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Jessica Rexach, M.D., Ph.D.

Jessica Rexach, M.D., Ph.D.

Faculty Member

Assistant Professor
Department of Neurology
David Geffen School of Medicine
University of California, Los Angeles

 

UCLA Neurology
P.O. Box 951769, GONDA 2309
Los Angeles, CA 90095-1769

 

Research Interests

New therapeutic targets are needed for neurodegenerative disease including Alzheimer’s and related dementias. The immune system includes many of the most successful therapeutic targets in medicine. My research lab seeks to uncover mechanism by which glia and immune factors influence disease pathology in dementia to inform novel therapeutic strategies. We integrate single cell and tissue transcriptomics, epigenetic profiling, human genetics, and stem cell-based experimental models to identify neuroimmune regulators of dementia. A major focus of our current work is the interplay of glial immune signaling and neuronal dysfunction in dementia, including the role of interferon-mediated immune suppression in disease pathology.

In addition to this basic research, I am an attending at the UCLA Neurogenetics clinic where we apply advanced genomics technologies to the molecular diagnosis of adult-onset genetic diseases, including inherited neurodegenerative disorders.

Pavak K. Shah

Pavak Shah, Ph.D.

Faculty Member

Assistant Professor
Department of Molecular, Cell, & Developmental Biology
College of Life Sciences
University of California, Los Angeles

 

 

Catherine Cahill, Ph.D.

Catherine Cahill, M.Sc., Ph.D.

Faculty Member

Biography

Catherine M. Cahill, Ph.D. trained as an opioid neuropharmaoclogist at Dalhousie University, Canada receiving her PhD in 1996. She was recruited to the Department of Anesthesiology and Perioperative Care at University of California Irvine in 2012 from Queen’s University in Canada where she held a Canada Research Chair in Chronic Pain for 10 years. She moved to UCLA in 2017 and is now a Professor in the Department of Psychiatry & Biobehavioral Sciences and a member of the Hatos Center for Neuropharmacology at the University of California Los Angeles.

She has more than 25 years experience in research that focuses on understanding mechanisms of chronic pain and opioid analgesia, tolerance, dependence and addiction. Her research spans both basic science and human research, which focuses on how chronic pain states modulate reward circuitry and changes dopaminergic transmission responsible for motivated behavior. A large emphasis of her research focuses on understanding the processes that influence the positive and negative reinforcement and changes in mesolimbic circuitry in order to identify novel treatment strategies for opioid dependence and chronic pain.

Dr. Cahill’s research is supported by the National Institutes of Drug abuse, the National Center for Advancing Translational Sciences, the National Institute of Aging, the National Institute of Dental and Craniofacial Research, the Department of Defense and the Shirley and Stefan Hatos Foundation.

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