Biography
Steve Shoptaw is a licensed psychologist and Professor in the UCLA Departments of Family Medicine and Psychiatry and Biobehavioral Sciences. Dr. Shoptaw joined the Department of Family Medicine as full professor in 2005. Prior to this, Dr. Shoptaw was a Research Psychologist with the Integrated Substance Abuse Program in the Dept. of Psychiatry & Behavioral Science since 2003. Dr. Shoptaw earned his BA (1982) in Psychology and MA (1985) and Ph.D. (1990) in Psychology at UCLA. His dissertation was nominated for the Gingerelli Award for Excellence in the Department of Psychology. Dr. Shoptaw completed his postdoctoral training in Psychophysiology at the UCLA NPI/VAMC in Sepulveda, CA in 1991. Following that, Dr. Shoptaw worked for 10 years as a Principal Investigator with Friends Research Institute, Inc., during which time, his program of clinical research with substance abusers supported opening several treatment research clinics in Rancho Cucamonga, Hollywood, South Los Angeles, and West Hollywood. Dr. Shoptaw received the FRI Daniel Mendelsohn Young Investigator Award in 1996 and a mentoring award in 2000. In 1996, Dr. Shoptaw opened Safe House, a 24 bed facility that provides emergency, transitional and permanent housing to persons living with HIV/AIDS, chemical dependency, transitional and permanent housing to persons living with HIV/AIDS, chemical dependency, and mental illness who are homeless or at risk for homelessness. He continues with this program as a volunteer Executive Director. These linkages of clinical research and community collaboration have led Dr. Shoptaw???s work to influence practice guidelines in intervening with substance abusers, especially those at high risk for HIV transmission, locally, nationally and in emerging international epidemics.
Publications
A selected list of publications:
Ling Murtaugh Kimberly, Krishnamurti Tamar, Davis Alexander L, Reback Cathy J, Shoptaw Steven Spend today, clean tomorrow: Predicting methamphetamine abstinence in a randomized controlled trial Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2013; 32(9): 958-66.
Koblin Beryl A, Mayer Kenneth H, Eshleman Susan H, Wang Lei, Mannheimer Sharon, Del Rio Carlos, Shoptaw Steven, Magnus Manya, Buchbinder Susan, Wilton Leo, Liu Ting-Yuan, Cummings Vanessa, Piwowar-Manning Estelle, Fields Sheldon D, Griffith Sam, Elharrar Vanessa, Wheeler Darrell, Wheeler Darrell Correlates of HIV Acquisition in a Cohort of Black Men Who Have Sex with Men in the United States: HIV Prevention Trials Network (HPTN) 061 PloS one, 2013; 8(7): e70413.
Landovitz Raphael J, Tseng Chi-Hong, Weissman Matthew, Haymer Michael, Mendenhall Brett, Rogers Kathryn, Veniegas Rosemary, Gorbach Pamina M, Reback Cathy J, Shoptaw Steven Epidemiology, Sexual Risk Behavior, and HIV Prevention Practices of Men who Have Sex with Men Using GRINDR in Los Angeles, California Journal of urban health : bulletin of the New York Academy of Medicine, 2013; 90(4): 729-39.
Reback Cathy J, Fletcher Jesse B, Shoptaw Steven, Grella Christine E Methamphetamine and other substance use trends among street-recruited men who have sex with men, from 2008 to 2011 Drug and alcohol dependence, 2013; 8(7): .
Swanson Aimee-Noelle, Shoptaw Steven, Heinzerling Keith Gregory, Wade Adam C, Worley Matthew, McCracken James, Wilson Sarah A, Asarnow Joan, London Edythe D Up in Smoke? A Preliminary Open-Label Trial of Nicotine Replacement Therapy and Cognitive Behavioral Motivational Enhancement for Smoking Cessation Among Youth in Los Angeles Substance use & misuse, 2013; 8(7): .
