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David S. Williams, Ph.D.

David Williams, Ph.D.

Publications

A selected list of publications:

Esteve-Rudd Julian, Hazim Roni A, Diemer Tanja, Paniagua Antonio E, Volland Stefanie, Umapathy Ankita, Williams David S   Defective phagosome motility and degradation in cell nonautonomous RPE pathogenesis of a dominant macular degeneration Proceedings of the National Academy of Sciences of the United States of America, 2018; 115(21): 5468-5473.
Hazim Roni A, Williams David S   Cell Culture Analysis of the Phagocytosis of Photoreceptor Outer Segments by Primary Mouse RPE Cells Methods in molecular biology (Clifton, N.J.), 2018; 1753(3): 63-71.
Volland Stefanie, Williams David S   Preservation of Photoreceptor Nanostructure for Electron Tomography Using Transcardiac Perfusion Followed by High-Pressure Freezing and Freeze-Substitution Advances in experimental medicine and biology, 2018; 1074(3): 603-607.
Hazim Roni A, Karumbayaram Saravanan, Jiang Mei, Dimashkie Anupama, Lopes Vanda S, Li Douran, Burgess Barry L, Vijayaraj Preethi, Alva-Ornelas Jackelyn A, Zack Jerome A, Kohn Donald B, Gomperts Brigitte N, Pyle April D, Lowry William E, Williams David S   Differentiation of RPE cells from integration-free iPS cells and their cell biological characterization Stem cell research & therapy, 2017; 8(1): 217.
Galloway Chad A, Dalvi Sonal, Hung Sandy S C, MacDonald Leslie A, Latchney Lisa R, Wong Raymond C B, Guymer Robyn H, Mackey David A, Williams David S, Chung Mina M, Gamm David M, Pébay Alice, Hewitt Alex W, Singh Ruchira   Drusen in patient-derived hiPSC-RPE models of macular dystrophies Proceedings of the National Academy of Sciences of the United States of America, 2017; 114(39): E8214-E8223.
Goldberg Andrew F X, Moritz Orson L, Williams David S   Molecular basis for photoreceptor outer segment architecture Progress in retinal and eye research, 2016; 55(1): 52-81.
Hazim Roni, Jiang Mei, Esteve-Rudd Julian, Diemer Tanja, Lopes Vanda S, Williams David S   Live-Cell Imaging of Phagosome Motility in Primary Mouse RPE Cells Advances in experimental medicine and biology, 2016; 854(30): 751-5.
Volland Stefanie, Hughes Louise C, Kong Christina, Burgess Barry L, Linberg Kenneth A, Luna Gabriel, Zhou Z Hong, Fisher Steven K, Williams David S   Three-dimensional organization of nascent rod outer segment disk membranes Proceedings of the National Academy of Sciences of the United States of America, 2015; 112(48): 14870-5.
Jiang Mei, Esteve-Rudd Julian, Lopes Vanda S, Diemer Tanja, Lillo Concepción, Rump Agrani, Williams David S   Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis The Journal of cell biology, 2015; 210(4): 595-611.
Volland Stefanie, Esteve-Rudd Julian, Hoo Juyea, Yee Claudine, Williams David S   A comparison of some organizational characteristics of the mouse central retina and the human macula PloS one, 2015; 10(4): e0125631.
Eblimit Aiden, Nguyen Thanh-Minh T, Chen Yiyun, Esteve-Rudd Julian, Zhong Hua, Letteboer Stef, Van Reeuwijk Jeroen, Simons David L, Ding Qian, Wu Ka Man, Li Yumei, Van Beersum Sylvia, Moayedi Yalda, Xu Huidan, Pickard Patrick, Wang Keqing, Gan Lin, Wu Samuel M, Williams David S, Mardon Graeme, Roepman Ronald, Chen Rui   Spata7 is a retinal ciliopathy gene critical for correct RPGRIP1 localization and protein trafficking in the retina Human molecular genetics, 2015; 24(6): 1584-601.
Lopes Vanda S, Williams David S   Gene Therapy for the Retinal Degeneration of Usher Syndrome Caused by Mutations in MYO7A Cold Spring Harbor perspectives in medicine, 2015; 5(6): 1584-601.
Frost Laura S, Lopes Vanda S, Bragin Alvina, Reyes-Reveles Juan, Brancato Jennifer, Cohen Art, Mitchell Claire H, Williams David S, Boesze-Battaglia Kathleen   The Contribution of Melanoregulin to Microtubule-Associated Protein 1 Light Chain 3 (LC3) Associated Phagocytosis in Retinal Pigment Epithelium Molecular neurobiology, 2014; .
Crouse Jacquelin A, Lopes Vanda S, Sanagustin Jovenal T, Keady Brian T, Williams David S, Pazour Gregory J   Distinct functions for IFT140 and IFT20 in opsin transport Cytoskeleton (Hoboken, N.J.), 2014; 71(5): 302-10.
Almenar-Queralt Angels, Falzone Tomas L, Shen Zhouxin, Lillo Concepcion, Killian Rhiannon L, Arreola Angela S, Niederst Emily D, Ng Kheng S, Kim Sonia N, Briggs Steven P, Williams David S, Goldstein Lawrence S B   UV irradiation accelerates amyloid precursor protein (APP) processing and disrupts APP axonal transport The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014; 34(9): 3320-39.
Lopes VS, Boye SE, Louie CM, Boye S, Dyka F, Chiodo V, Fofo H, Hauswirth WW, Williams DS   Retinal gene therapy with a large MYO7A cDNA using Adeno-associated virus Gene Therapy, 2013; .
