Student Resources | Faculty, Postdoc, & Staff Resources
Search for:
Login

Posts classified under: M

HomeUCLA Brain Research Institute (BRI)  > People  > Alphabetical  > M
Gary W. Mathern, M.D.

Gary Mathern, M.D.

Biography

Dr. Mathern graduated from the Case Western Reserve University School of Medicine in 1982. He completed his Rotating Internship at the Cleveland Clinic Foundation in 1983 and his Residencies in Surgery (1985) and Neurosurgery (1986-1991) at UCLA Harbor Medical Center and UCLA School of Medicine, respectively.  Dr. Mathern received his Board Certification in Neurological Surgery in 1996.  He currently practices medicine at the David Geffen UCLA School of Medicine and specializes in Neurological Surgery and Pediatric Neurological Surgery. Dr. Mathern is affiliated with both Santa Monica UCLA Medical Center and Ronald Reagan UCLA Medical Center.

Istvan Mody, Ph.D.

Istvan Mody, Ph.D.

Biography

Synaptic Signaling in Health and Disease Our research focuses on 1) the physiology, pharmacology, and pathology of synaptic transmission in the mammalian brain, and 2) the regulation of intracellular calcium homeostasis. The two themes ultimately converge in our quest for understanding how long-term alterations in the excitability of nerve cells and circuits are responsible for offsetting the frail balance between excitation and inhibition. Tipping this balance, either acutely of chronically, results in the nervous system showing signs of abnormal activity leading to specific brain disorders. We study synaptic transmission and the activation of extrasynaptic receptors in the healthy and the diseased brain. We presently carry out research in animal models of epilepsy, Huntington’s disease, stress, alcoholism, PMS/PMDD, postpartum depression, while also recording from human brain tissue surgically removed for the treatment of epilepsies. By studying the fundamental mechanisms responsible for the altered synapses and circuits our studies will lead to novel therapies for a number of devastating neurological and psychiatric disorders. The experimental approaches we use include patch-clamp recordings (whole-cell, single channel and perforated patch) in brain slices, in acutely isolated animal and human neurons, or in cultured neurons/slices; chronic recordings in vivo to monitor long-term changes in the excitability of circuits; infrared and fluorescent video microscopy and simultaneous recordings in live brain tissue; various neuroanatomical and immunohistochemical techniques; measurement of intraneuronal calcium and the binding kinetics of calcium to various calcium-binding proteins; molecular biological approaches aimed at reducing or altering specific brain proteins as in genetic knockouts/knockins and various methods aimed at altering cellular protein levels.

Walter Metzner, Ph.D.

Walter Metzner, Ph.D.

Publications

A selected list of publications:

