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HomeUCLA Brain Research Institute (BRI)  > People  > Alphabetical  > W
Hong M. Wu, M.D., Ph.D.

Hong Wu, M.D., Ph.D.

Publications

A selected list of publications:

Donahue, T., Tran, L., Wu, H., Toste, P., Wu, N., Wong, J., Li, X., Dawson, D., Wu, X., and Malkhassian, D   Endoscopically Acquired Pancreatic Cyst Fluid MicroRNA 21 and 221 are associated with Invasive Cancer , American Journal of Gastroenterology, 2013; .
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Smith Kathleen B, Tran Linh M, Tam Brenna M, Shurell Elizabeth M, Li Yunfeng, Braas Daniel, Tap William D, Christofk Heather R, Dry Sarah M, Eilber Fritz C, Wu Hong   Novel dedifferentiated liposarcoma xenograft models reveal PTEN down-regulation as a malignant signature and response to PI3K pathway inhibition The American journal of pathology, 2013; 182(4): 1400-11.
Ruscetti, Marcus and Wu, Hong   PTEN and Prostate Cancer, In D.J. Tindall’s Book “Prostate Cancer: Biochemistry, Molecular Biology, and Genetics, Protein Reviews”, 2013; (Chapter 4): 87-137.
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Mulholland, David, and Wu, Hong   Stem Cell Cells and Prostate Cancer , In Scott Cramer’s Book “Stem Cells and Prostate Cancer”, 2013; (Chapter 6): 77-90.
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Schlacher Katharina, Wu Hong, Jasin Maria   A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2 Cancer cell, 2012; 22(1): 106-16.
Hill Reginald, Li Yunfeng, Tran Linh M, Dry Sarah, Hargan Calvopina Joseph, Garcia Alejandro J, Kim Christine, Wang Ying, Donahue Timothy R, Herschman Harvey R, Wu Hong   Cell Intrinsic Role of Cox-2 in Pancreatic Cancer Development Molecular cancer therapeutics, 2012; .
Tran Linh M, Chang Chun-Ju, Plaisier Seema, Wu Shumin, Dang Julie, Mischel Paul S, Liao James C, Graeber Thomas G, Wu Hong   Determining PTEN functional status by network component deduced transcription factor activities PloS one, 2012; 7(2): e31053.
Graham Nicholas A, Tahmasian Martik, Kohli Bitika, Komisopoulou Evangelia, Zhu Maggie, Vivanco Igor, Teitell Michael A, Wu Hong, Ribas Antoni, Lo Roger S, Mellinghoff Ingo K, Mischel Paul S, Graeber Thomas G   Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death Molecular systems biology, 2012; 8(1): 589.
Jiao Jing, Hindoyan Antreas, Wang Shunyou, Tran Linh M, Goldstein Andrew S, Lawson Devon, Chen Donghui, Li Yunfeng, Guo Changyong, Zhang Baohui, Fazli Ladan, Gleave Martin, Witte Owen N, Garraway Isla P, Wu Hong   Identification of CD166 as a surface marker for enriching prostate stem/progenitor and cancer initiating cells PloS one, 2012; 7(8): e42564.
Donahue Timothy R, Tran Linh M, Hill Reginald, Li Yunfeng, Kovochich Anne, Calvopina Joseph H, Patel Sanjeet G, Wu Nanping, Hindoyan Antreas, Farrell James J, Li Xinmin, Dawson David W, Wu Hong   Integrative survival-based molecular profiling of human pancreatic cancer Clinical cancer research : an official journal of the American Association for Cancer Research, 2012; 18(5): 1352-63.
Hübner Anette, Mulholland David J, Standen Claire L, Karasarides Maria, Cavanagh-Kyros Julie, Barrett Tamera, Chi Hongbo, Greiner Dale L, Tournier Cathy, Sawyers Charles L, Flavell Richard A, Wu Hong, Davis Roger J   JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(30): 12046-51.
Di Vizio Dolores, Morello Matteo, Dudley Andrew C, Schow Peter W, Adam Rosalyn M, Morley Samantha, Mulholland David, Rotinen Mirja, Hager Martin H, Insabato Luigi, Moses Marsha A, Demichelis Francesca, Lisanti Michael P, Wu Hong, Klagsbrun Michael, Bhowmick Neil A, Rubin Mark A, D’Souza-Schorey Crislyn, Freeman Michael R   Large oncosomes in human prostate cancer tissues and in the circulation of mice with metastatic disease The American journal of pathology, 2012; 181(5): 1573-84.
Braas Daniel, Ahler Ethan, Tam Brenna, Nathanson David, Riedinger Mirielle, Benz Matthias R, Smith Kathleen B, Eilber Fritz C, Witte Owen N, Tap William D, Wu Hong, Christofk Heather R   Metabolomics Strategy Reveals Subpopulation of Liposarcomas Sensitive to Gemcitabine Treatment Cancer discovery, 2012; 2(12): 1109-1117.
Pope Whitney B, Prins Robert M, Albert Thomas M, Nagarajan Rajakumar, Yen Katharine E, Bittinger Mark A, Salamon Noriko, Chou Arthur P, Yong William H, Soto Horacio, Wilson Neil, Driggers Edward, Jang Hyun G, Su Shinsan M, Schenkein David P, Lai Albert, Cloughesy Timothy F, Kornblum Harley I, Wu Hong, Fantin Valeria R, Liau Linda M   Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy Journal of neuro-oncology, 2012; 107(1): 197-205.
Mulholland David J, Kobayashi Naoko, Ruscetti Marcus, Zhi Allen, Tran Linh M, Huang Jiaoti, Gleave Martin, Wu Hong   Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells Cancer research, 2012; 72(7): 1878-89.
Kim Tae Hyong, Song Jieun, Alcantara Llaguno Sheila R, Murnan Eric, Liyanarachchi Sandya, Palanichamy Kamalakannan, Yi Ji-Yeun, Viapiano Mariano Sebastian, Nakano Ichiro, Yoon Sung Ok, Wu Hong, Parada Luis F, Kwon Chang-Hyuk   Suppression of peroxiredoxin 4 in glioblastoma cells increases apoptosis and reduces tumor growth PloS one, 2012; 7(8): e42818.
Palaskas Nicolaos, Larson Steven M, Schultz Nikolaus, Komisopoulou Evangelia, Wong Justin, Rohle Dan, Campos Carl, Yannuzzi Nicolas, Osborne Joseph R, Linkov Irina, Kastenhuber Edward R, Taschereau Richard, Plaisier Seema B, Tran Chris, Heguy Adriana, Wu Hong, Sander Chris, Phelps Michael E, Brennan Cameron, Port Elisa, Huse Jason T, Graeber Thomas G, Mellinghoff Ingo K   18F-fluorodeoxy-glucose positron emission tomography marks MYC-overexpressing human basal-like breast cancers Cancer research, 2011; 71(15): 5164-74.
McCabe Katelyn E, Liu Bin, Marks James D, Tomlinson James S, Wu Hong, Wu Anna M   An Engineered Cysteine-Modified Diabody for Imaging Activated Leukocyte Cell Adhesion Molecule (ALCAM)-Positive Tumors Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 2011; 111(6): .
Tsutsui Hideaki, Valamehr Bahram, Hindoyan Antreas, Qiao Rong, Ding Xianting, Guo Shuling, Witte Owen N, Liu Xin, Ho Chih-Ming, Wu Hong   An optimized small molecule inhibitor cocktail supports long-term maintenance of human embryonic stem cells Nature communications, 2011; 2(1): 167.
Mulholland David J, Tran Linh M, Li Yunfeng, Cai Houjian, Morim Ashkan, Wang Shunyou, Plaisier Seema, Garraway Isla P, Huang Jiaoti, Graeber Thomas G, Wu Hong   Cell Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer Growth Cancer cell, 2011; 19(6): 792-804.
Valamehr Bahram, Tsutsui Hideaki, Ho Chih-Ming, Wu Hong   Developing defined culture systems for human pluripotent stem cells Regenerative medicine, 2011; 6(5): 623-34.
Santiskulvong Chintda, Konecny Gottfried E, Fekete Mirela, Chen Kuang-Yui Michael, Karam Amer, Mulholland David, Eng Carol, Wu Hong, Song Min, Dorigo Oliver   Dual targeting of phosphoinositide 3-kinase and mammalian target of rapamycin using NVP-BEZ235 as a novel therapeutic approach in human ovarian carcinoma Clinical cancer research : an official journal of the American Association for Cancer Research, 2011; 17(8): 2373-84.