Harkewicz R, Du H, Tong Z, Alkuraya H, Bedell M, Sun W, Wang X, Hsu YH, Esteve-Rudd J, Hughes G, Su Z, Zhang M, Lopes VS, Molday RS, Williams DS, Dennis EA, Zhang K   Essential role of ELOVL4 in very long chain fatty acid synthesis and retinal function Journal of Biological Chemistry , 2012; 287: 11469-11480.
Engelhardt M, Tosha C, Lopes VS, Chen B, Nguyen L, Nusinowitz S, Williams DS   Functional and morphological analysis of the subretinal injection of RPE cells Visual Neuroscience, 2012; 29: 83-93.
Trivedi D, Colin E, Louie CM, Williams DS   Live-cell imaging evidence for the ciliary transport of rod photoreceptor opsin by heterotrimeric kinesin-2 Journal of Neuroscience, 2012; 32: 10587-10593.
Da Cruz Sandrine, Parone Philippe A, Lopes Vanda S, Lillo Concepción, McAlonis-Downes Melissa, Lee Sandra K, Vetto Anne P, Petrosyan Susanna, Marsala Martin, Murphy Anne N, Williams David S, Spiegelman Bruce M, Cleveland Don W   Elevated PGC-1α activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS Cell metabolism, 2012; 15(5): 778-86.
Phillips JB, Blanco-Sanchez B, Lentz JJ, Tallafuss A, Khanobdee K, Sampath S, Jacobs ZG, Han PF, Mishra M, Williams DS, Keats BJ, Washbourne P, Westerfield M   Harmonin (Ush1c) is required in zebrafish Muller glial cells for photoreceptor synaptic development and function Disease Models & Mechanisms , 2011; 4: 786-800.
Jacobson SG, Cideciyan AV, Gibbs D, Sumaroka A, Roman AJ, Aleman TS, Schwartz SB, Olivares MB, Russell RC, Steinberg JD, Kenna MA, Kimberling WJ, Rehm HL, Williams DS   Retinal Disease Course in Usher Syndrome 1B due to MYO7A Mutations Investigative Ophthalmology & Visual Science, 2011; 52: 7924-7936.
Lopes VS, Gibbs D, Libby RT, Aleman TS, Welch DL, Lillo C, Jacobson SG, Radu RA, Steel KP, Williams DS   The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65 Human Molecular Genetics, 2011; 20: 2560-2570.
Williams DS, Lopes VS   The many different cellular functions of MYO7A in the retina Biochemical Society transactions, 2011; 39: 1207-10.
Louie CM, Caridi G, Lopes VS, Brancati F, Kispert A, Lancaster MA, Schlossman AM, Otto EA, Leitges M, Grone HJ, Lopez I, Gudiseva HV, O’Toole JF, Vallespin E, Ayyagari R, Ayuso C, Cremers FP, den Hollander Al, Koenekoop RK, Dallapiccola B, Ghiggeri GM, Hildebrandt F, Valente EM, Williams DS, Gleeson JG   AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis Nature Genetics , 2010; 42: 175-180.
Lopes VS, Jimeno D, Khanobdee K, Song X, Chen B, Nusinowitz S, Williams DS   Dysfunction of Heterotrimeric Kinesin-2 in Rod Photoreceptor Cells and the Role of Opsin Mislocalization in Rapid Cell Death Molecular Biology of the Cell, 2010; 21: 4076-4088.
Gibbs D, Diemer T, Khanobdee K, Hu J, Bok D, Williams DS   Function of MYO7A in the human RPE and the validity of shaker1 mice as a model for Usher syndrome 1B Investigative Ophthalmology and Visual Science, 2010; 51: 1130-1135.
Liao JL,Yu J, Huang K, Hu J, Diemer T, Ma Z, Dvash T, Yang XJ, Travis GH, Williams DS, Bok D, Fan G   Molecular signature of primary retinal pigment epithelium and stem-cell-derived RPE cells Human Molecular Genetics , 2010; 19: 4229-4238.
Louie Carrie M, Caridi Gianluca, Lopes Vanda S, Brancati Francesco, Kispert Andreas, Lancaster Madeline A, Schlossman Andrew M, Otto Edgar A, Leitges Michael, Gröne Hermann-Josef, Lopez Irma, Gudiseva Harini V, O’Toole John F, Vallespin Elena, Ayyagari Radha, Ayuso Carmen, Cremers Frans P M, den Hollander Anneke I, Koenekoop Robert K, Dallapiccola Bruno, Ghiggeri Gian Marco, Hildebrandt Friedhelm, Valente Enza Maria, Williams David S, Gleeson Joseph G   AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis Nature genetics, 2010; 42(2): 175-80.
Williams David S, Cash Alan, Hamadani Lara, Diemer Tanja   Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway Aging cell, 2009; 8(6): 765-8.
Gibbs Daniel, Cideciyan Artur V, Jacobson Samuel G, Williams David S   Retinal pigment epithelium defects in humans and mice with mutations in MYO7A: imaging melanosome-specific autofluorescence Investigative ophthalmology & visual science, 2009; 50(9): 4386-93.
Schwander M, Lopes V, Sczaniecka A, Gibbs D, Lillo C, Delano D, Tarantino LM, Wiltshire T, Williams DS, Müller U   A novel allele of myosin VIIa reveals a critical function for the C-terminal FERM domain for melanosome transport in retinal pigment epithelial cells Journal of Neuroscience, 2009; 29: 15810-15818.
Falzone Tomás L, Stokin Gorazd B, Lillo Concepción, Rodrigues Elizabeth M, Westerman Eileen L, Williams David S, Goldstein Lawrence S B   Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009; 29(18): 5758-67.
Damek-Poprawa Monika, Diemer Tanja, Lopes Vanda S, Lillo Concepción, Harper Dawn C, Marks Michael S, Wu Yalin, Sparrow Janet R, Rachel Rivka A, Williams David S, Boesze-Battaglia Kathleen   Melanoregulin (MREG) modulates lysosome function in pigment epithelial cells The Journal of biological chemistry, 2009; 284(16): 10877-89.
James G. Tidball, Ph.D.

