Dr. Crosbie-Watson has pioneered work on the function of sarcospan within the dystrophin-glycoprotein complex. Introduction of sarcospan into dystrophin-deficient mice ameliorates muscular dystrophy in a me. The Crosbie lab has generated all the molecular tools and reagents for the study of sarcospan, which are not available elsewhere. Building on expertise in sarcospan and the dystrophin-glycoprotein complex, the Crosbie lab is collaborating with the Baum lab in development of HTS assays to detect alteration in sarcospan expression as a therapy for Duchenne Muscular Dystrophy. Dr. Crosbie has also collaborated with the Spencer group at UCLA to develop and characterize novel methodologies for creating mouse models of muscle disease. In addition to her research, Dr. Crosbie is a dedicated educator. She has trained several HHMI, Beckman, and Dean’s undergraduate and graduate scholars. She successfully mentored a successful recipient of the prestigious Marshall Scholarship. This student was one of only thirteen students to be awarded the Marshall in UCLA?s history. Based on her excellence in classroom instruction, Dr. Crosbie was nominated for a Teaching Distinction Award at UCLA and she is Faculty Director of the Beckman Undergraduate Scholars Program.
A selected list of publications:
Christopher S. Colwell is a Neuroscientist who has served on the UCLA School of Medicine faculty since he joined the Department of Psychiatry and Biobehavioral Sciences in 1997. He became a Professor in 2008. Dr. Colwell earned his B.S. in Neuroscience from Vanderbilt University in 1985. During this time, he started his research in circadian rhythms under the mentorship of Dr. T. Page. Dr. Colwell earned his Ph.D. in Biology at the University of Virginia in 1991. His thesis work explored the neural mechanisms by which light regulates circadian rhythms. Dr. Colwell continued this line of research during a postdoctoral fellowship at the University of Virginia with Dr. G. Block. A second postdoctoral fellowship was carried out on the topics of motor control and excitotoxicity in the laboratory of Dr. M. Levine at UCLA. Dr. Colwell learned how to utilize imaging techniques to measure calcium levels inside neurons while a visiting scientist in the laboratory of Dr. Konnerth at the University of Saarland, Germany. Since Dr. Colwell’s faculty appointment at UCLA, his laboratory’s research has focused on understanding the mechanisms underlying circadian rhythms in mammals. Dysfunction in the timing these daily cycles is a key symptom in a number of neurological and psychiatric disorders. Better understanding the basic biology of this timing system should result in new therapies to improve the quality of life of these patients and the people who care for them.
Denson G. Fujikawa is a neurologist and neuroscientist who has been a member of the UCLA faculty since he joined the Department of Neurology in as a clinical instructor in 1981. Dr. Fujikawa is at the Sepulveda VA Ambulatory Care Center. He became an Adjunct Professor in 1996, and has been a Staff Neurologist at Sepulveda since 1983. Dr. Fujikawa earned his A.B. degree magna cum laude in psychology at Harvard University, and his M.D. degree at the University of Southern California School of Medicine. He did two years of general surgery residency at Columbia-Presbyterian Medical Center in New York, two years of of neurosurgery residency at UCLA Medical Center, then switched to neurology, completing his residency at Harbor-UCLA Medical Center in 1981. He then spent two years as a research fellow in Dr. Claude Wasterlain’s Epilepsy Research Laboratory at Sepulveda. He spends half his time in clinical neurology, training UCLA neurology residents, with a subspecialty interest in epilepsy, and half his time doing basic research on in vivo mechanisms of naturally occurring apoptotic and pathologically induced necrotic neuronal death.