Posts classified under: Computational Neuroscience

Steve Cannon, M.D., Ph.D.

Biography

The primary research interests of our laboratory are how ion channels regulate the electrical excitability of cells and how defects in these channels lead to human disease. In the past two decades, mutations of ion channel genes have been found to be the primary cause for over 100 human diseases. Our research program is focused on the mechanistic basis for a group of inherited conditions that alter the electrical excitability of skeletal muscle, including periodic paralysis and myotonia. We have characterized the gating defects of mutant channels, generated computational models of muscle excitability, and produced genetically-engineered mice to gain insights on the pathomechanisms of these disorders and to explore therapeutic interventions.

Neil Harris, Ph.D.

Biography

Professor Harris directs NEIL lab with over 25 years of experience with rodent CNS injury models and in particular using MRI and PET to assess structure and function. He received his B.Sc. in Biology/Neuroscience from University of Portsmouth in 1988, and his Ph.D. in Physiology from King’s College London in 1991. Dr. Harris’s early focus of research addressed the question of optimal timing for intervention after the diagnosis of infantile hydrocephalus. Prior to joining University of California Los Angeles (UCLA), Dr. Harris received training in multimodality imaging techniques, including PET, structural MRI, fMRI, DTI, and Glucose/blood-flow autoradiography at Kings college University of London, University of Florida McKnight Brain Institute, the Royal College of Surgeons unit of Biophysics in the Institute of Child Health, and University of Cambridge Department of Neurosurgery. Subsequently, Dr. Harris conducted studies to address forebrain ischemic stroke looking at the potential use of non-invasive biomarkers to determine salvageable areas of brain. The studies were cited amongst primary reported findings on biophysical mechanism of the change in water diffusion after stroke. Dr. Harris currently resides as Professor in Residence of UCLA Department of Neurosurgery where he primarily conducts investigations on Traumatic Brain Injury and is the scientific director of UCLA 7T animal imaging core.

Keith Holyoak, Ph.D.

Biography

Combining behavioral studies of normal cognition, computational modeling, and neuropsychological and neuroimaging studies, to understand the role of the prefrontal cortex in human thinking Keith J. Holyoak conducts research in human reasoning and problem solving. Much of his work is concerned with the role of analogy in thinking. One of the major themes of this work is the way in which analogy serves as a psychological mechanism for learning and transfer of knowledge. In his book Mental Leaps with Paul Thagard, he presents a general theory of analogical thinking that includes analysis of how the capacity to use analogy evolved in primates, how it develops in children, and how it is used to reason in domains ranging from law and politics to science. Other related reserach, in collaboration with Dan Simon, deals with complex decision-making in fields such as the law. Holyoaks research combines studies of thinking in normal adults with neuropsychological studies of how thinking in brain-damaged individuals. This work, in collaboration with Barbara Knowlton and others, is investigating the role of prefrontal cortex in complex human reasoning. In addition to experimental work, Holyoak works with John Hummel to develop computational models of human thinking based on neural-network models. These models use neural synchrony to preform dynamic variable binding, and thereby represent and maniputlate symbolic knowledge. The overall goal is to understand the neural basis for human thought.

Zili Liu, Ph.D.

Biography

Zili Liu studies visual perception — how people see and why they see the way they do (http://zililab.psych.ucla.edu). He joined UCLA’s Psychology Department in 2001. Dr. Liu received his Ph.D. in Cognitive and Linguistic Sciences, and his M.S. in Applied Mathematics, both from Brown University. He received his B.Sc. in Physics, from Beijing (Peking) University, China. He supports Rural China Education Foundation (http://www.ruralchina.org/)

Publications

A selected list of publications:

Lucy Cui and Zili Liu.   Synergy between Research on Ensemble Perception, Data Visualization, and Statistics Education: A Tutorial Review, Attention, Perception, & Psychophysics, 2020; (in press)(Special Issue on Ensemble Perception): .
Alan L.F. Lee, Zili Liu, Hongjing Lu.   Parts beget parts: Bootstrapping hierarchical object representations through visual statistical learning, Cognition, 2020; (in press): .
Download
Gennady Erlikhman, Gurjyot Singh, Tandra Ghose, Zili Liu   The effect of perceptual contour orientation uncertainty on the tilt aftereffect Vision Research, 2019; 158: 126-134.
Download
Yang (Mac) Xing, Zili Liu.   A Preference for Minimal Deformation Constrains the Perceived Depth of a Stereokinetic Stimulus Vision Research, 2018; 153: 53–59.
Download
Daniele Zavagno, Olga Daneyko, and Zili Liu.   The influence of physical illumination on lightness perception in simultaneous contrast displays i-Perception, 2018; 9(4): 1-22.
Download
Willey, C. and Liu, Z.   Long-term motor learning: Effects of varied and specific practice Vision Research, 2018; 152: 10-16.
Download
Jinfeng Huang; Ju Liang; Yifeng Zhou; Zili Liu   Transfer in motion discrimination learning was no greater in double training than in single training Journal of Vision, 2017; 17(6): 1-10.
Download
Hongjing Lu, Bosco S. Tjan, and Zili Liu   Human efficiency in detecting and discriminating biological motion Journal of Vision, 2017; 17(6): 1 — 14.
Jiawei Zhou, Zili Liu, Simon Clavagnier, Alexandre Reynaud, and Fang Hou.   Visual Plasticity in Adults, Neural Plasticity, 2017; 2017: 2.
Benjamin Thompson; Choi Deblieck; Allan D Wu; Marco Iacoboni; Zili Liu.   Psychophysical and rTMS evidence for the presence of motion opponency in human V5 Brain Stimulation, 2016; .
Download
Ju Liang, Yifeng Zhou, Zili Liu.   Examining the Standard Model of Signal Detection Theory in motion discrimination, Journal of Vision (Special Issue on Perceptual Learning), 2016; 16(9): doi:10.1167/16.7.9.
Download
Zili Liu, Xiaoyang Yang, Helene Intraub.   Boundary extension: Insights from Signal Detection Theory Journal of Vision, 2016; 16(8): 1–10.
Download
Jennifer Chang, Yifeng Zhou, Zili Liu.   Limited top-down influence from recognition to same-different matching of Chinese characters PLoS ONE, 2016; 11(6): e0156517. doi:10.1371/journal.pone.0156517.
Download
Ju Liang, Yifeng Zhou, Manfred Fahle, and Zili Liu   Limited Transfer of Long-Term Motion Perceptual Learning with Double Training Journal of Vision (Special Issue: Perceptual Learning), 2015; 15(1): 1 – 9.
Download
Ju Liang, Yifeng Zhou, Manfred Fahle, Zili Liu   Specificity of motion discrimination learning even with double training and staircase Journal of Vision (Special Issue: Perceptual Learning), 2015; 15(3): 1 – 10.
Download
Nihong Chen, Taiyong Bi, Tiangang Zhou, Sheng Li, Zili Liu, and Fang Fang.   Sharpened cortical tuning and enhanced cortico-cortical communication contribute to the long-term neural mechanisms of visual motion perceptual learning Neuro Image, 2015; 115: 17 — 29.
Download
Tandra Ghose, Zili Liu.   Generalization between canonical and non-canonical views in object recognition Journal of Vision, 2013; 13(1): 1–15.
Download
Xiaoxiao Wang, Yifeng Zhou, Zili Liu.   Transfer in motion perceptual learning depends on the difficulty of the training task Journal of Vision, 2013; 13((7):5): 1 — 9.
Download
Xuan Huang, Hongjing Lu, Yifeng Zhou, Zili Liu.   General and specific perceptual learning in radial speed discrimination Journal of Vision, 2011; 11(4, article 7): 1 — 11.
Download
Zhou J, Tjan B S, Zhou Y, Liu Z   Better discrimination for illusory than for occluded perceptual completions Journal of Vision, 2008; 8(7(26)): 1-17.