James Tidball, Ph.D.

Biography

Interactions between skeletal muscle and the immune system. A major project in our lab concerns the pathophysiology of muscular dystrophy (dystrophinopathy). Our research has shown that the immune system plays an important role in influencing the severity of muscular dystrophy, and that immune-based interventions can significantly reduce dystrophic muscle pathology and promote muscle regeneration. Our continuing efforts are directed toward identifying the key effector cells and molecules involved in influencing the course of the disease, and examining the interplay between those effectors. Our technical approaches include the generation and analysis of transgenic, dystrophic mice so that the effects of increased or decreased expression of selected effector molecules can be assessed. We also examine the systemic effects of experimental depletions of selected immune cell populations and the efficacy of selected, pharmaceutical interventions on the progress of the disease. In other studies, we are studying the mechanisms through which the immune system influences the wasting of skeletal muscle that occurs during aging, a process called sarcopenia. We are particularly interested in identifying the mechanisms through which specific populations of myeloid cells affect muscle wasting and regeneration, and identifying strategies to slow the wasting process.

Publications

A selected list of publications:

Wang Ying, Wehling-Henricks Michelle, Welc Steven S, Fisher Allison L, Zuo Qun, Tidball James G   Aging of the immune system causes reductions in muscle stem cell populations, promotes their shift to a fibrogenic phenotype, and modulates sarcopenia FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019; 8(4): fj201800973R.
Welc Steven S, Flores Ivan, Wehling-Henricks Michelle, Ramos Julian, Wang Ying, Bertoni Carmen, Tidball James G   Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy Nature communications, 2019; 10(1): 2788.
Tidball James G, Welc Steven S, Wehling-Henricks Michelle   Immunobiology of Inherited Muscular Dystrophies Comprehensive Physiology, 2018; 8(4): 1313-1356.
Wehling-Henricks Michelle, Welc Steven S, Samengo Guiseppina, Rinaldi Chiara, Lindsey Catherine, Wang Ying, Lee Jeongyoon, Kuro-O Makoto, Tidball James G   Macrophages escape Klotho gene silencing in the mdx mouse model of Duchenne muscular dystrophy and promote muscle growth and increase satellite cell numbers through a Klotho-mediated pathway Human Molecular Genetics, 2018; 27(1): 14-29.
Wang Ying, Welc Steven S, Wehling-Henricks Michelle, Tidball James G   Myeloid cell-derived tumor necrosis factor-alpha promotes sarcopenia and regulates muscle cell fusion with aging muscle fibers Aging cell, 2018; 8(4): e12828.
Tidball James G   Regulation of muscle growth and regeneration by the immune system Nature Reviews. Immunology, 2017; 17(3): 165-178.
Wehling-Henricks Michelle, Li Zhenzhi, Lindsey Catherine, Wang Ying, Welc Steven S, Ramos Julian N, Khanlou Négar, Kuro-O Makoto, Tidball James G   Klotho gene silencing promotes pathology in the mdx mouse model of Duchenne muscular dystrophy Human Molecular Genetics, 2016; 25(12): 2465-2482.
Chadwick Jessica A, Swager Sarah A, Lowe Jeovanna, Welc Steven S, Tidball James G, Gomez-Sanchez Celso E, Gomez-Sanchez Elise P, Rafael-Fortney Jill A   Myeloid cells are capable of synthesizing aldosterone to exacerbate damage in muscular dystrophy Human Molecular Genetics, 2016; 25(23): 5167-5177.
Wang Ying, Wehling-Henricks Michelle, Samengo Giuseppina, Tidball James G   Increases of M2a macrophages and fibrosis in aging muscle are influenced by bone marrow aging and negatively regulated by muscle-derived nitric oxide Aging Cell, 2015; 14(4): 678-88.
Tidball James G, Welc Steven S   Macrophage-Derived IGF-1 Is a Potent Coordinator of Myogenesis and Inflammation in Regenerating Muscle Molecular therapy : the journal of the American Society of Gene Therapy, 2015; 23(7): 1134-1135.
Tidball James G, Wehling-Henricks Michelle   Shifts in macrophage cytokine production drive muscle fibrosis Nature Medicine, 2015; 21(7): 665-6.
Tidball James G, Wehling-Henricks Michelle   Nitric oxide synthase deficiency and the pathophysiology of muscular dystrophy The Journal of Physiology, 2014; 592(Pt 21): 4627-4638.
Tidball James G, Bertoni Carmen   Purloined mechanisms of bacterial immunity can cure muscular dystrophy Cell Metabolism, 2014; 20(6): 927-9.
Villalta S Armando, Rosenthal Wendy, Martinez Leonel, Kaur Amanjot, Sparwasser Tim, Tidball James G, Margeta Marta, Spencer Melissa J, Bluestone Jeffrey A   Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy Science Translational Medicine, 2014; 6(258): 258ra142.
Tidball James G, Dorshkind Kenneth, Wehling-Henricks Michelle   Shared signaling systems in myeloid cell-mediated muscle regeneration Development (Cambridge, England), 2014; 141(6): 1184-96.
Samengo Giuseppina, Avik Anna, Fedor Brian, Whittaker Daniel, Myung Kyu H, Wehling-Henricks Michelle, Tidball James G   Age-related loss of nitric oxide synthase in skeletal muscle causes reductions in calpain S-nitrosylation that increase myofibril degradation and sarcopenia Aging Cell, 2012; 11(6): 1036-45.
Deng Bo, Wehling-Henricks Michelle, Villalta S Armando, Wang Ying, Tidball James G   IL-10 triggers changes in macrophage phenotype that promote muscle growth and regeneration Journal of immunology (Baltimore, Md. : 1950), 2012; 189(7): 3669-80.
Villalta, S.A., Deng, B., Rinaldi, C., Wehling-Henricks, M. and J. G. Tidball   IFNγ promotes muscle damage in the mdx mouse model of Duchenne muscular dystrophy by suppressing M2 macrophage activation and inhibiting muscle cell proliferation, J. Immunol, 2011; 187: 5419-5428 .
Villalta, S.A., Rinaldi, C., Deng, B., Liu, G., Fedor, B. and J. G. Tidball   Interleukin-10 reduces the pathology of mdx muscular dystrophy by deactivating M1 macrophages and modulating macrophage phenotype, Human Molecular Genetics , 2011; 20: 790-805.
Tidball James G   Mechanisms of muscle injury, repair, and regeneration Comprehensive Physiology, 2011; 1(4): 2029-62.
Wehling-Henricks, M. and J.G. Tidball   Neuronal nitric oxide synthase-rescue of dystrophin/utrophin double knockout mice does not require nNOS localization to the cell membrane, PLoS One , 2011; 6: e25071.
Sakellariou, G.K., Pye, D., Vasilaki, A., Zibrik, L., Palomero, J., Kabayo, T., McArdle, F., Van Remmen, H., Richardson, A., Tidball, J.G., McArdle, A. and M. J. Jackson   Role of superoxide-nitric oxide interactions in the accelerated age-related loss of muscle mass in mice lacking Cu,Zn superoxide dismutase, Aging Cell , 2011; 10: 749-760.
Wehling-Henricks, M., M. C. Jordan, T. Gotoh, W. W. Grody, K. P. Roos and J. G. Tidball   Arginine metabolism by macrophages promotes cardiac and muscle fibrosis in mdx muscular dystrophy, PLoS One, 2010; 5(5): e10763. doi:10.1371/journal.pone.0010763.
Tidball, J.G. and S.A. Villalta   Interactions between muscle and the immune system regulate muscle growth and regeneration, Amer. J. Physiol, 2010; 298: R1173-1187.
Perez Antonio L, Bachrach Estanislao, Illigens Ben M W, Jun Susan J, Bagden Eric, Steffen Leta, Flint Alan, McGowan Francis X, Del Nido Pedro, Montecino-Rodriguez Enca, Tidball James G, Kunkel Louis M   CXCR4 enhances engraftment of muscle progenitor cells Muscle & nerve, 2009; 40(4): 562-72.
Tidball, J.G. and M. Wehling-Henricks   Inflammatory mechanisms in genetic neuromuscular disorders, Inflammatory and autoimmune disorders of the nervous system in children, 2009; 455-479.
Wehling-Henricks, M., M. Oltmann, C. Rinaldi, K. H. Myung, and J. G. Tidball   Loss of positive allosteric interactions between neuronal nitric oxide synthase and phosphofructokinase contributes to defects in glycolysis and increased fatigability in muscular dystrophy, Human Molecular Genetics, 2009; 18: 3439-3451.
