Alcino Silva, Ph.D., ICLM Director Emeritus

alcinojsilva@gmail.com

Faculty Member

Professor
Department of Neurobiology
Department of Psychiatry & Biobehavioral Sciences
David Geffen School of Medicine
University of California, Los Angeles

Publications

Madruga BA, Dorian CC, Yang L, Sehgal M, Silva AJ, Shtrahman M, Aharoni D, Golshani P. Open-source, high performance miniature 2-photon microscopy systems for freely behaving animals.. Nature communications, 2025.
Tian M, Kawaguchi R, Shen Y, Machnicki M, Villegas NG, Cooper DR, Montgomery N, Cai Y, Haring J, Lan R, Yuan AH, Williams CK, Magaki S, Vinters HV, Zhang Y, De Biase LM, Silva AJ, Carmichael ST. Deconstructing the intercellular interactome in vascular dementia with focal ischemia for therapeutic applications.. Cell, 2025.
Bickle J, Churchland P, Firestein S, Lehman MN, Parker DJ, Silva AJ, Walters BJ, Williams RW. How Might a 'Philosopher's Toolkit' Help Advance Neuroscience? Let's Ask Some Neuroscientists.. The European journal of neuroscience, 2025.
Giovanniello JR, Paredes N, Wiener A, Ramírez-Armenta K, Oragwam C, Uwadia HO, Yu AL, Lim K, Pimenta JS, Vilchez GE, Nnamdi G, Wang A, Sehgal M, Reis FM, Sias AC, Silva AJ, Adhikari A, Malvaez M, Wassum KM. A dual-pathway architecture for stress to disrupt agency and promote habit.. Nature, 2025.
Sehgal M, Filho DA, Kastellakis G, Kim S, Lee J, Shen Y, Huang S, Lavi A, Fernandes G, Davila Mejia I, Martin SS, Pekcan A, Wu MS, Heo WD, Poirazi P, Trachtenberg JT, Silva AJ. Compartmentalized dendritic plasticity in the mouse retrosplenial cortex links contextual memories formed close in time.. Nature neuroscience, 2025.
Zaki Y, Pennington ZT, Morales-Rodriguez D, Bacon ME, Ko B, Francisco TR, LaBanca AR, Sompolpong P, Dong Z, Lamsifer S, Chen HT, Carrillo Segura S, Christenson Wick Z, Silva AJ, Rajan K, van der Meer M, Fenton A, Shuman T, Cai DJ. Offline ensemble co-reactivation links memories across days.. Nature, 2024.
Matiasz NJ, Wood J, Silva AJ. Quantifying convergence and consistency.. The European journal of neuroscience, 2024.
Giovanniello JR, Paredes N, Wiener A, Ramírez-Armenta K, Oragwam C, Uwadia HO, Yu AL, Lim K, Pimenta JS, Vilchez GE, Nnamdi G, Wang A, Sehgal M, Reis FM, Sias AC, Silva AJ, Adhikari A, Malvaez M, Wassum KM. A dual-pathway architecture enables chronic stress to disrupt agency and promote habit formation.. bioRxiv : the preprint server for biology, 2024.
Tian M, Kawaguchi R, Shen Y, Machnicki M, Villegas NG, Cooper DR, Montgomery N, Haring J, Lan R, Yuan AH, Williams CK, Magaki S, Vinters HV, Zhang Y, De Biase LM, Silva AJ, Carmichael ST. Intercellular Signaling Pathways as Therapeutic Targets for Vascular Dementia Repair.. bioRxiv : the preprint server for biology, 2024.
Reis FMCV, Maesta-Pereira S, Ollivier M, Schuette PJ, Sethi E, Miranda BA, Iniguez E, Chakerian M, Vaughn E, Sehgal M, Nguyen DCT, Yuan FTH, Torossian A, Ikebara JM, Kihara AH, Silva AJ, Kao JC, Khakh BS, Adhikari A. Control of feeding by a bottom-up midbrain-subthalamic pathway.. Nature communications, 2024.
López-Aranda MF, Bach K, Bui R, Phan M, Lu O, Thadani C, Luchetti A, Mandanas R, Herrera I, López-Ávalos MD, Silva AJ. Early Post-Natal Immune Activation Leads to Object Memory Deficits in Female Tsc2+/- Mice: The Importance of Including Both Sexes in Neuroscience Research.. Biomedicines, 2024.
Levine AJ, Thadani C, Soontornniyomkij V, Lopez-Aranda MF, Mesa YG, Kitchen S, Rezek V, Silva A, Kolson DL. Behavioral and histological assessment of a novel treatment of neuroHIV in humanized mice.. Research square, 2023.
