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David Glanzman, Ph.D.

Publications

A selected list of publications:

Roberts Adam C, Bill Brent R, Glanzman David L   Learning and memory in zebrafish larvae Frontiers in neural circuits, 2013; 7: 126.
Glanzman David L   PKM and the maintenance of memory F1000 biology reports, 2013; 5: 4.
Glanzman David L   David L. Glanzman Current biology : CB, 2012; 22(21): R895-7.
Cai Diancai, Pearce Kaycey, Chen Shanping, Glanzman David L   Reconsolidation of long-term memory in Aplysia Current biology : CB, 2012; 22(19): 1783-8.
Glanzman David L   Behavioral neuroscience: no easy path from genes to cognition Current biology : CB, 2012; 22(9): R302-4.
Glanzman David L   Olfactory habituation: fresh insights from flies Proceedings of the National Academy of Sciences of the United States of America, 2011; 108(36): 14711-2.
Cai Diancai, Pearce Kaycey, Chen Shanping, Glanzman David L   Protein kinase M maintains long-term sensitization and long-term facilitation in aplysia The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011; 31(17): 6421-31.
Roberts Adam C, Reichl Jun, Song Monica Y, Dearinger Amanda D, Moridzadeh Naseem, Lu Elaine D, Pearce Kaycey, Esdin Joseph, Glanzman David L   Habituation of the C-start response in larval zebrafish exhibits several distinct phases and sensitivity to NMDA receptor blockade PloS one, 2011; 6(12): e29132.
Issa Fadi A, O’Brien Georgeann, Kettunen Petronella, Sagasti Alvaro, Glanzman David L, Papazian Diane M   Neural circuit activity in freely behaving zebrafish (Danio rerio) The Journal of experimental biology, 2011; 214(Pt 6): 1028-38.
Glanzman David L   Common mechanisms of synaptic plasticity in vertebrates and invertebrates Current biology : CB, 2010; 20(1): R31-6.
Glanzman David L   Ion pumps get more glamorous Nature neuroscience, 2010; 13(1): 4-5.
Esdin Joseph, Pearce Kaycey, Glanzman David L   Long-term habituation of the gill-withdrawal reflex in aplysia requires gene transcription, calcineurin and L-type voltage-gated calcium channels Frontiers in behavioral neuroscience, 2010; 4(1): 181.
Glanzman David L   Habituation in Aplysia: the Cheshire cat of neurobiology Neurobiology of learning and memory, 2009; 92(2): 147-54.
Villareal Greg, Li Quan, Cai Diancai, Fink Ann E, Lim Travis, Bougie Joanna K, Sossin Wayne S, Glanzman David L   Role of protein kinase C in the induction and maintenance of serotonin-dependent enhancement of the glutamate response in isolated siphon motor neurons of Aplysia californica The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009; 29(16): 5100-7.
Fulton Daniel, Condro Michael C, Pearce Kaycey, Glanzman David L   The potential role of postsynaptic phospholipase C activity in synaptic facilitation and behavioral sensitization in Aplysia Journal of neurophysiology, 2008; 100(1): 108-16.
Glanzman DL   New tricks for an old slug: The critical role of postsynaptic mechanisms in learning and memory in Aplysia, Prog. Brain Res, 2008; 169C: 277-292.
Glanzman David L   New tricks for an old slug: the critical role of postsynaptic mechanisms in learning and memory in Aplysia Progress in brain research, 2008; 169(12): 277-92.
Glanzman David L   Octopus conditioning: a multi-armed approach to the LTP–learning question Current biology : CB, 2008; 18(12): R527-30.
Cai Diancai, Chen Shanping, Glanzman David L   Postsynaptic regulation of long-term facilitation in Aplysia Current biology : CB, 2008; 18(12): 920-5.
Villareal Greg, Li Quan, Cai Diancai, Glanzman David L   The role of rapid, local, postsynaptic protein synthesis in learning-related synaptic facilitation in aplysia Current biology : CB, 2007; 17(23): 2073-80.
Jami SA, Wright WG, Glanzman DL.   Differential classical conditioning of the gill-withdrawal reflex in Aplysia recruits both NMDA receptor-dependent enhancement and NMDA receptor-dependent depression of the reflex, J Neurosci, 2007; 27(12): 3064-8.
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Glanzman, D. L   Simple minds: the neurobiology of invertebrate learning and memory, Invertebrate Neurobiology, 2007; 347-380.
Villareal G, Li Q, Cai D, Glanzman DL   The role of rapid, local, postsynaptic protein synthesis in learning-related synaptic facilitation in Aplysia, Curr. Biol, 2007; 17(23): 2073-2080.
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Jami Shekib A, Wright William G, Glanzman David L   Differential classical conditioning of the gill-withdrawal reflex in Aplysia recruits both NMDA receptor-dependent enhancement and NMDA receptor-dependent depression of the reflex The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007; 27(12): 3064-8.
Glanzman DL.   The cellular mechanisms of learning in Aplysia: of blind men and elephants, Biol Bull, 2006; 210(3): 271-9.
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Glanzman David L   The cellular mechanisms of learning in Aplysia: of blind men and elephants The Biological bulletin, 2006; 210(3): 271-9.
Li Q, Roberts AC, Glanzman DL.   Synaptic facilitation and behavioral dishabituation in Aplysia: dependence on release of Ca2+ from postsynaptic intracellular stores, postsynaptic exocytosis, and modulation of postsynaptic AMPA receptor efficacy, J Neurosci, 2005; 25(23): 5623-37.
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Li Quan, Roberts Adam C, Glanzman David L   Synaptic facilitation and behavioral dishabituation in Aplysia: dependence on release of Ca2+ from postsynaptic intracellular stores, postsynaptic exocytosis, and modulation of postsynaptic AMPA receptor efficacy The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005; 25(23): 5623-37.
Roberts AC, Glanzman DL.   Learning in Aplysia: looking at synaptic plasticity from both sides, Trends Neurosci, 2003; 26(12): 662-70.
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Ezzeddine Y, Glanzman DL.   Prolonged habituation of the gill-withdrawal reflex in Aplysia depends on protein synthesis, protein phosphatase activity, and postsynaptic glutamate receptors, J Neurosci, 2003; 23(29): 9585-94.
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Chitwood RA, Li Q, Glanzman DL.   Serotonin facilitates AMPA-type reponses in isolated siphon motor neurons of Aplysia in culture, J Physiol, 2001; 534(Pt 2): 501-10.
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Murphy GG, Glanzman DL.   Cellular analog of differential classical conditioning in Aplysia: disruption by the NMDA receptor antagonist DL-2-amino-5-phosphonovalerate, J Neurosci, 1999; 19(23): 10595-602.
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Mark A. Frye, Ph.D.