Deng, B., D. Glanzman and J.G. Tidball   Nitric oxide generated by muscle corrects defects in hippocampal neurogenesis and neural differentiation caused by muscular dystrophy, Journal of Physiology, 2009; 587: 1769-1778.
Tidball, J.G. and S.A. Villalta   Nitric oxide may prompt calcium leakage in dystrophic muscle, Nature Medicine, 2009; 15: 243-244.
Villalta, S.A., H.X. Nguyen, B. Deng, T. Gotoh and J.G. Tidball   Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy, Human Molecular Genetics, 2009; 18: 482-496.
Tidball, J.G.   Inflammation in skeletal muscle regeneration, Skeletal muscle repair and regeneration, 2008; 243-268.
Wehling-Henricks, M., Sokolow, S., Lee, J.J., Myung, K.H., Villalta, A., and J.G. Tidball   Major basic protein-1 promotes fibrosis of dystrophic muscle and attenuates the cellular immune response in muscular dystrophy, Human Molecular Genetics, 2008; 17:2280-2292: .
Hao, M., K. Akrami, K. Wei, C. De Diego, N. Che, J.H. Ku, J.G. Tidball, M.C. Graves, P.B. Shieh and F. Chen   Muscleblind-like 2 (Mbnl2) -deficient mice as a model for myotonic dystrophy, Developmental Dynamics, 2008; 237: 403-410.
Acharyya, S., S.A. Villalta, N. Bakkar, T. Bupha-Intr, P.M.L. Janssen, M. Carathers, M. Karin, Z. Li, A. Beg, S. Ghosh, Z. Sahenk, M. Weinstein, K.L. Gardner, J.A. Rafael-Fortney, J.G. Tidball, A.S. Baldwin and D.C. Guttridge   IKK/NF-kB signaling interplay in macrophages and myofibers promotes muscle wasting in Duchenne muscular dystrophy, Journal of Clinical Investigation, 2007; 117: 889-901.
Acharyya Swarnali, Villalta S Armando, Bakkar Nadine, Bupha-Intr Tepmanas, Janssen Paul M L, Carathers Micheal, Li Zhi-Wei, Beg Amer A, Ghosh Sankar, Sahenk Zarife, Weinstein Michael, Gardner Katherine L, Rafael-Fortney Jill A, Karin Michael, Tidball James G, Baldwin Albert S, Guttridge Denis C   Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy The Journal of clinical investigation, 2007; 117(4): 889-901.
Tidball, J.G. and M. Wehling-Henricks   Macrophages promote muscle membrane repair and muscle fiber growth and regeneration during modified muscle loading in mice in vivo, Journal of Physiology, 2007; 578.1: 327-336.
Tidball James G, Wehling-Henricks Michelle   Macrophages promote muscle membrane repair and muscle fibre growth and regeneration during modified muscle loading in mice in vivo The Journal of physiology, 2007; 578(Pt 1): 327-36.
Pfister, K., J. Radons, J.G. Tidball, M. Pfeifer, L. Freitag, H-J. Feldmann, V. Milani, R. Issels and G. Multhoff   Patient survival by Hsp70 membrane-phenotype: association with different routes of metastasis, Cancer, 2007; 110: 926-35.
Tidball James G, Wehling-Henricks Michelle   The role of free radicals in the pathophysiology of muscular dystrophy Journal of applied physiology (Bethesda, Md. : 1985), 2007; 102(4): 1677-86.
Wehling-Henricks, M Jordan, MC Roos, KP Deng, B Tidball, JG   Cardiomyopathy in dystrophin-deficient hearts is prevented by expression of a neuronal nitric oxide synthase transgene in the myocardium Human Molecular Genetics, 2005; 14(14): 1921-33.
Tidball, JG Wehling-Henricks, M   Damage and inflammation in muscular dystrophy: potential implications and relationships with autoimmune myositis Current Opinion in Rheumatology, 2005; 17(6): 707-13.
Tidball, JG   Inflammatory processes in muscle injury and repair American Journal of Physiology, 2005; 288(2): R345-53.
Tidball James G   Inflammatory processes in muscle injury and repair American journal of physiology. Regulatory, integrative and comparative physiology, 2005; 288(2): R345-53.
Tidball James G   Mechanical signal transduction in skeletal muscle growth and adaptation Journal of applied physiology (Bethesda, Md. : 1985), 2005; 98(5): 1900-8.
Shiao, T Fond, A Deng, B Wehling-Henricks, M Adams, ME Froehner, SC Tidball, JG   Defects in neuromuscular junction structure in dystrophic muscle are corrected by expression of a NOS transgene in dystrophin-deficient muscles, but not in muscles lacking alpha- and beta1-syntrophins Human Molecular Genetics, 2004; 13(17): 1873-84.
Tidball, JG Wehling-Henricks, M   Evolving therapeutic strategies for Duchenne muscular dystrophy: targeting downstream events Pediatric Research, 2004; 56(6): 831-41.
Kramerova, I Kudryashova, E Tidball, JG Spencer, MJ   Null mutation of calpain 3 (p94) in mice causes abnormal sarcomere formation in vivo and in vitro Human Molecular Genetics, 2004; 13(13): 1373-88.
Wehling-Henricks, M Lee, JJ Tidball, JG   Prednisolone decreases cellular adhesion molecules required for inflammatory cell infiltration in dystrophin-deficient skeletal muscle Neuromuscular Disorders, 2004; 14(8-9): 483-90.
Nguyen, HX Tidball, JG   Interactions between neutrophils and macrophages promote macrophage killing of rat muscle cells in vitro Journal of Physiology, 2003; 547(Pt 1): 125-32.
Nguyen, HX Tidball, JG   Null mutation of gp91phox reduces muscle membrane lysis during muscle inflammation in mice Journal of Physiology, 2003; 553(Pt 3): 833-41.
Tidball James G, Spencer Melissa J   Skipping to new gene therapies for muscular dystrophy Nature medicine, 2003; 9(8): 997-8.
Tidball, JG   Interactions between muscle and the immune system during modified musculoskeletal loading Clinical Orthopaedics and Related Research, 2002; 403S(403 Suppl): S100-9.
Wehling, M., Spencer, M. and J.G. Tidball   A nitric oxide synthase transgene ameliorates muscular dystrophy in mdx mice Journal of Cell Biology, 2001; 155(1): 123-31.
Spencer, MJ Tidball, JG   Do immune cells promote the pathology of dystrophin-deficient myopathies? Neuromuscular Disorders, 2001; 11(6-7): 556-64.
Spencer, MJ Montecino-Rodriguez, E Dorshkind, K Tidball, JG   Helper (CD4(+)) and cytotoxic (CD8(+)) T cells promote the pathology of dystrophin-deficient muscle Clinical Immunology , 2001; 98(2): 235-43.
Frenette, J Cai, B Tidball, JG   Complement activation promotes muscle inflammation during modified muscle use American Journal of Pathology, 2000; 156(6): 2103-10.
Zhu, X Hadhazy, M Wehling, M Tidball, JG McNally, EM   Dominant negative myostatin produces hypertrophy without hyperplasia in muscle FEBS Letters, 2000; 474(1): 71-5.
Cai, B Spencer, MJ Nakamura, G Tseng-Ong, L Tidball, JG   Eosinophilia of dystrophin-deficient muscle is promoted by perforin-mediated cytotoxicity by T cell effectors American Journal of Pathology, 2000; 156(5): 1789-96.
Wehling, M Cai, B Tidball, JG   Modulation of myostatin expression during modified muscle use FASEB Journal, 2000; 14(1): 103-10.
Koh, TJ Tidball, JG   Nitric oxide inhibits calpain-mediated proteolysis of talin in skeletal muscle cells American Journal of Physiology, 2000; 279(3): C806-12.
Koh, TJ Tidball, JG   Nitric oxide synthase inhibitors reduce sarcomere addition in rat skeletal muscle Journal of Physiology, 1999; 519 Pt 1: 189-96.
Tidball, JG Spencer, MJ Wehling, M Lavergne, E   Nitric-oxide synthase is a mechanical signal transducer that modulates talin and vinculin expression Journal of Biological Chemistry , 1999; 274(46): 33155-60.
Tidball, JG Lavergne, E Lau, KS Spencer, MJ Stull, JT Wehling, M   Mechanical loading regulates NOS expression and activity in developing and adult skeletal muscle American Journal of Physiology, 1998; 275(1 Pt 1): C260-6.
Spencer, MJ Walsh, CM Dorshkind, KA Rodriguez, EM Tidball, JG   Myonuclear apoptosis in dystrophic mdx muscle occurs by perforin-mediated cytotoxicity Journal of Clinical Investigation, 1997; 99(11): 2745-51.
Chang, W., S. Iannaccone, K. Lau, B. Masters, T. McCabe K. McMillan, R. Padre, M.J. Spencer, J.G. Tidball and J.T. Stull   Neuronal nitric oxide synthase and dystrophin-deficient muscular dystrophy, Proc. Natl. Acad. Sci. USA, 1996; 93: 9142-47.

