciences of the United States of America, 2009; 106(46): 19479-84.
Arikkah, J., Peng, F., Ng, Y., Israely, I., Liu, X., Ullian, E., Reichardt, L.   Delta-catenin regulates spine and synapse morphogenesis and function in hippocampal neurons, J. Neuroscience, 2009; 29(17): 5435-5442.
Valamehr Bahram, Jonas Steven J, Polleux Julien, Qiao Rong, Guo Shuling, Gschweng Eric H, Stiles Bangyan, Kam Korey, Luo Tzy-Jiun M, Witte Owen N, Liu Xin, Dunn Bruce, Wu Hong   Hydrophobic surfaces for enhanced differentiation of embryonic stem cell-derived embryoid bodies Proceedings of the National Academy of Sciences of the United States of America, 2008; 105(38): 14459-64.
Arikkath Jyothi, Israely Inbal, Tao Yanmei, Mei Lin, Liu Xin, Reichardt Louis F   Erbin controls dendritic morphogenesis by regulating localization of delta-catenin The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008; 28(28): 7047-56.
Arikkath, J., Israely, I., Tao, Y., Mei, L., Liu, X., and Reigardt, L   Erbin controls dendritic morphogenesis by regulating localization of -catenin, J. Neuroscience, 2008; 28(28): 7047-7056.
Freeman Dan, Lesche Ralf, Kertesz Nathalie, Wang Shungyou, Li Gang, Gao Jing, Groszer Matthias, Martinez-Diaz Hilda, Rozengurt Nora, Thomas George, Liu Xin, Wu Hong   Genetic background controls tumor development in PTEN-deficient mice Cancer research, 2006; 66(13): 6492-6.
Li, G., Hu, Y., Huo, Y., Liu, M., Freeman, D., Gao, J., Liu, X., Wu, DC., and Wu, H.   PTEN deletion leads to up-regulation of a secreted growth factor pleiotrophin. , J Biol Chem. , 2006; 281(16): 10663-8.
Groszer, M., Erickson, R., Scripture-Adams, D., Dougherty, J., LeBelle, J., Zack, J., Geschwind, D., Liu, X., Kornblum, H., Wu, H.   PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry, Proc. Natl. Acad. Sci. USA, 2006; 103: 111-116.
He, XP., Bulter, L., Liu, X., and McNamara, JO.   The tyrosine receptor kinase B ligand, neurotrophin-4, is not required for either epileptogenesis or tyrosine receptor kinase B activation in the kindling model, Neuroscience, 2006; 141(1): 515-520.
Lei Qunying, Jiao Jing, Xin Li, Chang Chun-Ju, Wang Shunyou, Gao Jing, Gleave Martin E, Witte Owen N, Liu Xin, Wu Hong   NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss Cancer cell, 2006; 9(5): 367-78.
Tsai Peter T, Ohab John J, Kertesz Nathalie, Groszer Matthias, Matter Cheryl, Gao Jing, Liu Xin, Wu Hong, Carmichael S Thomas   A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006; 26(4): 1269-74.
Yue Q, Groszer M, Gil JS, Berk AJ, Messing A, Wu H, Liu X   PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization Development (Cambridge, England) , 2005; 132(14): 3281-91.
Nakano, I., Paucar, A., Bajpai, R., Dougherty, J., Zewail, A., Kim, K., Ou, J., Groszer, M., Imura, T., Freije, W., Nelson, S., Sofroniew, M., Wu, H., Liu, X., Terskikh, A., Geschwind, D., Kornblum, H.   Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation, J. Cell Biol, 2005; 170: 413-427.
Kosik KS, Donahue CP, Israely I, Liu X, Ochiishi T   Delta-catenin at the synaptic-adherens junction Trends in cell biology, 2005; 15(3): 172-8.
Israely I, Costa RM, Xie CW, Silva AJ, Kosik K and Liu X   The neuronal specific protein Delta-Catenin is essential for cognitive function. , Current Biology, 2004; 14 (18): 1657-1663.
Tan M, Groszer M, Tan AM, Pandya A, Liu X, Xie CW   Phosphoinositide 3-kinase cascade facilitates mu-opioid desensitization in sensory neurons by altering G-protein-effector interactions The Journal of neuroscience : the official journal of the Society for Neuroscience. , 2003; 23(32): 10292-301.
Colwell CS, Michel S, Itri J, Rodriguez W, Tam J, Lelievre V, Hu Z, Liu X, Waschek JA   Disrupted circadian rhythms in VIP- and PHI-deficient mice American journal of physiology. Regulatory, integrative and comparative physiology. , 2003; 285(5): R939-49.
Wang S, Gao J, Lei Q, Rozengurt N, Pritchard C, Jiao J, Thomas GV, Li G, Roy-Burman P, Nelson PS, Liu X, Wu H   Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer Cancer cell. , 2003; 4(3): 209-21.
Smith DJ, Leil TA, Liu X   Neurotrophin-4 is required for tolerance to morphine in the mouse Neuroscience letters. , 2003; 340(2): 103-6.
