The UCLA Joint Seminars in Neuroscience Presents - Ilana Witten, Ph.D.

Tuesday, January 26, 2021 - 12:00pm
The Integrative Center for Learning and Memory Distinguished Lecturer

The UCLA Joint Seminars in Neuroscience Presents - Ilana Witten, Ph.D.

"Specialized and Spatially Organized Dopamine Signals"

Ilana Witten, Ph.D., Associate Professor
Department of Psychology
Princeton Neuroscience Institute

Abstract: I will describe our work showing surprising heterogeneity at the single-cell level in the dopamine system, based on 2-photon calcium imaging during a virtual reality decision-making task. These findings contradict a classic view of a homogenous reinforcement signal in the dopamine system. I will then present unpublished work showing that spikes can be accurately inferred from calcium imaging in dopamine neurons, which leads us to believe that the recording modality is not the source of the discrepancy with the classic view. Finally, I will discuss new work (in collaboration with Prof. Nathaniel Daw) attempting to reconcile this newly observed heterogeneity with classic models regarding the neural instantiation of reinforcement learning.

Host: Kate Wassum/Michele Basso, and ICLM

Zoom Seminar Registration: https://uclahs.zoom.us/meeting/register/tJMofuqtrzMiG9Q26wDQrpoeNgZ_ymj7...

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