James Waschek, Ph.D.

Biography

Dr. Waschek is a Professor of Psychiatry and Biobehavioral Science at the David Geffen School of Medicine at the University of California at Los Angeles (UCLA), and is an expert in the molecular and cellular biology and physiological actions of neuropeptides. Dr. Waschek received a Ph.D. in Pharmaceutical Chemistry in 1984 from the University of California at San Francisco, after which he took a postdoctoral position at the National Institutes of Health (NIH). In 1988 he came to UCLA, where his research has centered on three broad, but related topics: 1) CNS development, degeneration, injury, and repair, 2) neuroinflammatory conditions such as multiple sclerosis, and maternal inflammation-induced perinatal white matter disease, and 3) brain tumor pathogenesis. A past and continuing objective has been to better understand the biological roles of neuropeptides in these processes, especially the two related peptides PACAP and VIP (pituitary adenylyl cyclase activating peptide and vasoactive intestinal peptide, respectively). A major contribution in this area was his discovery first reported in 1998 that PACAP and functional PACAP receptors are highly expressed in the murine neural tube and other germinal centers, and that PACAP acts in part via cAMP and protein kinase A to regulate neural patterning and proliferation via antagonism of hedgehog signaling. Using gene targeting and other approaches, he found this interaction to be relevant not only during brain development, but also in the pathogenesis of malignant pediatric brain tumors. In other work, he has demonstrated growth factor-like actions of PACAP in the maturation of white matter (myelin) and in axon regeneration after injury. Most recently, he determined that VIP and PACAP are critically involved in inflammatory responses after nerve injury and in other pathologies such as lung and liver injury, colitis, cystitis, viral infection, and in an animal model of multiple sclerosis. These studies have revealed significant effects of PACAP and VIP PACAP loss on innate cellular responses to injury, as well as in Th1, Th2, and Th17 differentiation, regulatory T cell production, and immune cell invasion of the CNS parenchyma. Has been continuously funding for his research by the NIH since 1984, and is also currently receiving funding through major grants from the National Institutes of Health, the National Multiple Sclerosis Society, the Department of Defense, and the Simons Foundation. Dr. Waschek has served on NIH study sections almost continuously since 2006, and served as an external reviewer for the newly-formed LOWEE Institute on Tumors and Inflammation in Marburg, Germany, and a consultant for the Japanese-Israeli Scientific and Technological Cooperation Agreement in Life Sciences in the Topic of Stem Cell Research.