Mark Frye, Ph.D.

Publications

A selected list of publications:

Mongeau Jean-Michel, Frye Mark A   Drosophila Spatiotemporally Integrates Visual Signals to Control Saccades Current biology : CB, 2017; 27(19): 2901-2914.e2.
Frye Mark A   Insect Vision: A Neuron that Anticipates an Object’s Path Current biology : CB, 2017; 27(19): R1076-R1078.
Omoto Jaison Jiro, Keleş Mehmet Fatih, Nguyen Bao-Chau Minh, Bolanos Cheyenne, Lovick Jennifer Kelly, Frye Mark Arthur, Hartenstein Volker   Visual Input to the Drosophila Central Complex by Developmentally and Functionally Distinct Neuronal Populations Current biology : CB, 2017; 27(8): 1098-1110.
Keleş Mehmet F, Frye Mark A   Object-Detecting Neurons in Drosophila Current biology : CB, 2017; 27(5): 680-687.
Keleş Mehmet, Frye Mark A   The eyes have it eLife, 2017; 6(Pt A): 204-213.
Wasserman Sara M, Frye Mark A   Group behavior: social context modulates behavioral responses to sensory stimuli Current biology : CB, 2015; 25(11): R467-9.
Aptekar Jacob W, Keleş Mehmet F, Lu Patrick M, Zolotova Nadezhda M, Frye Mark A   Neurons forming optic glomeruli compute figure-ground discriminations in Drosophila The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015; 35(19): 7587-99.
Frye Mark   Elementary motion detectors Current biology : CB, 2015; 25(6): R215-R217.
Wasserman Sara M, Aptekar Jacob W, Lu Patrick, Nguyen Jade, Wang Austin L, Keles Mehmet F, Grygoruk Anna, Krantz David E, Larsen Camilla, Frye Mark A   Olfactory neuromodulation of motion vision circuitry in Drosophila Current biology : CB, 2015; 25(4): 467-72.
Aptekar Jacob W, Keles Mehmet F, Mongeau Jean-Michel, Lu Patrick M, Frye Mark A, Shoemaker Patrick A   Method and software for using m-sequences to characterize parallel components of higher-order visual tracking behavior in Drosophila Frontiers in neural circuits, 2014; 8(11): 130.
Theobald, JC Frye, MA   Animal Behavior: flying back-to-front, Curr. Biol. , 2008; 18(4): r169.
Chow DM Frye MA   Context dependent olfactory enhanced optomotor flight control in Drosophila, J. Exp. Biol. , 2008; 211: 2478-2485.
Duistermars, BJ Frye, MA   Cross-modal visual input for odor tracking during fly flight, Curr. Biol. , 2008; 18(4): 270-275.
Theobald JC Duistermars BJ Ringach DL Frye MA   Flies see second order motion, Curr. Biol. , 2008; 18(11): r464.
Reynolds, A. Frye, M.A.   Free-flight odor tracking in Drosophila is consistent with a mathematically optimal intermittent scale-free search, PLoS ONE, 2007; 2(4): 354.
Frye, MA   The neuromechanics of fly flight control, Invertebrate Neurobiology, 2007; 209-229.
Duistermars, BJ Chow, D Condro, M Frye, MA   The spatial, temporal, and contrast properties of expansion and rotation flight optomotor responses in Drosophila, J. Exp. Biol. , 2007; 210: 3218-3227.
Frye, MA Dickinson, MH   Visual edge orientation shapes free-flight behavior in Drosophila, Fly, 2007; 3: 153-154.
Humbert, J.S. Frye, M.A.   Extracting behaviorally relevant retinal image motion cues via wide-field integration, Proc. IEEE American Controls Conference, 2006; 2724-2729.
Frye, MA Dickinson, MH   Closing the loop between neurobiology and flight behavior in Drosophila Current opinion in neurobiology. , 2004; 14(6): 729-36.
Frye, MA Dickinson, MH   Fly flight: a model for the neural control of complex behavior Neuron. , 2001; 32(3): 385-8.
Fernando Gómez-Pinilla, Ph.D.