Download
Zhou J, Gotch C, Zhou Y, Liu Z   Perceiving an object in its context — is the context cultural or perceptual? Journal of Vision, 2008; 8(12(2)): 1-5.
Download
Huang X, Lu H, Tjan BS, Zhou Y, Liu Z   Motion perceptual learning: When only task-relevant information is learned Journal of Vision, 2007; 7(10:14): 1-10.
Download
Hou F, Lu H, Zhou Y, Liu Z.   “Amodal completion impairs stereo acuity discrimination”, Vision Research, 2006; 46: 2061-2068.
Download
Lu H, Zavagno D, Liu Z.   “The glare effect does not give rise to a longer lasting afterimage”, Perception, 2006; 35: 701 — 707.
Thompson B, Liu Z.   Learning motion discrimination with suppressed and unsuppressed MT, Vision Research, 2006; 46: 2110-2121.
Download
Rokers B, Yuille A, Liu Z.   The perception of a stereokinetic stimulus, Vision Research, 2006; 46: 2375 — 2387.
Download
Lu H, Liu Z   Computing dynamic classification images from correlation maps Journal of Vision [electronic resource], 2006; 6: 475 — 483.
Download
Lu H, Tjan B S, Liu Z.   “Shape recognition alters sensitivity in stereoscopic depth discrimination” Journal of Vision [electronic resource], 2006; 6: 75–86.
Download
Tjan, B S Liu, Z.   Symmetry impedes symmetry discrimination Journal of vision [electronic resource], 2005; 5(10): 888-900.
Rokers B, Liu Z.   “On the minimal relative motion principle — lateral displacement of a contracting bar”, Journal of Mathematical Psychology, 2004; 48(4): 292-295.
Download
Liu Z.   “On the principle of minimal relative motion — the oscillating tilted bar” Journal of Mathematical Psychology, 2004; 48: 196-198.
Download
Lu, H Qian, N Liu, Z   Learning motion discrimination with suppressed MT Vision research. , 2004; 44(15): 1817-25.
Download
Liu, Z Kersten, D   Three-dimensional symmetric shapes are discriminated more efficiently than asymmetric ones Journal of the Optical Society of America. A, Optics, image science, and vision, 2003; 20(7): 1331-40.
Download
Liu Z.   “On the principle of minimal relative motion — the bar, the circle with a dot, and the ellipse” Journal of Vision [electronic resource], 2003; 3: 625–629.
Download
Matthews N, Liu Z, Qian N.   “The effect of orientation learning on contrast sensitivity” Vision Research, 2001; 41: 463-471.
Download
Liu, Z Weinshall, D   Mechanisms of generalization in perceptual learning Vision research, 2000; 40(1): 97-109.
Download
Liu Z.   “Learning a visual skill that generalizes across motion directions” Proceedings of the National Academy of Sciences USA, 1999; 96: 14085-14087.
Download
Matthews N, Liu Z, Geesaman B J, Qian N.   “Perceptual learning on orientation and direction discrimination” Vision Research, 1999; 39: 3692-3701.
Download
Liu, Z Jacobs, DW Basri, R   The role of convexity in perceptual completion: beyond good continuation Vision research. , 1999; 39(25): 4244-57.
Download
Liu, Z Kersten, D Knill, DC   Dissociating stimulus information from internal representation–a case study in object recognition Vision research, 1999; 39(3): 603-12.
Download
Liu, Z Kersten, D   2D observers for human 3D object recognition? Vision research. , 1998; 38(15-16): 2507-19.
Download
Liu, Z Vaina, LM   Simultaneous learning of motion discrimination in two directions Brain research. Cognitive brain research, 1998; 6(4): 347-9.
Download
Liu, Z   Viewpoint dependency in object representation and recognition Spatial vision, 1996; 9(4): 491-521.
Download
Liu, Z Knill, DC Kersten, D   Object classification for human and ideal observers Vision research, 1995; 35(4): 549-68.
Download
Zhang, S. W. Wang, X. Liu, Z. Srinivasan, M V.   Visual tracking of moving targets by freely flying honeybees Visual neuroscience, 1990; 4(4): 379-86.
Download