Zaki Y, Pennington ZT, Morales-Rodriguez D, Francisco TR, LaBanca AR, Dong Z, Lamsifer S, Segura SC, Chen HT, Wick ZC, Silva AJ, van der Meer M, Shuman T, Fenton A, Rajan K, Cai DJ. Aversive experience drives offline ensemble reactivation to link memories across days.. bioRxiv : the preprint server for biology, 2023.
Guo C, Blair GJ, Sehgal M, Sangiuliano Jimka FN, Bellafard A, Silva AJ, Golshani P, Basso MA, Blair HT, Aharoni D. Miniscope-LFOV: A large-field-of-view, single-cell-resolution, miniature microscope for wired and wire-free imaging of neural dynamics in freely behaving animals.. Science advances, 2023.
Lavi A, Sehgal M, de Sousa AF, Ter-Mkrtchyan D, Sisan F, Luchetti A, Okabe A, Bear C, Silva AJ. Local memory allocation recruits memory ensembles across brain regions.. Neuron, 2022.
Chowdhury A, Luchetti A, Fernandes G, Filho DA, Kastellakis G, Tzilivaki A, Ramirez EM, Tran MY, Poirazi P, Silva AJ. A locus coeruleus-dorsal CA1 dopaminergic circuit modulates memory linking.. Neuron, 2022.
Bickle J, De Sousa AF, Silva AJ. New research tools suggest a "levels-less" image of the behaving organism and dissolution of the reduction vs. anti-reduction dispute.. Frontiers in psychology, 2022.
Shen Y, Zhou M, Cai D, Filho DA, Fernandes G, Cai Y, de Sousa AF, Tian M, Kim N, Lee J, Necula D, Zhou C, Li S, Salinas S, Liu A, Kang X, Kamata M, Lavi A, Huang S, Silva T, Heo WD, Silva AJ. CCR5 closes the temporal window for memory linking.. Nature, 2022.
López-Aranda MF, Boxx GM, Phan M, Bach K, Mandanas R, Herrera I, Taloma S, Thadani C, Lu O, Bui R, Liu S, Li N, Zhou Y, Cheng G, Silva AJ. Role of Type I Interferon Signaling and Microglia in the Abnormal Long-term Potentiation and Object Place Recognition Deficits of Male Mice With a Mutation of the Tuberous Sclerosis 2 Gene.. Biological psychiatry global open science, 2022.
Shen Y, Luchetti A, Fernandes G, Do Heo W, Silva AJ. The emergence of molecular systems neuroscience.. Molecular brain, 2022.
López-Aranda MF, Chattopadhyay I, Boxx GM, Fraley ER, Silva TK, Zhou M, Phan M, Herrera I, Taloma S, Mandanas R, Bach K, Gandal M, Geschwind DH, Cheng G, Rzhetsky A, White SA, Silva AJ. Postnatal immune activation causes social deficits in a mouse model of tuberous sclerosis: Role of microglia and clinical implications.. Science advances, 2021.
Wang W, Schuette PJ, La-Vu MQ, Torossian A, Tobias BC, Ceko M, Kragel PA, Reis FM, Ji S, Sehgal M, Maesta-Pereira S, Chakerian M, Silva AJ, Canteras NS, Wager T, Kao JC, Adhikari A. Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats.. eLife, 2021.
de Sousa AF, Chowdhury A, Silva AJ. Dimensions and mechanisms of memory organization.. Neuron, 2021.
Matiasz NJ, Wood J, Wang W, Silva AJ, Hsu W. Experiment Selection in Meta-Analytic Piecemeal Causal Discovery.. IEEE access : practical innovations, open solutions, 2021.
Liraz-Zaltsman S, Friedman-Levi Y, Shabashov-Stone D, Gincberg G, Atrakcy-Baranes D, Joy MT, Carmichael ST, Silva AJ, Shohami E. Chemokine Receptors CC Chemokine Receptor 5 and C-X-C Motif Chemokine Receptor 4 Are New Therapeutic Targets for Brain Recovery after Traumatic Brain Injury.. Journal of neurotrauma, 2021.
Friedman-Levi Y, Liraz-Zaltsman S, Shemesh C, Rosenblatt K, Kesner EL, Gincberg G, Carmichael ST, Silva AJ, Shohami E. Pharmacological blockers of CCR5 and CXCR4 improve recovery after traumatic brain injury.. Experimental neurology, 2021.