Publications

A selected list of publications:

Tan Yossan-Var, Abad Catalina, Wang Yuqi, Lopez Robert, Waschek James A   Pituitary Adenylate Cyclase Activating Peptide Deficient Mice Exhibit Impaired Thymic and Extrathymic Regulatory T Cell Proliferation during EAE PloS one, 2013; 8(4): e61200.
Yan Yan, Zhou Xiaofeng, Pan Zui, Ma Jianjie, Waschek James A, DiCicco-Bloom Emanuel   Pro- and anti-mitogenic actions of pituitary adenylate cyclase-activating polypeptide in developing cerebral cortex: potential mediation by developmental switch of PAC1 receptor mRNA isoforms The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013; 33(9): 3865-78.
Tyagi Ethika, Agrawal Rahul, Zhuang Yumei, Abad Catalina, Waschek James A, Gomez-Pinilla Fernando   Vulnerability imposed by diet and brain trauma for anxiety-like phenotype: implications for post-traumatic stress disorders PloS one, 2013; 8(3): e57945.
Ji Haofeng, Zhang Yu, Shen Xiuda, Gao Feng, Huang Cynthia Y, Abad Catalina, Busuttil Ronald W, Waschek James A, Kupiec-Weglinski Jerzy W   Neuropeptide PACAP in mouse liver ischemia and reperfusion injury: immunomodulation via cAMP-PKA pathway Hepatology (Baltimore, Md.), 2012; 166(1): .
Nobuta Hiroko, Ghiani Cristina A, Paez Pablo M, Spreuer Vilma, Dong Hongmei, Korsak Rose A, Manukyan Armine, Li Jiaxi, Vinters Harry V, Huang Eric J, Rowitch David H, Sofroniew Michael V, Campagnoni Anthony T, de Vellis Jean, Waschek James A   STAT3-mediated astrogliosis protects myelin development in neonatal brain injury Annals of neurology, 2012; 72(5): 750-65.
Abad Catalina, Tan Yossan-Var, Cheung-Lau Gardenia, Nobuta Hiroko, Waschek James A   VIP deficient mice exhibit resistance to lipopolysaccharide induced endotoxemia with an intrinsic defect in proinflammatory cellular responses PloS one, 2012; 7(5): e36922.
Abad Catalina, Gomariz Rosa, Waschek James, Leceta Javier, Martinez Carmen, Juarranz Yasmina, Arranz Alicia   VIP in inflammatory bowel disease: state of the art Endocrine, metabolic & immune disorders drug targets, 2012; 12(4): 316-22.
Ghiani Cristina A, Mattan Natalia S, Nobuta Hiroko, Malvar Jemily S, Boles Julie, Ross Michael G, Waschek James A, Carpenter Ellen M, Fisher Robin S, de Vellis Jean   Early effects of lipopolysaccharide-induced inflammation on foetal brain development in rat ASN neuro, 2011; 3(4): .
Loh Dawn H, Dragich Joanna M, Kudo Takashi, Schroeder Analyne M, Nakamura Takahiro J, Waschek James A, Block Gene D, Colwell Christopher S   Effects of vasoactive intestinal Peptide genotype on circadian gene expression in the suprachiasmatic nucleus and peripheral organs Journal of biological rhythms, 2011; 26(3): 200-9.
Alexandre David, Alonzeau Jessy, Bill Brent R, Ekker Stephen C, Waschek James A   Expression analysis of PAC1-R and PACAP genes in zebrafish embryos Journal of molecular neuroscience : MN, 2011; 43(1): 94-100.
Abad Catalina, Waschek James A   Immunomodulatory roles of VIP and PACAP in models of multiple sclerosis Current pharmaceutical design, 2011; 17(10): 1025-35.
Hirose Megumi, Niewiadomski Pawel, Tse Gary, Chi Gloria C, Dong Hongmei, Lee Alice, Carpenter Ellen M, Waschek James A   Pituitary adenylyl cyclase-activating peptide counteracts hedgehog-dependent motor neuron production in mouse embryonic stem cell cultures Journal of neuroscience research, 2011; 89(9): 1363-74.
Tan Yossan-Var, Waschek James A   Targeting VIP and PACAP receptor signalling: new therapeutic strategies in multiple sclerosis ASN neuro, 2011; 3(4): .
Dragich Joanna M, Loh Dawn H, Wang Louisa M, Vosko Andrew M, Kudo Takashi, Nakamura Takahiro J, Odom Irene H, Tateyama Sei, Hagopian Arkady, Waschek James A, Colwell Christopher S   The role of the neuropeptides PACAP and VIP in the photic regulation of gene expression in the suprachiasmatic nucleus The European journal of neuroscience, 2010; 31(5): 864-75.
Abad Catalina, Tan Yossan-Var, Lopez Robert, Nobuta Hiroko, Dong Hongmei, Phan Phu, Feng Ji-Ming, Campagnoni Anthony T, Waschek James A   Vasoactive intestinal peptide loss leads to impaired CNS parenchymal T-cell infiltration and resistance to experimental autoimmune encephalomyelitis Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(45): 19555-60.
Kim Woo-Kyun, Meliton Vicente, Park Kye Won, Hong Cynthia, Tontonoz Peter, Niewiadomski Pawel, Waschek James A, Tetradis Sotirios, Parhami Farhad   Negative regulation of Hedgehog signaling by liver X receptors Molecular endocrinology (Baltimore, Md.), 2009; 23(10): 1532-43.
Tan Yossan-Var, Abad Catalina, Lopez Robert, Dong Hongmei, Liu Shen, Lee Alice, Gomariz Rosa P, Leceta Javier, Waschek James A   Pituitary adenylyl cyclase-activating polypeptide is an intrinsic regulator of Treg abundance and protects against experimental autoimmune encephalomyelitis Proceedings of the National Academy of Sciences of the United States of America, 2009; 106(6): 2012-7.
Stack Conor M, Lim Maria A, Cuasay Katrina, Stone Madeleine M, Seibert Kimberly M, Spivak-Pohis Irit, Crawley Jacqueline N, Waschek James A, Hill Joanna M   Deficits in social behavior and reversal learning are more prevalent in male offspring of VIP deficient female mice Experimental neurology, 2008; 211(1): 67-84.
Lelievre Vincent, Seksenyan Akop, Nobuta Hiroko, Yong William H, Chhith Seririthanar, Niewiadomski Pawel, Cohen Joseph R, Dong Hongmei, Flores Avegail, Liau Linda M, Kornblum Harley I, Scott Matthew P, Waschek James A   Disruption of the PACAP gene promotes medulloblastoma in ptc1 mutant mice Developmental biology, 2008; 313(1): 359-70.