Hage Steffen R, Jiang Tinglei, Berquist Sean W, Feng Jiang, Metzner Walter   Ambient noise induces independent shifts in call frequency and amplitude within the Lombard effect in echolocating bats Proceedings of the National Academy of Sciences of the United States of America, 2013; 110(10): 4063-8.
Liu Ying, Feng Jiang, Metzner Walter   Different auditory feedback control for echolocation and communication in horseshoe bats PloS one, 2013; 8(4): e62710.
Hage Steffen R, Metzner Walter   Potential effects of anthropogenic noise on echolocation behavior in horseshoe bats Communicative & integrative biology, 2013; 6(4): e24753.
Kobayasi Kohta I, Hage Steffen R, Berquist Sean, Feng Jiang, Zhang Shuyi, Metzner Walter   Behavioural and neurobiological implications of linear and non-linear features in larynx phonations of horseshoe bats Nature communications, 2012; 3(18): 1184.
Yamase Hiroyuki, Metzner Walter   Fermi-surface truncation from thermal nematic fluctuations Physical review letters, 2012; 108(18): 186405.
Jiang Tinglei, Metzner Walter, You Yuyan, Liu Sen, Lu Guanjun, Li Shi, Wang Lei, Feng Jiang   Variation in the resting frequency of Rhinolophus pusillus in Mainland China: effect of climate and implications for conservation The Journal of the Acoustical Society of America, 2010; 128(4): 2204-11.
Luo Feng, Metzner Walter, Wu Feijian, Wu Feijian J, Zhang Shuyi, Zhang Shuyi Y, Chen Qicai, Chen Qicai C   Duration-sensitive neurons in the inferior colliculus of horseshoe bats: adaptations for using CF-FM echolocation pulses Journal of neurophysiology, 2008; 99(1): 284-96.
Ma, J. Liang, B. Zhang, S. Metzner, W.   Dietary composition and echolocation call design of three sympatric insectivorous bat species from China, Ecological Research, 2007; DOI 10.1007/s11284-007-0344-5: .
Dell’Anna Luca, Metzner Walter   Electrical resistivity near Pomeranchuk instability in two dimensions Physical review letters, 2007; 98(13): 136402.
Smotherman Michael, Kobayasi Kohta, Ma Jie, Zhang Shuyi, Metzner Walter   A mechanism for vocal-respiratory coupling in the mammalian parabrachial nucleus The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006; 26(18): 4860-9.
Ma, J. Zhang, J. Liang, B. Zhang, L. Zhang, S. Metzner, W.   Dietary characteristics of Myotis ricketti in Beijing, North China, Journal of Mammalogy, 2006; 87: 339-344.
Ma Jie, Kobayasi Kohta, Zhang Shuyi, Metzner Walter   Vocal communication in adult greater horseshoe bats, Rhinolophus ferrumequinum Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 2006; 192(5): 535-50.
Smotherman Michael, Metzner Walter   Auditory-feedback control of temporal call patterns in echolocating horseshoe bats Journal of neurophysiology, 2005; 93(3): 1295-303.
Gozalo Alfonso S, Schwiebert Rebecca S, Metzner Walter, Lawson Gregory W   Spontaneous, generalized lipidosis in captive greater horseshoe bats (Rhinolophus ferrumequinum) Contemporary topics in laboratory animal science / American Association for Laboratory Animal Science, 2005; 44(6): 49-52.
Ma, Jie Metzner, W. Liang, B. Zhang, L. Zhang, J. Zhang, S. Shen, J..   Differences in diet and echolocation in four sympatric bat species and their respective ecological niches, Acta Zoologica Sinica, 2004; 50(2): 145-150.
Tian, L. Liang, B. Maeda, K. Metzner, W. Zhang, S.   Molecular studies on the classification of Miniopterus schreibersii (Chiroptera: Vespertilionidae) inferred from mitochondrial cytochrome b sequences, Folia Zoologica, 2004; 53(3): .
Smotherman Michael, Zhang Shuyi, Metzner Walter   A neural basis for auditory feedback control of vocal pitch The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003; 23(4): 1464-77.
Ma, Jie Jones, G. Zhang, S. Shen, J. Metzner, W. Zhang, L. Liang, B.   Dietary analysis confirms that Rickett’s big-footed bat (Myotis ricketti) is a piscivore, Journal of Zoology (London), 2003; 261(3): 245-248.
Smotherman Michael, Metzner Walter   Effects of echo intensity on Doppler-shift compensation behavior in horseshoe bats Journal of neurophysiology, 2003; 89(2): 814-21.
Smotherman, M. Metzner, W.   Fine control of call frequency by horseshoe bats, Journal of Comparative Physiology A, 2003; 189: 435-446.
Metzner Walter, Zhang Shuyi, Smotherman Michael   Doppler-shift compensation behavior in horseshoe bats revisited: auditory feedback controls both a decrease and an increase in call frequency The Journal of experimental biology, 2002; 205(Pt 11): 1607-16.
Krahe Rüdiger, Kreiman Gabriel, Gabbiani Fabrizio, Koch Christof, Metzner Walter   Stimulus encoding and feature extraction by multiple sensory neurons The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002; 22(6): 2374-82.
Kreiman, G. Krahe, R. Metzner, W. Koch, C. Gabbiani, F.   Robustness and variability of neuronal coding by amplitude-sensitive afferents in the weakly electric fish eigenmannia J Neurophysiol, 2000; 84(1): 189-204.
Gabbiani, F. Metzner, W.   Encoding and processing of sensory information in neuronal spike trains J Exp Biol, 1999; 202(# (Pt 10)): 1267-79.
Metzner, W.   Why are there so many sensory brain maps? Cell Mol Life Sci, 1999; 56(1-2): 1-4.
Metzner, W. Koch, C. Wessel, R. Gabbiani, F.   Feature extraction by burst-like spike patterns in multiple sensory maps J Neurosci, 1998; 18(6): 2283-300.
Metzner, W.   Measuring distance in two dimensions Nature, 1998; 395(6705): 838-9.
Juranek, J. Metzner, W.   Segregation of behavior-specific synaptic inputs to a vertebrate neuronal oscillator J Neurosci, 1998; 18(21): 9010-9.
Metzner, W. Juranek, J.   A sensory brain map for each behavior? Proc Natl Acad Sci U S A, 1997; 94(26): 14798-803.
Juranek, J. Metzner, W.   Cellular characterization of synaptic modulations of a neuronal oscillator in electric fish, J Comp Physiol A, 1997; 181(4): 393-414.
Metzner, W.   Anatomical basis for audio-vocal integration in echolocating horseshoe bats, Journal of Comparative Neurology, 1996; 368(2): 252-69.
Gabbiani, F. Metzner, W. Wessel, R. Koch, C.   From stimulus encoding to feature extraction in weakly electric fish Nature, 1996; 384(6609): 564-7.
Heiligenberg, W. Metzner, W. Wong, C. J. Keller, C. H.   Motor control of the jamming avoidance response of Apteronotus leptorhynchus: evolutionary changes of a behavior and its neuronal substrates J Comp Physiol A, 1996; 179(5): 653-74.
Metzner, W.   An audio-vocal interface in echolocating horseshoe bats, Journal of Neuroscience, 1993; 13(5): 1899-915.
Metzner, W.   The jamming avoidance response in Eigenmannia is controlled by two separate motor pathways Journnal of Neuroscience, 1993; 13(5): 1862-78.
Metzner, W.   Echolocation behaviour in bats, Science Progress, 1991; 75(298): 453-465.
Krull, D. Schumm, A. Metzner, W. Neuweiler, G.   Foraging areas and foraging behavior in the notch-eared bat Myotis emarginatus, Behavioral Ecology and Sociobiology, 1991; 28(4): 247-254.
Metzner, W.   A possible neuronal basis for Doppler-shift compensation in echo-locating horseshoe bats, Nature, 1989; 341(6242): 529-32.
Neuweiler, G. Metzner, W. Heilmann, U. Rubsamen, R. Eckrich, M. Costa, H.H.   Foraging behaviour and echolocation in the rufous horseshoe bats, Rhinolophus rouxi, of Sri Lanka, Behavioral Ecology and Sociobiology, 1987; 20: 53-67.
Metzner, W. Radtke-Schuller, S.   The nuclei of the lateral lemniscus in the rufous horseshoe bat, Rhinolophus rouxi. A neurophysiological approach, Journal of Comparative Physiology. a, Sensory, Neural, and Behavioral Physiology, 1987; 160(3): 395-411.
1 2 3 4 … 6