Murphy Ryan D, Gorbach Pamina M, Weiss Robert E, Hucks-Ortiz Christopher, Shoptaw Steven J Seroadaptation in a sample of very poor Los Angeles area men who have sex with men AIDS and behavior, 2013; 17(5): 1862-72.
Herrick Amy L, Stall Ron, Chmiel Joan S, Guadamuz Thomas E, Penniman Typhanye, Shoptaw Steven, Ostrow David, Plankey Michael W It gets better: resolution of internalized homophobia over time and associations with positive health outcomes among MSM AIDS and behavior, 2013; 17(4): 1423-30.
Ding Yingying, He Na, Shoptaw Steven, Gao Meiyang, Detels Roger Severity of club drug dependence and perceived need for treatment among a sample of adult club drug users in Shanghai, China Social psychiatry and psychiatric epidemiology, 2013; 17(5): .
Brensilver Matthew, Heinzerling Keith G, Shoptaw Steven Pharmacotherapy of amphetamine-type stimulant dependence: An update Drug and alcohol review, 2013; 17(4): .
Heinzerling Keith G, Gadzhyan Janette, van Oudheusden Henry, Rodriguez Felipe, McCracken James, Shoptaw Steven Pilot randomized trial of bupropion for adolescent methamphetamine abuse/dependence The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 2013; 52(4): 502-5.
Herrick Amy L, Lim Sin How, Plankey Michael W, Chmiel Joan S, Guadamuz Thomas E, Guadamuz Thomas T, Kao Uyen, Shoptaw Steven, Carrico Adam, Ostrow David, Stall Ron Adversity and syndemic production among men participating in the multicenter AIDS cohort study: a life-course approach American journal of public health, 2013; 103(1): 79-85.
Nyamathi Adeline, Salem Benissa, Reback Cathy J, Shoptaw Steven, Branson Catherine M, Idemundia Faith E, Kennedy Barbara, Khalilifard Farinaz, Marfisee Mary, Liu Yihang Correlates of hepatitis B virus and HIV knowledge among gay and bisexual homeless young adults in Hollywood American journal of men’s health, 2013; 7(1): 18-26.
Reback Cathy J, Grant Deborah Ling, Fletcher Jesse B, Branson Catherine M, Shoptaw Steven, Bowers Jane Rohde, Charania Mahnaz, Mansergh Gordon Erratum to: Text Messaging Reduces HIV Risk Behaviors Among Methamphetamine-Using Men Who Have Sex with Men AIDS and behavior, 2012; .
Strathdee Steffanie A, Shoptaw Steven, Dyer Typhanye Penniman, Quan Vu Minh, Aramrattana Apinun, Aramrattana Apinun Towards combination HIV prevention for injection drug users: addressing addictophobia, apathy and inattention Current opinion in HIV and AIDS, 2012; 7(4): 320-325.
Landovitz Raphael J, Fletcher Jesse B, Inzhakova Galina, Lake Jordan E, Shoptaw Steven, Reback Cathy J A Novel Combination HIV Prevention Strategy: Post-Exposure Prophylaxis with Contingency Management for Substance Abuse Treatment Among Methamphetamine-Using Men Who Have Sex with Men AIDS patient care and STDs, 2012; 26(6): 320-8.
Reback Cathy J, Grant Deborah Ling, Fletcher Jesse B, Branson Catherine M, Shoptaw Steven, Bowers Jane Rohde, Charania Mahnaz, Mansergh Gordon Text Messaging Reduces HIV Risk Behaviors Among Methamphetamine-Using Men Who Have Sex with Men AIDS and behavior, 2012; 26(6): .
Brensilver Matthew, Heinzerling Keith G, Swanson Aimee-Noelle, Shoptaw Steven J A retrospective analysis of two randomized trials of bupropion for methamphetamine dependence: Suggested guidelines for treatment discontinuation/augmentation Drug and alcohol dependence, 2012; 26(6): .