Tap William D, Eilber Fritz C, Ginther Charles, Dry Sarah M, Reese Nicholas, Barzan-Smith Kate, Chen Hsiao-Wang, Wu Hong, Eilber Frederick R, Slamon Dennis J, Anderson Lee   Evaluation of well-differentiated/de-differentiated liposarcomas by high-resolution oligonucleotide array-based comparative genomic hybridization Genes, chromosomes & cancer, 2011; 50(2): 95-112.
Lindgren Anne G, Natsuhara Kyle, Tian E, Vincent John J, Li Xinmin, Jiao Jing, Wu Hong, Banerjee Utpal, Clark Amander T   Loss of Pten causes tumor initiation following differentiation of murine pluripotent stem cells due to failed repression of Nanog PloS one, 2011; 6(1): e16478.
Le Belle Janel E, Orozco Nicolas M, Paucar Andres A, Saxe Jonathan P, Mottahedeh Jack, Pyle April D, Wu Hong, Kornblum Harley I   Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner Cell stem cell, 2011; 8(1): 59-71.
Guo Wei, Schubbert Suzanne, Chen James Y, Valamehr Bahram, Mosessian Sherly, Shi Hubing, Dang Nhi H, Garcia Consuelo, Theodoro Mariana F, Varella-Garcia Marileila, Wu Hong   Suppression of leukemia development caused by PTEN loss Proceedings of the National Academy of Sciences of the United States of America, 2011; 108(4): 1409-14.
Sun Jing, Masterman-Smith Michael D, Graham Nicholas A, Jiao Jing, Mottahedeh Jack, Laks Dan R, Ohashi Minori, DeJesus Jason, Kamei Ken-ichiro, Lee Ki-Bum, Wang Hao, Yu Zeta T F, Lu Yi-Tsung, Hou Shuang, Li Keyu, Liu Max, Zhang Nangang, Wang Shutao, Angenieux Brigitte, Panosyan Eduard, Samuels Eric R, Park Jun, Williams Dirk, Konkankit Vera, Nathanson David, van Dam R Michael, Phelps Michael E, Wu Hong, Liau Linda M, Mischel Paul S, Lazareff Jorge A, Kornblum Harley I, Yong William H, Graeber Thomas G, Tseng Hsian-Rong   A microfluidic platform for systems pathology: multiparameter single-cell signaling measurements of clinical brain tumor specimens Cancer research, 2010; 70(15): 6128-38.
Lukacs Rita U, Memarzadeh Sanaz, Wu Hong, Witte Owen N   Bmi-1 is a crucial regulator of prostate stem cell self-renewal and malignant transformation Cell stem cell, 2010; 7(6): 682-93.
Lillehoj Peter B, Tsutsui Hideaki, Valamehr Bahram, Wu Hong, Ho Chih-Ming   Continuous sorting of heterogeneous-sized embryoid bodies Lab on a chip, 2010; 10(13): 1678-82.
Tsutsui Hideaki, Yu Edmond, Marquina Sabrina, Valamehr Bahram, Wong Ieong, Wu Hong, Ho Chih-Ming   Efficient dielectrophoretic patterning of embryonic stem cells in energy landscapes defined by hydrogel geometries Annals of biomedical engineering, 2010; 38(12): 3777-88.
Hill Reginald, Calvopina Joseph Hargan, Kim Christine, Wang Ying, Dawson David W, Donahue Timothy R, Dry Sarah, Wu Hong   PTEN loss accelerates KrasG12D-induced pancreatic cancer development Cancer research, 2010; 70(18): 7114-24.
He Lina, Hou Xiaogang, Kanel Gary, Zeng Ni, Galicia Vivian, Wang Ying, Yang Jian, Wu Hong, Birnbaum Morris J, Stiles Bangyan L   The critical role of AKT2 in hepatic steatosis induced by PTEN loss The American journal of pathology, 2010; 176(5): 2302-8.
Conway Anne E, Lindgren Anne, Galic Zoran, Pyle April D, Wu Hong, Zack Jerome A, Pelligrini Matteo, Teitell Michael A, Clark Amander T   A self-renewal program controls the expansion of genetically unstable cancer stem cells in pluripotent stem cell-derived tumors Stem cells (Dayton, Ohio), 2009; 27(1): 18-28.
Mosessian Sherly, Avliyakulov Nuraly K, Mulholland David J, Boontheung Pinmanee, Loo Joseph A, Wu Hong   Analysis of PTEN complex assembly and identification of heterogeneous nuclear ribonucleoprotein C as a component of the PTEN-associated complex The Journal of biological chemistry, 2009; 284(44): 30159-66.
Ruan,R., Ren, S., Li, J., Li, G., Kim, R., Gao, J., Wu, H., Wang Y.   Inducible and Cardiac Specific PTEN Inactivation Protects Ischemia/Reperfusion Injury, Journal of Molecular and Cellular Cardiology, 2009; 46(2): 193-200.
Mulholland David J, Xin Li, Morim Ashkan, Lawson Devon, Witte Owen, Wu Hong   Lin-Sca-1+CD49fhigh stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer model Cancer research, 2009; 69(22): 8555-62.
Gregorian Caroline, Nakashima Jonathan, Dry Sarah M, Nghiemphu P Leia, Smith Kate Barzan, Ao Yan, Dang Julie, Lawson Gregory, Mellinghoff Ingo K, Mischel Paul S, Phelps Michael, Parada Luis F, Liu Xin, Sofroniew Michael V, Eilber Fritz C, Wu Hong   PTEN dosage is essential for neurofibroma development and malignant transformation Proceedings of the National Academy of Sciences of the United States of America, 2009; 106(46): 19479-84.
Haga, K., Tomioka, A., Liao, C., Kimura, T., Matsumoto, H., Ohno, I., Hermann, K., Logg, C., Tanaka, M., Hirao, Y., Wu, H., Kruse, C., Roy-Burman, P., and Kasahara N.   PTEN knockout prostate cancer as a model for experimental immunotherapy, The Journal of Urology, 2009; 181: 354-362.
Hill Reginald, Wu Hong   PTEN, stem cells, and cancer stem cells The Journal of biological chemistry, 2009; 284(18): 11755-9.
Gregorian Caroline, Nakashima Jonathan, Le Belle Janel, Ohab John, Kim Rachel, Liu Annie, Smith Kate Barzan, Groszer Matthias, Garcia A Denise, Sofroniew Michael V, Carmichael S Thomas, Kornblum Harley I, Liu Xin, Wu Hong   Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009; 29(6): 1874-86.
Couto Suzana S, Cao Mei, Duarte Paulo C, Banach-Petrosky Whitney, Wang Shunyou, Romanienko Peter, Wu Hong, Cardiff Robert D, Abate-Shen Cory, Cunha Gerald R   Simultaneous haploinsufficiency of Pten and Trp53 tumor suppressor genes accelerates tumorigenesis in a mouse model of prostate cancer Differentiation; research in biological diversity, 2009; 77(1): 103-11.
Guertin David A, Stevens Deanna M, Saitoh Maki, Kinkel Stephanie, Crosby Katherine, Sheen Joon-Ho, Mullholland David J, Magnuson Mark A, Wu Hong, Sabatini David M   mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice Cancer cell, 2009; 15(2): 148-59.
Majumder Pradip K, Grisanzio Chiara, O’Connell Fionnuala, Barry Marc, Brito Joseph M, Xu Qing, Guney Isil, Berger Raanan, Herman Paula, Bikoff Rachel, Fedele Giuseppe, Baek Won-Ki, Wang Shunyou, Ellwood-Yen Katharine, Wu Hong, Sawyers Charles L, Signoretti Sabina, Hahn William C, Loda Massimo, Sellers William R   A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression Cancer cell, 2008; 14(2): 146-55.
Burton Jeremy B, Johnson Mai, Sato Makoto, Koh Sok Boon S, Mulholland David J, Stout David, Chatziioannou Arion F, Phelps Michael E, Wu Hong, Wu Lily   Adenovirus-mediated gene expression imaging to directly detect sentinel lymph node metastasis of prostate cancer Nature medicine, 2008; 14(8): 882-8.
Degtyarev, M., De Mazière, A., Orr, C., Lin, J., Tien, J., Prior, W., Lee, B., van Dijk, S., Gray, D., Wu, H., Davis, D., Stern, H., Murray, L., Hoeflich, K., Klumperman, J., Friedman, L. and Lin, K.   Akt Inhibition Promotes Autophagy And Sensitizes PTEN-Null Tumors To Late-Stage Autophagy Inhibition, Journal of Cell Biology, 2008; 186: 101-106.
Yao Denggao, Alexander Claire L, Quinn Jean A, Chan Weng-Chyn, Wu Hong, Greenhalgh David A   Fos cooperation with PTEN loss elicits keratoacanthoma not carcinoma, owing to p53/p21 WAF-induced differentiation triggered by GSK3beta inactivation and reduced AKT activity Journal of cell science, 2008; 121(Pt 10): 1758-69.
