The UCLA Joint Seminars in Neuroscience, ICLM Distinguished Lecture - Eric Klann, Ph.D.

Tuesday, March 2, 2021 - 12:00pm

The UCLA Joint Seminars in Neuroscience Presents - Eric Klann, Ph.D.
The Integrative Center for Learning and Memory Distinguished Lecture

"Local and Cell Type-Specific Translation in Emotional Memory"

Eric Klann, Ph.D.
Associate Professor
Departments of Neuroscience, Molecular Physiology & Biophysics
Center for Neural Science, New York University

Abstract: We have shown that eIF4E-dependent translation in the lateral amygdala is required for the consolidation of auditory threat memory. We also have found evidence for alterations in local dendritic and axonal translation during memory consolidation. We recently developed chemogenetic mouse models for conditional and inducible protein synthesis inhibition (ciPSI) where translation initiation mediated by either eIF4E or eIF2 can be inhibited in a cell type-specific manner. Using these novel ciPSI mouse lines, we have found that translation in discrete cell types in the lateral and centrolateral amygdala make distinct, yet complementary contributions to the consolidation of differential threat memory. Finally, we have developed optogenetic tools that can be used to determine whether local dendritic and/or axonal translation is required for the consolidation of threat memory. Collectively, our findings demonstrate that cell type-specific, and perhaps local, translation initiation is required for threat memory consolidation.

Host: Dr. Alcino Sliva & ILCM

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