Heinzerling Keith G, Shoptaw Steven Gender, brain-derived neurotrophic factor Val66Met, and frequency of methamphetamine use Gender medicine, 2012; 9(2): 112-20.
Brensilver Matthew, Heinzerling Keith G, Swanson Aimee-Noelle, Telesca Donatello, Furst Benjamin A, Shoptaw Steven J Cigarette smoking as a target for potentiating outcomes for methamphetamine abuse treatment Drug and alcohol review, 2012; 9(2): .
Heinzerling Keith G, McCracken James T, Swanson Aimee-Noelle, Ray Lara A, Shoptaw Steven J COMT Val158Met, BDNF Val66Met, and OPRM1 Asn40Asp and methamphetamine dependence treatment response: preliminary investigation Journal of clinical psychopharmacology, 2012; 32(1): 135-7.
Ling Walter, Shoptaw Steven, Hillhouse Maureen, Bholat Michelle A, Charuvastra Charles, Heinzerling Keith, Chim David, Annon Jeffrey, Dowling Patrick T, Doraimani Geetha Double-blind placebo-controlled evaluation of the PROMETA⢠protocol for methamphetamine dependence Addiction (Abingdon, England), 2012; 107(2): 361-9.
Reback Cathy J, Shoptaw Steven Development of an evidence-based, gay-specific cognitive behavioral therapy intervention for methamphetamine-abusing gay and bisexual men Addictive behaviors, 2011; 32(1): .
Xu Hongquan, Shen Qing, Yang Xiaowei, Shoptaw Steven A quasi F-test for functional linear models with functional covariates and its application to longitudinal data Statistics in medicine, 2011; 30(23): 2842-53.
Ober Allison J, Iguchi Martin Y, Weiss Robert E, Gorbach Pamina M, Heimer Robert, Ouellet Lawrence J, Shoptaw Steven, Anglin M Douglas, Zule William A The relative role of perceived partner risks in promoting condom use in a three-city sample of high-risk, low-income women AIDS and behavior, 2011; 15(7): 1347-58.
Tross Susan, Campbell Aimee N C, Calsyn Donald A, Metsch Lisa R, Sorensen James L, Shoptaw Steven, Haynes Louise, Woody George E, Malow Robert M, Brown Lawrence S, Feaster Daniel J, Booth Robert E, Mandler Raul N, Masson Carmen, Holmes Beverly W, Colfax Grant, Brooks Audrey J, Hien Denise A, Schackman Bruce R, Korthuis P Todd, Miele Gloria M, Miele Gloria M NIDA’s Clinical Trials Network: an opportunity for HIV research in community substance abuse treatment programs The American journal of drug and alcohol abuse, 2011; 37(5): 283-93.
Young Sean D, Shoptaw Steven, Weiss Robert E, Munjas Brett, Gorbach Pamina M Predictors of unrecognized HIV infection among poor and ethnic men who have sex with men in Los Angeles AIDS and behavior, 2011; 15(3): 643-9.
Publications
A selected list of publications:
Teter Bruce, LaDu Mary Jo, Sullivan Patrick M, Frautschy Sally A, Cole Greg M Apolipoprotein E isotype-dependent modulation of microRNA-146a in plasma and brain Neuroreport, 2016; 27(11): 791-5.
Teter, B. Life-span influences of apoE4 on CNS function. Invited Peer Commentary on: Schonheit, B., Glockner, F., and Ohm, T.G. (2006) Apolipoprotein E polymorphism and dendritic shape. , Neurobiology of Aging, 2006; 28(5): 693-703; discussion 704-6..
Teter, B., Finch, C.E. Caliban’s Inheritance: Genetics of Neuronal Aging, Trends in Neuroscience , 2004; 10: 627-32.
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Teter B, Xu P-T, Gilbert JR, Roses AD, Galasko D, Cole GM Defective neuronal sprouting supported by human Apolipoprotein E4 represents a gain-of-deleterious function, J. Neurosci. Res, 2002; (687): 331-336.