Armstrong B D, Abad C, Chhith S, Cheung-Lau G, Hajji O E, Nobuta H, Waschek J A   Impaired nerve regeneration and enhanced neuroinflammatory response in mice lacking pituitary adenylyl cyclase activating peptide Neuroscience, 2008; 151(1): 63-73.
Nemetz Nicole, Abad Catalina, Lawson Greg, Nobuta Hiroko, Chhith Seririthanar, Duong Lucy, Tse Gary, Braun Jonathan, Waschek James A   Induction of colitis and rapid development of colorectal tumors in mice deficient in the neuropeptide PACAP International journal of cancer. Journal international du cancer, 2008; 122(8): 1803-9.
Niewiadomski Pawel, Coûté-Monvoisin Anne-Claire, Abad Catalina, Ngo Danny, Menezes Adrian, Waschek James A   Mice Deficient in both Pituitary Adenylyl Cyclase-activating Polypeptide and Vasoactive Intestinal Peptide Survive, but Display Growth Retardation and Sex-dependent Early Death Journal of molecular neuroscience : MN, 2008; 36(1-3): 200-7.
Lim Maria A, Stack Conor M, Cuasay Katrina, Stone Madeleine M, McFarlane Hewlet G, Waschek James A, Hill Joanna M   Regardless of genotype, offspring of VIP-deficient female mice exhibit developmental delays and deficits in social behavior International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2008; 26(5): 423-34.
Studeny Simon, Cheppudira Bopaiah P, Meyers Susan, Balestreire Elena M, Apodaca Gerard, Birder Lori A, Braas Karen M, Waschek James A, May Victor, Vizzard Margaret A   Urinary bladder function and somatic sensitivity in vasoactive intestinal polypeptide (VIP)-/- mice Journal of molecular neuroscience : MN, 2008; 36(1-3): 175-87.
Loh Dawn H, Abad Catalina, Colwell Christopher S, Waschek James A   Vasoactive intestinal peptide is critical for circadian regulation of glucocorticoids Neuroendocrinology, 2008; 88(4): 246-55.
Lacombe Arnaud, Lelievre Vincent, Roselli Charles E, Muller Jean-Marc, Waschek James A, Vilain Eric   Lack of vasoactive intestinal peptide reduces testosterone levels and reproductive aging in mouse testis The Journal of endocrinology, 2007; 194(1): 153-60.
Lacombe Arnaud, Lelievre Vincent, Roselli Charles E, Salameh Wael, Lue Yan-he, Lawson Gregory, Muller Jean-Marc, Waschek James A, Vilain Eric   Delayed testicular aging in pituitary adenylate cyclase-activating peptide (PACAP) null mice Proceedings of the National Academy of Sciences of the United States of America, 2006; 103(10): 3793-8.
Aton Sara J, Colwell Christopher S, Harmar Anthony J, Waschek James, Herzog Erik D   Vasoactive intestinal polypeptide mediates circadian rhythmicity and synchrony in mammalian clock neurons Nature neuroscience, 2005; 8(4): 476-83.
Colwell Christopher S, Michel Stephan, Itri Jason, Rodriguez Williams, Tam J, Lelievre Vincent, Hu Zhou, Liu X, Waschek James A   Disrupted circadian rhythms in VIP- and PHI-deficient mice American journal of physiology. Regulatory, integrative and comparative physiology, 2003; 285(5): R939-49.
Nicot Arnaud, Lelièvre Vincent, Tam Jimmy, Waschek James A, DiCicco-Bloom Emanuel   Pituitary adenylate cyclase-activating polypeptide and sonic hedgehog interact to control cerebellar granule precursor cell proliferation The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002; 22(21): 9244-54.
Niewiadomski Pawel, Zhujiang Annie, Youssef Mary, Waschek James A   Interaction of PACAP with Sonic hedgehog reveals complex regulation of the hedgehog pathway by PKA Cellular signalling, 2013; 25(11): 2222-30.
Li Jian-Ming, Southerland Lauren, Hossain Mohammad S, Giver Cynthia R, Wang Ying, Darlak Kasia, Harris Wayne, Waschek James, Waller Edmund K   Absence of vasoactive intestinal peptide expression in hematopoietic cells enhances Th1 polarization and antiviral immunity in mice Journal of immunology (Baltimore, Md. : 1950), 2011; 187(2): 1057-65.
Ji Haofeng, Zhang Yu, Liu Yuanxing, Shen Xiu-Da, Gao Feng, Nguyen Terry T, Busuttil Ronald W, Waschek James A, Kupiec-Weglinski Jerzy W   Vasoactive intestinal peptide attenuates liver ischemia/reperfusion injury in mice via the cyclic adenosine monophosphate-protein kinase a pathway Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2013; 19(9): 945-56.
Abad Catalina, Nobuta Hiroko, Li Jiaxi, Kasai Atsushi, Yong William H, Waschek James A   Targeted STAT3 disruption in myeloid cells alters immunosuppressor cell abundance in a murine model of spontaneous medulloblastoma Journal of leukocyte biology, 2014; 95(2): 357-67.
Marquez Paul, Bebawy David, Lelièvre Vincent, Coûté Anne-Claire, Evans Christopher J, Waschek James A, Lutfy Kabirullah   The role of endogenous PACAP in motor stimulation and conditioned place preference induced by morphine in mice Psychopharmacology, 2009; 204(3): 457-63.
Kim Kyun-Do, Srikanth Sonal, Tan Yossan-Var, Yee Ma-Khin, Jew Marcus, Damoiseaux Robert, Jung Michael E, Shimizu Saki, An Dong Sung, Ribalet Bernard, Waschek James A, Gwack Yousang   Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation Journal of immunology (Baltimore, Md. : 1950), 2014; 192(1): 110-22.
Vu John P, Million Mulugeta, Larauche Muriel, Luong Leon, Norris Joshua, Waschek James A, Pothoulakis Charalabos, Pisegna Joseph R, Germano Patrizia M   Inhibition of vasoactive intestinal polypeptide (VIP) induces resistance to dextran sodium sulfate (DSS)-induced colitis in mice Journal of molecular neuroscience : MN, 2014; 52(1): 37-47.
