Faculty Member
Assistant Professor
Department of Neurology
David Geffen School of Medicine
University of California, Los Angeles
UCLA Neurology
P.O. Box 951769, GONDA 2309
Los Angeles, CA 90095-1769
Research Interests
New therapeutic targets are needed for neurodegenerative disease including Alzheimer’s and related dementias. The immune system includes many of the most successful therapeutic targets in medicine. My research lab seeks to uncover mechanism by which glia and immune factors influence disease pathology in dementia to inform novel therapeutic strategies. We integrate single cell and tissue transcriptomics, epigenetic profiling, human genetics, and stem cell-based experimental models to identify neuroimmune regulators of dementia. A major focus of our current work is the interplay of glial immune signaling and neuronal dysfunction in dementia, including the role of interferon-mediated immune suppression in disease pathology.
In addition to this basic research, I am an attending at the UCLA Neurogenetics clinic where we apply advanced genomics technologies to the molecular diagnosis of adult-onset genetic diseases, including inherited neurodegenerative disorders.