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Teter B, Ashford JW Neuroplasticity in Alzheimer’s Disease, Journal of Neuroscience Research, 2002; 70(Aging Brain and Alzheimer’s Disease Special Issue): 402-437.
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Teter B, Raber J, Nathan B, Crutcher KA The presence of apoE4, not the absence of apoE3, contributes to AD pathology, J. Alzheimer’s Disease, 2002; (4): 155-163.
Biography
Interactions between skeletal muscle and the immune system. A major project in our lab concerns the pathophysiology of muscular dystrophy (dystrophinopathy). Our research has shown that the immune system plays an important role in influencing the severity of muscular dystrophy, and that immune-based interventions can significantly reduce dystrophic muscle pathology and promote muscle regeneration. Our continuing efforts are directed toward identifying the key effector cells and molecules involved in influencing the course of the disease, and examining the interplay between those effectors. Our technical approaches include the generation and analysis of transgenic, dystrophic mice so that the effects of increased or decreased expression of selected effector molecules can be assessed. We also examine the systemic effects of experimental depletions of selected immune cell populations and the efficacy of selected, pharmaceutical interventions on the progress of the disease. In other studies, we are studying the mechanisms through which the immune system influences the wasting of skeletal muscle that occurs during aging, a process called sarcopenia. We are particularly interested in identifying the mechanisms through which specific populations of myeloid cells affect muscle wasting and regeneration, and identifying strategies to slow the wasting process.
Publications
A selected list of publications:
Wang Ying, Wehling-Henricks Michelle, Welc Steven S, Fisher Allison L, Zuo Qun, Tidball James G Aging of the immune system causes reductions in muscle stem cell populations, promotes their shift to a fibrogenic phenotype, and modulates sarcopenia FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019; 8(4): fj201800973R.
Welc Steven S, Flores Ivan, Wehling-Henricks Michelle, Ramos Julian, Wang Ying, Bertoni Carmen, Tidball James G Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy Nature communications, 2019; 10(1): 2788.
Tidball James G, Welc Steven S, Wehling-Henricks Michelle Immunobiology of Inherited Muscular Dystrophies Comprehensive Physiology, 2018; 8(4): 1313-1356.
Wehling-Henricks Michelle, Welc Steven S, Samengo Guiseppina, Rinaldi Chiara, Lindsey Catherine, Wang Ying, Lee Jeongyoon, Kuro-O Makoto, Tidball James G Macrophages escape Klotho gene silencing in the mdx mouse model of Duchenne muscular dystrophy and promote muscle growth and increase satellite cell numbers through a Klotho-mediated pathway Human Molecular Genetics, 2018; 27(1): 14-29.
Wang Ying, Welc Steven S, Wehling-Henricks Michelle, Tidball James G Myeloid cell-derived tumor necrosis factor-alpha promotes sarcopenia and regulates muscle cell fusion with aging muscle fibers Aging cell, 2018; 8(4): e12828.
Tidball James G Regulation of muscle growth and regeneration by the immune system Nature Reviews. Immunology, 2017; 17(3): 165-178.
Wehling-Henricks Michelle, Li Zhenzhi, Lindsey Catherine, Wang Ying, Welc Steven S, Ramos Julian N, Khanlou Négar, Kuro-O Makoto, Tidball James G Klotho gene silencing promotes pathology in the mdx mouse model of Duchenne muscular dystrophy Human Molecular Genetics, 2016; 25(12): 2465-2482.
Chadwick Jessica A, Swager Sarah A, Lowe Jeovanna, Welc Steven S, Tidball James G, Gomez-Sanchez Celso E, Gomez-Sanchez Elise P, Rafael-Fortney Jill A Myeloid cells are capable of synthesizing aldosterone to exacerbate damage in muscular dystrophy Human Molecular Genetics, 2016; 25(23): 5167-5177.