Shuman T, Aharoni D, Cai DJ, Lee CR, Chavlis S, Page-Harley L, Vetere LM, Feng Y, Yang CY, Mollinedo-Gajate I, Chen L, Pennington ZT, Taxidis J, Flores SE, Cheng K, Javaherian M, Kaba CC, Rao N, La-Vu M, Pandi I, Shtrahman M, Bakhurin KI, Masmanidis SC, Khakh BS, Poirazi P, Silva AJ, Golshani P. Breakdown of spatial coding and interneuron synchronization in epileptic mice.. Nature neuroscience, 2020.
Yetton BD, Cai DJ, Spoormaker VI, Silva AJ, Mednick SC. Human Memories Can Be Linked by Temporal Proximity.. Frontiers in human neuroscience, 2019.
Luchetti A, Chowdhury A, Silva AJ. Getting the full picture.. eLife, 2019.
Ryu HH, Kim T, Kim JW, Kang M, Park P, Kim YG, Kim H, Ha J, Choi JE, Lee J, Lim CS, Kim CH, Kim SJ, Silva AJ, Kaang BK, Lee YS. Excitatory neuron-specific SHP2-ERK signaling network regulates synaptic plasticity and memory.. Science signaling, 2019.
Joy MT, Ben Assayag E, Shabashov-Stone D, Liraz-Zaltsman S, Mazzitelli J, Arenas M, Abduljawad N, Kliper E, Korczyn AD, Thareja NS, Kesner EL, Zhou M, Huang S, Silva TK, Katz N, Bornstein NM, Silva AJ, Shohami E, Carmichael ST. CCR5 Is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury.. Cell, 2019.
Aharoni D, Khakh BS, Silva AJ, Golshani P. All the light that we can see: a new era in miniaturized microscopy.. Nature methods, 2019.
Howe JR, Bear MF, Golshani P, Klann E, Lipton SA, Mucke L, Sahin M, Silva AJ. The mouse as a model for neuropsychiatric drug development.. Current biology : CB, 2018.
Matiasz NJ, Wood J, Doshi P, Speier W, Beckemeyer B, Wang W, Hsu W, Silva AJ. ResearchMaps.org for integrating and planning research.. PloS one, 2018.
Liraz-Zaltsman S, Slusher B, Atrakchi-Baranes D, Rosenblatt K, Friedman Levi Y, Kesner E, Silva AJ, Biegon A, Shohami E. Enhancement of Brain d-Serine Mediates Recovery of Cognitive Function after Traumatic Brain Injury.. Journal of neurotrauma, 2018.
Hultman R, Ulrich K, Sachs BD, Blount C, Carlson DE, Ndubuizu N, Bagot RC, Parise EM, Vu MT, Gallagher NM, Wang J, Silva AJ, Deisseroth K, Mague SD, Caron MG, Nestler EJ, Carin L, Dzirasa K. Brain-wide Electrical Spatiotemporal Dynamics Encode Depression Vulnerability.. Cell, 2018.
Stivaros S, Garg S, Tziraki M, Cai Y, Thomas O, Mellor J, Morris AA, Jim C, Szumanska-Ryt K, Parkes LM, Haroon HA, Montaldi D, Webb N, Keane J, Castellanos FX, Silva AJ, Huson S, Williams S, Gareth Evans D, Emsley R, Green J, SANTA Consortium. Randomised controlled trial of simvastatin treatment for autism in young children with neurofibromatosis type 1 (SANTA).. Molecular autism, 2018.
Lisman J, Cooper K, Sehgal M, Silva AJ. Memory formation depends on both synapse-specific modifications of synaptic strength and cell-specific increases in excitability.. Nature neuroscience, 2018.
Frank AC, Huang S, Zhou M, Gdalyahu A, Kastellakis G, Silva TK, Lu E, Wen X, Poirazi P, Trachtenberg JT, Silva AJ. Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory.. Nature communications, 2018.
Gonçalves J, Violante IR, Sereno J, Leitão RA, Cai Y, Abrunhosa A, Silva AP, Silva AJ, Castelo-Branco M. Testing the excitation/inhibition imbalance hypothesis in a mouse model of the autism spectrum disorder: in vivo neurospectroscopy and molecular evidence for regional phenotypes.. Molecular autism, 2017.
Silva AJ. Miniaturized two-photon microscope: seeing clearer and deeper into the brain.. Light, science & applications, 2017.
Ibrahim AFA, Montojo CA, Haut KM, Karlsgodt KH, Hansen L, Congdon E, Rosser T, Bilder RM, Silva AJ, Bearden CE. Spatial working memory in neurofibromatosis 1: Altered neural activity and functional connectivity.. NeuroImage. Clinical, 2017.