Fernando Gómez-Pinilla, Ph.D.

Biography

Mechanisms of Neural Repair Role of Trophic Factors on Activity-dependent Plasticity We are interested on the mechanisms by which environmental factors affect neuronal health. We have found that trophic factors endogenous to the brain and spinal cord can be induced by the practice of select behaviors. We have recently reported that physical activity, learning, and nutritional factors control neurotrophins in the brain. These findings opened the exciting possibility that regulation of trophic factors by behavior can be a pivotal mechanism by which specific experiences can impact the structure and function of the CNS. It may account for the improvement of CNS function after trauma provided by rehabilitative therapies. On the contrary, it may explain the decay in function in aging or degenerative diseases following a lack of stimulation. These two avenues provide direction for my research program: 1) How trophic factors induced by activity can help functional recovery following brain and spinal cord trauma. We are using several exercise models to boost the production of trophic factors in the brain and spinal cord. Our goal is to provide critical information to guide the design of behavioral therapies for the reduction of the severity of insult or disease, and to increase CNS function. 2) We are evaluating the effects of lifestyle on trophic factor production, with resulting effects on circuit remodeling, synaptic function, and cognition. We believe that changes in trophic factor as a result of select experiences can affect neuronal health with profound consequences for cognitive function.

Elaine Hsiao, Ph.D.

Biography

Elaine is an Assistant Professor at UCLA, where she is interested in all things microbial, neural and immune. She completed her B.S. in Microbiology, Immunology and Molecular Genetics at UCLA, which sparked her love for molecular biology and bacteria. She went on to complete her Ph.D. in Neurobiology at Caltech, where she studied the neurobiological bases of autism and schizophrenia, with a focus on maternal effects on fetal development, and neuroimmune and microbial contributions to behavioral disorders. Inspired by the amazing and complex interactions between body systems, the Hsiao laboratory is investigating how “peripheral” changes in the immune system and resident microbiota impact the nervous system.

 

Publications

A selected list of publications:

Hsiao Elaine Y   Gastrointestinal issues in autism spectrum disorder Harvard review of psychiatry, 2015; 22(2): 104-11.
Yano Jessica M, Yu Kristie, Donaldson Gregory P, Shastri Gauri G, Ann Phoebe, Ma Liang, Nagler Cathryn R, Ismagilov Rustem F, Mazmanian Sarkis K, Hsiao Elaine Y   Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis Cell, 2015; 161(2): 264-76.
Hsiao Elaine Y, McBride Sara W, Hsien Sophia, Sharon Gil, Hyde Embriette R, McCue Tyler, Codelli Julian A, Chow Janet, Reisman Sarah E, Petrosino Joseph F, Patterson Paul H, Mazmanian Sarkis K   Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders Cell, 2013; 155(7): 1451-63.
Hsiao Elaine Y   Immune dysregulation in autism spectrum disorder International review of neurobiology, 2013; 113(7): 269-302.
Garay Paula A, Hsiao Elaine Y, Patterson Paul H, McAllister A K   Maternal immune activation causes age- and region-specific changes in brain cytokines in offspring throughout development Brain, behavior, and immunity, 2013; 31(7): 54-68.
Hsiao Elaine Y, Patterson Paul H   Placental regulation of maternal-fetal interactions and brain development Developmental neurobiology, 2012; 72(10): 1317-26.
Hsiao Elaine Y, McBride Sara W, Chow Janet, Mazmanian Sarkis K, Patterson Paul H   Modeling an autism risk factor in mice leads to permanent immune dysregulation Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(31): 12776-81.
Malkova Natalia V, Yu Collin Z, Hsiao Elaine Y, Moore Marlyn J, Patterson Paul H   Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism Brain, behavior, and immunity, 2012; 26(4): 607-16.
Hsiao Elaine Y, Patterson Paul H   Activation of the maternal immune system induces endocrine changes in the placenta via IL-6 Brain, behavior, and immunity, 2011; 25(4): 604-15.
Ito Hiroshi T, Smith Stephen E P, Hsiao Elaine, Patterson Paul H   Maternal immune activation alters nonspatial information processing in the hippocampus of the adult offspring Brain, behavior, and immunity, 2010; 24(6): 930-41.
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