Wang Ying, Wehling-Henricks Michelle, Samengo Giuseppina, Tidball James G Increases of M2a macrophages and fibrosis in aging muscle are influenced by bone marrow aging and negatively regulated by muscle-derived nitric oxide Aging Cell, 2015; 14(4): 678-88.
Tidball James G, Welc Steven S Macrophage-Derived IGF-1 Is a Potent Coordinator of Myogenesis and Inflammation in Regenerating Muscle Molecular therapy : the journal of the American Society of Gene Therapy, 2015; 23(7): 1134-1135.
Tidball James G, Wehling-Henricks Michelle Shifts in macrophage cytokine production drive muscle fibrosis Nature Medicine, 2015; 21(7): 665-6.
Tidball James G, Wehling-Henricks Michelle Nitric oxide synthase deficiency and the pathophysiology of muscular dystrophy The Journal of Physiology, 2014; 592(Pt 21): 4627-4638.
Tidball James G, Bertoni Carmen Purloined mechanisms of bacterial immunity can cure muscular dystrophy Cell Metabolism, 2014; 20(6): 927-9.
Villalta S Armando, Rosenthal Wendy, Martinez Leonel, Kaur Amanjot, Sparwasser Tim, Tidball James G, Margeta Marta, Spencer Melissa J, Bluestone Jeffrey A Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy Science Translational Medicine, 2014; 6(258): 258ra142.
Tidball James G, Dorshkind Kenneth, Wehling-Henricks Michelle Shared signaling systems in myeloid cell-mediated muscle regeneration Development (Cambridge, England), 2014; 141(6): 1184-96.
Samengo Giuseppina, Avik Anna, Fedor Brian, Whittaker Daniel, Myung Kyu H, Wehling-Henricks Michelle, Tidball James G Age-related loss of nitric oxide synthase in skeletal muscle causes reductions in calpain S-nitrosylation that increase myofibril degradation and sarcopenia Aging Cell, 2012; 11(6): 1036-45.
Deng Bo, Wehling-Henricks Michelle, Villalta S Armando, Wang Ying, Tidball James G IL-10 triggers changes in macrophage phenotype that promote muscle growth and regeneration Journal of immunology (Baltimore, Md. : 1950), 2012; 189(7): 3669-80.
Villalta, S.A., Deng, B., Rinaldi, C., Wehling-Henricks, M. and J. G. Tidball IFNγ promotes muscle damage in the mdx mouse model of Duchenne muscular dystrophy by suppressing M2 macrophage activation and inhibiting muscle cell proliferation, J. Immunol, 2011; 187: 5419-5428 .
Villalta, S.A., Rinaldi, C., Deng, B., Liu, G., Fedor, B. and J. G. Tidball Interleukin-10 reduces the pathology of mdx muscular dystrophy by deactivating M1 macrophages and modulating macrophage phenotype, Human Molecular Genetics , 2011; 20: 790-805.
Tidball James G Mechanisms of muscle injury, repair, and regeneration Comprehensive Physiology, 2011; 1(4): 2029-62.
Wehling-Henricks, M. and J.G. Tidball Neuronal nitric oxide synthase-rescue of dystrophin/utrophin double knockout mice does not require nNOS localization to the cell membrane, PLoS One , 2011; 6: e25071.
Sakellariou, G.K., Pye, D., Vasilaki, A., Zibrik, L., Palomero, J., Kabayo, T., McArdle, F., Van Remmen, H., Richardson, A., Tidball, J.G., McArdle, A. and M. J. Jackson Role of superoxide-nitric oxide interactions in the accelerated age-related loss of muscle mass in mice lacking Cu,Zn superoxide dismutase, Aging Cell , 2011; 10: 749-760.