Silva AJ. Memory's Intricate Web.. Scientific American, 2017.
Oh JY, Rhee S, Silva AJ, Lee YS, Kim HK. Noonan syndrome-associated SHP2 mutation differentially modulates the expression of postsynaptic receptors according to developmental maturation.. Neuroscience letters, 2017.
Jonas RK, Roh E, Montojo CA, Pacheco LA, Rosser T, Silva AJ, Bearden CE. Risky Decision Making in Neurofibromatosis Type 1: An Exploratory Study.. Biological psychiatry. Cognitive neuroscience and neuroimaging, 2017.
Matiasz NJ, Wood J, Wang W, Silva AJ, Hsu W. Computer-Aided Experiment Planning toward Causal Discovery in Neuroscience.. Frontiers in neuroinformatics, 2017.
Zhou M, Greenhill S, Huang S, Silva TK, Sano Y, Wu S, Cai Y, Nagaoka Y, Sehgal M, Cai DJ, Lee YS, Fox K, Silva AJ. CCR5 is a suppressor for cortical plasticity and hippocampal learning and memory.. eLife, 2016.
Payne JM, Barton B, Ullrich NJ, Cantor A, Hearps SJ, Cutter G, Rosser T, Walsh KS, Gioia GA, Wolters PL, Tonsgard J, Schorry E, Viskochil D, Klesse L, Fisher M, Gutmann DH, Silva AJ, Hunter SJ, Rey-Casserly C, Cantor NL, Byars AW, Stavinoha PL, Ackerson JD, Armstrong CL, Isenberg J, O'Neil SH, Packer RJ, Korf B, Acosta MT, North KN, NF Clinical Trials Consortium. Randomized placebo-controlled study of lovastatin in children with neurofibromatosis type 1.. Neurology, 2016.
Kastellakis G, Silva AJ, Poirazi P. Linking Memories across Time via Neuronal and Dendritic Overlaps in Model Neurons with Active Dendrites.. Cell reports, 2016.
Silva AJ, Müller KR. Corrigendum: The need for novel informatics tools for integrating and planning research in molecular and cellular cognition.. Learning & memory (Cold Spring Harbor, N.Y.), 2016.
Rogerson T, Jayaprakash B, Cai DJ, Sano Y, Lee YS, Zhou Y, Bekal P, Deisseroth K, Silva AJ. Molecular and Cellular Mechanisms for Trapping and Activating Emotional Memories.. PloS one, 2016.
Cai DJ, Aharoni D, Shuman T, Shobe J, Biane J, Song W, Wei B, Veshkini M, La-Vu M, Lou J, Flores SE, Kim I, Sano Y, Zhou M, Baumgaertel K, Lavi A, Kamata M, Tuszynski M, Mayford M, Golshani P, Silva AJ. A shared neural ensemble links distinct contextual memories encoded close in time.. Nature, 2016.
Sahin M, Henske EP, Manning BD, Ess KC, Bissler JJ, Klann E, Kwiatkowski DJ, Roberds SL, Silva AJ, Hillaire-Clarke CS, Young LR, Zervas M, Mamounas LA, Tuberous Sclerosis Complex Working Group to Update the Research Plan. Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference.. Pediatric neurology, 2016.
Izquierdo A, Silva AJ. Hijacking translation in addiction.. eLife, 2016.
Bearden CE, Hellemann GS, Rosser T, Montojo C, Jonas R, Enrique N, Pacheco L, Hussain SA, Wu JY, Ho JS, McGough JJ, Sugar CA, Silva AJ. A randomized placebo-controlled lovastatin trial for neurobehavioral function in neurofibromatosis I.. Annals of clinical and translational neurology, 2016.
Tomson SN, Schreiner MJ, Narayan M, Rosser T, Enrique N, Silva AJ, Allen GI, Bookheimer SY, Bearden CE. Resting state functional MRI reveals abnormal network connectivity in neurofibromatosis 1.. Human brain mapping, 2015.
Silva AJ, Müller KR. The need for novel informatics tools for integrating and planning research in molecular and cellular cognition.. Learning & memory (Cold Spring Harbor, N.Y.), 2015.
Korf B, Ahmadian R, Allanson J, Aoki Y, Bakker A, Wright EB, Denger B, Elgersma Y, Gelb BD, Gripp KW, Kerr B, Kontaridis M, Lazaro C, Linardic C, Lozano R, MacRae CA, Messiaen L, Mulero-Navarro S, Neel B, Plotkin S, Rauen KA, Roberts A, Silva AJ, Sittampalam SG, Zhang C, Schoyer L. The third international meeting on genetic disorders in the RAS/MAPK pathway: towards a therapeutic approach.. American journal of medical genetics. Part A, 2015.