Mulholland, D.J., Jiao, J. and Wu, H.   Hormone refractory prostate cancer: lesions leaned from the PTEN prostate cancer model, Adv Exp Med Biol, 2008; 617: 87-95.
Valamehr Bahram, Jonas Steven J, Polleux Julien, Qiao Rong, Guo Shuling, Gschweng Eric H, Stiles Bangyan, Kam Korey, Luo Tzy-Jiun M, Witte Owen N, Liu Xin, Dunn Bruce, Wu Hong   Hydrophobic surfaces for enhanced differentiation of embryonic stem cell-derived embryoid bodies Proceedings of the National Academy of Sciences of the United States of America, 2008; 105(38): 14459-64.
Guo Wei, Lasky Joseph L, Chang Chun-Ju, Mosessian Sherly, Lewis Xiaoman, Xiao Yun, Yeh Jennifer E, Chen James Y, Iruela-Arispe M Luisa, Varella-Garcia Marileila, Wu Hong   Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation Nature, 2008; 453(7194): 529-33.
Chang Chun-Ju, Mulholland David J, Valamehr Bahram, Mosessian Sherly, Sellers William R, Wu Hong   PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression Molecular and cellular biology, 2008; 28(10): 3281-9.
Kwon Chang-Hyuk, Zhao Dawen, Chen Jian, Alcantara Sheila, Li Yanjiao, Burns Dennis K, Mason Ralph P, Lee Eva Y-H P, Wu Hong, Parada Luis F   Pten haploinsufficiency accelerates formation of high-grade astrocytomas Cancer research, 2008; 68(9): 3286-94.
Iwanaga, K., Yang, Y., Raso, M., Ma, L., Hanna, A., Thilaganathan N., Moghaddam, S., Evans, C., Li, H., Cai, W., Sato, M., Minna, H., Wu, H., Creighton, C., Demayo, F., Wistuba, I. and Kurie, J.   Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer, Cancer Research, 2008; 68: 1119-1127.
Vivanco, I., Rohle, D., Versele, M., Palaskas, N., Evans, M., Hsueh, T., Brennan, C., Mulholland, D., Rajasekaran, S., Wolle, D., Rajasekaran, R., Dikic, I., Wu, H., Perera, T. and Mellinghoff, I.K.   Regulation of Epidermal Growth Factor Receptor Signaling by the PTEN Tumor Suppressor, , 2008; Submitted: .
Tahk S., Liu, B., Chenishof, V., Wong, K., Wu, H. and Shuai, K.   Control of specificity and magnitude of NF-kB and STAT1-mediated gene activation through PIASy and PIAS1 co-operation Proceddings of the National Academy of Sciences, USA, 2007; 104(28): 11643-11648.
Memarzadeh, S., Xin, L., Mulholland, D., Mansukhani,A., Wu, H., Teitell,M., and Witte, O.   Enhanced Paracrine FGF10 Expression Promotes Formation of Multifocal Prostate Adenocarcinoma and an Increase in Epithelial Androgen Receptor Cancer Cell, 2007; 12(6): 572-585.
Shen, W. H., Balajee, A.S., Wang, J., Wu, H., Eng, C., Pandolfi, PP, and Yin, Y.   Essential Role for Nuclear PTEN in Maintaining Chromosomal Integrity, Cell, 2007; (128): 157-170.
Vivanco, I., Palaskas, N., Tran, C., Finn, S.P., Getz, G., Kennedy, N.G., Jiao, J., Rose, J., Xie, W., Loda, M., Golub, T., Mellinghoff, I., Davis, R., Wu, H. and Sawyers, C.L   Identification of the JNK Signaling Pathway as a Functional Target of the Tumor Suppressor PTEN, Cancer Cell, 2007; (11): 555-569.
He, X., Zhang, J., Grindley, J.C., Tian, Q., Sato, T., Tao, W.A., Dirisina, R., Porter-Westpfahl, K.S., Hembree, M., Johnson, T., Wiedemann, L., Barrett, T., Hood, L., Wu, H. and Li, L.   Inactivation of PTEN leads to enhanced activation of intestinal stem cells and biasing on lineage fate determination, Nature Genetics, 2007; (39): 189-198.
Berquin, I.M., Min, Y., Wu, R., Wu, J., Perry, D., Cline, J.M., Thomas, M.J., Thornburg, T., Kulik. G., Smith, A., Edward, I.J., D’Agostino, R., Zhang, H., Wu, H., Kang, J.X., Chen, Y.Q.   Modulation of Prostate Cancer Genetic Risk by Omega-3 and Omega-6 Fatty Acids Journal of Clinical Investigation, 2007; 117(7): 1866-1875.
Jiao, J., Wang, S., Qiao, R., Vivanco, I., Watson, P., Sawyers, C. and Wu, H.   Murine Cell Lines Derived from Pten Null Prostate Cancer Demonstrate the Critical Role of PTEN in Hormone Refractory Prostate Cancer Development, Cancer Research, 2007; (67): 6083-6091.
Tsai PT, Ohab JJ, Kertesz N, Groszer M, Matter C, Gao J, Liu X, Wu H, Carmichael ST   A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery J Neurosci, 2006; 26(4): 1269-74.
Horvath, S. Zhang, B. Carlson, M. Lu, K. V. Zhu, S. Felciano, R. M. Laurance, M. F. Zhao, W. Qi, S. Chen, Z. Lee, Y. Scheck, A. C. Liau, L. M. Wu, H. Geschwind, D. H. Febbo, P. G. Kornblum, H. I. Cloughesy, T. F. Nelson, S. F. Mischel, P. S.   Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target Proc Natl Acad Sci U S A, 2006; 103(46): 17402-7.
Guo, W. Lasky, J. L., 3rd Wu, H.   Cancer stem cells Pediatr Res, 2006; 59(4 Pt 2): 59R-64R.
Stiles, B., Kurlawalla-Martinez, C., Guo, W., Tian, J. Wang, Y., and Wu, H.   Deletion of Pten in insulin producing pancreatic -cells leads to increased -cell mass and rescues STZ-induced diabetes, Molecular Cell Biology, 2006; (26): 2772-2781.
Huang, W. Chang, H. Y. Fei, T. Wu, H. Chen, Y. G.   GSK3beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN Oncogene, 2006; .
Freeman, D. Lesche, R. Kertesz, N. Wang, S. Li, G. Gao, J. Groszer, M. Martinez-Diaz, H. Rozengurt, N. Thomas, G. Liu, X. Wu, H.   Genetic background controls tumor development in PTEN-deficient mice Cancer Res, 2006; 66(13): 6492-6.
Khodavirdi, A. C. Song, Z. Yang, S. Zhong, C. Wang, S. Wu, H. Pritchard, C. Nelson, P. S. Roy-Burman, P.   Increased expression of osteopontin contributes to the progression of prostate cancer Cancer Res, 2006; 66(2): 883-8.
Xu, X. Kobayashi, S. Qiao, W. Li, C. Xiao, C. Radaeva, S. Stiles, B. Wang, R. H. Ohara, N. Yoshino, T. LeRoith, D. Torbenson, M. S. Gores, G. J. Wu, H. Gao, B. Deng, C. X.   Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice J Clin Invest, 2006; 116(7): 1843-52.
Lei, Q. Jiao, J. Xin, L. Chang, C. J. Wang, S. Gao, J. Gleave, M. E. Witte, O. N. Liu, X. Wu, H.   NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss Cancer Cell, 2006; 9(5): 367-78.
Mulholland, D. J. Dedhar, S. Wu, H. Nelson, C. C.   PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer Oncogene, 2006; 25(3): 329-37.
Li, G. Hu, Y. Huo, Y. Liu, M. Freeman, D. Gao, J. Liu, X. Wu, D. Wu, H.   PTEN deletion leads to up-regulation of a secreted growth factor pleiotrophin J Biol Chem, 2006; .
Zhang, J. Grindley, J. C. Yin, T. Jayasinghe, S. He, X. C. Ross, J. T. Haug, J. S. Rupp, D. Porter-Westpfahl, K. S. Wiedemann, L. M. Wu, H. Li, L.   PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention Nature, 2006; 441(7092): 518-22.
Groszer M, Erickson R, Scripture-Adams DD, Dougherty JD, Le Belle J, Zack JA, Geschwind DH, Liu X, Kornblum HI, Wu H   PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry Proc Natl Acad Sci U S A, 2006; 103(1): 111-6.
Yoo, L. I. Liu, D. W. Le Vu, S. Bronson, R. T. Wu, H. Yuan, J.   Pten deficiency activates distinct downstream signaling pathways in a tissue-specific manner Cancer Res, 2006; 66(4): 1929-39.