Wehling-Henricks, M., M. C. Jordan, T. Gotoh, W. W. Grody, K. P. Roos and J. G. Tidball Arginine metabolism by macrophages promotes cardiac and muscle fibrosis in mdx muscular dystrophy, PLoS One, 2010; 5(5): e10763. doi:10.1371/journal.pone.0010763.
Tidball, J.G. and S.A. Villalta Interactions between muscle and the immune system regulate muscle growth and regeneration, Amer. J. Physiol, 2010; 298: R1173-1187.
Perez Antonio L, Bachrach Estanislao, Illigens Ben M W, Jun Susan J, Bagden Eric, Steffen Leta, Flint Alan, McGowan Francis X, Del Nido Pedro, Montecino-Rodriguez Enca, Tidball James G, Kunkel Louis M CXCR4 enhances engraftment of muscle progenitor cells Muscle & nerve, 2009; 40(4): 562-72.
Tidball, J.G. and M. Wehling-Henricks Inflammatory mechanisms in genetic neuromuscular disorders, Inflammatory and autoimmune disorders of the nervous system in children, 2009; 455-479.
Wehling-Henricks, M., M. Oltmann, C. Rinaldi, K. H. Myung, and J. G. Tidball Loss of positive allosteric interactions between neuronal nitric oxide synthase and phosphofructokinase contributes to defects in glycolysis and increased fatigability in muscular dystrophy, Human Molecular Genetics, 2009; 18: 3439-3451.
Deng, B., D. Glanzman and J.G. Tidball Nitric oxide generated by muscle corrects defects in hippocampal neurogenesis and neural differentiation caused by muscular dystrophy, Journal of Physiology, 2009; 587: 1769-1778.
Tidball, J.G. and S.A. Villalta Nitric oxide may prompt calcium leakage in dystrophic muscle, Nature Medicine, 2009; 15: 243-244.
Villalta, S.A., H.X. Nguyen, B. Deng, T. Gotoh and J.G. Tidball Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy, Human Molecular Genetics, 2009; 18: 482-496.
Tidball, J.G. Inflammation in skeletal muscle regeneration, Skeletal muscle repair and regeneration, 2008; 243-268.
Wehling-Henricks, M., Sokolow, S., Lee, J.J., Myung, K.H., Villalta, A., and J.G. Tidball Major basic protein-1 promotes fibrosis of dystrophic muscle and attenuates the cellular immune response in muscular dystrophy, Human Molecular Genetics, 2008; 17:2280-2292: .
Hao, M., K. Akrami, K. Wei, C. De Diego, N. Che, J.H. Ku, J.G. Tidball, M.C. Graves, P.B. Shieh and F. Chen Muscleblind-like 2 (Mbnl2) -deficient mice as a model for myotonic dystrophy, Developmental Dynamics, 2008; 237: 403-410.
Acharyya, S., S.A. Villalta, N. Bakkar, T. Bupha-Intr, P.M.L. Janssen, M. Carathers, M. Karin, Z. Li, A. Beg, S. Ghosh, Z. Sahenk, M. Weinstein, K.L. Gardner, J.A. Rafael-Fortney, J.G. Tidball, A.S. Baldwin and D.C. Guttridge IKK/NF-kB signaling interplay in macrophages and myofibers promotes muscle wasting in Duchenne muscular dystrophy, Journal of Clinical Investigation, 2007; 117: 889-901.
Acharyya Swarnali, Villalta S Armando, Bakkar Nadine, Bupha-Intr Tepmanas, Janssen Paul M L, Carathers Micheal, Li Zhi-Wei, Beg Amer A, Ghosh Sankar, Sahenk Zarife, Weinstein Michael, Gardner Katherine L, Rafael-Fortney Jill A, Karin Michael, Tidball James G, Baldwin Albert S, Guttridge Denis C Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy The Journal of clinical investigation, 2007; 117(4): 889-901.
Tidball, J.G. and M. Wehling-Henricks Macrophages promote muscle membrane repair and muscle fiber growth and regeneration during modified muscle loading in mice in vivo, Journal of Physiology, 2007; 578.1: 327-336.