Kastellakis G, Cai DJ, Mednick SC, Silva AJ, Poirazi P. Synaptic clustering within dendrites: an emerging theory of memory formation.. Progress in neurobiology, 2015.
Sano Y, Shobe JL, Zhou M, Huang S, Shuman T, Cai DJ, Golshani P, Kamata M, Silva AJ. CREB regulates memory allocation in the insular cortex.. Current biology : CB, 2014.
Lee YS, Ehninger D, Zhou M, Oh JY, Kang M, Kwak C, Ryu HH, Butz D, Araki T, Cai Y, Balaji J, Sano Y, Nam CI, Kim HK, Kaang BK, Burger C, Neel BG, Silva AJ. Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome.. Nature neuroscience, 2014.
Le Belle JE, Sperry J, Ngo A, Ghochani Y, Laks DR, López-Aranda M, Silva AJ, Kornblum HI. Maternal inflammation contributes to brain overgrowth and autism-associated behaviors through altered redox signaling in stem and progenitor cells.. Stem cell reports, 2014.
Achterberg KG, Buitendijk GH, Kool MJ, Goorden SM, Post L, Slump DE, Silva AJ, van Woerden GM, Kushner SA, Elgersma Y. Temporal and region-specific requirements of αCaMKII in spatial and contextual learning.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014.
Czajkowski R, Jayaprakash B, Wiltgen B, Rogerson T, Guzman-Karlsson MC, Barth AL, Trachtenberg JT, Silva AJ. Encoding and storage of spatial information in the retrosplenial cortex.. Proceedings of the National Academy of Sciences of the United States of America, 2014.
Rogerson T, Cai DJ, Frank A, Sano Y, Shobe J, Lopez-Aranda MF, Silva AJ. Synaptic tagging during memory allocation.. Nature reviews. Neuroscience, 2014.
Landreth A, Silva AJ. The need for research maps to navigate published work and inform experiment planning.. Neuron, 2013.
Caccamo A, Magrì A, Medina DX, Wisely EV, López-Aranda MF, Silva AJ, Oddo S. mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies.. Aging cell, 2013.
Han X, Chen M, Wang F, Windrem M, Wang S, Shanz S, Xu Q, Oberheim NA, Bekar L, Betstadt S, Silva AJ, Takano T, Goldman SA, Nedergaard M. Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice.. Cell stem cell, 2013.
Zhou M, Li W, Huang S, Song J, Kim JY, Tian X, Kang E, Sano Y, Liu C, Balaji J, Wu S, Zhou Y, Zhou Y, Parivash SN, Ehninger D, He L, Song H, Ming GL, Silva AJ. mTOR Inhibition ameliorates cognitive and affective deficits caused by Disc1 knockdown in adult-born dentate granule neurons.. Neuron, 2013.
Karlsgodt KH, Rosser T, Lutkenhoff ES, Cannon TD, Silva A, Bearden CE. Alterations in white matter microstructure in neurofibromatosis-1.. PloS one, 2012.
Gutmann DH, Parada LF, Silva AJ, Ratner N. Neurofibromatosis type 1: modeling CNS dysfunction.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012.
Acosta MT, Bearden CE, Castellanos FX, Castellanos XF, Cutting L, Elgersma Y, Gioia G, Gutmann DH, Lee YS, Legius E, Muenke M, North K, Parada LF, Ratner N, Hunter-Schaedle K, Silva AJ. The Learning Disabilities Network (LeaDNet): using neurofibromatosis type 1 (NF1) as a paradigm for translational research.. American journal of medical genetics. Part A, 2012.
Gdalyahu A, Tring E, Polack PO, Gruver R, Golshani P, Fanselow MS, Silva AJ, Trachtenberg JT. Associative fear learning enhances sparse network coding in primary sensory cortex.. Neuron, 2012.
Cho J, Bhatt R, Elgersma Y, Silva AJ. α-Calcium calmodulin kinase II modulates the temporal structure of hippocampal bursting patterns.. PloS one, 2012.
Halt AR, Dallapiazza RF, Zhou Y, Stein IS, Qian H, Juntti S, Wojcik S, Brose N, Silva AJ, Hell JW. CaMKII binding to GluN2B is critical during memory consolidation.. The EMBO journal, 2012.
Silva AJ. Obituary: A career that transformed neuroscience.. Brain research bulletin, 2011.