Brown T M, Colwell C S, Waschek J A, Piggins H D   Disrupted neuronal activity rhythms in the suprachiasmatic nuclei of vasoactive intestinal polypeptide-deficient mice Journal of neurophysiology, 2007; 97(3): 2553-8.
Watson M B, Nobuta H, Abad C, Lee S K, Bala N, Zhu C, Richter F, Chesselet M-F, Waschek J A   PACAP deficiency sensitizes nigrostriatal dopaminergic neurons to paraquat-induced damage and modulates central and peripheral inflammatory activation in mice Neuroscience, 2013; 240: 277-86.
Waschek J A   VIP and PACAP: neuropeptide modulators of CNS inflammation, injury, and repair British journal of pharmacology, 2013; 169(3): 512-23.
Colwell C S, Michel S, Itri J, Rodriguez W, Tam J, Lelièvre V, Hu Z, Waschek J A   Selective deficits in the circadian light response in mice lacking PACAP American journal of physiology. Regulatory, integrative and comparative physiology, 2004; 287(5): R1194-201.
Vu John P, Larauche Muriel, Flores Martin, Luong Leon, Norris Joshua, Oh Suwan, Liang Li-Jung, Waschek James, Pisegna Joseph R, Germano Patrizia M   Regulation of Appetite, Body Composition, and Metabolic Hormones by Vasoactive Intestinal Polypeptide (VIP) Journal of molecular neuroscience : MN, 2015; 56(2): 377-87.
Ago Yukio, Condro Michael C, Tan Yossan-Var, Ghiani Cristina A, Colwell Christopher S, Cushman Jesse D, Fanselow Michael S, Hashimoto Hitoshi, Waschek James A   Reductions in synaptic proteins and selective alteration of prepulse inhibition in male C57BL/6 mice after postnatal administration of a VIP receptor (VIPR2) agonist Psychopharmacology, 2015; 232(12): 2181-9.
Onaka Yusuke, Shintani Norihito, Nakazawa Takanobu, Haba Ryota, Ago Yukio, Wang Hyper, Kanoh Takuya, Hayata-Takano Atsuko, Hirai Hiroyuki, Nagata Kin-Ya, Nakamura Masataka, Hashimoto Ryota, Matsuda Toshio, Waschek James A, Kasai Atsushi, Nagayasu Kazuki, Baba Akemichi, Hashimoto Hitoshi   CRTH2, a prostaglandin D2 receptor, mediates depression-related behavior in mice Behavioural brain research, 2015; 284(12): 131-7.
Tan Yossan-Var, Abad Catalina, Wang Yuqi, Lopez Robert, Waschek James A   VPAC2 (vasoactive intestinal peptide receptor type 2) receptor deficient mice develop exacerbated experimental autoimmune encephalomyelitis with increased Th1/Th17 and reduced Th2/Treg responses Brain, behavior, and immunity, 2015; 44(12): 167-75.
Yamasaki Atsushi, Kasai Atsushi, Toi Akihiro, Kurita Maki, Kimoto Saki, Hayata-Takano Atsuko, Nakazawa Takanobu, Nagayasu Kazuki, Shintani Norihito, Hashimoto Ryota, Ito Akira, Meltzer Herbert Y, Ago Yukio, Waschek James A, Onaka Yusuke, Matsuda Toshio, Baba Akemichi, Hashimoto Hitoshi   Identification of the role of bone morphogenetic protein (BMP) and transforming growth factor-β (TGF-β) signaling in the trajectory of serotonergic differentiation in a rapid assay in mouse embryonic stem cells in vitro Journal of neurochemistry, 2015; 132(4): 418-28.
Abad Catalina, Cheung-Lau Gardenia, Coûté-Monvoisin Anne-Claire, Waschek James A   Vasoactive intestinal peptide-deficient mice exhibit reduced pathology in trinitrobenzene sulfonic acid-induced colitis Neuroimmunomodulation, 2015; 22(3): 203-12.
Wu Xiujuan, Conlin Victoria S, Morampudi Vijay, Ryz Natasha R, Nasser Yasmin, Bhinder Ganive, Bergstrom Kirk S, Yu Hong B, Waterhouse Chris C M, Buchan Allison M J, Popescu Oana E, Gibson William T, Waschek James A, Vallance Bruce A, Jacobson Kevan   Vasoactive intestinal polypeptide promotes intestinal barrier homeostasis and protection against colitis in mice PloS one, 2015; 10(5): e0125225.
Castorina Alessandro, Waschek James A, Marzagalli Rubina, Cardile Venera, Drago Filippo   PACAP interacts with PAC1 receptors to induce tissue plasminogen activator (tPA) expression and activity in schwann cell-like cultures PloS one, 2015; 10(2): e0117799.
Teuchner Barbara, Dimmer Andreas, Humpel Christian, Amberger Albert, Fischer-Colbrie Reiner, Nemeth Jozsef, Waschek James A, Kieselbach Gerhard, Kralinger Martina, Schmid Eduard, Bechrakis Nikolaos, Troger Josef   VIP, PACAP-38, BDNF and ADNP in NMDA-induced excitotoxicity in the rat retina Acta ophthalmologica, 2011; 89(7): 670-5.
Cohen Joseph R, Resnick Daniel Z, Niewiadomski Pawel, Dong Hongmei, Liau Linda M, Waschek James A   Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures BMC cancer, 2010; 10(7): 676.
Martin Bronwen, Shin Yu-Kyong, White Caitlin M, Ji Sunggoan, Kim Wook, Carlson Olga D, Napora Joshua K, Chadwick Wayne, Chapter Megan, Waschek James A, Mattson Mark P, Maudsley Stuart, Egan Josephine M   Vasoactive intestinal peptide-null mice demonstrate enhanced sweet taste preference, dysglycemia, and reduced taste bud leptin receptor expression Diabetes, 2010; 59(5): 1143-52.
Girard Beatrice M, Malley Susan E, Braas Karen M, Waschek James A, May Victor, Vizzard Margaret A   Exaggerated expression of inflammatory mediators in vasoactive intestinal polypeptide knockout (VIP-/-) mice with cyclophosphamide (CYP)-induced cystitis Journal of molecular neuroscience : MN, 2008; 36(1-3): 188-99.
Nakano Ichiro, Masterman-Smith Michael, Saigusa Kuniyasu, Paucar Andres A, Horvath Steve, Shoemaker Lorelei, Watanabe Momoko, Negro Alejandra, Bajpai Ruchi, Howes Amy, Lelievre Vincent, Waschek James A, Lazareff Jorge A, Freije William A, Liau Linda M, Gilbertson Richard J, Cloughesy Timothy F, Geschwind Daniel H, Nelson Stanley F, Mischel Paul S, Terskikh Alexey V, Kornblum Harley I   Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells Journal of neuroscience research, 2008; 86(1): 48-60.
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