Wang S, Garcia AJ, Wu M, Lawson DA, Witte ON, Wu H   Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation Proc Natl Acad Sci U S A, 2006; 103(5): 1480-5.
Yilmaz, O. H. Valdez, R. Theisen, B. K. Guo, W. Ferguson, D. O. Wu, H. Morrison, S. J.   Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells Nature, 2006; 441(7092): 475-82.
Wu, H. Khodavirdi, A Roy-Burman, P.   Capturing signal anomalies of human prostate cancer into mouse models, Prostate cancer: basic mechanisms and therapeutic approaches, 2005; in press.
Berquin, I. M. Min, Y. Wu, R. Wu, H. Chen, Y. Q.   Expression signature of the mouse prostate J Biol Chem, 2005; 280(43): 36442-51.
Kurlawalla-Martinez C, Stiles B, Wang Y, Devaskar SU, Kahn BB, Wu H   Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue Molecular and cellular biology. , 2005; 25(6): 2498-510.
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Nakano I, Paucar AA, Bajpai R, Dougherty JD, Zewail A, Kelly TK, Kim KJ, Ou J, Groszer M, Imura T, Freije WA, Nelson SF, Sofroniew MV, Wu H, Liu X, Terskikh AV, Geschwind DH, Kornblum HI   Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation J Cell Biol, 2005; 170(3): 413-27.
Lasky JL, Wu H   Notch signaling, brain development, and human disease Pediatric research. , 2005; 57(5 Pt 2): 104R-109R.
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Liu B, Yang R, Wong KA, Getman C, Stein N, Cheng G, Wu H, and Shuai K   PIAS1 Participates in the Negative Regulation of NF-kB Signaling, Mol. Cell Biol, 2005; 25: 1113-23.
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Sanchez, T. Thangada, S. Wu, M. T. Kontos, C. D. Wu, D. Wu, H. Hla, T.   PTEN as an effector in the signaling of antimigratory G protein-coupled receptor Proc Natl Acad Sci U S A, 2005; 102(12): 4312-7.
Yue Q, Groszer M, Gil JS, Berk AJ, Messing A, Wu H, Liu X   PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization Development (Cambridge, England) , 2005; 132(14): 3281-91.
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Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, Wang Y, Greenwood A, Cheng KH, McLaughlin M, Brown D, Depinho RA, Wu H, Melton DA, Dor Y   Pten constrains centroacinar cell expansion and malignant transformation in the pancreas Cancer cell. , 2005; 8(3): 185-95.
Tsao H, Goel V, Wu H, Yang G, Haluska FG   Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma The Journal of investigative dermatology. , 2004; 122(2): 337-41.
Roy-Burman P, Wu H, Powell WC, Hagenkord J, Cohen MB   Genetically defined mouse models that mimic natural aspects of human prostate cancer development Endocrine-related cancer. , 2004; 11(2): 225-54.
Stiles B, Wang Y, Stahl A, Bassilian S, Lee WP, Kim YJ, Sherwin R, Devaskar S, Lesche R, Magnuson MA, Wu H   Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected] Proc Natl Acad Sci U S A, 2004; 101(7): 2082-7.
Sundaresan G, Paulmurugan R, Berger F, Stiles B, Nagayama Y, Wu H, Gambhir SS   MicroPET imaging of Cre-loxP-mediated conditional activation of a herpes simplex virus type 1 thymidine kinase reporter gene Gene therapy. , 2004; 11(7): 609-18.
Liu B, Mink S, Wong KA, Stein N, Getman C, Dempsey PW, Wu H, Shuai K   PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity Nat Immunol, 2004; 5(9): 891-8.
Chang CJ, Freeman DJ, Wu H   PTEN regulates Mdm2 expression through the P1 promoter The Journal of biological chemistry. , 2004; 279(28): 29841-8.
Stiles B, Groszer M, Wang S, Jiao J, Wu H   PTENless means more Dev Biol, 2004; 273(2): 175-84.
Lim, M. A. Yang, L. Zheng, Y. Wu, H. Dong, L. Q. Liu, F.   Roles of PDK-1 and PKN in regulating cell migration and cortical actin formation of PTEN-knockout cells Oncogene, 2004; 23(58): 9348-58.
Johnson JD, Han Z, Otani K, Ye H, Zhang Y, Wu H, Horikawa Y, Misler S, Bell GI, Polonsky KS   RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets J Biol Chem, 2004; 279(23): 24794-802.
Kertesz N, Wu J, Chen TH, Sucov HM, Wu H   The role of erythropoietin in regulating angiogenesis Dev Biol, 2004; 276(1): 101-10.
Tsai, P. T. Lee, R. A. Wu, H.   BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis Blood, 2003; 102(12): 3947-53.
Freeman DJ, Li AG, Wei G, Li HH, Kertesz N, Lesche R, Whale AD, Martinez-Diaz H, Rozengurt N, Cardiff RD, Liu X, Wu H   PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms Cancer Cell, 2003; 3(2): 117-30.
Wang S, Gao J, Lei Q, Rozengurt N, Pritchard C, Jiao J, Thomas GV, Li G, Roy-Burman P, Nelson PS, Liu X, Wu H   Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer Cancer cell. , 2003; 4(3): 209-21.
Anzelon AN, Wu H, Rickert RC   Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function Nat Immunol, 2003; 4(3): 287-94.
Kertesz, N. Samson, J. Debacker, C. Wu, H. Labastie, M. C.   Cloning and characterization of human and mouse SNRK sucrose non-fermenting protein (SNF-1)-related kinases Gene, 2002; 294(1-2): 13-24.
Li G, Robinson GW, Lesche R, Martinez-Diaz H, Jiang Z, Rozengurt N, Wagner KU, Wu DC, Lane TF, Liu X, Hennighausen L, Wu H   Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland Development, 2002; 129(17): 4159-70.
Lesche R, Groszer M, Gao J, Wang Y, Messing A, Liu X, and Wu H   Cre/loxp-Mediated Inactivation of The Murine Pten Tumor Suppressor Gene Genesis, 2002; 32: 148-149.
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Osawa M, Yamaguchi T, Nakamura Y, Kaneko S, Onodera M, Sawada K, Jegalian A, Wu H, Nakauchi H, Iwama A   Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis Blood. , 2002; 100(8): 2769-77.
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Wong K, Tsai P, Jegalian A, Kertesz N, Lee R and Wu H   Erythropoietin, In Encyclopedia of Hormones and Related Cell Regulators; , 2002; .
Stiles B, Gilman V, Khanzenzon N, Lesche R, Li A, Qiao R, Liu X, Wu H   Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis Mol Cell Biol, 2002; 22(11): 3842-51.
Makita, T. Hernandez-Hoyos, G. Chen, T. H. Wu, H. Rothenberg, E. V. Sucov, H. M.   A developmental transition in definitive erythropoiesis: erythropoietin expression is sequentially regulated by retinoic acid receptors and HNF4 Genes Dev, 2001; 15(7): 889-901.
Dubey P, Wu H, Reiter RE, Witte ON   Alternative pathways to prostate carcinoma activate prostate stem cell antigen expression Cancer Res, 2001; 61(8): 3256-61.
Neshat MS, Mellinghoff IK, Tran C, Stiles B, Thomas G, Petersen R, Frost P, Gibbons JJ, Wu H, Sawyers CL   Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR Proc Natl Acad Sci U S A, 2001; 98(18): 10314-9.
Lee R, Kertesz N, Joseph SB, Jegalian A, Wu H   Erythropoietin (Epo) and EpoR expression and 2 waves of erythropoiesis Blood, 2001; 98(5): 1408-15.
Hisakawa H, Sugiyama D, Nishijima I, Xu MJ, Wu H, Nakao K, Watanabe S, Katsuki M, Asano S, Arai K, Nakahata T, Tsuji K   Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) stimulates primitive and definitive erythropoiesis in mouse embryos expressing hGM-CSF receptors but not erythropoietin receptors Blood, 2001; 98(13): 3618-25.
Groszer, M. Erickson, R. Scripture-Adams, D. D. Lesche, R. Trumpp, A. Zack, J. A. Kornblum, H. I. Liu, X. Wu, H.   Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo Science, 2001; 294(5549): 2186-9.
Mamillapalli R, Gavrilova N, Mihaylova VT, Tsvetkov LM, Wu H, Zhang H, Sun H   PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2) Curr Biol, 2001; 11(4): 263-7.
Satterthwaite, A. B. Willis, F. Kanchanastit, P. Fruman, D. Cantley, L. C. Helgason, C. D. Humphries, R. K. Lowell, C. A. Simon, M. Leitges, M. Tarakhovsky, A. Tedder, T. F. Lesche, R. Wu, H. Witte, O. N.   A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton’s tyrosine kinase Proc Natl Acad Sci U S A, 2000; 97(12): 6687-92.