Kye MJ, Neveu P, Lee YS, Zhou M, Steen JA, Sahin M, Kosik KS, Silva AJ. NMDA mediated contextual conditioning changes miRNA expression.. PloS one, 2011.
Lee YS, Silva AJ. Modeling hyperactivity: of mice and men.. Nature medicine, 2011.
Ehninger D, Silva AJ. Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders.. Trends in molecular medicine, 2010.
Kaneko M, Cheetham CE, Lee YS, Silva AJ, Stryker MP, Fox K. Constitutively active H-ras accelerates multiple forms of plasticity in developing visual cortex.. Proceedings of the National Academy of Sciences of the United States of America, 2010.
Ehninger D, Silva AJ. Increased levels of anxiety-related behaviors in a Tsc2 dominant negative transgenic mouse model of tuberous sclerosis.. Behavior genetics, 2010.
Wiltgen BJ, Zhou M, Cai Y, Balaji J, Karlsson MG, Parivash SN, Li W, Silva AJ. The hippocampus plays a selective role in the retrieval of detailed contextual memories.. Current biology : CB, 2010.
Shilyansky C, Karlsgodt KH, Cummings DM, Sidiropoulou K, Hardt M, James AS, Ehninger D, Bearden CE, Poirazi P, Jentsch JD, Cannon TD, Levine MS, Silva AJ. Neurofibromin regulates corticostriatal inhibitory networks during working memory performance.. Proceedings of the National Academy of Sciences of the United States of America, 2010.
Buard I, Coultrap SJ, Freund RK, Lee YS, Dell'Acqua ML, Silva AJ, Bayer KU. CaMKII "autonomy" is required for initiating but not for maintaining neuronal long-term information storage.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010.
Matynia A, Ng CH, Dansithong W, Chiang A, Silva AJ, Reddy S. Muscleblind1, but not Dmpk or Six5, contributes to a complex phenotype of muscular and motivational deficits in mouse models of myotonic dystrophy.. PloS one, 2010.
Feng J, Zhou Y, Campbell SL, Le T, Li E, Sweatt JD, Silva AJ, Fan G. Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons.. Nature neuroscience, 2010.
Rauen KA, Schoyer L, McCormick F, Lin AE, Allanson JE, Stevenson DA, Gripp KW, Neri G, Carey JC, Legius E, Tartaglia M, Schubbert S, Roberts AE, Gelb BD, Shannon K, Gutmann DH, McMahon M, Guerra C, Fagin JA, Yu B, Aoki Y, Neel BG, Balmain A, Drake RR, Nolan GP, Zenker M, Bollag G, Sebolt-Leopold J, Gibbs JB, Silva AJ, Patton EE, Viskochil DH, Kieran MW, Korf BR, Hagerman RJ, Packer RJ, Melese T. Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back.. American journal of medical genetics. Part A, 2010.
Silva AJ, Zhou Y, Rogerson T, Shobe J, Balaji J. Molecular and cellular approaches to memory allocation in neural circuits.. Science (New York, N.Y.), 2009.
Zhou Y, Won J, Karlsson MG, Zhou M, Rogerson T, Balaji J, Neve R, Poirazi P, Silva AJ. CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala.. Nature neuroscience, 2009.
Ehninger D, Silva AJ. Genetics and neuropsychiatric disorders: treatment during adulthood.. Nature medicine, 2009.
Huynh DP, Maalouf M, Silva AJ, Schweizer FE, Pulst SM. Dissociated fear and spatial learning in mice with deficiency of ataxin-2.. PloS one, 2009.
Silva AJ, Ehninger D. Adult reversal of cognitive phenotypes in neurodevelopmental disorders.. Journal of neurodevelopmental disorders, 2009.
Hutnick LK, Golshani P, Namihira M, Xue Z, Matynia A, Yang XW, Silva AJ, Schweizer FE, Fan G. DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation.. Human molecular genetics, 2009.
Lee YS, Silva AJ. The molecular and cellular biology of enhanced cognition.. Nature reviews. Neuroscience, 2009.
Ehninger D, Li W, Fox K, Stryker MP, Silva AJ. Reversing neurodevelopmental disorders in adults.. Neuron, 2008.
Cui Y, Costa RM, Murphy GG, Elgersma Y, Zhu Y, Gutmann DH, Parada LF, Mody I, Silva AJ. Neurofibromin regulation of ERK signaling modulates GABA release and learning.. Cell, 2008.
Kimura R, Silva AJ, Ohno M. Autophosphorylation of alphaCaMKII is differentially involved in new learning and unlearning mechanisms of memory extinction.. Learning & memory (Cold Spring Harbor, N.Y.), 2008.
