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Andrew M. Wikenheiser, Ph.D.

Andrew Wikenheiser, Ph.D.

Biography

Our lab studies how neural representations support behaviors like decision making. We approach this question by recording the electrical activity of neurons as rats perform behavioral tasks. Electrophysiological techniques are augmented with optogenetics and computational analyses. Current projects are exploring how interactions between the hippocampus and the orbitofrontal cortex support decision making, the encoding of spatial goals, and the formation of neural representations for abstract stimulus spaces.

Publications

A selected list of publications:

Wikenheiser Andrew M, Marrero-Garcia Yasmin, Schoenbaum Geoffrey   Suppression of Ventral Hippocampal Output Impairs Integrated Orbitofrontal Encoding of Task Structure Neuron, 2017; 95(5): 1197-1207.e3.
Langdon Angela J, Wikenheiser Andrew M, Schoenbaum Geoffrey   Rat mPFC and M2 Play a Waiting Game (at Different Timescales) Neuron, 2017; 94(4): 700-702.
Sadacca Brian F, Wikenheiser Andrew M, Schoenbaum Geoffrey   Toward a theoretical role for tonic norepinephrine in the orbitofrontal cortex in facilitating flexible learning Neuroscience, 2017; 345(4): 124-129.
Wikenheiser Andrew M, Schoenbaum Geoffrey   Over the river, through the woods: cognitive maps in the hippocampus and orbitofrontal cortex Nature reviews. Neuroscience, 2016; 17(8): 513-23.
Sharpe Melissa J, Wikenheiser Andrew M, Niv Yael, Schoenbaum Geoffrey   The State of the Orbitofrontal Cortex Neuron, 2015; 88(6): 1075-1077.
Wikenheiser Andrew M, Redish A David   Decoding the cognitive map: ensemble hippocampal sequences and decision making Current opinion in neurobiology, 2015; 32(6): 8-15.
Wikenheiser Andrew M, Redish A David   Hippocampal theta sequences reflect current goals Nature neuroscience, 2015; 18(2): 289-94.
Wikenheiser Andrew M, Stephens David W, Redish A David   Subjective costs drive overly patient foraging strategies in rats on an intertemporal foraging task Proceedings of the National Academy of Sciences of the United States of America, 2013; 110(20): 8308-13.
Wikenheiser Andrew M, Redish A David   The balance of forward and backward hippocampal sequences shifts across behavioral states Hippocampus, 2013; 23(1): 22-9.
Wikenheiser Andrew M, Redish A David   Hippocampal sequences link past, present, and future Trends in cognitive sciences, 2012; 16(7): 361-2.
Wikenheiser Andrew M, Redish A David   Changes in reward contingency modulate the trial-to-trial variability of hippocampal place cells Journal of neurophysiology, 2011; 106(2): 589-98.
Catherine Cahill, Ph.D.

Catherine Cahill, M.Sc., Ph.D.

Biography

Catherine M. Cahill, Ph.D. trained as an opioid neuropharmaoclogist at Dalhousie University, Canada receiving her PhD in 1996. She was recruited to the Department of Anesthesiology and Perioperative Care at University of California Irvine in 2012 from Queen’s University in Canada where she held a Canada Research Chair in Chronic Pain for 10 years. She moved to UCLA in 2017 and is now a Professor in the Department of Psychiatry & Biobehavioral Sciences and a member of the Hatos Center for Neuropharmacology at the University of California Los Angeles.

She has more than 25 years experience in research that focuses on understanding mechanisms of chronic pain and opioid analgesia, tolerance, dependence and addiction. Her research spans both basic science and human research, which focuses on how chronic pain states modulate reward circuitry and changes dopaminergic transmission responsible for motivated behavior. A large emphasis of her research focuses on understanding the processes that influence the positive and negative reinforcement and changes in mesolimbic circuitry in order to identify novel treatment strategies for opioid dependence and chronic pain.

Dr. Cahill’s research is supported by the National Institutes of Drug abuse, the National Center for Advancing Translational Sciences, the National Institute of Aging, the National Institute of Dental and Craniofacial Research, the Department of Defense and the Shirley and Stefan Hatos Foundation.

Ranmal Samarasignhe, Ph.D.

Ranmal Samarasignhe, M.D., Ph.D.

Biography

Dr. Ranmal Samarasinghe received his MD and PhD degrees from the University of Pittsburgh in 2013. He completed his residency in adult neurology at UCLA in 2017 and then completed an NIH funded post-doctoral research and clinical fellowship at UCLA from 2017-2020. During this period, Dr. Samarasinghe obtained clinical training in epilepsy and neurophysiologic intraoperative monitoring. He also performed research developing stem cell-based models of epilepsy and autism, which is the foundation of his own laboratory.

Dr. Samarasinghe’s laboratory seeks to understand the mechanisms of neural network formation and dysfunction in epilepsy and autism. His efforts are focused on 3D brain-like structures called human brain organoids that are grown in a laboratory dish and that are derived from stem cells. Brain organoids can be generated from the stem cells of individual patients and may provide unique insights into the causes of human neurological diseases such as epilepsy and autism. His laboratory is developing and utilizing multiple methodologies including whole-organoid multiphoton based calcium indicator imaging, voltage sensors, traditional extracellular recordings, high throughput genomic screens, and super-resolution synaptic imaging to interrogate the developmental trajectory of nascent neural networks in organoid models. Dr. Samarasinghe will also continue to manage patients with epilepsy and autism in his clinic and perform neurophysiologic intraoperative monitoring for surgical cases performed at UCLA and affiliated hospitals.

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