Liliental J, Moon SY, Lesche R, Mamillapalli R, Li D, Zheng Y, Sun H, Wu H   Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases Curr Biol, 2000; 10(7): 401-4.
Ghaffari, S. Wu, H. Gerlach, M. Han, Y. Lodish, H. F. Daley, G. Q.   BCR-ABL and v-SRC tyrosine kinase oncoproteins support normal erythroid development in erythropoietin receptor-deficient progenitor cells Proc Natl Acad Sci U S A, 1999; 96(23): 13186-90.
Wu H, Lee SH, Gao J, Liu X, Iruela-Arispe ML   Inactivation of erythropoietin leads to defects in cardiac morphogenesis Development (Cambridge, England) , 1999; 126(16): 3597-605.
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Sun H, Lesche R, Li DM, Liliental J, Zhang H, Gao J, Gavrilova N, Mueller B, Liu X, Wu H   PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway Proc Natl Acad Sci U S A, 1999; 96(11): 6199-204.
Neubauer H, Cumano A, Muller M, Wu H, Huffstadt U, Pfeffer K   Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis Cell, 1998; 93(3): 397-409.
Constantinescu, S. N. Wu, H. Liu, X. Beyer, W. Fallon, A. Lodish, H. F.   The anemic Friend virus gp55 envelope protein induces erythroid differentiation in fetal liver colony-forming units-erythroid Blood, 1998; 91(4): 1163-72.
Wu H, Klingmuller U, Acurio A, Hsiao JG and Lodish HF   Functional Interaction of Erythropoietin and Stem Cell Factor Receptors is Essential for Erythroid Colony Formation Proc. Natl. Acad. Sci. USA. , 1997; 94: 1806-1810.
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Wu, H. Klingmuller, U. Acurio, A. Hsiao, J. G. Lodish, H. F.   Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation Proc Natl Acad Sci U S A, 1997; 94(5): 1806-10.
Klingmuller K, Wu H, Hsiao J, Duckworth B, Toker A, Cantley LC and Lodish HF   Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors Proc. Natl. Acad. Sci. USA , 1997; 94: 3016-3021.
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Klingmuller U, Wu H, Hsiao JG, Toker A, Duckworth BC, Cantley LC, Lodish HF   Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors Proc Natl Acad Sci U S A, 1997; 94(7): 3016-21.
Liu X, Wu H, Loring J, Hormuzdi S, Disteche CM, Bornstein P, Jaenisch R   Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission Developmental dynamics : an official publication of the American Association of Anatomists. , 1997; 209(1): 85-91.
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Liu X, Wu H, Byrne M, Krane S, Jaenisch R   Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development Proc Natl Acad Sci U S A, 1997; 94(5): 1852-6.
Watowich SS, Wu H, Socolovsky M, Klingmuller U, Constantinescu SN, Lodish HF   Cytokine receptor signal transduction and the control of hematopoietic cell development Annu Rev Cell Dev Biol, 1996; 12: 91-128.
Krane SM, Byrne M, Henrie P, Lemaitre V, Jeffrey JJ, Witter J, Liu X, Wu H, Jaenisch R and Eeckhout Y   Different collagenase gene products have different roles in remodeling of type I collagen-containing extracellular matrices J. Biol. Chem. , 1996; 271: 28509-28515.
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Wu H and Lodish H   The erythropoietin receptor: dimerization and intracellular signal transduction, Journal of Experimental hematology, 1996; 4: 229-235.
Iruela ML, Vernon RB, Wu H, Jeanisch R and Sage H   Type I collagen is required for the association of SPARC with the extracellular matrix in Mov-13 mice: implications for fibroblast function Developmental Dynamics , 1996; 207: 171-183.
Liu X, Wu H, Byrne M, Jeffrey J, Krane S, Jaenisch R   A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling The Journal of cell biology. , 1995; 130(1): 227-37.
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Wu, H. Klingmuller, U. Besmer, P. Lodish, H. F.   Interaction of the erythropoietin and stem-cell-factor receptors Nature, 1995; 377(6546): 242-6.
Lodish HF, Hilton DJ, Klingmuller U, Watowich SS, Wu H   The erythropoietin receptor: biogenesis, dimerization, and intracellular signal transduction Cold Spring Harb Symp Quant Biol, 1995; 60: 93-104.
Dzamba, B. J. Wu, H. Jaenisch, R. Peters, D. M.   Fibronectin binding site in type I collagen regulates fibronectin fibril formation J Cell Biol, 1993; 121(5): 1165-72.
Hasty K, Wu H, Byrne M, Goldring M, Jaenisch R, Krane S and Mainardi C   Susceptibility of type I collagen containing mutated alpha1(I) chains to cleavage by human neutrophil collagenase Matrix, 1993; 13: 181-186.
Wu, H. Fassler, R. Schnieke, A. Barker, D. Lee, K. H. Chapman, V. Francke, U. Jaenisch, R.   An X-linked human collagen transgene escapes X inactivation in a subset of cells Development, 1992; 116(3): 687-95.
Barker DD, Wu H, Hartung S, Breindl M, Jaenisch R   Retrovirus-induced insertional mutagenesis: mechanism of collagen mutation in Mov13 mice Molecular and cellular biology. , 1991; 11(10): 5154-63.
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Wu, H. Byrne, M. H. Stacey, A. Goldring, M. B. Birkhead, J. R. Jaenisch, R. Krane, S. M.   Generation of collagenase-resistant collagen by site-directed mutagenesis of murine pro alpha 1(I) collagen gene Proc Natl Acad Sci U S A, 1990; 87(15): 5888-92.
Wu H, Bateman JF, Schnieke A, Sharpe A, Barker D, Mascara T, Eyre D, Bruns R, Krimpenfort P, Berns A   Human-mouse interspecies collagen I heterotrimer is functional during embryonic development of Mov13 mutant mouse embryos Molecular and cellular biology. , 1990; 10(4): 1452-60.
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Silverman, D. H. Wu, H. Karnovsky, M. L.   Muramyl peptides and serotonin interact at specific binding sites on macrophages and enhance superoxide release Biochem Biophys Res Commun, 1985; 131(3): 1160-7.

Benjamin Wu, D.D.S., Ph.D.

Biography

Prof. Ben Wu received his D.D.S. from the University of Pacific, his advanced prosthodontics specialty certificate at the Harvard School of Dental Medicine, and his Ph.D. in Materials Science and Engineering from the Massachusetts Institute of Technology. He is currently Professor and Chair of the UCLA Department of Bioengineering, and Chair of the Division of Advanced Prosthodontics in the School of Dentistry. He holds joint appointment in the Department of Materials Science and Engineering, and in the Department of Orthopedic Surgery in the School of Medicine. Prof. Wu is Director of the Weintraub Center for Reconstructive Biotechnology, and a member of the UCLA Brain Research Institute, the California NanoSystems Institute, and Fellow of the the Academy of Prosthodontics.

Publications

A selected list of publications:

Lee M, Siu RK, Ting K, Wu BM   Effect of nell-1 delivery on chondrocyte proliferation and cartilaginous extracellular matrix deposition Tissue Eng Part A, 2010; 16(5): 1791-800.
Yuki I, Uchiyama N, Murayama Y, Nien YL, Lee D, Ebara M, Ishii A, Chiang A, Vinters HV, Nishimura I, Wu BM, Vinuela F   Intravascular tissue reactions induced by various types of bioabsorbable polymeric materials: correlation between the degradation profiles and corresponding tissue reactions Neuroradiology, 2010; 52(11): 1017-24.
Pham EA, Ho WJ, Kamei DT, Wu BM   Modification of the diphenylamine assay for cell quantification in three-dimensional biodegradable polymeric scaffolds J Biomed Mater Res B Appl Biomater, 2010; 92(2): 499-507.
Aghaloo T, Cowan CM, Zhang X, Freymiller E, Soo C, Wu B, Ting K, Zhang Z   The effect of NELL1 and bone morphogenetic protein-2 on calvarial bone regeneration J Oral Maxillofac Surg, 2010; 68(2): 300-8.
Lee M, Li W, Siu RK, Whang J, Zhang X, Soo C, Ting K, Wu BM.   Biomimetic apatite-coated alginate/chitosan microparticles as osteogenic protein carriers Biomaterials, 2009; 30(30): 6094-101.
Choi CH, Heydarkhan-Hagvall S, Wu BM, Dunn JC, Beygui RE, Kim CJ.   Cell growth as a sheet on three-dimensional sharp-tip nanostructures J Biomed Mater Res A, 2009; 89(3): 804-17.