Wayman GA, Lee YS, Tokumitsu H, Silva AJ, Silva A, Soderling TR. Calmodulin-kinases: modulators of neuronal development and plasticity.. Neuron, 2008.
Krab LC, de Goede-Bolder A, Aarsen FK, Pluijm SM, Bouman MJ, van der Geest JN, Lequin M, Catsman CE, Arts WF, Kushner SA, Silva AJ, de Zeeuw CI, Moll HA, Elgersma Y. Effect of simvastatin on cognitive functioning in children with neurofibromatosis type 1: a randomized controlled trial.. JAMA, 2008.
Ehninger D, Han S, Shilyansky C, Zhou Y, Li W, Kwiatkowski DJ, Ramesh V, Silva AJ. Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis.. Nature medicine, 2008.
Matynia A, Anagnostaras SG, Wiltgen BJ, Lacuesta M, Fanselow MS, Silva AJ. A high through-put reverse genetic screen identifies two genes involved in remote memory in mice.. PloS one, 2008.
Rauen KA, Hefner E, Carrillo K, Taylor J, Messier L, Aoki Y, Gripp KW, Matsubara Y, Proud VK, Hammond P, Allanson JE, Delrue MA, Axelrad ME, Lin AE, Doyle DA, Kerr B, Carey JC, McCormick F, Silva AJ, Kieran MW, Hinek A, Nguyen TT, Schoyer L. Molecular aspects, clinical aspects and possible treatment modalities for Costello syndrome: Proceedings from the 1st International Costello Syndrome Research Symposium 2007.. American journal of medical genetics. Part A, 2008.
Silva AJ. The science of research: the principles underlying the discovery of cognitive and other biological mechanisms.. Journal of physiology, Paris, 2008.
Zhou Y, Takahashi E, Li W, Halt A, Wiltgen B, Ehninger D, Li GD, Hell JW, Kennedy MB, Silva AJ. Interactions between the NR2B receptor and CaMKII modulate synaptic plasticity and spatial learning.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007.
Li W, Zhou Y, Jentsch JD, Brown RA, Tian X, Ehninger D, Hennah W, Peltonen L, Lönnqvist J, Huttunen MO, Kaprio J, Trachtenberg JT, Silva AJ, Cannon TD. Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice.. Proceedings of the National Academy of Sciences of the United States of America, 2007.
Won J, Silva AJ. Molecular and cellular mechanisms of memory allocation in neuronetworks.. Neurobiology of learning and memory, 2007.
Hojjati MR, van Woerden GM, Tyler WJ, Giese KP, Silva AJ, Pozzo-Miller L, Elgersma Y. Kinase activity is not required for alphaCaMKII-dependent presynaptic plasticity at CA3-CA1 synapses.. Nature neuroscience, 2007.
Han JH, Kushner SA, Yiu AP, Cole CJ, Matynia A, Brown RA, Neve RL, Guzowski JF, Silva AJ, Josselyn SA. Neuronal competition and selection during memory formation.. Science (New York, N.Y.), 2007.
Wiltgen BJ, Silva AJ. Memory for context becomes less specific with time.. Learning & memory (Cold Spring Harbor, N.Y.), 2007.
Murphy GG, Rahnama NP, Silva AJ. Investigation of age-related cognitive decline using mice as a model system: behavioral correlates.. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2006.
Murphy GG, Shah V, Hell JW, Silva AJ. Investigation of age-related cognitive decline using mice as a model system: neurophysiological correlates.. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2006.
Frankland PW, Ding HK, Takahashi E, Suzuki A, Kida S, Silva AJ. Stability of recent and remote contextual fear memory.. Learning & memory (Cold Spring Harbor, N.Y.), 2006.
Ohno M, Sametsky EA, Silva AJ, Disterhoft JF. Differential effects of alphaCaMKII mutation on hippocampal learning and changes in intrinsic neuronal excitability.. The European journal of neuroscience, 2006.
Acosta MT, Gioia GA, Silva AJ. Neurofibromatosis type 1: new insights into neurocognitive issues.. Current neurology and neuroscience reports, 2006.
Nagy V, Bozdagi O, Matynia A, Balcerzyk M, Okulski P, Dzwonek J, Costa RM, Silva AJ, Kaczmarek L, Huntley GW. Matrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memory.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006.
Chen AP, Ohno M, Giese KP, Kühn R, Chen RL, Silva AJ. Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory.. Journal of neuroscience research, 2006.
Li W, Cui Y, Kushner SA, Brown RA, Jentsch JD, Frankland PW, Cannon TD, Silva AJ. The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1.. Current biology : CB, 2005.