Tidball James G, Wehling-Henricks Michelle Macrophages promote muscle membrane repair and muscle fibre growth and regeneration during modified muscle loading in mice in vivo The Journal of physiology, 2007; 578(Pt 1): 327-36.
Pfister, K., J. Radons, J.G. Tidball, M. Pfeifer, L. Freitag, H-J. Feldmann, V. Milani, R. Issels and G. Multhoff Patient survival by Hsp70 membrane-phenotype: association with different routes of metastasis, Cancer, 2007; 110: 926-35.
Tidball James G, Wehling-Henricks Michelle The role of free radicals in the pathophysiology of muscular dystrophy Journal of applied physiology (Bethesda, Md. : 1985), 2007; 102(4): 1677-86.
Wehling-Henricks, M Jordan, MC Roos, KP Deng, B Tidball, JG Cardiomyopathy in dystrophin-deficient hearts is prevented by expression of a neuronal nitric oxide synthase transgene in the myocardium Human Molecular Genetics, 2005; 14(14): 1921-33.
Tidball, JG Wehling-Henricks, M Damage and inflammation in muscular dystrophy: potential implications and relationships with autoimmune myositis Current Opinion in Rheumatology, 2005; 17(6): 707-13.
Tidball, JG Inflammatory processes in muscle injury and repair American Journal of Physiology, 2005; 288(2): R345-53.
Tidball James G Inflammatory processes in muscle injury and repair American journal of physiology. Regulatory, integrative and comparative physiology, 2005; 288(2): R345-53.
Tidball James G Mechanical signal transduction in skeletal muscle growth and adaptation Journal of applied physiology (Bethesda, Md. : 1985), 2005; 98(5): 1900-8.
Nguyen, HX Lusis, AJ Tidball, JG Null mutation of myeloperoxidase in mice prevents mechanical activation of neutrophil lysis of muscle cell membranes in vitro and in vivo Journal of Physiology, 2005; 565(Pt 2): 403-13.
Shiao, T Fond, A Deng, B Wehling-Henricks, M Adams, ME Froehner, SC Tidball, JG Defects in neuromuscular junction structure in dystrophic muscle are corrected by expression of a NOS transgene in dystrophin-deficient muscles, but not in muscles lacking alpha- and beta1-syntrophins Human Molecular Genetics, 2004; 13(17): 1873-84.
Tidball, JG Wehling-Henricks, M Evolving therapeutic strategies for Duchenne muscular dystrophy: targeting downstream events Pediatric Research, 2004; 56(6): 831-41.
Tidball, JG Wehling-Henricks, M Expression of a NOS transgene in dystrophin-deficient muscle reduces muscle membrane damage without increasing the expression of membrane-associated cytoskeletal proteins Molecular Genetics and Metabolism, 2004; 82(4): 312-20.
Kramerova, I Kudryashova, E Tidball, JG Spencer, MJ Null mutation of calpain 3 (p94) in mice causes abnormal sarcomere formation in vivo and in vitro Human Molecular Genetics, 2004; 13(13): 1373-88.
Wehling-Henricks, M Lee, JJ Tidball, JG Prednisolone decreases cellular adhesion molecules required for inflammatory cell infiltration in dystrophin-deficient skeletal muscle Neuromuscular Disorders, 2004; 14(8-9): 483-90.
Nguyen, HX Tidball, JG Expression of a muscle-specific, nitric oxide synthase transgene prevents muscle membrane injury and reduces muscle inflammation during modified muscle use in mice Journal of Physiology, 2003; 550(Pt 2): 347-56.
Nguyen, HX Tidball, JG Interactions between neutrophils and macrophages promote macrophage killing of rat muscle cells in vitro Journal of Physiology, 2003; 547(Pt 1): 125-32.