Kramerova I, Kudryashova E, Wu B, Germain S, Vandenborne K, Romain N, Haller RG, Verity MA, Spencer MJ.   Mitochondrial abnormalities, energy deficit and oxidative stress are features of calpain 3 deficiency in skeletal muscle Hum Mol Genet, 2009; 18(17): 3194-205.
Lee, M. Wu, B. M. Dunn, J. C. Y.   Effect of scaffold architecture and pore size on smooth muscle cell growth Journal of Biomedical Materials Research Part A, 2008; 87A(4): 1010-1016.
Brown, D. A. MacLellan, W. R. Dunn, J. C. Y. Wu, B. M. Beygui, R. E.   Hypoxic cell death is reduced by pH buffering in a model of engineered heart tissue Artificial Cells Blood Substitutes and Biotechnology, 2008; 36(2): 94-113.
Lee, M. Wu, B. M. Stelzner, M. Reichardt, H. M. Dunn, J. C. Y.   Intestinal smooth muscle cell maintenance by basic fibroblast growth factor Tissue Engineering Part A, 2008; 14(8): 1395-1402.
Lee M, Wu BM, Stelzner M, Reichardt HM, Dunn JC.   Intestinal smooth muscle cell maintenance by basic fibroblast growth factor Tissue Eng Part A, 2008; 14(8): 1395-402.
Chow, M. Duong, H. Wu, B. Tawil, B.   Mesenchymal stem cells differentiation into osteoblasts on 2D and in 3D fibrin scaffolds Wound Repair and Regeneration, 2008; 16(2): 175.
Kramerova, I. Kudryashova, E. Wu, B. Ottenheijm, C. Granzier, H. Spencer, M. J.   Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle Human Molecular Genetics, 2008; 17(21): 3271-3280.
Dave, D. S. Gunther-Lopez, V. Zhang, R. Leung, J. Kun, S. Gollapudi, K. Wu, B. Rodriguez, L. V.   Periurethral injection of autologous adipose-derived stem cells with hepatocyte growth factor-impregnated PLGA microspheres for treatment of stress urinary incontinence in an animal model Journal of Urology, 2008; 179(4): 109-109.
Heydarkhan-Hagvall, S. Schenke-Layland, K. Dhanasopon, A. P. Rofail, F. Smith, H. Wu, B. M. Shemin, R. Beygui, R. E. MacLellan, W. R.   Three-dimensional electrospun ECM-based hybrid scaffolds for cardiovascular tissue engineering Biomaterials, 2008; 29(19): 2907-2914.
Brown DA, MacLellan WR, Laks H, Dunn JC, Wu BM, Beygui RE   Analysis of oxygen transport in a diffusion-limited model of engineered heart tissue Biotechnol Bioeng, 2007; 97(4): 962-75.
Brown DA, MacLellan WR, Wu BM, Beygui RE   Analysis of pH gradients resulting from mass transport limitations in engineered heart tissue Annals of Biomed Eng, 2007; 35(11): 1885-1897.
Choi CH. Hagwall SH. Wu BM. Dunn JCY. Kim CJ   Cell interactions with 3D sharp tip nanotopography Biomaterials, 2007; 28(9): 1672-9.
Lee M. Wu BM. Dunn JYC   Effect of scaffold architecture and pore size on smooth muscle cell growth J. Biomed. Mat Res. Part A, 2007; 87(4): 1010-6.
Hagerman E. Shim J. Gupta V. Wu BM   Evaluation of laser spallation as a technique for measurement of cell adhesion strength J. Biomed. Mat. Res. Part A 82A, 2007; 82(4): 852-860.
Mack JJ, Cox BN, Lee M, Dunn JYC, Wu BM   Magnetically Actuable Polymer Nanocomposites for Bioengineering Applications J. Mater. Sci, 2007; 42(15): 6139-6147.
Cowan CM, Aghaloo T, Chou YF, Walder B, Zhang X, Soo C, Ting K, Wu BM.   MicroCT Evaluation of Three-Dimensional Mineralization in Response to BMP-2 Doses In Vitro and in Critical Sized Rat Calvarial Defects, Tissue Engineering, 2007; 13(3): 501-512.
Lee M. Iruela Arispe ML. Wu BM. Dunn JCY   Modulation of protein delivery from modular polymer scaffolds Biomaterials, 2007; 28(10): 1862-70.
Lee, M. Chen, T. T. Iruela-Arispe, M. L. Wu, B. M. Dunn, J. C. Y.   Modulation of protein delivery from modular polymer scaffolds Biomaterials, 2007; 28(10): 1862-1870.
Wan DC, Pomerantz JH, Brunet LJ, Kim JB, Chou YF, Wu, BM, Harland R, Blau HM, Longaker MT   Noggin suppression enhances in vitro osteogenesis and accelerates in vivo bone formation J. Biol Chem, 2007; 282(36): 26450-26459.
Aghaloo T, Amantea CM. Cowan KM, Richardson JA, Wu B, Parhami F, Tetradis S   Oxysterols enhance osteoblast differentiation in vitro and bone healing in vivo J. Orthop Res, 2007; 25(11): 1488-1497.
Wan DC, Siedhoff MT, Kwan MD, Nacamuli RP, Wu BM, Longaker MT   Refining Retinoic Acid Stimulation for Osteogenic Differentiation of Murine Adipose-Derived Adult Stromal Cells Tissue Engineering, 2007; 13(7): 1623-1631.
Cowan, C. M. Jiang, X. Q. Hsu, T. Soo, C. Zhang, B. J. Wang, J. Z. Kuroda, S. Wu, B. Zhang, Z. Y. Zhang, X. L. Ting, K.   Synergistic effects of Nell-1 and BMP-2 on the osteogenic differentiation of myoblasts Journal of Bone and Mineral Research, 2007; 22(6): 918-930.
Cowan CM, Jiang X, Hsu T, Soo C, Zhang J, Wang J, Kuroda S, Wu B, Zhang Z, Zhang X, Ting K   Synergistic effects of Nell-1 and BMP-2 on the osteogenic differentiation of myoblasts J Bone Mineral Res, 2007; 22(6): 918-30.
Petrigliano FA, English C. Barba D. Esmende S. Wu BM. McAllister MD   The Effects of Local bFGF Release and Uniaxial Strain on Cellular Adaptation and Gene Expression in a 3D Environment: Implications for Ligament Tissue Engineering Tissue Engineering, 2007; 13(11): 1-11.
Lu SS, Zhang X, Soo C, Hsu T, Napoli A, Aghaloo T, Wu BM, Tsou P, Ting K, Wang JC   The osteoinductive properties of Nell-1 in rat spinal fusion model The Spine Journal, 2007; 7(1): 50-60.
Yuki I, Lee D, Murayama Y, Chiang A, Vinters HV, Nishimura I, Wang CJ, Ishii A, Wu BM, Vinuela V   Thrombus organization and healing in an experimental aneurysm model. Part II. The effect of various types of bioabsorbable polymeric coils J. Neurosurgery, 2007; 107(1): 109-120.
Lee D, Yuki I, Murayama Y, Chiang A, Nishimura I, Vinters HV, Wang CJ, Nien YL, Ishii A, Wu BM, Vinuela F   Thrombus organization and healing in the swine experimental aneurysm model. Part I. A histological and molecular analysis J. Neurosurgery, 2007; 107(1): 94-108.
Dunn JCY. Chan WY, Cristini V. Kim JS. Lowengrub J. Singha S. Wu BM   Analysis of Cell Growth in Three-Dimensional Scaffolds Tissue Engineering, 2006; 12: 705-716.
Rodriguez LV. Alfonso Z. Zhang R. Leung J. Wu BM. Ignarro LJ.   Clonogenic multipotent stem cells in human adipose tissue differentiate into functional smooth muscle cells PNAS, 2006; 103(32): 12167-12172.
Mendoza J., Chang C., Blalock CL., Atkinson JB., WU BM., Dunn JYC.   Contractile Function of the Mechanically Lengthened Intestine J. Surgical Research, 2006; 136(1): 8-12.
Puapong DP., Wu BM., Lam MM., Atkinson JB., Dunn JCY.   Distension enterogenesis: Increasing the Size and Function of Small Intestine J. Pediatric Surgery , 2006; 41(4): 763-7.
Catelas I. Sese N. Dunn JCY. Helgerson S. Tawil B. Wu BM   Human Mesenchymal Stem Cells Proliferation and Osteogenic Differentiation in Fibrin Gels in vitro Tissue Engineering, 2006; 12(8): 1-12.
Hagerman EM. Chao SHH. Dunn JCY. Wu BM   Initial Adhesion Events for IEC-6: signal transduction, cell spreading, and cell adhesion strength Journal of Biomedical Materials Research , 2006; 76(2): 272-278.