Kushner SA, Elgersma Y, Murphy GG, Jaarsma D, van Woerden GM, Hojjati MR, Cui Y, LeBoutillier JC, Marrone DF, Choi ES, De Zeeuw CI, Petit TL, Pozzo-Miller L, Silva AJ. Modulation of presynaptic plasticity and learning by the H-ras/extracellular signal-regulated kinase/synapsin I signaling pathway.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005.
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Ohno M, Tseng W, Silva AJ, Disterhoft JF. Trace eyeblink conditioning requires the hippocampus but not autophosphorylation of alphaCaMKII in mice.. Learning & memory (Cold Spring Harbor, N.Y.), 2005.
Ehninger D, Matynia A, Silva AJ. Trafficking in emotions.. Nature neuroscience, 2005.
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Israely I, Costa RM, Xie CW, Silva AJ, Kosik KS, Liu X. Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction.. Current biology : CB, 2004.
Suzuki A, Josselyn SA, Frankland PW, Masushige S, Silva AJ, Kida S. Memory reconsolidation and extinction have distinct temporal and biochemical signatures.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004.
Frankland PW, Bontempi B, Talton LE, Kaczmarek L, Silva AJ. The involvement of the anterior cingulate cortex in remote contextual fear memory.. Science (New York, N.Y.), 2004.
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Frankland PW, Josselyn SA, Anagnostaras SG, Kogan JH, Takahashi E, Silva AJ. Consolidation of CS and US representations in associative fear conditioning.. Hippocampus, 2004.
Wang J, Ren K, Pérez J, Silva AJ, Peña de Ortiz S. The antimetabolite ara-CTP blocks long-term memory of conditioned taste aversion.. Learning & memory (Cold Spring Harbor, N.Y.), 2003.
Costa RM, Honjo T, Silva AJ. Learning and memory deficits in Notch mutant mice.. Current biology : CB, 2003.
Bozon B, Kelly A, Josselyn SA, Silva AJ, Davis S, Laroche S. MAPK, CREB and zif268 are all required for the consolidation of recognition memory.. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2003.
Frankland PW, Ohno M, Takahashi E, Chen AR, Costa RM, Kushner SA, Silva AJ. Pharmacologically regulated induction of silent mutations (PRISM): combined pharmacological and genetic approaches for learning and memory.. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2003.
Dhaka A, Costa RM, Hu H, Irvin DK, Patel A, Kornblum HI, Silva AJ, O'Dell TJ, Colicelli J. The RAS effector RIN1 modulates the formation of aversive memories.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003.
Silva AJ. Molecular and cellular cognitive studies of the role of synaptic plasticity in memory.. Journal of neurobiology, 2003.
Costa RM, Silva AJ. Mouse models of neurofibromatosis type I: bridging the GAP.. Trends in molecular medicine, 2003.
Anagnostaras SG, Murphy GG, Hamilton SE, Mitchell SL, Rahnama NP, Nathanson NM, Silva AJ. Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice.. Nature neuroscience, 2003.
Taha S, Hanover JL, Silva AJ, Stryker MP. Autophosphorylation of alphaCaMKII is required for ocular dominance plasticity.. Neuron, 2002.
Elgersma Y, Fedorov NB, Ikonen S, Choi ES, Elgersma M, Carvalho OM, Giese KP, Silva AJ. Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning.. Neuron, 2002.
Matynia A, Kushner SA, Silva AJ. Genetic approaches to molecular and cellular cognition: a focus on LTP and learning and memory.. Annual review of genetics, 2002.
Silva AJ, Josselyn SA. The molecules of forgetfulness.. Nature, 2002.
Costa RM, Silva AJ. Molecular and cellular mechanisms underlying the cognitive deficits associated with neurofibromatosis 1.. Journal of child neurology, 2002.
Ohno M, Frankland PW, Silva AJ. A pharmacogenetic inducible approach to the study of NMDA/alphaCaMKII signaling in synaptic plasticity.. Current biology : CB, 2002.
Kida S, Josselyn SA, Peña de Ortiz S, Kogan JH, Chevere I, Masushige S, Silva AJ. CREB required for the stability of new and reactivated fear memories.. Nature neuroscience, 2002.
Givogri MI, Costa RM, Schonmann V, Silva AJ, Campagnoni AT, Bongarzone ER. Central nervous system myelination in mice with deficient expression of Notch1 receptor.. Journal of neuroscience research, 2002.
Costa RM, Federov NB, Kogan JH, Murphy GG, Stern J, Ohno M, Kucherlapati R, Jacks T, Silva AJ. Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1.. Nature, 2002.