Nguyen, HX Tidball, JG Null mutation of gp91phox reduces muscle membrane lysis during muscle inflammation in mice Journal of Physiology, 2003; 553(Pt 3): 833-41.
Tidball James G, Spencer Melissa J Skipping to new gene therapies for muscular dystrophy Nature medicine, 2003; 9(8): 997-8.
Tidball, J.G. and Spencer, M. Expression of a calpastatin transgene slows muscle wasting and obviates changes in myosin isoform expression during murine muscle disuse Journal of Physiology, 2002; 545(Pt 3): 819-28.
Tidball, JG Interactions between muscle and the immune system during modified musculoskeletal loading Clinical Orthopaedics and Related Research, 2002; 403S(403 Suppl): S100-9.
Wehling, M., Spencer, M. and J.G. Tidball A nitric oxide synthase transgene ameliorates muscular dystrophy in mdx mice Journal of Cell Biology, 2001; 155(1): 123-31.
Spencer, MJ Tidball, JG Do immune cells promote the pathology of dystrophin-deficient myopathies? Neuromuscular Disorders, 2001; 11(6-7): 556-64.
Spencer, MJ Montecino-Rodriguez, E Dorshkind, K Tidball, JG Helper (CD4(+)) and cytotoxic (CD8(+)) T cells promote the pathology of dystrophin-deficient muscle Clinical Immunology , 2001; 98(2): 235-43.
Frenette, J Cai, B Tidball, JG Complement activation promotes muscle inflammation during modified muscle use American Journal of Pathology, 2000; 156(6): 2103-10.
Zhu, X Hadhazy, M Wehling, M Tidball, JG McNally, EM Dominant negative myostatin produces hypertrophy without hyperplasia in muscle FEBS Letters, 2000; 474(1): 71-5.
Cai, B Spencer, MJ Nakamura, G Tseng-Ong, L Tidball, JG Eosinophilia of dystrophin-deficient muscle is promoted by perforin-mediated cytotoxicity by T cell effectors American Journal of Pathology, 2000; 156(5): 1789-96.
Wehling, M Cai, B Tidball, JG Modulation of myostatin expression during modified muscle use FASEB Journal, 2000; 14(1): 103-10.
Koh, TJ Tidball, JG Nitric oxide inhibits calpain-mediated proteolysis of talin in skeletal muscle cells American Journal of Physiology, 2000; 279(3): C806-12.
Koh, TJ Tidball, JG Nitric oxide synthase inhibitors reduce sarcomere addition in rat skeletal muscle Journal of Physiology, 1999; 519 Pt 1: 189-96.
Tidball, JG Spencer, MJ Wehling, M Lavergne, E Nitric-oxide synthase is a mechanical signal transducer that modulates talin and vinculin expression Journal of Biological Chemistry , 1999; 274(46): 33155-60.
Tidball, JG Lavergne, E Lau, KS Spencer, MJ Stull, JT Wehling, M Mechanical loading regulates NOS expression and activity in developing and adult skeletal muscle American Journal of Physiology, 1998; 275(1 Pt 1): C260-6.
Spencer, MJ Walsh, CM Dorshkind, KA Rodriguez, EM Tidball, JG Myonuclear apoptosis in dystrophic mdx muscle occurs by perforin-mediated cytotoxicity Journal of Clinical Investigation, 1997; 99(11): 2745-51.
Albrecht, DE Tidball, JG Platelet-derived growth factor-stimulated secretion of basement membrane proteins by skeletal muscle occurs by tyrosine kinase-dependent and -independent pathways Journal of Biological Chemistry, 1997; 272(4): 2236-44.
Chang, W., S. Iannaccone, K. Lau, B. Masters, T. McCabe K. McMillan, R. Padre, M.J. Spencer, J.G. Tidball and J.T. Stull Neuronal nitric oxide synthase and dystrophin-deficient muscular dystrophy, Proc. Natl. Acad. Sci. USA, 1996; 93: 9142-47.