Aghaloo T, Cowan K, Chou YF, Zhang X, Lee HF, Miao S, Hong N, Kuroda S, Wu B, Ting K, Soo C   Nell-1 Induced Bone Regeneration in Calvarial Defects Am J Pathol, 2006; 169(3): 903-15.
Cowan, C. M. Cheng, S. Ting, K. Soo, C. Walder, B. Wu, B. Kuroda, S. Zhang, X. L.   Nell-1 induced bone formation within the distracted intermaxillary suture Bone, 2006; 38(1): 48-58.
Cowan, C. M. Cheng, S. Ting, K. Soo, C. Walder, B. Wu, B. Kuroda, S. Zhang, X.   Nell-1 induced bone formation within the distracted intermaxillary suture Bone, 2006; 38(1): 48-58.
Zhang X, Cowan K, Jiang X, Soo C, Miao S, Carpenter D, Wu, B, Kuroda K, and Ting K.   Nell-1 induces acrania-like cranioskeletal deformities during mouse embryonic development Lab Invest, 2006; 86(7): 633-44.
Kramerova, I. Kudryashova, E. Wu, B. Spencer, M. J.   Regulation of the M-cadherin-beta-catenin complex by calpain 3 during terminal stages of myogenic differentiation Molecular and Cellular Biology, 2006; 26(22): 8437-8447.
Chu Y. Wu BM. McCabe ER. Dunn JCY   Serum Free cultures of murine adrenal cortical cells. J. Pediatric Surgery, 2006; 41(12): 2008-2012.
Chang P.C.Y. Mendoza J. Park J. Lam MM. Wu BM. Atkinson JB. Dunn JCY.   Sustainability of mechanically lengthened bowel in rats J. Pediactric Surgery, 2006; 41(12): 2019-2022.
Ho, W. Tawil, B. Dunn, J. C. Y. Wu, B. M.   The behavior of human mesenchymal stem cells in 3D fibrin clots: Dependence on fibrinogen concentration and clot structure Tissue Engineering, 2006; 12(6): 1587-1595.
Dunn, JCY. Wu, BM   Tissue Engineering of Intestine, Encyclopedia of Biomaterials and Biomedical Engineering, 2006; 1-7.
Petrigliano FA., McAllister MD., Wu BM.   Tissue Engineering of the ACL: A Review of Current Strategies Arthroscopy, 2006; 22(4): 441-451.
Wu, B. Kitagawa, K. Liu, B. Zhang, N. Y. Xiong, Z. M. Inagaki, C.   Attenuation of amyloid beta (Abeta)-induced inhibition of phosphatidylinositol 4-kinase activity by Abeta fragments, Abeta20-29 and Abeta31-35 Neurosci Lett, 2006; 396(2): 148-52.
Wu, B. K. Li, C. C. Chen, H. J. Chang, J. L. Jeng, K. S. Chou, C. K. Hsu, M. T. Tsai, T. F.   Blocking of G1/S transition and cell death in the regenerating liver of Hepatitis B virus X protein transgenic mice Biochem Biophys Res Commun, 2006; 340(3): 916-28.
Wu, B. Liu, J.   Commutability between the semiclassical and adiabatic limits Phys Rev Lett, 2006; 96(2): 020405.
Chang, T. H. Wu, B. R. Chiang, M. Y. Liao, S. C. Ong, C. W. Hsu, H. F. Lin, S. Y.   Synthesis and mesomorphic behavior of a donor-acceptor-type hexaazatriphenylene Org Lett, 2005; 7(19): 4075-8.
Brown, D. A. Beygui, R. E. MacLellan, W. R. Laks, H. Dunn, J. C. Wu, B. M.   Modulation of gene expression in neonatal rat cardiomyocytes by surface modification of polylactide-co-glycolide substrates J Biomed Mater Res A, 2005; 74(3): 419-29.
Wu, B. T. Hung, P. F. Chen, H. C. Huang, R. N. Chang, H. H. Kao, Y. H.   The apoptotic effect of green tea (-)-epigallocatechin gallate on 3T3-L1 preadipocytes depends on the Cdk2 pathway J Agric Food Chem, 2005; 53(14): 5695-701.
Lee, M Dunn, JC Wu, BM   Scaffold fabrication by indirect three-dimensional printing Biomaterials. , 2005; 26(20): 4281-9.
Chou, Y.F., Wulur, I., Dunn, JCY., Wu, BM.   Biomimetic Nano-Ordered Apatites , Handbook of Nanostructured Biomaterials and Their Applications. edited by H. S. Nalwa,, 2005; 2(6): 198-222.
Cowan, C. M. Aalami, O. O. Shi, Y. Y. Chou, Y. F. Mari, C. Thomas, R. Quarto, N. Nacamuli, R. P. Contag, C. H. Wu, B. Longaker, M. T.   Bone morphogenetic protein 2 and retinoic acid accelerate in vivo bone formation, osteoclast recruitment, and bone turnover Tissue Eng, 2005; 11(3-4): 645-58.
Wu, B. Sun, Y. H. Wang, Y. W. Wang, Y. P. Zhu, Z. Y.   Characterization of transgene integration pattern in F4 hGH-transgenic common carp (Cyprinus carpio L.) Cell Res, 2005; 15(6): 447-54.
Yang CY. Brooks E. Li Y. Wong DTW. Denny P. Ho CM. Qi F. Shi W. Wolinsky L. Wu BM. Montemagno CD.   Detection of Picomolar levels of interleukin-8 in human saliva by SPR Lab on a Chip, 2005; 5(10): 1017-1023.
Wu, B. Gao, J. Wang, M. W.   Development of a complex scintillation proximity assay for high-throughput screening of PPARgamma modulators Acta Pharmacol Sin, 2005; 26(3): 339-44.
Cowan, CM Soo, C Ting, K Wu, B   Evolving concepts in bone tissue engineering Current topics in developmental biology, 2005; 66(86): 239-85.
Brown DA. Chou YF. Lam M. Beygui RE. Dunn JYC. Wu BM   Gelatin embedding cell-polymer constructs for frozen sections, J. Biomedical Materials Research, 2005; 72B: 79-85.
Chou YF. Dunn JCY. Wu BM   In vitro response of MC3T3-E1 preosteoblasts within three-dimensional apatite-coated PLGA scaffolds Journal of Biomedical Materials Research , 2005; 75(1): 81-90.
Wu, B. N. Tu, H. F. Welsh, D. G. Chen, I. J.   KMUP-1 activates BKCa channels in basilar artery myocytes via cyclic nucleotide-dependent protein kinases Br J Pharmacol, 2005; 146(6): 862-71.
Brown DA. Beygui RE. Antrobus S. Ross RS. MacLellan WR. Laks H. Dunn JYC. Wu BM.   Modulation of hypertrophy in neonatal rat cardiomyocytes by surface modification of synthetic substrates, J. Biomedical Materials Research, 2005; 74A(3): 419-429.
Wu, B. Wong, D. Lu, S. Dickstein, S. Silva, M. Gelety, T. J.   Optimal use of fresh and frozen-thawed testicular sperm for intracytoplasmic sperm injection in azoospermic patients J Assist Reprod Genet, 2005; 22(11-12): 389-94.
Jarrahy R., Huang W., Rudkin GH., Lee JM., Ishida K., Berry MD., Sukkarieh M., Wu BM., Yamaguchi DT., Miller TA.   Osteogenic differentiation is inhibited and angiogenic expression is enhanced in MC3T3-E1 cells cultured on three-dimensional scaffolds Am J Physiology – Cell Physiology, 2005; 289: 408-414.
Wu, B. Elmariah, S. Kaplan, F. S. Cheng, G. Mohler, E. R., 3rd   Paradoxical effects of statins on aortic valve myofibroblasts and osteoblasts: implications for end-stage valvular heart disease Arterioscler Thromb Vasc Biol, 2005; 25(3): 592-7.
Wu, B. Klatzky, R. L. Shelton, D. Stetten, G. D.   Psychophysical evaluation of in-situ ultrasound visualization IEEE Trans Vis Comput Graph, 2005; 11(6): 684-93.
Lee M. Dunn JCY. Wu BM.   Scaffold Fabrication by Indirect 3D Printing, Biomaterials, 2005; 26(20): 4281-4289.
Puk CK., Gamradt S., Wu B.M., McAllister D   The Effects of Short-Term Stimulation on Fibroblast Spreading in an Invitro 3D Syste J. Biomedical Materials Research , 2005; 76(4): 665-673.
Li Y, Denny P, Ho CM, Montemagno C, Shi W, Qi F, Wu B, Wolinsky L, Wong DT.   The Oral Fluid MEMS/ NEMS Chip (OFMNC): diagnostic and translational applications Advanced Dental Resesarch, 2005; 18(1): 3-5.