Li G, Robinson GW, Lesche R, Martinez-Diaz H, Jiang Z, Rozengurt N, Wagner KU, Wu DC, Lane TF, Liu X, Hennighausen L, Wu H   Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland Development (Cambridge, England) , 2002; 129(17): 4159-70.
Lesche R, Groszer M, Gao J, Wang Y, Messing A, Liu X and Wu H   Cre/loxp-Mediated Inactivation of The Murine Pten Tumor Suppressor Gene, Genesis, 2002; 32: 148-149.
Stiles B, Gilman V, Khanzenzon N, Lesche R, Li A, Qiao R, Liu X, Wu H   Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis Molecular and cellular biology. , 2002; 22(11): 3842-51.
Groszer M, Erickson R, Scripture-Adams DD, Lesche R, Trumpp A, Zack JA, Kornblum HI, Liu X, Wu H   Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo Science. , 2001; 294(5549): 2186-9.
Xie CW, Sayah D, Chen QS, Wei Wz, Smith D and Liu X   Deficient long-term memory and long-term potentiation with a targeted null mutation in neurotrophin-4 gene, Proc. Natl. Acad. Sci. USA , 2000; 97: 8116-8121.
Endres M, Fan GP, Hirt L, Fujii M, Liu X, Jaenisch R, Moskowitz MA   Ischemic brain damage in mice after selectively modifying BDNF or NT4 gene expression, Journal of Cerebral Blood Flow and Metabolism , 2000; 20(1): 139-144.
Liu X, Jaenisch R   Severe peripheral sensory neuron loss and modest motor neuron reduction in mice with combined deficiency of brain-derived neurotrophic factor, neurotrophin 3 and neurotrophin 4/5 Developmental dynamics : an official publication of the American Association of Anatomists. , 2000; 218(1): 94-101.
Wu H, Lee SH, Gao J, Liu X, Iruela-Arispe ML   Inactivation of erythropoietin leads to defects in cardiac morphogenesis Development (Cambridge, England) , 1999; 126(16): 3597-605.
Sun H, Lesche R, Li Dm, Liliental J, Zhang H, Gao J, Gavriola N, Mueller B, Liu X, and Wu H   PTEN Modulates Cell Cycle Progression and Cell Survival by Regulating Phosphatidylinositol 3,4,5,-Triphophate and Akt/Protein Kinase B Signaling Pathway, PNAS, 1999; 96: 6199-6204.
Liu X, Wu H, Loring J, Hormuzdi S, Disteche CM, Bornstein P, Jaenisch R   Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission Developmental dynamics : an official publication of the American Association of Anatomists. , 1997; 209(1): 85-91.
Liu X, Wu H, Byrne M, Krane S, Jaenisch R   Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development Proceedings of the National Academy of Sciences of the United States of America. , 1997; 94(5): 1852-6.
Byrne M, Eeckhout Y, Henriet P, Lemaitre V, Jeffrey JJ, Witter J, Liu X, Wu H, Jaenisch R and Krane SM   Different collagenase gene products have different roles in degradation of type I collagen, J. Biol. Chem. , 1996; 271: 28509-28515.
Liu X, Wu H, Byrne M, Jeffrey J, Krane S, Jaenisch R   A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling The Journal of cell biology. , 1995; 130(1): 227-37.
Wu H, Liu X, Jaenisch R and Lodish H   Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor, Cell, 1995; 83: 59-67.
Liu X, Enfors P, Wu H and Jaenisch R   Sensory but not motor neuron deficits in mice lacking NT4 and BDNF, Nature, 1995; 375: 238-241.
Andrikopoulos K, Liu X, Keene DR, Jaenisch R, Ramirez F   Targeted mutation in the col5a2 gene reveals a regulatory role for type V collagen during matrix assembly Nature genetics. , 1995; 9(1): 31-6.
Wu H, Liu X and Jaenisch R   Double Replacement: A Strategy for Efficient Introduction of Subtle Mutations into Col1a1 gene by Homologous Recombination in ES Cells, Proc. Natl. Acad. Sci. USA, 1994; 91: 2819-2823.
Liu X, Zwiebel LJ, Hinton D, Benzer S, Hall JC, Rosbash M   The period gene encodes a predominantly nuclear protein in adult Drosophila The Journal of neuroscience : the official journal of the Society for Neuroscience. , 1992; 12(7): 2735-44.
Zwieble L, Hardin P, Liu X, Hall J and Rosbash M   A post-transcriptional mechanism contributes to circadian cycling of per-b-galactosidase fusion protein, Proc. Natl. Acad. Sci. USA , 1991; 88: 3882-3886.
Liu X, Yu QA, Huang ZS, Zwiebel LJ, Hall JC, Rosbash M   The strength and periodicity of D. melanogaster circadian rhythms are differentially affected by alterations in period gene expression Neuron. , 1991; 6(5): 753-66.
Liu X, Lorenz L, Yu Q, Hall J and Rosbash M   Spatial and temporal expression of the period gene in Drosophila melanogaster, Genes Dev. , 1988; 2: 228-238.