Chou, Y. F. Huang, W. Dunn, J. C. Miller, T. A. Wu, B. M.   The effect of biomimetic apatite structure on osteoblast viability, proliferation, and gene expression Biomaterials, 2005; 26(3): 285-95.
Wu, B. Muller, J. D.   Time-integrated fluorescence cumulant analysis in fluorescence fluctuation spectroscopy Biophys J, 2005; 89(4): 2721-35.
Wu, B. Zhang, G. Zhang, Y. Shuang, S. Choi, M. M.   Measurement of glucose concentrations in human plasma using a glucose biosensor Anal Biochem, 2005; 340(1): 181-3.
Brown, D. A. Chou, Y. F. Beygui, R. E. Dunn, J. C. Wu, B. M.   Gelatin-embedded cell-polymer constructs for histological cryosectioning J Biomed Mater Res B Appl Biomater, 2005; 72(1): 79-85.
Wu, B. Liu, Q. Sulikowski, G. A.   Total synthesis of apoptolidinone Angew Chem Int Ed Engl, 2004; 43(48): 6673-5.
Deng, Y. M. Wu, B. J. Witting, P. K. Stocker, R.   Probucol protects against smooth muscle cell proliferation by upregulating heme oxygenase-1 Circulation, 2004; 110(13): 1855-60.
Wu, B. T. Su, Y. H. Tsai, M. T. Wasserman, S. M. Topper, J. N. Yang, R. B.   A novel secreted, cell-surface glycoprotein containing multiple epidermal growth factor-like repeats and one CUB domain is highly expressed in primary osteoblasts and bones J Biol Chem, 2004; 279(36): 37485-90.
St. John M. Li Y. Zhou XF. DennyD. Ho CM. Montemagno C. Shi WY. Qi FX. Wu BM. Sinha U. Jordan R. Wolinsky L. Park NH. Abemayor E. Wong DTW   IL-6 and IL-8: Potential Biomarkers for Oral Cavity and Oropharyngeal SSC, Arch of Otolaryngology/Head & Neck Surgery , 2004; 130(8): 929-35.
Cowan, CM., Shi S., Alami, OO., Chou, YF., Thomas R. Marie C., Quarto N., Wu BM. Longaker MT.   Adipose-derived Mesenchymal Stromal Cells Tissue Engineer Bone in Critical Sized Mouse Calvarial Defects Nature Biotechnology, 2004; 22(5): 560-567.
Dunn, J. C. Chu, Y. Lam, M. M. Wu, B. M. Atkinson, J. B. McCabe, E. R.   Adrenal cortical cell transplantation J Pediatr Surg, 2004; 39(12): 1856-8.
Park J. Puapong DP. Wu BM. Atkinson JB. Dunn JCY   Enterogenesis by Mechanical Lengthening: Morphology and Function of the Lengthened Small Intestine J. Pediatric Surg, 2004; 39(12): 1823-1827.
Wu, B. N. Lin, R. J. Lo, Y. C. Shen, K. P. Wang, C. C. Lin, Y. T. Chen, I. J.   KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channels Br J Pharmacol, 2004; 142(7): 1105-14.
Kreth, J., Hagerman, E., Tam, K., Merritt, J., Wu, B.M., Myung, M., Shi, W., and Qi, F   Quantitative Analyses of Streptococcus mutans Biofilms with Quartz Crystal Microbalance, Microjet Impingement, and Confocal Microscopy Biofilms, 2004; 1(4): 277-284.
Chen, X. Grzegorczyk, T. M. Wu, B. I. Pacheco, J., Jr. Kong, J. A.   Robust method to retrieve the constitutive effective parameters of metamaterials Phys Rev E Stat Nonlin Soft Matter Phys, 2004; 70(1 Pt 2): 016608.
Yang, W. Wu, B. Asakura, S. Kohno, I. Matsuda, M.   Soluble fibrin augments spreading of fibroblasts by providing RGD sequences of fibrinogen in soluble fibrin Thromb Res, 2004; 114(4): 293-300.
Wu, B. M. Nakamura, M. Rezaee, M.   Stent implantation for coronary aneurysm with edge stenosis: angiographic and intravascular analysis J Invasive Cardiol, 2004; 16(3): 149-51.
Wu, B.   Testing three competing hypotheses for explaining lethal violence Violence Vict, 2004; 19(4): 399-411.
Chou YF. Chiou WA. Xu Y. Dunn JCY. Wu BM   The Effect of pH on Structural Evolution of Accelerated Biomimetic Apatite Formation Biomaterials, 2004; 25(22): 5323-5331.
Wu, B. Li, P. Liu, Y. Lou, Z. Ding, Y. Shu, C. Ye, S. Bartlam, M. Shen, B. Rao, Z.   3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex Proc Natl Acad Sci U S A, 2004; 101(22): 8348-53.
Liu, B. Hattori, N. Jiang, B. Nakayama, Y. Zhang, N. Y. Wu, B. Kitagawa, K. Taketo, M. Matsuda, H. Inagaki, C.   Single cell RT-PCR demonstrates differential expression of GABAC receptor rho subunits in rat hippocampal pyramidal and granule cells Brain Res Mol Brain Res, 2004; 123(1-2): 1-6.
He, Y. Yang, J. Wu, B. Robinson, D. Sprankle, K. Kung, P. P. Lowery, K. Mohan, V. Hofstadler, S. Swayze, E. E. Griffey, R.   Synthesis and evaluation of novel bacterial rRNA-binding benzimidazoles by mass spectrometry Bioorg Med Chem Lett, 2004; 14(3): 695-9.
De Ugarte DA. Choi E. Weitzbuch H. Wulur I. Caulkins C. Wu BM. Fonkalsrud EW. Atkinson JB. Dunn JCY   Mucosal regeneration of a duodenal defect using small intestine submucosa The American Surgeon, 2004; 70(1): 49-51.
Wu, B. Yang, J. Robinson, D. Hofstadler, S. Griffey, R. Swayze, E. E. He, Y.   Synthesis of linked carbohydrates and evaluation of their binding for 16S RNA by mass spectrometry Bioorg Med Chem Lett, 2003; 13(22): 3915-8.
Wu, B. Abbott, T. Fishman, D. McMurray, W. Mor, G. Stone, K. Ward, D. Williams, K. Zhao, H.   Comparison of statistical methods for classification of ovarian cancer using mass spectrometry data Bioinformatics, 2003; 19(13): 1636-43.
Qin, W. Tyshenko, M. G. Wu, B. S. Walker, V. K. Robertson, R. M.   Cloning and characterization of a member of the Hsp70 gene family from Locusta migratoria, a highly thermotolerant insect Cell Stress Chaperones, 2003; 8(2): 144-52.
Sukotjo C. Lin A. Song KK. Ogawa I. Wu BM. Nishimura I   Oral fibroblast expression of wound inducible transcript-3.0 (wit-3.0) accelerates collagen gel contraction in vitro J. Biological Chemistry, 2003; 278(51): 51527-51534.
Zhang X. Carpenter D. Bokui N. Soo C. MiaoS. Truong T. Wu BM. Chen I. Vastardis H. Tanizawa K. Kuroda S. Ting K.   Overexpression of Nell-1, a craniosynostosis associated gene, induces apoptosis in osteoblasts during craniofacial development Journal of Bone and Mineral Research , 2003; 18(12): 2126-2134.
Nishimura I. Garrell R. Hedrick M. Iida K. Osher S. Wu BM   Precursor tissue analogs as a tissue-engineering strategy Tissue Engineering, 2003; 9(1): 77-89.
Hong, B. Wu, B. Li, Y.   Production of C-terminal amidated recombinant salmon calcitonin in Streptomyces lividans Appl Biochem Biotechnol, 2003; 110(2): 113-23.
Wu, B. Yee, A. Pineda-Lucena, A. Semesi, A. Ramelot, T. A. Cort, J. R. Jung, J. W. Edwards, A. Lee, W. Kennedy, M. Arrowsmith, C. H.   Solution structure of ribosomal protein S28E from Methanobacterium thermoautotrophicum Protein Sci, 2003; 12(12): 2831-7.
Drachman, D. B. Wu, J. M. Miagkov, A. Williams, M. A. Adams, R. N. Wu, B.   Specific immunotherapy of experimental myasthenia by genetically engineered APCs: the “guided missile” strategy Ann N Y Acad Sci, 2003; 998: 520-32.
Chen, J. Guo, J. Sun, J. Jiang, W. Wu, B.   TCM treatment of Parkinson’s syndrome–a report of 40 cases J Tradit Chin Med, 2003; 23(3): 168-9.
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